Calm Beta 10 Mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Slow, shallow, or difficulty breathing
- Severe dizziness, fainting, or irregular heartbeat
- Confusion, hallucinations, or unusual behavior
- Seizures or convulsions
- Severe allergic reaction (rash, swelling of face, lips, or throat)
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is clovik beta 0.25mg/10mg tablet used for?
This medicine is a prescription combination of clonazepam (0.25 mg) and propranolol (10 mg) used for short-term treatment of anxiety disorders. It works by calming the brain and reducing physical anxiety symptoms like rapid heartbeat and tremors. It can cause drowsiness and dependence, so it must be taken exactly as prescribed and never stopped suddenly.
- Generic Name: Clonazepam + Propranolol
- Manufacturer: Viking Pharma Opc Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 clovik beta 0.25mg/10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोनाज़ेपम 0.25 मिलीग्राम और प्रोप्रानोलोल 10 मिलीग्राम का संयोजन है, जिसका उपयोग चिंता विकार, घबराहट, और शारीरिक लक्षणों जैसे तेज़ धड़कन और कंपन के इलाज के लिए किया जाता है। यह दवा केवल डॉक्टर के पर्चे पर मिलती है और इसे डॉक्टर की सलाह के अनुसार ही लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, थकान, हाथ-पैर ठंडे होना, और हृदय गति कम होना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, बेहोशी, धीमी धड़कन, भ्रम, और अवसाद हो सकते हैं। लंबे समय तक उपयोग से निर्भरता और छोड़ने पर लक्षण उत्पन्न हो सकते हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। बिना सलाह के खुराक न बढ़ाएं या घटाएं। दवा लेते समय वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन न करें। दवा अचानक बंद न करें, इससे दौरे पड़ सकते हैं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 clovik beta 0.25mg/10mg tablet Uses & Benefits
[{"condition":"Anxiety disorders","description":"Used for short-term relief of severe anxiety symptoms, including panic attacks and generalized anxiety, when other treatments are not effective.","evidence":"Well-established for clonazepam; propranolol has moderate evidence for performance anxiety."},{"condition":"Situational anxiety (performance anxiety)","description":"Propranolol reduces physical symptoms of anxiety such as tremors and rapid heartbeat before public speaking or exams.","evidence":"Moderate evidence for propranolol; clonazepam adds central calming effect."},{"condition":"Movement disorders (e.g., essential tremor)","description":"Propranolol is used to reduce tremors; clonazepam may help with associated anxiety.","evidence":"Propranolol is well-established for essential tremor; clonazepam has limited evidence."}]
Off-label uses: [{"condition":"Insomnia","description":"Clonazepam is sometimes prescribed off-label for short-term sleep difficulties, but this is not a first-line treatment.","evidence":"Limited"},{"condition":"Migraine prophylaxis","description":"Propranolol is used off-label for preventing migraines, though the combination with clonazepam is not standard.","evidence":"Propranolol has moderate evidence; combination is not established."}]
Primary treatment for: Anxiety disorders
Also treats: Panic disorder, Performance anxiety, Essential tremor, Migraine prophylaxis (propranolol component)
📋 Drug Information
| Generic Name(s) | Clonazepam + Propranolol |
| Brand Name | Avene (Abbott) 0.5mg/10mg Tablet |
| Manufacturer | Viking Pharma Opc Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Benzodiazepine + Beta-blocker |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture, or as indicated on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Clonazepam enhances the inhibitory effect of gamma-aminobutyric acid (GABA) at GABA-A receptors in the brain, leading to increased neuronal membrane permeability to chloride ions, hyperpolarization, and reduced neuronal excitability. Propranolol is a non-selective beta-adrenergic receptor blocker that competitively inhibits beta-1 and beta-2 receptors, reducing heart rate, cardiac output, and renin release, and also blocking peripheral vasodilation. The combination provides central anxiolytic effects from clonazepam and peripheral sympatholytic effects from propranolol.
Mechanism Steps
💡 How to Take clovik beta 0.25mg/10mg tablet
Strength: Each tablet contains clonazepam 0.25 mg and propranolol 10 mg. Immediate-release oral tablet.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and clinical response. Typically, for anxiety, the starting dose is one tablet taken once or twice daily, and the dose may be gradually adjusted. The maximum daily dose should not exceed the limit prescribed by your doctor. Do not self-adjust the dose. Take this medicine exactly as prescribed, with or without food, but consistently. Do not crush or chew the tablet unless advised. If you have been taking this medicine for a long time, do not stop suddenly; your doctor will taper the dose gradually. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the effects of clonazepam and propranolol. Start with a lower dose and titrate slowly. Monitor for increased sedation, confusion, dizziness, and falls. Regular review of the need for continued therapy is recommended. |
| Renal Impairment | Dose adjustment may be required in patients with severe renal impairment. Clonazepam and propranolol are not significantly removed by dialysis. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Clonazepam and propranolol are extensively metabolized in the liver. Dose reduction and close monitoring are recommended. Avoid in severe liver disease. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the patient's condition and response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of clovik beta 0.25mg/10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | |
| Metformin | Minor | |
| Insulin | Moderate | |
| Verapamil | Major | |
| Diltiazem | Major | |
| Fluoxetine | Moderate | |
| Ketoconazole | Moderate | |
| Rifampin | Moderate | |
| Clonidine | Major | |
| Theophylline | Moderate |
🚨 Major Interactions
- CNS depressants (e.g., alcohol, opioids, barbiturates)
- MAO inhibitors
- Calcium channel blockers (e.g., verapamil, diltiazem)
- Digoxin
- Clonidine
⚡ Moderate Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- NSAIDs
- Antacids
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both clonazepam and propranolol can cause drowsiness and dizziness, and alcohol significantly enhances these effects. Combining alcohol with clonazepam can lead to severe respiratory depression, coma, and even death. Alcohol may also increase the risk of stomach bleeding and affect blood pressure control.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to clonazepam, propranolol, or any component of the formulation","Severe respiratory depression or acute narrow-angle glaucoma (clonazepam)","Severe liver disease","Asthma or severe chronic obstructive pulmonary disease (propranolol)","Sinus bradycardia, second- or third-degree heart block, cardiogenic shock, or decompensated heart failure (propranolol)","Myasthenia gravis","Concomitant use with MAO inhibitors"]
⚠️ Warnings & Precautions
["This medicine can cause physical and psychological dependence. Use with caution in patients with a history of substance abuse.","Do not stop this medicine abruptly, as it can precipitate withdrawal seizures, anxiety, and insomnia.","May impair mental and physical abilities required for driving or operating machinery.","Avoid alcohol and other CNS depressants.","Use with caution in elderly patients due to increased risk of falls, confusion, and cognitive impairment.","Propranolol may mask symptoms of hypoglycemia in diabetic patients.","Propranolol may worsen symptoms of asthma, peripheral vascular disease, and Raynaud's phenomenon.","Clonazepam may cause paradoxical reactions such as agitation, aggression, and hallucinations.","Use with caution in patients with renal or hepatic impairment; dose adjustment may be needed."]
🤱 Lactation Safety
Clonazepam and propranolol are excreted in breast milk. Clonazepam may cause sedation and poor feeding in the infant. Propranolol may cause bradycardia and hypotension in the infant. Breastfeeding is not recommended while taking this medicine. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, coma, respiratory depression, bradycardia, hypotension, and cardiac arrest. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic. Gastric lavage may be considered if within 1-2 hours of ingestion. Activated charcoal may be administered. Flumazenil, a benzodiazepine antagonist, can reverse clonazepam effects but may precipitate seizures in dependent patients. For propranolol toxicity, glucagon, atropine, and vasopressors may be used. Hemodialysis is not effective for clonazepam but may be considered for propranolol in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you miss multiple doses, contact your doctor for guidance. Do not stop taking this medicine abruptly without medical advice.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose without medical advice. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not drink alcohol while taking this medicine, as it can increase drowsiness and dizziness. Do not stop this medicine suddenly, especially if you have been taking it for more than a few weeks, as this can cause withdrawal seizures or rebound anxiety. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of clonazepam and propranolol. They are at higher risk of falls, confusion, cognitive impairment, and bradycardia. Start with a lower dose and titrate slowly. Regular monitoring of heart rate, blood pressure, and mental status is recommended. Avoid long-term use if possible.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Clonazepam and propranolol may harm the fetus. Your doctor may switch you to a safer alternative or adjust the dose. Use effective contraception while taking this medicine. If you become pregnant while taking this medicine, contact your doctor immediately.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. Propranolol may interact with anesthetic agents and cause bradycardia or hypotension. Clonazepam may increase the sedative effects of anesthesia. Your doctor may advise you to stop or adjust the dose before surgery. Do not stop the medicine without medical advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. This medicine can cause dry mouth, which may increase the risk of dental problems. Propranolol may interact with local anesthetics containing epinephrine, causing hypertension or bradycardia. Your dentist may need to adjust the anesthetic used.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness, dizziness, and reduced heart rate. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you experience dizziness or shortness of breath during exercise, stop and consult your doctor. Propranolol can reduce exercise tolerance by blunting heart rate response.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job involves operating heavy machinery. The sedative effects may also impact your productivity and concentration. Discuss with your doctor if you experience significant impairment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will gradually taper the dose to prevent withdrawal symptoms such as seizures, anxiety, and insomnia. If you experience severe side effects or wish to discontinue, contact your doctor for a safe tapering plan. In case of a serious allergic reaction or emergency, seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, dependence, and withdrawal symptoms. Clonazepam may cause cognitive impairment, memory problems, and falls, especially in the elderly. Propranolol may cause fatigue, cold extremities, and sexual dysfunction. Regular monitoring of heart rate, blood pressure, and mental status is recommended. Periodic review of the need for continued therapy is essential. Do not stop the medicine without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A type of talk therapy that helps change negative thought patterns and behaviors contributing to anxiety.
Evidence: Well-establishedFirst-line medications for anxiety disorders with a better safety profile for long-term use.
Evidence: Well-establishedPractices such as meditation, yoga, and deep breathing can help reduce anxiety symptoms.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking. Live vaccines should be avoided if you are on immunosuppressive therapy, but this medicine is not immunosuppressive.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Do not pack it in checked baggage. Check local customs regulations regarding controlled substances before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after taking a dose. However, the full benefits for anxiety may take a few days to weeks of regular use.
A: Yes, you can take this medicine with or without food. Taking it with food may reduce stomach upset. Avoid grapefruit juice as it can increase the effects of clonazepam.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, you should never stop this medicine suddenly as it can cause withdrawal symptoms including seizures. Your doctor will gradually reduce the dose over time.
A: This medicine may harm the fetus. Consult your doctor if you are pregnant or planning to become pregnant. It is not recommended during pregnancy unless clearly needed.
🤔 Common Patient Concerns
🔄 Substitutes for clovik beta 0.25mg/10mg tablet
View AllAlternative brands with exact same active ingredient:
-
klocalm-plus hd tabletOSR Pharmaceuticals Pvt Ltd ₹23.44 21.9% CHEAPER
-
clotas plus hd 0.25mg/10mg tabletTas Med India Pvt Ltd ₹25.31 15.6% CHEAPER
-
lonafest p 0.25mg/10mg tabletArinna Lifescience Pvt Ltd ₹26.25 12.5% CHEAPER
-
calm beta 10 mg tabletMed Manor Organics Pvt Ltd ₹26.81 10.6% CHEAPER
-
mizral c 0.25mg/10mg tabletRyon Pharma ₹27.00 10% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is primarily used for anxiety, not as a sleeping aid. It may cause drowsiness as a side effect. - Myth: I can stop this medicine whenever I want.
Fact: Stopping this medicine suddenly can cause serious withdrawal symptoms, including seizures. Always taper under medical supervision. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol increases the sedative effects and can cause dangerous respiratory depression. Avoid alcohol completely. - Myth: This medicine is not addictive.
Fact: Clonazepam can cause physical and psychological dependence, especially with long-term use.
🔄 Alternative Options
Generic Alternatives
- Clonazepam 0.25 mg + Propranolol 10 mg tablet (generic)
Brand Alternatives
- Calm Beta 10 mg Tablet