Petril Beta 10 Tablet: Complete Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Very slow heartbeat or fainting
- Difficulty breathing or wheezing
- Severe dizziness or confusion
- Swelling of face, lips, tongue, or throat
- Yellowing of skin or eyes
- Unusual bruising or bleeding
- Seizures or severe tremors
- Thoughts of self-harm or suicide
If experiencing severe symptoms, call emergency services immediately.
What is klocalm-plus hd tablet used for?
This medicine is a prescription combination of clonazepam 0.25 mg and propranolol 10 mg used to treat anxiety disorders with both psychological and physical symptoms. It works by calming the brain and reducing heart rate and tremor. It must be taken exactly as prescribed and not stopped suddenly.
- Generic Name: Clonazepam (0.25mg) + Propranolol (10mg)
- Manufacturer: OSR Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 klocalm-plus hd tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोनाजेपम 0.25 मिलीग्राम और प्रोप्रानोलोल 10 मिलीग्राम का संयोजन है, जिसका उपयोग चिंता विकार के इलाज के लिए किया जाता है। यह मानसिक तनाव को कम करने और दिल की धड़कन, कंपन और पसीने जैसे शारीरिक लक्षणों को नियंत्रित करने में मदद करती है। यह दवा केवल डॉक्टर के पर्चे पर ही मिलती है और इसे डॉक्टर के बताए अनुसार ही लेना चाहिए। इसे अचानक बंद नहीं करना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, थकान और हाथ-पैर ठंडे होना शामिल हैं। गंभीर दुष्प्रभावों में धीमी हृदय गति, सांस लेने में कठिनाई, और गंभीर एलर्जी प्रतिक्रिया हो सकती है। दुर्लभ मामलों में रक्त विकार और त्वचा पर गंभीर प्रतिक्रिया हो सकती है। लंबे समय तक उपयोग से निर्भरता हो सकती है।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं या तोड़ें नहीं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। शराब का सेवन न करें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। इसे अचानक बंद न करें। बच्चों की पहुंच से दूर रखें।
💊 klocalm-plus hd tablet Uses & Benefits
[{"condition":"Anxiety disorders with prominent physical symptoms","description":"This medicine may be prescribed to reduce both the psychological symptoms of anxiety, such as excessive worry, and the physical symptoms, such as palpitations, tremor, and sweating.","evidence":"Established for the individual components; combination use is based on clinical judgment."},{"condition":"Situational anxiety with autonomic hyperactivity","description":"Sometimes used short-term for anxiety triggered by specific situations where physical symptoms like rapid heartbeat and trembling are prominent.","evidence":"Limited for the combination; individual components have evidence."}]
Off-label uses: [{"condition":"Performance anxiety","description":"Propranolol is sometimes used off-label for performance anxiety, and clonazepam may be added for its anxiolytic effect, but this combination is not standard.","evidence":"Limited"},{"condition":"Essential tremor with anxiety","description":"Propranolol is used for essential tremor, and clonazepam may be added for anxiety, but the combination is not formally approved for this purpose.","evidence":"Limited"}]
Primary treatment for: Anxiety disorders
Also treats: Panic disorder, Situational anxiety, Essential tremor with anxiety
📋 Drug Information
| Generic Name(s) | Clonazepam (0.25mg) + Propranolol (10mg) |
| Brand Name | klocalm-plus hd tablet |
| Manufacturer | OSR Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not store in the bathroom. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Clonazepam enhances the inhibitory effects of gamma-aminobutyric acid (GABA) in the brain by binding to benzodiazepine sites on GABA-A receptors, leading to increased chloride channel opening and neuronal hyperpolarization, which produces anxiolytic, sedative, and muscle relaxant effects. Propranolol is a non-selective beta-adrenergic receptor antagonist that blocks beta-1 and beta-2 receptors, reducing heart rate, cardiac output, and renin release, and also blocking the physical manifestations of anxiety such as tremor, palpitations, and sweating. Together, they target both central and peripheral symptoms of anxiety.
Mechanism Steps
💡 How to Take klocalm-plus hd tablet
Strength: Tablet containing clonazepam 0.25 mg and propranolol 10 mg.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to therapy. Typically, treatment is initiated at a low dose and gradually titrated upward to achieve the desired effect while minimizing side effects. The usual starting dose may be one tablet taken once or twice daily, but this can vary. Do not adjust the dose without consulting your doctor. Take the tablet with a glass of water, with or without food, but consistently in relation to meals. Do not crush or chew the tablet. Follow your doctor's instructions exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the effects of this medicine, especially to clonazepam's sedative and cognitive effects and propranolol's cardiovascular effects. Start with a lower dose and titrate slowly. Monitor closely for falls, confusion, and bradycardia. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Monitor renal function. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Monitor liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the patient's condition and response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of klocalm-plus hd tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| CYP3A4 inhibitors | Major | |
| CYP2D6 inhibitors | Major | |
| Calcium channel blockers | Major | |
| Digoxin | Major | |
| CNS depressants | Moderate | |
| NSAIDs | Moderate | |
| Oral hypoglycemics | Moderate | |
| Antacids | Minor | |
| Cimetidine | Minor |
🚨 Major Interactions
- MAO inhibitors
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
- Calcium channel blockers (e.g., verapamil, diltiazem)
- Digoxin
⚡ Moderate Interactions
- CNS depressants (e.g., opioids, alcohol, antihistamines)
- NSAIDs
- Oral hypoglycemics and insulin
- Thyroid hormones
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol enhances the sedative effects of clonazepam and can lead to severe drowsiness, respiratory depression, and impaired motor skills. It may also exacerbate the blood pressure-lowering effect of propranolol, causing dizziness and fainting.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to clonazepam, propranolol, or any component of the formulation","Severe respiratory insufficiency","Acute narrow-angle glaucoma","Severe bradycardia","Second- or third-degree heart block","Cardiogenic shock","Decompensated heart failure","Bronchial asthma or severe chronic obstructive pulmonary disease","Myasthenia gravis","Severe hepatic impairment","Pregnancy (especially first trimester)","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine can cause physical and psychological dependence. Use with caution in patients with a history of substance abuse.","Do not stop this medicine abruptly, as it can cause withdrawal symptoms including seizures, tremors, and anxiety.","May impair mental and physical abilities required for driving or operating machinery.","Avoid alcohol and other CNS depressants.","Use with caution in elderly patients due to increased risk of falls, confusion, and cognitive impairment.","May mask symptoms of hypoglycemia in diabetic patients.","May exacerbate symptoms of myasthenia gravis.","Use with caution in patients with a history of depression or suicidal ideation.","May cause fetal harm when administered to a pregnant woman.","Not recommended for use in children."]
🤱 Lactation Safety
Clonazepam and propranolol are both excreted in breast milk. Clonazepam may cause sedation and poor feeding in the infant. Propranolol may cause bradycardia and hypotension in the infant. Breastfeeding is not recommended while taking this medicine. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, coma, respiratory depression, bradycardia, hypotension, and cardiac arrest. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic. Gastric lavage may be considered if within 1-2 hours of ingestion. Activated charcoal may be administered. Flumazenil may be used cautiously for benzodiazepine overdose, but it can precipitate seizures in dependent patients. For propranolol overdose, glucagon, atropine, and vasopressors may be used. Hemodialysis may be considered for severe propranolol toxicity.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, consult your doctor before resuming.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet unless instructed. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not consume alcohol while taking this medicine, as it can increase drowsiness and dizziness. Inform your doctor about all other medicines, supplements, and herbal products you are taking. Do not stop this medicine suddenly, as it can cause withdrawal symptoms. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and cognitive effects of clonazepam and the cardiovascular effects of propranolol. They are at increased risk of falls, confusion, and bradycardia. Start with a lower dose and titrate slowly. Regular monitoring of heart rate, blood pressure, and mental status is recommended. Avoid driving and activities requiring alertness until the effects are known.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy as it may harm the fetus. If you are planning to become pregnant, consult your doctor to discuss alternative treatments. Use effective contraception while taking this medicine. If you become pregnant while taking this medicine, contact your doctor immediately.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. Propranolol may interact with anesthetic agents and can affect heart rate and blood pressure during surgery. Clonazepam may increase the sedative effects of anesthesia. Your doctor may advise you to temporarily stop or adjust the dose before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. This medicine may cause dry mouth, which can increase the risk of dental problems. Propranolol may interact with local anesthetics containing epinephrine, potentially causing changes in heart rate and blood pressure. Your dentist may need to adjust the anesthetic used.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness, dizziness, and reduced heart rate, which can affect your ability to exercise safely. Avoid strenuous exercise until you know how this medicine affects you. Stay hydrated during exercise. If you experience dizziness, shortness of breath, or chest pain, stop exercising and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and impaired concentration, which may affect your ability to perform work tasks, especially those requiring alertness or operating machinery. Avoid driving or operating heavy machinery until you know how this medicine affects you. Inform your employer if your job involves safety-sensitive tasks. Take regular breaks and avoid working late hours if you feel excessively drowsy.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will gradually reduce the dose over time to prevent withdrawal symptoms. If you experience side effects that are bothersome, contact your doctor for advice. If you wish to discontinue, discuss a tapering plan with your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to physical and psychological dependence, especially due to the clonazepam component. Withdrawal symptoms may occur upon discontinuation. Propranolol can cause reduced heart rate and blood pressure, and may mask symptoms of hypoglycemia. Regular monitoring of heart rate, blood pressure, liver and kidney function, and mental status is recommended. Periodic review by your doctor is essential to assess the need for continued therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
CBT is an effective non-drug treatment for anxiety disorders and can complement or replace medication in some cases.
Evidence: Well-establishedDeep breathing, progressive muscle relaxation, and mindfulness meditation can help reduce anxiety symptoms.
Evidence: Well-establishedRegular physical activity can reduce anxiety and improve overall well-being.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking. Continue taking this medicine as prescribed unless your doctor advises otherwise.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Do not pack it in checked baggage. Check local customs regulations regarding controlled substances before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after taking a dose. However, the full therapeutic effect for anxiety may take a few days to weeks of regular use.
A: Yes, you can take this medicine with or without food. Taking it with food may help reduce stomach upset. Be consistent with how you take it.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop this medicine suddenly. It can cause withdrawal symptoms such as seizures, tremors, and anxiety. Your doctor will taper the dose gradually.
A: This medicine may harm the fetus. Consult your doctor immediately if you are pregnant or planning to become pregnant. It is not recommended during pregnancy.
🤔 Common Patient Concerns
🔄 Substitutes for klocalm-plus hd tablet
View AllAlternative brands with exact same active ingredient:
-
clotas plus hd 0.25mg/10mg tabletTas Med India Pvt Ltd ₹25.31 8% COSTLIER
-
lonafest p 0.25mg/10mg tabletArinna Lifescience Pvt Ltd ₹26.25 12% COSTLIER
-
calm beta 10 mg tabletMed Manor Organics Pvt Ltd ₹26.81 14.4% COSTLIER
-
mizral c 0.25mg/10mg tabletRyon Pharma ₹27.00 15.2% COSTLIER
-
clovik beta 0.25mg/10mg tabletViking Pharma Opc Pvt Ltd ₹30.00 28% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is primarily used for anxiety, not as a sleeping aid. It may cause drowsiness as a side effect. - Myth: I can stop this medicine whenever I feel better.
Fact: Stopping suddenly can cause withdrawal symptoms. Always taper under medical supervision. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol increases the sedative effects and can be dangerous. Avoid alcohol completely. - Myth: This medicine is not addictive.
Fact: Clonazepam can cause dependence and withdrawal. Use only as prescribed.
🔄 Alternative Options
Generic Alternatives
- Clonazepam 0.25 mg + Propranolol 10 mg tablet (generic)
Brand Alternatives
- Petril Beta 10 Tablet