Pause-MF Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is klott m 500mg/250mg tablet used for?
This medicine is a combination of Tranexamic Acid 500 mg and Mefenamic Acid 250 mg used to treat heavy menstrual bleeding and menstrual pain. It works by reducing blood clot breakdown and decreasing prostaglandins that cause pain and cramping. It is usually taken during menstruation for up to 5 days, as prescribed by a doctor.
- Generic Name: Tranexamic Acid (500mg) + Mefenamic Acid (250mg)
- Manufacturer: Nebulae Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 klott m 500mg/250mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा ट्रैनेक्सैमिक एसिड और मेफेनैमिक एसिड का संयोजन है, जिसका उपयोग अत्यधिक मासिक धर्म रक्तस्राव (मेनोरेजिया) और मासिक धर्म के दर्द को कम करने के लिए किया जाता है। यह रक्त के थक्के को टूटने से रोकती है और दर्द पैदा करने वाले प्रोस्टाग्लैंडिन को कम करती है। यह दवा आमतौर पर मासिक धर्म के दौरान 5 दिनों तक ली जाती है, लेकिन इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द, चक्कर आना और दस्त शामिल हैं। ये आमतौर पर हल्के होते हैं और खाने के साथ दवा लेने पर कम हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें रक्त के थक्के बनना, गंभीर एलर्जी, गुर्दे की समस्या और पेट में रक्तस्राव शामिल हो सकते हैं। यदि आपको सांस लेने में कठिनाई, सीने में दर्द, या पैर में सूजन जैसे लक्षण दिखें, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक या अवधि से अधिक न लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ सकता है। यदि आपको रक्त के थक्के, स्ट्रोक, या दिल की बीमारी की history है, तो यह दवा न लें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। गुर्दे या लीवर की समस्या होने पर डॉक्टर से सलाह लें। दवा को बच्चों से दूर रखें और कमरे के तापमान पर स्टोर करें।
💊 klott m 500mg/250mg tablet Uses & Benefits
[{"condition":"Heavy menstrual bleeding (menorrhagia)","description":"This medicine reduces menstrual blood loss and relieves associated cramping and pain in women with heavy periods.","evidence":"Well-established"},{"condition":"Primary menorrhagia","description":"Used for heavy bleeding during menstruation when no structural cause is found.","evidence":"Well-established"},{"condition":"Painful menstruation (dysmenorrhea)","description":"The mefenamic acid component helps relieve menstrual cramps and pelvic pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Epistaxis (nosebleeds) in selected patients","description":"Tranexamic acid has been used off-label to control nosebleeds, but the combination with mefenamic acid is not standard for this use.","evidence":"Limited"},{"condition":"Postoperative bleeding prophylaxis","description":"Tranexamic acid alone is sometimes used to reduce bleeding after surgery, but the combination product is not typically used for this purpose.","evidence":"Limited"}]
Primary treatment for: Heavy menstrual bleeding (menorrhagia)
Also treats: Painful menstruation (dysmenorrhea), Primary menorrhagia
📋 Drug Information
| Generic Name(s) | Tranexamic Acid (500mg) + Mefenamic Acid (250mg) |
| Brand Name | klott m 500mg/250mg tablet |
| Manufacturer | Nebulae Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Store in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Tranexamic Acid is an antifibrinolytic agent that reversibly blocks lysine binding sites on plasminogen, preventing its conversion to plasmin and thereby inhibiting the breakdown of fibrin clots. This reduces excessive bleeding. Mefenamic Acid is a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase enzymes, reducing the production of prostaglandins, which are responsible for pain, inflammation, and uterine contractions. Together, they reduce both blood loss and pain associated with heavy menstrual bleeding.
Mechanism Steps
💡 How to Take klott m 500mg/250mg tablet
Strength: Each tablet contains Tranexamic Acid 500 mg and Mefenamic Acid 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken two to three times daily during menstruation, as prescribed by your doctor. The dose may vary depending on the severity of bleeding and your response to treatment. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding, kidney problems, and blood clots. Use with caution and under close medical supervision. Dose adjustment may be necessary based on kidney function. |
| Renal Impairment | Dose adjustment is required in patients with kidney impairment. Tranexamic acid is primarily excreted by the kidneys, and accumulation can occur. In patients with mild to moderate kidney impairment, the dose may need to be reduced or the dosing interval extended. This medicine is contraindicated in severe kidney disease. Consult your doctor for individualized dosing. |
| Hepatic Impairment | No specific dose adjustment is established for patients with liver impairment. However, mefenamic acid is metabolized in the liver, and caution is advised. Monitor liver function if used in patients with liver disease. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets (providing 1500 mg tranexamic acid and 750 mg mefenamic acid) per day, unless otherwise directed by your doctor. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of klott m 500mg/250mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Ibuprofen | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| Furosemide | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Other NSAIDs (e.g., aspirin, ibuprofen, naproxen)
- Methotrexate
- Lithium
⚡ Moderate Interactions
- ACE inhibitors and angiotensin receptor blockers (ARBs)
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- Corticosteroids
- Selective serotonin reuptake inhibitors (SSRIs)
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can worsen side effects such as dizziness and stomach upset. It may also increase the risk of liver problems.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active blood clots or history of thrombosis","Severe kidney disease (e.g., creatinine clearance less than 30 mL/min)","Active peptic ulcer disease or gastrointestinal bleeding","Known allergy to tranexamic acid or mefenamic acid","Severe heart failure","History of stroke or transient ischemic attack","Pregnancy (especially third trimester)","Breastfeeding without medical advice"]
⚠️ Warnings & Precautions
["Use with caution in patients with a history of blood clots or cardiovascular disease.","Avoid in patients with active bleeding or ulcer disease.","Monitor kidney function in patients with kidney disease.","May cause visual disturbances; stop and consult a doctor if these occur.","Do not use for more than 5 days without medical advice.","Avoid alcohol during treatment.","May increase the risk of seizures in susceptible individuals.","Use with caution in elderly patients due to increased risk of side effects.","Inform your doctor if you are taking any other medications, especially blood thinners.","Do not drive or operate machinery if you experience dizziness or visual changes."]
🤱 Lactation Safety
Tranexamic acid is excreted in breast milk in small amounts. Mefenamic acid also passes into breast milk. This medicine is not recommended during breastfeeding unless the potential benefit outweighs the risk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, gastrointestinal bleeding, dizziness, and potentially seizures or blood clots. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if the overdose is recent. Monitor vital signs, kidney function, and for signs of bleeding or clotting.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Swallow the tablet whole with a full glass of water, preferably with food to reduce stomach upset. Avoid taking this medicine with alcohol, as it can increase the risk of stomach bleeding. Do not use this medicine if you have a history of blood clots, stroke, or heart attack. Inform your doctor about all other medicines you are taking, especially blood thinners, other pain relievers, or hormonal contraceptives. If you have kidney or liver problems, your doctor may need to adjust your dose or monitor you more closely. Do not drive or operate heavy machinery if you feel dizzy or have visual changes. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. If you miss a dose, follow the missed dose instructions provided by your doctor. Do not start or stop this medicine without consulting your healthcare provider.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly women are more likely to have underlying health conditions such as kidney or heart disease, which may increase the risk of side effects. This medicine should be used with caution in elderly patients, and kidney function should be monitored. Dose adjustment may be necessary.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during pregnancy, especially in the third trimester, as it may harm the fetus. Discuss alternative treatments for heavy menstrual bleeding if you are trying to conceive.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon or doctor before taking this medicine. Tranexamic acid may increase the risk of blood clots after surgery, and mefenamic acid can increase bleeding risk. Your doctor will decide if it is safe for you.
🦷 Dental Procedures
Before any dental procedure, inform your dentist that you are taking this medicine. It may affect bleeding during dental work. Your dentist may recommend stopping the medicine temporarily or taking precautions to control bleeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
You can continue light to moderate exercise while taking this medicine, but avoid strenuous activities if you feel dizzy or fatigued. If you experience heavy bleeding, take rest and avoid intense workouts until you feel better. Consult your doctor before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or visual disturbances in some people. If you experience these effects, avoid driving or operating heavy machinery. Otherwise, you can continue your normal daily activities. It is advisable to take it with food to minimize stomach upset that could affect your workday.
🛑 When to Stop This Medicine
Stop taking this medicine after the prescribed duration, usually at the end of your menstrual period or after 5 days, unless your doctor advises otherwise. If you experience any serious side effects, stop immediately and seek medical attention. Do not stop or change the dose without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine without medical supervision may increase the risk of kidney problems, gastrointestinal bleeding, and blood clots. It is not intended for continuous use. If you need treatment for more than a few cycles, your doctor should evaluate the underlying cause of your heavy bleeding and consider other treatment options. Regular monitoring of kidney function, liver function, and blood counts may be required if prolonged use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Birth control pills can help regulate and reduce heavy menstrual bleeding.
Evidence: Well-establishedA device placed in the uterus that reduces menstrual bleeding.
Evidence: Well-establishedHelps prevent or treat anemia caused by heavy periods.
Evidence: Well-establishedFor severe cases, procedures like endometrial ablation or hysterectomy may be considered.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccinations as scheduled. However, if you are feeling unwell due to heavy bleeding or side effects, consult your doctor before getting vaccinated.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription in case you need to show it at customs. Store it in a cool, dry place away from direct sunlight. If you are crossing time zones, continue taking the medicine as prescribed during your menstrual period; no specific time zone adjustment is needed for short-term use. Always pack it in your carry-on luggage to avoid loss.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts reducing bleeding and pain within a few hours of taking the first dose. However, the full effect may take a day or two.
A: You should avoid taking other NSAIDs (like ibuprofen or aspirin) with this medicine due to increased risk of stomach bleeding. Consult your doctor before taking any other painkiller.
A: This medicine is not recommended during pregnancy, especially in the third trimester, unless clearly needed and prescribed by a doctor. Consult your doctor immediately if you are pregnant or planning to become pregnant.
A: No, this medicine is intended for short-term use during menstruation, usually for up to 5 days. Prolonged use should only be done under medical supervision.
🤔 Common Patient Concerns
🔄 Substitutes for klott m 500mg/250mg tablet
View AllAlternative brands with exact same active ingredient:
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cyclosym tx tabletSymbiosis Lab ₹13.14 91.8% CHEAPER
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tramed p 500 mg/250 mg tabletView Laboratories ₹26.25 83.5% CHEAPER
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femidol 500 mg/250 mg tabletWest-Coast Pharmaceutical Works Ltd ₹29.84 81.3% CHEAPER
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orsik tabletOrnate Labs Pvt Ltd ₹44.01 72.4% CHEAPER
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Transpa 500mg/250mg TabletNature Biotech ₹45.00 71.8% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of bleeding.
Fact: This medicine is specifically approved for heavy menstrual bleeding and should not be used for other types of bleeding without medical advice. - Myth: This medicine is safe to take every day.
Fact: This medicine is intended for short-term use during menstruation, usually for up to 5 days per cycle. Long-term use requires medical supervision. - Myth: This medicine can be taken without a prescription.
Fact: This medicine is a prescription drug and should only be taken under the guidance of a qualified clinician. - Myth: This medicine can be used to prevent pregnancy.
Fact: This medicine is not a contraceptive and does not prevent pregnancy.
🔄 Alternative Options
Generic Alternatives
- Tranexamic Acid + Mefenamic Acid
Brand Alternatives
- Pause-MF Tablet