kaytec d tablet - Domperidone (NA) + Ranitidine (NA) medicine

Kaytec D Tablet: Complete Guide to Uses, Side Effects, and Safety

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🏭 Khandelwal Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 21, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for combination use in GERD and dyspepsia.
Reviewed by
SaathiMed Expert Panel | Oct 21, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Irregular heartbeat or palpitations
  • Uncontrollable muscle spasms or rigidity

If experiencing severe symptoms, call emergency services immediately.

What is kaytec d tablet used for?

This medicine is a combination of domperidone and ranitidine used to treat acid reflux, heartburn, and functional dyspepsia. Domperidone improves stomach emptying and reduces nausea, while ranitidine reduces stomach acid production. It is available as an immediate-release tablet and should be taken as prescribed by a doctor.

  • Generic Name: Domperidone (NA) + Ranitidine (NA)
  • Manufacturer: Khandelwal Laboratories Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 kaytec d tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डोम्पेरिडोन और रैनिटिडीन का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, हार्टबर्न, अपच और मतली के इलाज के लिए किया जाता है। डोम्पेरिडोन पेट की गति को बढ़ाता है और उल्टी को कम करता है, जबकि रैनिटिडीन पेट में एसिड का उत्पादन कम करता है। यह दवा डॉक्टर के परामर्श से ही लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, सिरदर्द, चक्कर आना, दस्त और पेट में असुविधा शामिल हैं। कुछ लोगों को नींद आ सकती है। दुर्लभ मामलों में स्तन में दर्द, दूध का स्राव, या अनियमित मासिक धर्म हो सकता है। गंभीर दुष्प्रभाव जैसे हृदय की अनियमित धड़कन, गंभीर एलर्जी, या लीवर की समस्या हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक या अवधि से अधिक न लें। यदि आपको चक्कर या नींद आती है तो वाहन चलाने या मशीन चलाने से बचें। इस दवा के साथ शराब न पिएं। यदि आपको हृदय, लीवर, या गुर्दे की समस्या है तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर की सलाह के बिना न लें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 kaytec d tablet Uses & Benefits

[{"condition":"Gastro-oesophageal reflux disease (GERD)","description":"This medicine helps reduce acid reflux and heartburn by decreasing stomach acid production and improving stomach emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"It relieves symptoms such as bloating, early satiety, and upper abdominal discomfort by promoting gastric emptying.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with gastritis","description":"Domperidone component helps control nausea and vomiting by blocking dopamine receptors in the chemoreceptor trigger zone.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes prescribed off-label to improve gastric emptying in diabetic patients with gastroparesis.","evidence":"Limited"}]

Primary treatment for: Gastro-oesophageal reflux disease (GERD) and functional dyspepsia

Also treats: Gastritis, Nausea and vomiting, Diabetic gastroparesis

📋 Drug Information

Generic Name(s)Domperidone (NA) + Ranitidine (NA)
Brand Namekaytec d tablet
ManufacturerKhandelwal Laboratories Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Stay well hydrated throughout the day.
3
Avoid alcohol while taking this medicine.
4
Do not take more than the prescribed dose.
5
Consult your doctor if symptoms persist beyond 7 days.
6
Report any unusual bleeding or bruising immediately.
7
Inform your doctor if you have heart, liver, or kidney problems.
8
Do not drive or operate machinery if you feel dizzy or drowsy.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Heartburn
This medicine is commonly prescribed for this.
Likely Use
✅
Acid reflux
This medicine helps reduce acid reflux.
Likely Use
✅
Bloating
This medicine improves gastric emptying and reduces bloating.
Likely Use
✅
Nausea
Domperidone component helps control nausea.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDomperidone is rapidly absorbed after oral administration, but its bioavailability is low due to extensive first-pass metabolism. Ranitidine is also rapidly absorbed from the gastrointestinal tract, with a bioavailability of approximately 50%. Food may slightly delay the absorption of ranitidine but does not significantly affect the extent of absorption.
DistributionDomperidone is widely distributed in the body but does not readily cross the blood-brain barrier. It is highly protein-bound. Ranitidine is distributed throughout the body, including breast milk, and crosses the placenta. It has a volume of distribution of about 1.4 L/kg.
Protein BindingDomperidone is approximately 91-93% bound to plasma proteins. Ranitidine is about 15% bound to plasma proteins.
MetabolismDomperidone undergoes extensive first-pass metabolism in the liver and gut wall via CYP3A4 and CYP1A2 enzymes. Ranitidine is metabolised in the liver to N-oxide, S-oxide, and desmethyl metabolites, with N-oxide being the major metabolite.
Half-LifeThe elimination half-life of domperidone is approximately 7-9 hours in healthy individuals. Ranitidine has an elimination half-life of about 2-3 hours.
ExcretionDomperidone is excreted mainly in the faeces (about 66%) and urine (about 33%) as metabolites. Ranitidine is primarily excreted unchanged in the urine (about 70%) and in faeces (about 30%).
BioavailabilityDomperidone has a low oral bioavailability of about 13-17% due to first-pass metabolism. Ranitidine has an oral bioavailability of approximately 50%.
Onset of ActionDomperidone begins to relieve nausea and improve gastric motility within 30-60 minutes after oral administration. Ranitidine starts reducing gastric acid secretion within 1 hour.
Peak Plasma TimeDomperidone reaches peak plasma concentrations in about 1-2 hours. Ranitidine reaches peak plasma concentrations in about 1-3 hours.
Duration of ActionThe prokinetic effect of domperidone lasts about 6-8 hours. The acid-suppressing effect of ranitidine lasts about 8-12 hours.

How It Works

This medicine combines two active ingredients with complementary actions. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the gastrointestinal tract, leading to increased gastric motility and accelerated gastric emptying. It also acts on the chemoreceptor trigger zone to reduce nausea and vomiting. Ranitidine is a competitive histamine H2-receptor antagonist that reduces gastric acid secretion by blocking histamine's action on parietal cells. Together, they provide symptomatic relief from acid-related and motility-related upper gastrointestinal disorders.

Mechanism Steps

1
Domperidone blocks dopamine D2 receptors: Domperidone binds to dopamine D2 receptors in the gastrointestinal tract and chemoreceptor trigger zone, preventing dopamine from inhibiting gastric motility.
2
Increased gastric emptying: Blockade of dopamine receptors leads to enhanced gastric peristalsis and faster emptying of stomach contents into the duodenum.
3
Ranitidine blocks histamine H2 receptors: Ranitidine competitively binds to histamine H2 receptors on gastric parietal cells, reducing the production of gastric acid.
4
Reduced acid secretion: By blocking H2 receptors, ranitidine decreases both basal and stimulated acid secretion, lowering the acidity of stomach contents.
5
Combined symptomatic relief: The prokinetic effect of domperidone and the acid-suppressing effect of ranitidine together alleviate symptoms of reflux, dyspepsia, and nausea.

💡 How to Take kaytec d tablet

Strength: Domperidone 10 mg + Ranitidine 150 mg tablet (immediate release).

1Take the tablet orally with a glass of water.
2Swallow the tablet whole; do not crush or chew.
3Take it at the same time each day, preferably before meals.
4Follow the dose and duration exactly as prescribed by your doctor.
5Do not take more than the recommended dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally once or twice daily, preferably before meals, as prescribed by your doctor. The exact dose and duration depend on the condition being treated and your response to therapy. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially dizziness, drowsiness, and cardiac effects. Use with caution and lower doses may be considered. Dose must be individualized by a qualified clinician.
Renal ImpairmentRanitidine requires dose reduction in patients with renal impairment. For creatinine clearance less than 50 mL/min, the dose may need to be reduced. Domperidone should be used with caution in severe renal impairment. Consult your doctor for dose adjustment.
Hepatic ImpairmentThis medicine is contraindicated in moderate to severe hepatic impairment. In mild hepatic impairment, use with caution and consider dose reduction. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose of domperidone is 30 mg and ranitidine is 300 mg. However, the exact maximum dose for this combination product must be determined by a qualified clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and improves tolerability.
Grapefruit
Avoid
May increase drug levels and risk of side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of kaytec d tablet

✅ Common Side Effects

Dry mouth (Common (1-10%))
Sip water frequently and maintain good oral hygiene. Consult doctor if persistent.
Headache (Common (1-10%))
Rest and stay hydrated. If headache is severe or persistent, consult your doctor.
Dizziness (Common (1-10%))
Avoid driving or operating machinery until you know how this medicine affects you.
Diarrhoea (Common (1-10%))
Stay hydrated. If diarrhoea is severe or lasts more than 2 days, consult your doctor.
Abdominal discomfort (Common (1-10%))
Take the medicine with food to reduce stomach upset. Consult doctor if pain persists.

🚨 Serious Side Effects

Abnormal heart rhythms (QT prolongation, ventricular arrhythmias) (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations, fainting, or shortness of breath.
Severe allergic reactions (anaphylaxis, angioedema) (Rare (<0.1%))
Call emergency services if you notice swelling of face, lips, throat, or difficulty breathing.
Liver toxicity (hepatitis, jaundice) (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe abdominal pain to your doctor immediately.
Neuroleptic malignant syndrome (NMS) (Very rare (<0.01%))
Seek emergency care if you develop high fever, muscle rigidity, confusion, or irregular pulse.

⚠️ Rare Side Effects

Galactorrhoea (breast milk secretion)
Consult your doctor if you notice unexpected breast milk secretion.
Gynaecomastia (breast enlargement in men)
Report to your doctor if you notice breast enlargement or tenderness.
Amenorrhoea (absence of menstrual periods)
Consult your doctor if your menstrual cycle becomes irregular or stops.
Blood dyscrasias (thrombocytopenia, leukopenia)
Seek medical attention if you experience unusual bleeding, bruising, or frequent infections.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Clarithromycin Major
Amiodarone Major
Warfarin Moderate
Antacids Moderate
Metoclopramide Moderate
Atropine Moderate
Paracetamol Minor
Diazepam Minor
Grapefruit juice Moderate

🚨 Major Interactions

  • Ketoconazole, itraconazole, clarithromycin, ritonavir
  • QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
  • Warfarin

⚡ Moderate Interactions

  • Antacids (aluminium/magnesium hydroxide)
  • Metoclopramide
  • Atropine and other anticholinergics

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine. Alcohol can increase drowsiness and dizziness caused by domperidone and may worsen stomach irritation. It can also increase the risk of liver problems.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to domperidone or ranitidine","Prolactin-releasing pituitary tumour (prolactinoma)","Moderate to severe hepatic impairment","Known QT interval prolongation or congenital long QT syndrome","Concurrent use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)","Concurrent use with QT-prolonging drugs","Gastrointestinal obstruction, perforation, or bleeding","Severe renal impairment (creatinine clearance < 30 mL/min) for ranitidine component"]

⚠️ Warnings & Precautions

["Use with caution in patients with heart disease, electrolyte abnormalities, or bradycardia.","Avoid in patients with Parkinson's disease as domperidone may worsen symptoms.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not exceed recommended dose or duration without medical advice.","Use with caution in elderly patients due to increased risk of side effects.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Avoid alcohol while taking this medicine.","Do not use for non-prescribed indications."]

🤱 Lactation Safety

Domperidone is excreted in breast milk and may cause side effects in the infant. Ranitidine also passes into breast milk. This medicine should be used during breastfeeding only if the potential benefit justifies the potential risk. Consult your doctor.

💊 Overdose Management

Overdose may cause drowsiness, dizziness, extrapyramidal symptoms, and QT prolongation. Seek immediate medical attention. Treatment is symptomatic and supportive. Gastric lavage may be considered if within 1 hour of ingestion. Monitor ECG and vital signs. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Avoid driving or operating heavy machinery if you feel dizzy or drowsy. Do not drink alcohol while taking this medicine, as it can increase drowsiness and stomach irritation. Inform your doctor if you have heart, liver, or kidney problems before starting this medicine. Do not take this medicine if you are pregnant or breastfeeding without consulting your doctor. Keep this medicine out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more susceptible to side effects such as dizziness, drowsiness, and cardiac arrhythmias. Use with caution, and lower doses may be considered. Regular monitoring of heart, liver, and kidney function is advised.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed and prescribed by a doctor.

🏥 Post-Surgery Considerations

This medicine may be used after surgery to prevent nausea and vomiting, but it should be prescribed by a doctor. It may interact with anaesthetic agents, so inform your anaesthesiologist about all medicines you are taking.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may interact with certain medications used during dental procedures. It is generally safe to continue, but medical advice is recommended.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce acid reflux.
🥗
Avoid lying down immediately after meals.
😴
Eat smaller, more frequent meals.
💧
Avoid spicy, fatty, and acidic foods.
🧘
Quit smoking and limit alcohol consumption.
🌞
Elevate the head of your bed while sleeping.

🏋️ Exercise Considerations

Avoid strenuous exercise immediately after taking this medicine if you experience dizziness or drowsiness. Mild to moderate exercise is generally safe, but listen to your body and stay hydrated.

🥗 Diet Recommendations

Include fibre-rich foods like fruits and vegetables.
Avoid spicy and fatty foods that can worsen reflux.
Stay well hydrated with water.
Limit caffeine and carbonated drinks.
Eat smaller meals more frequently.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people, which can affect driving or operating machinery. It is advisable to avoid these activities until you know how the medicine affects you. Otherwise, it should not significantly impact your daily work life.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms resolve, your doctor may advise tapering or stopping. Abrupt discontinuation is generally not associated with withdrawal, but medical guidance is recommended.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of QT prolongation, hyperprolactinaemia, and liver problems. Regular monitoring of ECG, liver function, and prolactin levels may be required. It should be used for the shortest duration necessary and only under medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Dietary and lifestyle modifications

Avoiding trigger foods, eating smaller meals, and losing weight can help manage acid reflux and dyspepsia.

Evidence: Well-established
Proton pump inhibitors (PPIs)

Medicines like omeprazole or pantoprazole may be prescribed for stronger acid suppression.

Evidence: Well-established
Surgery

In severe cases of GERD, surgical options like fundoplication may be considered.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, inform your healthcare provider about all medicines you are taking before receiving any vaccine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When travelling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust dosing times gradually as advised by your doctor. Keep enough supply for the entire trip and check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic acid reflux and bloating
Started this medicine as prescribed for GERD and functional dyspepsia. Within a week, noticed significant improvement in heartburn and bloating. Emphasized taking it before meals to enhance absorption and effectiveness.
💡 Lesson: Consistency with prescribed dose and timing before meals improves both efficacy and tolerability.
👤 A 60-year-old woman with diabetic gastroparesis and nausea
Was prescribed this medicine off-label for gastroparesis. Experienced relief from nausea and early satiety within 10 days. Regular monitoring of ECG and prolactin levels was done due to long-term use.
💡 Lesson: Off-label use requires close medical supervision and monitoring for potential side effects.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving symptoms within 30-60 minutes, but noticeable improvement in acid reflux and dyspepsia may take a few days of regular use.

Q: Can I take this medicine with other medications?

A: It can interact with several medicines, especially those affecting heart rhythm or liver enzymes. Always inform your doctor about all medicines you are taking.

Q: Is it safe to take this medicine during pregnancy?

A: Consult your doctor before taking this medicine during pregnancy. It should be used only if clearly needed and prescribed.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for kaytec d tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any stomach pain.
    Fact: This medicine is specifically for acid reflux and motility disorders. It is not a general painkiller and should not be used for all types of stomach pain.
  • Myth: It is safe to take this medicine for a long time without monitoring.
    Fact: Long-term use requires medical supervision due to potential side effects like QT prolongation and hyperprolactinaemia.
  • Myth: This medicine can be taken with alcohol without any issues.
    Fact: Alcohol can increase drowsiness and stomach irritation, and should be avoided while taking this medicine.

🔄 Alternative Options

Generic Alternatives

  • Domperidone + Ranitidine combination tablets from other manufacturers

Brand Alternatives

  • Not established from the available information.

📊 Comparison with Similar Medicines

[{"medicine":"Domperidone + Ranitidine","composition":"Domperidone 10 mg + Ranitidine 150 mg","uses":"GERD, dyspepsia, nausea","notes":"Combines prokinetic and acid-suppressing effects."},{"medicine":"Domperidone + Pantoprazole","composition":"Domperidone 10 mg + Pantoprazole 40 mg","uses":"GERD, dyspepsia","notes":"Pantoprazole is a proton pump inhibitor with stronger acid suppression."},{"medicine":"Ranitidine alone","composition":"Ranitidine 150 mg","uses":"Acid reflux, heartburn","notes":"No prokinetic effect."}]

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