Dapabite M 5mg/1000mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or rapid breathing
- Severe nausea, vomiting, or abdominal pain
- Extreme tiredness or muscle pain
- Pain, redness, or swelling in the genital area with fever
- Signs of low blood sugar: shakiness, sweating, confusion, rapid heartbeat
- Decreased urine output or swelling in the legs
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is justoza-m 5/1000 tablet er used for?
This medicine is a combination of dapagliflozin and metformin used to treat type 2 diabetes. It helps lower blood sugar by increasing glucose excretion in urine and reducing glucose production in the liver. It is taken orally with meals, usually once or twice daily, as prescribed by a doctor.
- Generic Name: Dapagliflozin (5mg) + Metformin (1000mg)
- Manufacturer: Mankind Pharma Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 justoza-m 5/1000 tablet er के बारे में (Hindi Summary)
उपयोग: यह दवा डैपाग्लिफ्लोज़िन और मेटफॉर्मिन का संयोजन है, जिसका उपयोग टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए किया जाता है। यह रक्त शर्करा (ब्लड शुगर) को नियंत्रित करने में मदद करती है। डैपाग्लिफ्लोज़िन गुर्दे के माध्यम से अतिरिक्त ग्लूकोज को मूत्र के साथ बाहर निकालता है, जबकि मेटफॉर्मिन लिवर में ग्लूकोज के उत्पादन को कम करता है और शरीर की इंसुलिन के प्रति संवेदनशीलता को बढ़ाता है। यह दवा उन वयस्कों के लिए है जिनका ब्लड शुगर सिर्फ डाइट और एक्सरसाइज से नियंत्रित नहीं हो पाता। यह दवा हृदय और गुर्दे की बीमारियों वाले मरीजों के लिए भी फायदेमंद हो सकती है। इसे भोजन के साथ लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जननांग में फंगल संक्रमण, मूत्र मार्ग में संक्रमण, मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द और चक्कर आना शामिल हैं। कुछ लोगों को मुंह में धातु जैसा स्वाद या हल्का वजन घटना भी हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें डायबिटिक कीटोएसिडोसिस, गंभीर मूत्र मार्ग संक्रमण, गुर्दे की समस्या और लैक्टिक एसिडोसिस (मेटफॉर्मिन के कारण) शामिल हो सकते हैं। लैक्टिक एसिडोसिस एक मेडिकल इमरजेंसी है। यदि आपको तेजी से सांस लेने, अत्यधिक थकान, मांसपेशियों में दर्द या पेट में परेशानी महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो और मेटफॉर्मिन अच्छी तरह काम करे। इस दवा को लेते समय भोजन न छोड़ें, क्योंकि इससे ब्लड शुगर कम होने का खतरा बढ़ सकता है, खासकर अगर आप इंसुलिन या सल्फोनिलयूरिया भी ले रहे हैं। दिनभर पर्याप्त पानी पिएं। शराब का अत्यधिक सेवन न करें, क्योंकि इससे लैक्टिक एसिडोसिस का खतरा बढ़ सकता है। अगर आपको गुर्दे या लिवर की समस्या है, तो डॉक्टर को बताएं। डॉक्टर की सलाह के बिना दवा बंद न करें। नियमित रूप से ब्लड शुगर की जांच कराएं।
💊 justoza-m 5/1000 tablet er Uses & Benefits
[{"condition":"Type 2 Diabetes Mellitus","description":"This medicine is used to improve blood sugar control in adults with type 2 diabetes when metformin alone or other therapies are not sufficient.","evidence":"Well-established"},{"condition":"Type 2 Diabetes with Heart Failure","description":"Dapagliflozin, a component of this medicine, has been shown to reduce the risk of hospitalization for heart failure in patients with type 2 diabetes and heart failure.","evidence":"Well-established"},{"condition":"Type 2 Diabetes with Chronic Kidney Disease","description":"This medicine may be used in patients with type 2 diabetes and chronic kidney disease to slow the progression of kidney damage, as dapagliflozin has kidney-protective effects.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Weight management in type 2 diabetes","description":"Dapagliflozin can cause modest weight loss, and this medicine is sometimes used off-label to help with weight reduction in people with type 2 diabetes.","evidence":"Limited"},{"condition":"Non-alcoholic fatty liver disease (NAFLD)","description":"Some studies suggest that dapagliflozin may improve liver enzymes in patients with NAFLD, but this is not an approved indication.","evidence":"Limited"}]
Primary treatment for: Type 2 Diabetes Mellitus
Also treats: Heart failure, Chronic kidney disease
📋 Drug Information
| Generic Name(s) | Dapagliflozin (5mg) + Metformin (1000mg) |
| Brand Name | justoza-m 5/1000 tablet er |
| Manufacturer | Mankind Pharma Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization (WHO) recommends metformin as a first-line treatment for type 2 diabetes. SGLT2 inhibitors like dapagliflozin are recommended as add-on therapy in patients with cardiovascular or kidney disease. However, specific recommendations for this fixed-dose combination may vary. Consult your doctor for personalized advice. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines for the management of type 2 diabetes recommend metformin as initial therapy. Dapagliflozin may be added for better glycemic control and cardiovascular/kidney benefits. The combination is used when monotherapy is insufficient. Always follow your doctor's advice. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works in the kidneys to block the reabsorption of glucose, leading to increased urinary glucose excretion and lowering blood sugar levels. Metformin is a biguanide that decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Together, they provide effective blood sugar control through different pathways.
Mechanism Steps
💡 How to Take justoza-m 5/1000 tablet er
Strength: Dapagliflozin 5 mg + Metformin 1000 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily with meals, as prescribed by your doctor. The dose may be adjusted based on your blood sugar levels, kidney function, and overall health. The maximum recommended dose of dapagliflozin is 10 mg per day, and metformin is 2000 mg per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially the risk of kidney problems and low blood sugar. Dose adjustments may be needed based on kidney function. Regular monitoring is advised. |
| Renal Impairment | Dapagliflozin dose may need to be adjusted in patients with moderate renal impairment. It is not recommended in severe renal impairment (eGFR <30 mL/min/1.73 m²). Metformin is contraindicated in severe renal impairment. Consult your doctor for dose adjustments based on your kidney function. |
| Hepatic Impairment | This medicine should be used with caution in patients with mild to moderate hepatic impairment. It is not recommended in severe hepatic impairment. Consult your doctor for dose adjustments. |
| Maximum Daily Dose | The maximum daily dose of dapagliflozin is 10 mg, and metformin is 2000 mg. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of justoza-m 5/1000 tablet er
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Insulin | Major | |
| Sulfonylureas | Major | |
| Alcohol | Major | |
| Diuretics | Moderate | |
| NSAIDs | Moderate | |
| Contrast media | Major | |
| Cationic drugs | Moderate | |
| ACE inhibitors | Minor | |
| ARBs | Minor | |
| Beta-blockers | Minor |
🚨 Major Interactions
- Insulin or sulfonylureas
- Alcohol
- Contrast media (iodinated)
⚡ Moderate Interactions
- Diuretics
- Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin)
🍷 Alcohol Interaction
Alcohol can increase the risk of lactic acidosis, a rare but serious side effect of metformin. It can also cause low blood sugar. It is advisable to avoid excessive alcohol consumption while taking this medicine. If you choose to drink alcohol, do so in moderation and never on an empty stomach.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Lactic acidosis: Rare but serious. Discontinue and seek immediate medical help if suspected.","Diabetic ketoacidosis: Can occur even with normal blood sugar. Report symptoms like nausea, vomiting, and abdominal pain.","Hypoglycemia: Risk increases when used with insulin or sulfonylureas. Monitor blood sugar regularly.","Genital fungal infections: Maintain good hygiene. Report symptoms to your doctor.","Urinary tract infections: Drink plenty of water. Report symptoms promptly.","Kidney function: Monitor regularly. Dose adjustments may be needed.","Vitamin B12 deficiency: Long-term metformin use may reduce B12 levels. Periodic monitoring is advised.","Surgery: Temporarily discontinue before surgery or procedures involving contrast media, as advised by your doctor.","Alcohol: Avoid excessive consumption to reduce the risk of lactic acidosis."]
🤱 Lactation Safety
This medicine is not recommended while breastfeeding. Both dapagliflozin and metformin are excreted in human milk, and potential adverse effects on the breastfed infant are unknown. Consult your doctor for alternative treatments if you are breastfeeding.
💊 Overdose Management
Overdose of this medicine may cause hypoglycemia, lactic acidosis, or severe kidney problems. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and may include monitoring of vital signs, blood glucose, and kidney function. Hemodialysis may be considered for metformin overdose.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, provided it is not too close to the time for your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Take it with meals to reduce the risk of stomach upset and to help the metformin component work effectively. Do not skip meals while taking this medicine, as it can increase the risk of low blood sugar, especially if you are also taking insulin or sulfonylureas. Stay well hydrated by drinking plenty of water throughout the day. Avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis. Inform your doctor if you have kidney or liver problems, as dose adjustments may be needed. Do not stop taking this medicine without consulting your doctor. If you are scheduled for surgery or a medical procedure, tell your doctor that you are taking this medicine. Monitor your blood sugar regularly as advised. Report any signs of infection, especially in the genital or urinary area, to your doctor promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine, especially the risk of kidney problems and low blood sugar. Dose adjustments may be needed based on kidney function. Regular monitoring of blood sugar and kidney function is advised. Falls and fractures should be monitored due to the risk of dizziness.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or if you are planning to become pregnant. Consult your doctor to switch to a safer alternative, such as insulin, before conception. Good blood sugar control before and during pregnancy is crucial for the health of both mother and baby.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily discontinued before surgery or procedures involving contrast media, as advised by your doctor. It is important to inform your surgeon and anesthesiologist that you are taking this medicine. Blood sugar levels should be monitored closely during the perioperative period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. Dental procedures may cause stress and affect blood sugar levels. It is important to maintain good oral hygiene and monitor blood sugar before and after dental work. Your dentist may consult with your doctor to adjust your medication if needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is beneficial for managing diabetes, but be cautious if you take insulin or sulfonylureas, as exercise can lower blood sugar. Monitor your blood sugar before and after exercise. Stay hydrated and carry a source of fast-acting sugar in case of hypoglycemia. Consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or low blood sugar, which can affect your ability to drive or operate machinery. Be cautious until you know how it affects you. It is important to take your medicine with meals, so plan your work schedule accordingly. Inform your employer about your condition in case of emergencies.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects like lactic acidosis or diabetic ketoacidosis, seek immediate medical attention and follow your doctor's advice. Your doctor may adjust or discontinue the medicine based on your kidney function, blood sugar control, and overall health.
📅 Long-Term Use Effects
Long-term use of this medicine can help maintain blood sugar control and reduce the risk of diabetes-related complications, including heart and kidney disease. However, it may also lead to vitamin B12 deficiency due to metformin, and kidney function should be monitored regularly. Some patients may experience persistent genital fungal infections. Regular follow-up with your doctor is essential to adjust the dose and monitor for any adverse effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are cornerstone treatments for type 2 diabetes and can complement medicine.
Evidence: Well-establishedDPP-4 inhibitors, sulfonylureas, or GLP-1 receptor agonists may be alternatives based on individual needs.
Evidence: Well-establishedMay be required if oral agents are insufficient to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with diabetes are advised to receive routine vaccinations, including influenza and pneumococcal vaccines, as they are at higher risk of infections. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust your dosing schedule as advised by your doctor. Carry enough supply for the entire trip. Check customs regulations for carrying prescription medicines. Stay hydrated during travel, especially on long flights.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Dapagliflozin starts lowering blood sugar within 1-2 hours, but the full effect on HbA1c may take several weeks to months. Metformin's effect develops over days to weeks. Your doctor will monitor your progress.
A: This medicine may be used in some patients with mild to moderate kidney disease, but dose adjustments may be needed. It is not recommended for severe kidney disease. Consult your doctor.
A: Signs include rapid breathing, extreme tiredness, muscle pain, stomach discomfort, and feeling cold. Seek immediate medical attention if you experience these symptoms.
A: When used alone, this medicine is unlikely to cause low blood sugar. However, the risk increases if you also take insulin or sulfonylureas. Monitor your blood sugar regularly.
A: This medicine is not recommended during pregnancy. Consult your doctor for alternative treatments, as insulin is generally preferred.
🤔 Common Patient Concerns
🔄 Substitutes for justoza-m 5/1000 tablet er
View AllAlternative brands with exact same active ingredient:
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dapagza m 5mg/1000mg tabletEmcure Pharmaceuticals Ltd ₹75.00 21.7% CHEAPER
-
dapixa dm 5mg/1000mg tablet erTas Med India Pvt Ltd ₹78.28 18.3% CHEAPER
-
dapabest m 5mg/1000mg tablet erPanacea Biotec Ltd ₹82.32 14% CHEAPER
-
dapaone-m 5/1000 tablet erMSN Laboratories ₹85.31 10.9% CHEAPER
-
dapacose-m 5 forte tablet erJ B Chemicals and Pharmaceuticals Ltd ₹87.04 9.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps manage blood sugar levels but does not cure diabetes. It must be taken regularly along with diet and exercise. - Myth: This medicine can be taken without food.
Fact: This medicine should be taken with meals to reduce stomach upset and improve tolerance. - Myth: This medicine is safe for everyone with diabetes.
Fact: This medicine is not suitable for people with type 1 diabetes, severe kidney or liver disease, or during pregnancy and breastfeeding. - Myth: You can stop taking this medicine once your blood sugar is controlled.
Fact: Diabetes is a chronic condition. Stopping this medicine without consulting your doctor can lead to uncontrolled blood sugar and complications.
🔄 Alternative Options
Generic Alternatives
- Dapagliflozin 5 mg + Metformin 1000 mg tablet
Brand Alternatives
- Dapabite M 5mg/1000mg Tablet