Kdex N Tablet: Comprehensive Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or persistent vomiting
- Yellowing of skin or eyes (jaundice)
- Dark urine or decreased urine output
- Swelling of face, lips, tongue, or throat
- Difficulty breathing or chest pain
- Severe skin rash with blisters or peeling
- Unusual bleeding or bruising
- Severe headache with stiff neck and fever
If experiencing severe symptoms, call emergency services immediately.
What is kdex n tablet used for?
This medicine is a combination of nimesulide and paracetamol used for short-term relief of acute pain, inflammation, and fever. It should be taken with food and not for more than 5-7 days due to risks of liver and kidney damage.
- Generic Name: Nimesulide (100mg) + Paracetamol (400mg)
- Manufacturer: Oyster Labs Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kdex n tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाइमसुलाइड और पैरासिटामोल का संयोजन है, जिसका उपयोग अल्पकालिक दर्द, सूजन और बुखार से राहत के लिए किया जाता है। यह मांसपेशियों और जोड़ों के दर्द, दांत दर्द, सर्जरी के बाद के दर्द और मासिक धर्म के दर्द में प्रभावी है। इसे भोजन के साथ लेना चाहिए और 5-7 दिनों से अधिक नहीं लेना चाहिए क्योंकि इससे लिवर और किडनी को नुकसान हो सकता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, लिवर और किडनी की समस्या, और गंभीर एलर्जी प्रतिक्रियाएं शामिल हैं। यदि आपको काला मल, उल्टी में खून, पीलिया, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब का सेवन बिल्कुल न करें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आपको पेट अल्सर, किडनी या लिवर की बीमारी है, तो डॉक्टर को बताएं। 5-7 दिनों से अधिक इसका उपयोग न करें।
💊 kdex n tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues due to sprains, strains, or injuries.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides short-term relief from toothache and pain after dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of mild to moderate pain after surgery.","evidence":"Moderate"},{"condition":"Fever","description":"Reduces fever due to its paracetamol content, though nimesulide also has antipyretic action.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Osteoarthritis flare-up","description":"May be used short-term for pain relief during flare-ups, but not for long-term management.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Fever, Dental pain, Musculoskeletal pain, Post-operative pain, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Nimesulide (100mg) + Paracetamol (400mg) |
| Brand Name | kdex n tablet |
| Manufacturer | Oyster Labs Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from direct sunlight, moisture, and heat. Do not refrigerate unless specified. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. Nimesulide is not approved in many countries due to safety concerns. The combination is not recommended by major international guidelines for routine use. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research has not issued specific guidelines for this combination. However, due to safety concerns, it is generally advised to use with caution and for short durations only. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are chemicals that cause pain, inflammation, and fever. Paracetamol works primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending pain pathways, providing analgesic and antipyretic effects. Together, they provide relief from pain and inflammation through complementary mechanisms.
Mechanism Steps
💡 How to Take kdex n tablet
Strength: Tablet containing nimesulide 100 mg and paracetamol 400 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally every 8 to 12 hours as needed for pain and fever, not exceeding 3 tablets in 24 hours. It should be taken with food or milk to reduce stomach upset. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not use for more than 5 to 7 days without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children under 12 years of age. Consult a pediatrician for appropriate alternatives. |
| Elderly Dosage | Elderly patients (above 65 years) are at higher risk of side effects, especially gastrointestinal bleeding, kidney problems, and liver toxicity. Use the lowest effective dose for the shortest duration possible. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing based on kidney function tests. |
| Hepatic Impairment | Avoid in patients with severe liver disease. In mild to moderate liver impairment, use with caution and at reduced dose. Consult a doctor for individualized dosing based on liver function tests. |
| Maximum Daily Dose | The maximum daily dose is 3 tablets (each containing nimesulide 100 mg and paracetamol 400 mg) in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kdex n tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Moderate | |
| Furosemide | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Corticosteroids | Major | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Other NSAIDs (e.g., ibuprofen, diclofenac)
- Corticosteroids
- Methotrexate
- ACE inhibitors and angiotensin receptor blockers (ARBs)
⚡ Moderate Interactions
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- Lithium
- SSRIs (e.g., fluoxetine, sertraline)
- Antihypertensives (beta-blockers, calcium channel blockers)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and nimesulide, and also raises the risk of stomach bleeding and ulcers. Even moderate drinking can be harmful.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to nimesulide, paracetamol, or any component of the formulation.","Active or history of peptic ulcer or gastrointestinal bleeding.","Severe liver disease or severe kidney disease.","Heart failure or severe cardiovascular disease.","Children under 12 years of age.","Pregnancy, especially third trimester, and breastfeeding.","Concurrent use with other NSAIDs or anticoagulants."]
⚠️ Warnings & Precautions
["Do not exceed the recommended dose or duration of treatment (usually not more than 5-7 days).","Take with food to reduce stomach irritation.","Avoid alcohol completely while taking this medicine.","Inform your doctor if you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma.","Do not use this medicine for minor pain that can be managed with safer alternatives like paracetamol alone.","Elderly patients are at higher risk of side effects and should use with caution.","Stop the medicine and consult a doctor if you experience signs of liver or kidney problems, or severe allergic reactions.","Do not take other medicines containing paracetamol or NSAIDs without consulting your doctor."]
🤱 Lactation Safety
Not established from the available information. Nimesulide and paracetamol may pass into breast milk. It is generally advised to avoid this medicine during breastfeeding unless clearly needed and advised by a doctor. Consult your doctor for safer options.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, kidney failure, and gastrointestinal bleeding. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and yellowing of skin or eyes. If you suspect an overdose, seek emergency medical help immediately. Treatment may include activated charcoal, acetylcysteine for paracetamol toxicity, and supportive care. Do not wait for symptoms to appear.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose or for longer than advised, as it can harm your liver and kidneys. Always take it with food or milk to reduce stomach upset. Avoid drinking alcohol while taking this medicine because it increases the risk of stomach bleeding and liver damage. Do not take other medicines containing paracetamol or other NSAIDs without consulting your doctor, as this can lead to overdose or increased side effects. If you have a history of stomach ulcers, kidney disease, liver disease, or heart problems, inform your doctor before taking this medicine. Do not use this medicine for minor aches that can be managed with safer alternatives. Keep out of reach of children. Store at room temperature away from moisture and direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at higher risk of gastrointestinal bleeding, kidney impairment, and liver toxicity. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function closely. Avoid if possible in frail elderly patients.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for women planning pregnancy or who may be pregnant. NSAIDs like nimesulide can interfere with ovulation and increase the risk of miscarriage. Consult your doctor for safer alternatives for pain relief.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain relief, but it can increase bleeding risk and interfere with wound healing. Consult your surgeon before taking it after surgery. Alternative pain management options may be safer.
🦷 Dental Procedures
This medicine can be used for dental pain, but it increases bleeding risk. Inform your dentist if you are taking this medicine before any dental procedure. Your dentist may recommend stopping it before surgery or using alternative pain relief.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel dizzy or tired. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have pain, gentle stretching and low-impact exercises are generally safe, but consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to work if you do not experience these side effects. Take it with food to minimize stomach upset during work hours.
🛑 When to Stop This Medicine
Stop taking this medicine after the prescribed duration (usually 5-7 days) or as soon as your pain and fever subside. If you experience any serious side effects like stomach bleeding, liver problems, or allergic reactions, stop immediately and seek medical help. Do not stop abruptly if you have been on long-term therapy without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to serious liver damage, kidney impairment, gastrointestinal bleeding, and increased cardiovascular risk. It is not intended for chronic use. Regular monitoring of liver and kidney function is advised if prolonged use is unavoidable. Always consult a doctor before using for more than 5-7 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help relieve localized pain and inflammation.
Evidence: ModerateSafer alternative for mild to moderate pain and fever, especially for short-term use.
Evidence: Well-establishedFor localized pain, topical gels may provide relief with fewer systemic side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There are no known interactions between this medicine and vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue your regular dosing schedule as prescribed, but do not exceed the maximum daily dose. Check customs regulations for carrying prescription medicines. Keep it in your carry-on luggage if flying. Do not leave it in a hot car.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it with food.
A: It should not be taken for more than 5 to 7 days without medical advice due to the risk of liver and kidney damage.
A: No, always take it with food or milk to reduce stomach irritation and the risk of ulcers.
A: It is generally not recommended during pregnancy, especially in the third trimester. Consult your doctor for safer alternatives.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for kdex n tablet
View AllAlternative brands with exact same active ingredient:
-
nimodex tabletPsychotropics India Ltd ₹42.19 7.1% COSTLIER
-
oxymark tabletUnimarck Healthcare Ltd ₹42.86 8.8% COSTLIER
-
deepex 100 mg/400 mg/32.5 mg tabletOrganic Laboratories ₹89.25 126.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is only for short-term use (5-7 days) due to risks of liver and kidney damage. - Myth: This medicine can be taken on an empty stomach.
Fact: It should always be taken with food to reduce stomach irritation and risk of ulcers. - Myth: This medicine is safe for children.
Fact: It is not recommended for children under 12 years of age. - Myth: This medicine can be taken with other painkillers.
Fact: Taking it with other NSAIDs or paracetamol-containing products can lead to overdose and serious side effects.
🔄 Alternative Options
Generic Alternatives
- Nimesulide + Paracetamol combination (generic)
- Paracetamol alone (for milder pain/fever)
- Ibuprofen + Paracetamol combination
Brand Alternatives
- Nise MR
- Nimulid
- Nimesulide + Paracetamol (various brands)