Atdim 1000mg Injection (Ceftazidime): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe or bloody diarrhea
- Seizures or confusion
- Unusual bleeding or bruising
- Decreased urine output or swelling
- Severe skin rash with blisters or peeling
- Persistent fever despite treatment
If experiencing severe symptoms, call emergency services immediately.
What is keftaglan 1000mg injection used for?
This medicine is a third-generation cephalosporin antibiotic containing Ceftazidime 1000mg. It is given by injection to treat serious bacterial infections, including pneumonia, urinary tract infections, and sepsis. It works by killing bacteria and must be administered by a healthcare professional.
- Generic Name: Ceftazidime (1000mg)
- Manufacturer: Gland Pharma Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 keftaglan 1000mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफ्टाज़िडाइम 1000mg इंजेक्शन के रूप में एक तीसरी पीढ़ी का सेफलोस्पोरिन एंटीबायोटिक है। इसका उपयोग गंभीर बैक्टीरियल संक्रमणों जैसे निमोनिया, मूत्र मार्ग संक्रमण, त्वचा संक्रमण, सेप्सिस और मेनिनजाइटिस के इलाज के लिए किया जाता है। यह दवा बैक्टीरिया की कोशिका भित्ति को नष्ट करके उन्हें मार देती है। यह केवल डॉक्टर या नर्स द्वारा इंजेक्शन के माध्यम से दी जाती है। इसे स्वयं न लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, लालिमा या सूजन, दस्त, मतली, उल्टी, और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभावों में एनाफिलेक्सिस, गंभीर दस्त, दौरे, और रक्त विकार शामिल हो सकते हैं। यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दस्त हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा दी जानी चाहिए। उपयोग से पहले अपने डॉक्टर को किसी भी एलर्जी, गुर्दे या यकृत की समस्या के बारे में बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें। उपचार के दौरान शराब से बचें। दवा का पूरा कोर्स पूरा करें।
💊 keftaglan 1000mg injection Uses & Benefits
[{"condition":"Lower respiratory tract infections","description":"Used to treat pneumonia and bronchitis caused by susceptible Gram-negative bacteria, including Pseudomonas aeruginosa.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated and uncomplicated UTIs caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for cellulitis, abscesses, and wound infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Bacteremia and sepsis","description":"Administered intravenously for bloodstream infections and sepsis caused by susceptible Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Meningitis","description":"Used in the treatment of bacterial meningitis, often in combination with other antibiotics.","evidence":"Well-established"},{"condition":"Febrile neutropenia","description":"Empiric therapy for febrile neutropenia in cancer patients, often combined with other antibiotics.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"Used for osteomyelitis and septic arthritis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for complicated intra-abdominal infections.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Melioidosis","description":"Ceftazidime is used off-label for the treatment of melioidosis, a bacterial infection caused by Burkholderia pseudomallei, especially in endemic areas.","evidence":"Limited"},{"condition":"Cystic fibrosis exacerbations","description":"Sometimes used off-label for acute pulmonary exacerbations in cystic fibrosis patients with Pseudomonas aeruginosa infection.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infections, Skin infections, Sepsis, Meningitis, Febrile neutropenia, Bone and joint infections, Intra-abdominal infections
📋 Drug Information
| Generic Name(s) | Ceftazidime (1000mg) |
| Brand Name | keftaglan 1000mg injection |
| Manufacturer | Gland Pharma Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 3 generation |
| Route of Administration | Parenteral (intravenous or intramuscular) |
| Storage | Store the unreconstituted powder at room temperature (20-25°C). Protect from light. After reconstitution, the solution should be used immediately or stored as per the manufacturer's instructions, typically refrigerated (2-8°C) for up to 24 hours. Do not freeze. |
| Shelf Life | The shelf life of the unreconstituted powder is typically 24 months from the date of manufacture. Check the expiry date on the packaging. |
| WHO Guideline | Ceftazidime is included in the WHO Model List of Essential Medicines for the treatment of various bacterial infections, including those caused by Pseudomonas aeruginosa. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines recommend ceftazidime for the treatment of hospital-acquired infections and infections caused by susceptible Gram-negative bacteria, based on local resistance patterns. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ceftazidime is a third-generation cephalosporin antibiotic that exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby blocking the cross-linking of peptidoglycan strands. This leads to weakening of the cell wall, cell lysis, and death of the bacteria. Ceftazidime is stable against many beta-lactamases produced by Gram-negative bacteria, but it can be hydrolyzed by extended-spectrum beta-lactamases (ESBLs) and carbapenemases.
Mechanism Steps
💡 How to Take keftaglan 1000mg injection
Strength: Powder for injection: 1000 mg per vial.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1 gram administered intravenously or intramuscularly every 8 to 12 hours, depending on the severity of the infection and the causative organism. For severe infections, doses up to 2 grams every 8 hours may be used. In patients with renal impairment, the dose must be reduced based on creatinine clearance. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have decreased renal function, which can increase the risk of toxicity. Dose should be adjusted based on creatinine clearance. Monitor renal function closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, the dose of ceftazidime must be reduced. For creatinine clearance 31-50 mL/min, administer 1 gram every 12 hours; for 16-30 mL/min, 1 gram every 24 hours; for 6-15 mL/min, 500 mg every 24 hours; for <5 mL/min, 500 mg every 48 hours. For patients on hemodialysis, a loading dose of 1 gram followed by 500 mg after each dialysis session is recommended. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No dose adjustment is necessary for hepatic impairment alone. However, if both hepatic and renal impairment are present, dose adjustment based on renal function is required. |
| Maximum Daily Dose | The maximum recommended daily dose is 6 grams per day in adults with normal renal function, but this may vary based on the severity of infection and clinical judgment. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of keftaglan 1000mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Gentamicin | Major | |
| Furosemide | Major | |
| Warfarin | Moderate | |
| Probenecid | Moderate | |
| Chloramphenicol | Major |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin, tobramycin)
- Loop diuretics (e.g., furosemide)
- Chloramphenicol
⚡ Moderate Interactions
- Warfarin
- Probenecid
🍷 Alcohol Interaction
Alcohol may worsen certain side effects such as nausea, dizziness, or drowsiness. It is advisable to avoid alcohol during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ceftazidime or other cephalosporins","Severe allergic reaction to penicillins (cross-reactivity possible)","Use in patients with a history of anaphylaxis to beta-lactam antibiotics"]
⚠️ Warnings & Precautions
["Before therapy, inquire about previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs.","Use with caution in patients with renal impairment; dose adjustment is required.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi.","Clostridioides difficile-associated diarrhea has been reported; consider this diagnosis in patients with diarrhea.","Seizures have been reported, particularly in patients with renal impairment; use with caution.","Safety and effectiveness in pediatric patients have been established for certain infections; consult a pediatrician.","Elderly patients may have reduced renal function; dose adjustment may be necessary."]
🤱 Lactation Safety
Ceftazidime is excreted in human breast milk in low concentrations. It is generally considered safe during breastfeeding, but consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose can lead to severe neurological effects such as seizures, encephalopathy, and neuromuscular excitability. There is no specific antidote. Treatment is symptomatic and supportive. Ceftazidime can be removed by hemodialysis or peritoneal dialysis. Monitor vital signs and provide supportive care.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer an extra dose.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional. Before use, inform your doctor about any allergies, especially to penicillins or cephalosporins, and about any kidney or liver problems. Your kidney function may be monitored during treatment. Do not use this medicine if the solution is cloudy or contains particles. Complete the full course as prescribed, even if you feel better, to prevent resistance. Avoid alcohol during treatment as it may worsen side effects. If you experience severe diarrhea, rash, or difficulty breathing, seek immediate medical attention. Pregnant or breastfeeding women should consult their doctor before use. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced renal function, which can increase the risk of side effects. Dose adjustment based on creatinine clearance is essential. Monitor renal function closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. It is classified as Pregnancy Category B, but use only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent surgical site infections. Follow your surgeon's instructions regarding its use.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may be used for prophylaxis in certain dental procedures if you have a history of infective endocarditis.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While on this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you feel fully recovered. Consult your doctor before resuming intense physical activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a healthcare setting, so it may require hospitalization or frequent clinic visits. You may need to take time off work during treatment. Avoid driving or operating machinery if you feel dizzy or unwell.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfection with resistant bacteria or fungi, and rarely, blood dyscrasias or renal impairment. Prolonged therapy should be guided by clinical response and culture results. Regular monitoring of renal function, liver function, and blood counts is advised for extended use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the causative organism and susceptibility, other antibiotics such as cefepime, piperacillin-tazobactam, or meropenem may be used.
Evidence: Well-establishedRest, hydration, and fever control are important adjuncts to antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, ensure you are up to date with recommended vaccinations, especially if you have underlying conditions.
📦 Storage Guide
✅ DO
Store the unreconstituted powder at room temperature (20-25°C)
❌ DON'T
Do not freeze the powder
✅ DO
Protect from light
❌ DON'T
Do not expose to direct sunlight
✅ DO
Use reconstituted solution immediately or refrigerate as per instructions
❌ DON'T
Do not use if solution is cloudy or contains particles
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel advice is limited. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed. Consult your doctor before traveling if you have ongoing infection.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: No, this medicine must be administered by a healthcare professional in a hospital or clinic setting.
A: Report any side effects to your doctor immediately. Severe reactions require emergency medical attention.
🤔 Common Patient Concerns
🔄 Substitutes for keftaglan 1000mg injection
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Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is an injection and must be given by a healthcare professional. It is not effective orally. - Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is not effective against viruses. - Myth: You can stop this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance.
🔄 Alternative Options
Generic Alternatives
- Ceftazidime injection (various manufacturers)
Brand Alternatives
- Fortum
- Tazid
- Ceftaz
- Zidime