Guficap 70mg Injection (Caspofungin): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, or throat or difficulty breathing during or after the infusion.
- A sudden drop in blood pressure, severe dizziness, or fainting.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- A painful spreading rash, blistering, or peeling of the skin.
- Persistent high fever with chills that does not improve.
- Decreased urine output or swelling of the legs and feet.
- Palpitations, chest discomfort, or irregular heartbeat.
If experiencing severe symptoms, call emergency services immediately.
What is kabifungin 70 injection used for?
This medicine is an intravenous echinocandin antifungal containing caspofungin. It treats serious fungal infections such as invasive candidiasis and candidemia by weakening the fungal cell wall. It is given by a healthcare professional, usually once daily, and the dose is adjusted for liver function and interacting medicines.
- Generic Name: Caspofungin (70mg)
- Manufacturer: Fresenius Kabi India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kabifungin 70 injection के बारे में (Hindi Summary)
उपयोग: यह दवा कैस्पोफंजिन नामक एंटीफंगल दवा है, जो गंभीर फंगल संक्रमणों के इलाज के लिए नस के माध्यम से दी जाती है। यह मुख्य रूप से खून में फैले कैंडिडा संक्रमण, अन्नप्रणाली के कैंडिडा संक्रमण, और कम सफेद रक्त कोशिकाओं वाले मरीजों में बुखार के साथ संभावित फंगल संक्रमण के इलाज में उपयोग की जाती है। यह दवा फंगस की कोशिका भित्ति को कमजोर करके उसे नष्ट करती है। यह दवा केवल डॉक्टर या प्रशिक्षित नर्स द्वारा अस्पताल या क्लिनिक में ही दी जाती है, घर पर खुद से नहीं लगाई जाती।
साइड इफेक्ट्स: इस दवा से आमतौर पर हल्के दुष्प्रभाव होते हैं, जैसे बुखार, ठंड लगना, सिरदर्द, जी मिचलाना, उल्टी, दस्त, पेट दर्द, और इंजेक्शन लगाने की जगह पर दर्द या लालिमा। कुछ मरीजों में लिवर एंजाइम बढ़ सकते हैं या पोटैशियम और मैग्नीशियम कम हो सकता है। गंभीर लेकिन दुर्लभ दुष्प्रभावों में तेज एलर्जी, सांस लेने में कठिनाई, चेहरे या गले में सूजन, और लिवर को नुकसान शामिल हैं। इन्फ्यूजन के दौरान कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर या नर्स को बताएं।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा नस के माध्यम से दी जानी चाहिए। अपने डॉक्टर को अपनी सभी दवाओं, विटामिन और हर्बल उत्पादों के बारे में बताएं, क्योंकि रिफैम्पिन, साइक्लोस्पोरिन, टैक्रोलिमस जैसी दवाएं इस दवा के असर को बदल सकती हैं। अगर आपको लिवर या किडनी की बीमारी है या पहले कभी एंटीफंगल दवा से एलर्जी हुई है, तो डॉक्टर को जरूर बताएं। इलाज के दौरान खून की जांच करवाते रहें। इंफ्यूजन के दौरान सांस लेने में तकलीफ, चेहरे या गले में सूजन, या गंभीर चक्कर आने पर तुरंत आपातकालीन मदद लें।
💊 kabifungin 70 injection Uses & Benefits
[{"condition":"Invasive candidiasis and candidemia","description":"This medicine is used as first-line therapy for serious bloodstream and deep-tissue infections caused by Candida species, including in critically ill patients.","evidence":"Well-established"},{"condition":"Oesophageal candidiasis","description":"It is used to treat Candida infection of the oesophagus, especially when other antifungal medicines are not suitable or have failed.","evidence":"Well-established"},{"condition":"Empirical antifungal therapy in febrile neutropenia","description":"It is given to patients with persistent fever and low white blood cell counts who are suspected of having a fungal infection.","evidence":"Well-established"},{"condition":"Invasive aspergillosis (salvage therapy)","description":"It is used in some patients with invasive aspergillosis who cannot tolerate or do not respond to standard therapy.","evidence":"Moderate"},{"condition":"Intra-abdominal abscess and peritonitis with Candida","description":"It may be used as part of treatment for Candida infections in the abdominal cavity, often along with drainage procedures.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prophylaxis in high-risk transplant patients","description":"Sometimes used to prevent invasive fungal infections in selected patients with prolonged neutropenia or after certain transplants.","evidence":"Limited"},{"condition":"Fungal infections of the heart valves (endocarditis)","description":"Occasionally used as part of combination therapy for Candida endocarditis when standard options are unsuitable.","evidence":"Limited"}]
Primary treatment for: Invasive candidiasis and candidemia
Also treats: Oesophageal candidiasis, Febrile neutropenia with suspected fungal infection, Invasive aspergillosis (salvage therapy), Intra-abdominal Candida infection
📋 Drug Information
| Generic Name(s) | Caspofungin (70mg) |
| Brand Name | kabifungin 70 injection |
| Manufacturer | Fresenius Kabi India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OTHERS |
| Action Class | Fungal cell wall synthesis inhibitor (Echiocandins) |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store the unopened vial in a refrigerator at 2°C to 8°C. Once reconstituted, the solution may be stored at room temperature for a limited time as directed by the manufacturer and the hospital pharmacy. Protect from freezing and excessive heat. |
| Shelf Life | The shelf life of the unopened vial is typically 24 months from the date of manufacture, but the exact expiry date printed on the pack should always be checked and followed. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the enzyme complex beta-1,3-D-glucan synthase, which is responsible for building beta-1,3-D-glucan, an essential structural component of the fungal cell wall. When this component is not produced, the fungal cell wall becomes weak and unstable, leading to loss of cell shape, leakage of cell contents, and ultimately death of the fungus. Because beta-1,3-D-glucan is not present in human cells, the medicine has a selective action against susceptible fungi and does not directly damage human cell membranes in the way that older antifungal medicines such as amphotericin B can.
Mechanism Steps
💡 How to Take kabifungin 70 injection
Strength: Caspofungin 70 mg powder for intravenous infusion
Dosage Information
| Adult Dosage | The usual adult dose of this medicine depends on the indication. For invasive candidiasis or candidemia, a single loading dose of 70 mg is commonly given on the first day, followed by 50 mg once daily. For oesophageal candidiasis, a loading dose of 70 mg is followed by 50 mg once daily. For empirical therapy in febrile neutropenia, a loading dose of 70 mg is followed by 50 mg once daily. In patients with moderate liver impairment, the maintenance dose is usually reduced to 35 mg once daily. If rifampin, carbamazepine, phenytoin, or dexamethasone is taken together, the maintenance dose may need to be increased to 70 mg once daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information for all age groups. In children above 3 months, weight-based dosing may be used by specialists, but the exact dose must be determined by a pediatrician or pediatric infectious disease specialist. Consult a pediatrician. |
| Elderly Dosage | Elderly patients usually receive the same adult dose as younger adults. However, because older adults may have reduced liver or kidney function and may take other medicines, the doctor will individualize the dose and monitor closely. |
| Renal Impairment | Dose adjustment is not usually required for mild to moderate kidney impairment. For patients with severe kidney impairment or those on dialysis, the doctor will decide whether any adjustment is needed based on the clinical situation. |
| Hepatic Impairment | For adults with moderate liver impairment, the maintenance dose is usually reduced to 35 mg once daily after the standard 70 mg loading dose. For severe liver impairment, there is limited information, and the doctor will decide the dose with caution and close monitoring. |
| Maximum Daily Dose | The maximum daily dose used in adults is generally 70 mg once daily, and this higher dose is used mainly when interacting medicines such as rifampin are given together. The exact maximum dose must be determined by the treating clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kabifungin 70 injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Rifampin | Major | |
| Cyclosporine | Major | |
| Tacrolimus | Major | |
| Carbamazepine | Moderate | |
| Phenytoin | Moderate | |
| Dexamethasone | Moderate | |
| Nelfinavir | Moderate | |
| Mycophenolate mofetil | Minor |
🚨 Major Interactions
- Rifampin
- Cyclosporine
- Tacrolimus
⚡ Moderate Interactions
- Carbamazepine, phenytoin, or dexamethasone
- Nelfinavir or other strong CYP3A4 inhibitors
🍷 Alcohol Interaction
There is no well-established direct interaction between this medicine and alcohol. However, because this medicine is used for serious infections and is often given to patients who are already unwell, alcohol should be avoided during treatment unless the treating doctor says it is safe.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to caspofungin or any other echinocandin antifungal","Known severe allergy to any ingredient in the product","Use in patients with a history of serious reaction to the medicine during a previous infusion"]
⚠️ Warnings & Precautions
["This medicine must be given only by a healthcare professional through an intravenous infusion.","Tell your doctor if you have liver disease, because a lower maintenance dose may be needed.","Tell your doctor about all other medicines you take, especially rifampin, cyclosporine, tacrolimus, carbamazepine, phenytoin, or dexamethasone.","Blood tests may be needed to monitor liver enzymes, kidney function, and electrolyte levels.","Stop the infusion and seek emergency help if a severe allergic reaction occurs.","Do not use this medicine to treat viral or bacterial infections, because it only works against susceptible fungi.","Use during pregnancy and breastfeeding only after discussing the risks and benefits with the doctor."]
🤱 Lactation Safety
It is not known whether this medicine passes into human breast milk in significant amounts. Because many medicines can pass into breast milk, breastfeeding should be discussed with the doctor, who will weigh the benefits of treatment against the risks to the infant.
💊 Overdose Management
There is limited information on overdose with this medicine. In case of suspected overdose, stop the infusion and provide supportive medical care with close monitoring of vital signs, liver function, kidney function, and electrolytes. There is no specific antidote. Contact a poison control centre or emergency department for guidance.
⏰ Missed Dose
Because this medicine is given by a healthcare professional in a hospital or clinic, a missed dose is uncommon. If a scheduled dose is missed, contact the treating doctor or infusion centre as soon as possible. Do not try to catch up by taking extra doses on your own, and do not change the schedule without medical advice.
Additional Safety Advice
This medicine must be given only by a qualified healthcare professional through an intravenous line, and it is not intended for self-administration at home unless a trained home-infusion service is supervising the treatment. Always tell your doctor about all prescription medicines, over-the-counter products, and herbal supplements you take, because some medicines such as rifampin, certain anticonvulsants, and tacrolimus can change how this medicine behaves in the body. Inform your doctor if you have liver disease, kidney disease, or a history of allergy to antifungal medicines. Blood tests to check liver enzymes, kidney function, and electrolyte levels may be needed before and during treatment. Do not stop or change the treatment schedule on your own, because stopping too early can allow the fungal infection to return or worsen. If you notice swelling of the face or throat, difficulty breathing, a widespread rash, or severe dizziness during or after the infusion, seek emergency medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients usually receive the same adult dose of this medicine. Because older adults may have reduced liver or kidney function and may take multiple medicines, the doctor will individualize the dose and monitor liver enzymes, kidney function, and electrolytes more closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this with your doctor before starting or continuing treatment. This medicine should be used during pregnancy only when the potential benefit justifies the potential risk. Your doctor will consider alternative treatments and the severity of the infection.
🏥 Post-Surgery Considerations
This medicine may be used after surgery if a patient develops a serious fungal infection, such as intra-abdominal Candida infection or candidemia related to surgical complications. The dose and duration will be decided by the treating team based on the infection site, clinical response, and any liver or kidney problems.
🦷 Dental Procedures
There is no specific restriction on dental procedures while receiving this medicine, but you should inform your dentist about your treatment and any medicines you are taking. If you are unwell or have a low platelet count, the dentist may advise delaying non-urgent procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine is used for serious infections, so strenuous exercise should be avoided until the treating doctor says it is safe. Light activity such as short walks may be allowed depending on your condition. Patients who feel weak, dizzy, or breathless should rest and seek medical advice before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so it may affect your work schedule during treatment. Patients who feel weak, dizzy, or unwell after treatment should not drive or operate heavy machinery until they feel fully alert. Discuss your work commitments with your doctor, who can advise on rest and return to work.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. The treating doctor will decide when to stop based on your clinical response, blood tests, and the type of infection. Stopping too early can allow the infection to return or worsen. If you develop serious side effects, the doctor may stop or change the treatment after assessing the risks and benefits.
📅 Long-Term Use Effects
Long-term use of this medicine is uncommon because treatment courses for serious fungal infections are usually time-limited and guided by clinical response. When prolonged therapy is needed, regular monitoring of liver enzymes, kidney function, and electrolyte levels is important. There is no strong evidence that this medicine causes permanent organ damage when used appropriately, but any new symptoms should be reported to the treating doctor. The duration of treatment should be reviewed regularly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Other echinocandin antifungals that may be used for similar infections.
Evidence: Well-establishedAn older antifungal with a broader spectrum but a higher risk of kidney-related side effects.
Evidence: Well-establishedAn oral or intravenous triazole used for some Candida infections when the species is susceptible.
Evidence: Well-establishedRemoving infected lines, draining abscesses, and supporting the immune system are important alongside antifungal therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There is no specific vaccine interaction established for this medicine. However, patients with serious fungal infections may have weakened immunity, so the treating doctor will advise on the timing of any vaccines. Live vaccines are usually avoided during severe immunosuppression.
📦 Storage Guide
✅ DO
Store the unopened vial in the refrigerator at 2°C to 8°C.
❌ DON'T
Do not freeze the vial.
✅ DO
Keep the vial in its original carton to protect it from light.
❌ DON'T
Do not store it in direct sunlight or near heat sources.
✅ DO
Use the reconstituted solution within the time specified by the manufacturer and hospital pharmacy.
❌ DON'T
Do not use the solution if it is cloudy or contains particles.
✅ DO
Keep all medicines out of the reach of children.
❌ DON'T
Do not transfer the medicine to unlabelled containers.
✈️ Traveling with This Medicine
This medicine is given in a hospital or clinic, so travel during active treatment should be planned with the treating doctor. If you need to travel, carry a copy of your prescription and a letter from your doctor explaining the treatment. Keep the medicine in its original packaging and store it as directed, usually refrigerated before reconstitution. If you are receiving treatment through a home-infusion service, arrange for a trained nurse to give the dose at your destination. Check airline and customs rules for carrying prescription medicines and medical documents. Do not interrupt treatment without medical advice.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Antifungal activity starts soon after the first infusion, but clinical improvement in serious fungal infections usually takes several days to weeks. The treating doctor will monitor your response with clinical checks and laboratory tests.
A: This medicine is usually given in a hospital or clinic by a healthcare professional. In some cases, a trained home-infusion service may supervise treatment at home, but this must be arranged by your doctor.
A: Tell the nurse or doctor immediately. They may slow the infusion and give supportive treatment. Most infusion-related reactions are manageable when reported early.
A: This medicine is generally considered to have a low risk of kidney damage compared with some older antifungals, but kidney function may still be monitored, especially in seriously ill patients.
A: No. Stopping too early can allow the fungal infection to return or worsen. Always follow the treating doctor's advice about the duration of treatment.
🤔 Common Patient Concerns
🔄 Substitutes for kabifungin 70 injection
View AllAlternative brands with exact same active ingredient:
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guficap 70mg injectionGufic Bioscience Ltd ₹4,059.00 61.6% CHEAPER
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caspledge 70mg injectionFusion Healthcare Pvt Ltd ₹4,999.00 52.8% CHEAPER
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casfung 70mg injectionGlenmark Pharmaceuticals Ltd ₹5,250.50 50.4% CHEAPER
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capsain 70mg injectionSun Pharmaceutical Industries Ltd ₹7,980.00 24.6% CHEAPER
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canducid 70mg injectionZyphar's Pharmaceuticals Pvt Ltd ₹8,477.13 19.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken as a tablet at home.
Fact: This medicine is given only by intravenous infusion under medical supervision. - Myth: This medicine works against all types of infections.
Fact: This medicine works only against susceptible fungi and does not treat viral or bacterial infections. - Myth: This medicine is the same as amphotericin B.
Fact: This medicine belongs to a different antifungal class called echinocandins and generally has a different safety profile. - Myth: You can stop treatment as soon as you feel better.
Fact: Stopping too early can allow the fungal infection to return or worsen. Always follow the doctor's advice.
🔄 Alternative Options
Generic Alternatives
- Caspofungin 70 mg powder for infusion
Brand Alternatives
- Guficap 70mg injection