Atorvastatin + Aspirin 20mg/150mg Capsule: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Severe muscle pain or weakness with dark urine
- Unusual bleeding that does not stop
If experiencing severe symptoms, call emergency services immediately.
What is jovastatin ap 20mg/150mg capsule used for?
This medicine is a combination of Atorvastatin 20 mg and Aspirin 150 mg used to lower cholesterol and prevent blood clots in patients at high risk of heart attack or stroke. It is taken orally once daily with food, under medical supervision.
- Generic Name: Atorvastatin (20mg) + Aspirin (150mg)
- Manufacturer: Johnlee Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 jovastatin ap 20mg/150mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा एटोरवास्टेटिन 20 मिलीग्राम और एस्पिरिन 150 मिलीग्राम का संयोजन है। इसका उपयोग उच्च कोलेस्ट्रॉल को कम करने और रक्त के थक्के बनने से रोकने के लिए किया जाता है, खासकर उन रोगियों में जिन्हें दिल का दौरा या स्ट्रोक का खतरा अधिक होता है। यह दवा हृदय रोगों की रोकथाम में मदद करती है और डॉक्टर की सलाह पर ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में पेट में जलन, मतली, सिरदर्द, मांसपेशियों में दर्द और आसानी से चोट लगना शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों से खून बहना, गंभीर मांसपेशियों में दर्द, और एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको काला मल, उल्टी में खून, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें क्योंकि इससे पेट में खून बहने और लीवर की समस्या का खतरा बढ़ सकता है। कोई भी सर्जरी या दंत चिकित्सा से पहले अपने डॉक्टर को इस दवा के बारे में बताएं। बिना डॉक्टर की सलाह के दवा बंद न करें। नियमित रूप से रक्त परीक्षण करवाते रहें।
💊 jovastatin ap 20mg/150mg capsule Uses & Benefits
[{"condition":"Secondary prevention of cardiovascular events","description":"Reduces the risk of heart attack, stroke, and cardiovascular death in patients with established coronary artery disease, peripheral artery disease, or a history of myocardial infarction.","evidence":"Well-established"},{"condition":"Primary prevention in high-risk individuals","description":"May be used in patients with multiple risk factors such as diabetes, hypertension, and dyslipidemia to prevent first cardiovascular events.","evidence":"Established"},{"condition":"Acute coronary syndrome","description":"Used as part of long-term management after an acute coronary syndrome to prevent recurrent events.","evidence":"Well-established"},{"condition":"Ischemic stroke prevention","description":"Helps prevent recurrent transient ischemic attacks and ischemic strokes in patients with atherosclerotic disease.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Antiphospholipid syndrome","description":"Aspirin may be used off-label in some patients with antiphospholipid syndrome for thrombosis prevention, but this combination is not standard.","evidence":"Limited"},{"condition":"Preeclampsia prevention","description":"Low-dose aspirin is sometimes used off-label to prevent preeclampsia in high-risk pregnancies, but this combination with atorvastatin is contraindicated in pregnancy.","evidence":"Limited"}]
Primary treatment for: Cardiovascular disease prevention
Also treats: Hyperlipidemia, Coronary artery disease, Ischemic stroke, Peripheral artery disease, Diabetes mellitus with high cardiovascular risk
📋 Drug Information
| Generic Name(s) | Atorvastatin (20mg) + Aspirin (150mg) |
| Brand Name | jovastatin ap 20mg/150mg capsule |
| Manufacturer | Johnlee Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in a cool, dry place away from direct sunlight. Do not refrigerate unless specified. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. Guidelines from various organizations recommend the use of statins and antiplatelet therapy in specific high-risk patients, but the combination product may not be specifically addressed. |
| ICMR Guideline | Not established from the available information. ICMR guidelines recommend statins for dyslipidemia and aspirin for secondary prevention of cardiovascular events, but specific recommendations for this fixed-dose combination are not available. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a precursor of cholesterol. By inhibiting this enzyme, atorvastatin reduces hepatic cholesterol synthesis, which leads to upregulation of LDL receptors on hepatocytes and increased clearance of LDL cholesterol from the bloodstream. It also decreases triglyceride levels and slightly increases HDL cholesterol. Aspirin is a nonsteroidal anti-inflammatory drug that irreversibly acetylates cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. In platelets, this prevents the formation of thromboxane A2, a potent vasoconstrictor and platelet aggregator. Because platelets lack the ability to synthesize new enzymes, the effect lasts for the lifespan of the platelet, typically 7 to 10 days. Together, these actions provide both lipid-lowering and antiplatelet effects, reducing the risk of atherosclerotic plaque progression and thrombotic events.
Mechanism Steps
💡 How to Take jovastatin ap 20mg/150mg capsule
Strength: Capsule containing Atorvastatin 20 mg and Aspirin 150 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one capsule taken orally once daily, preferably with food. The dose may be adjusted by your doctor based on your cholesterol levels, cardiovascular risk, and response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. Do not stop or change the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, particularly the risk of bleeding and muscle toxicity. The dose should be individualized by a clinician, and regular monitoring is recommended. |
| Renal Impairment | No specific dose adjustment is provided in the available information. Use with caution in patients with renal impairment. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | This medicine is contraindicated in patients with severe liver disease. In patients with mild to moderate hepatic impairment, dose adjustment may be necessary. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum recommended daily dose is one capsule containing Atorvastatin 20 mg and Aspirin 150 mg. Do not exceed this dose unless specifically instructed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of jovastatin ap 20mg/150mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ibuprofen | Major | |
| Clopidogrel | Major | |
| Methotrexate | Major | |
| Cyclosporine | Moderate | |
| Gemfibrozil | Moderate | |
| Itraconazole | Moderate | |
| Clarithromycin | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Warfarin
- Other anticoagulants (e.g., heparin, apixaban, rivaroxaban)
- NSAIDs (e.g., ibuprofen, naproxen)
- Clopidogrel
- Methotrexate
⚡ Moderate Interactions
- Cyclosporine
- Gemfibrozil
- Azole antifungals (e.g., itraconazole, ketoconazole)
- Macrolide antibiotics (e.g., clarithromycin, erythromycin)
- Protease inhibitors (e.g., ritonavir, saquinavir)
🍷 Alcohol Interaction
Alcohol should be avoided or limited while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding due to aspirin's antiplatelet effect and can also increase the risk of liver damage from atorvastatin. Chronic heavy alcohol use may worsen liver function and increase the risk of myopathy.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to atorvastatin, aspirin, or any component of the formulation","Active peptic ulcer disease or history of recurrent ulcers","Bleeding disorders such as hemophilia or von Willebrand disease","Active bleeding or severe thrombocytopenia","Severe liver disease or unexplained persistent elevations of liver enzymes","Pregnancy, especially in the third trimester","Breastfeeding","Children and adolescents under 18 years unless specifically prescribed","Concurrent use with live vaccines","Aspirin-exacerbated respiratory disease (asthma, rhinitis, nasal polyps)"]
⚠️ Warnings & Precautions
["This medicine may increase the risk of bleeding. Report any unusual bleeding or bruising to your doctor.","Avoid alcohol consumption as it increases the risk of liver damage and gastrointestinal bleeding.","Do not take other NSAIDs or blood thinners without consulting your doctor.","Inform your doctor if you have a history of liver or kidney disease, diabetes, or thyroid disorders.","Muscle pain, weakness, or dark urine should be reported immediately as it may indicate rhabdomyolysis.","This medicine may cause dizziness or blurred vision; avoid driving or operating machinery until you know how it affects you.","Regular monitoring of liver function, kidney function, and blood counts is required.","Do not stop taking this medicine abruptly without consulting your doctor.","This medicine should be used with caution in elderly patients due to increased risk of bleeding and muscle toxicity.","Inform your doctor if you are planning to become pregnant or are breastfeeding."]
🤱 Lactation Safety
Not established from the available information. Both atorvastatin and aspirin may pass into breast milk. This medicine is not recommended during breastfeeding unless specifically advised by a doctor.
💊 Overdose Management
Overdose of this medicine may cause symptoms such as severe nausea, vomiting, abdominal pain, dizziness, ringing in the ears, rapid breathing, and signs of bleeding. In case of suspected overdose, seek immediate medical attention. Treatment is supportive and symptomatic. Activated charcoal may be administered if the overdose is recent. Monitor vital signs, electrolytes, and signs of bleeding. There is no specific antidote for atorvastatin; hemodialysis is not effective. For aspirin overdose, urinary alkalinization may be used to enhance elimination.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Take the capsule with a full glass of water, preferably with food to reduce stomach upset. Avoid alcohol while taking this medicine, as it can increase the risk of stomach bleeding and liver problems. Inform your doctor if you have a history of ulcers, bleeding disorders, liver or kidney disease, or asthma. Before any surgery or dental procedure, tell your healthcare provider that you are taking this medicine, as it may need to be stopped temporarily. Do not take other pain relievers or blood thinners without consulting your doctor. If you miss a dose, follow the missed dose instructions provided. Store the medicine in a cool, dry place away from direct sunlight and out of reach of children. Regular blood tests may be needed to monitor your cholesterol levels, liver function, and blood counts.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of bleeding, muscle toxicity, and liver problems. Lower doses may be required, and regular monitoring is essential. Falls should be avoided due to increased bleeding risk.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative. Effective contraception should be used while taking this medicine.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding during and after surgery. Inform your surgeon that you are taking this medicine. It may need to be stopped several days before surgery as advised by your doctor.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may increase the risk of bleeding during dental work. Your dentist may recommend stopping the medicine temporarily or taking precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Regular exercise is encouraged, but avoid activities that may cause injury or bleeding, especially if you are prone to bruising. Contact sports should be avoided. If you experience muscle pain or weakness during exercise, stop and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or blurred vision in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue your daily activities, but take precautions to avoid cuts and bruises due to increased bleeding risk.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe bleeding, muscle pain, or allergic reactions, seek immediate medical attention. Your doctor may adjust the dose or switch to an alternative medicine.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and beneficial for cardiovascular risk reduction. However, it requires regular monitoring of liver function, kidney function, blood counts, and lipid levels. Prolonged use may slightly increase the risk of diabetes and bleeding. Do not stop the medicine without medical advice, as discontinuation may increase the risk of cardiovascular events.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise can help manage cholesterol and cardiovascular risk, but may not replace medication in high-risk patients.
Evidence: Well-establishedRosuvastatin or simvastatin may be used as alternatives to atorvastatin.
Evidence: Well-establishedClopidogrel or ticagrelor may be used instead of aspirin in some patients.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with most vaccines. However, live vaccines should be avoided in patients on immunosuppressive doses of statins, though this is rare. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, continue taking your dose at the same time each day as close as possible. Store at room temperature and avoid direct sunlight. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The antiplatelet effect of aspirin starts within 30-60 minutes, while the cholesterol-lowering effect of atorvastatin takes 2-4 weeks to reach maximum effect.
A: No, do not stop taking this medicine without consulting your doctor. It is often continued long-term to maintain cardiovascular protection.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Always inform your doctor about all other medications you are taking, as this medicine can interact with many drugs, especially blood thinners and NSAIDs.
🤔 Common Patient Concerns
🔄 Substitutes for jovastatin ap 20mg/150mg capsule
View AllAlternative brands with exact same active ingredient:
-
atorise asp 20mg/150mg capsuleCarise Pharmaceuticals Pvt Ltd ₹22.00 71% CHEAPER
-
davaindia atorvastatin+aspirin 20mg/150mg capsuleDavaindia Generic Pharmacy ₹23.00 69.7% CHEAPER
-
davaindia aspirin+atorvastatin+clopidogrel 150mg/20mg/75mg capsuleDavaindia Generic Pharmacy ₹42.00 44.7% CHEAPER
-
tonact-asp 20/150 capsuleLupin Ltd ₹43.40 42.8% CHEAPER
-
ecosprin av 150/20 capsuleUSV Ltd ₹73.45 3.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken without a prescription.
Fact: This medicine is a prescription drug and should only be taken under medical supervision. - Myth: It is safe to take this medicine with other pain relievers.
Fact: Taking other NSAIDs or blood thinners with this medicine can increase the risk of bleeding and other side effects. - Myth: Once cholesterol levels are normal, the medicine can be stopped.
Fact: This medicine is often continued long-term to maintain cardiovascular protection. Do not stop without consulting your doctor. - Myth: This medicine can be taken during pregnancy.
Fact: This medicine is contraindicated during pregnancy as it may harm the fetus.
🔄 Alternative Options
Generic Alternatives
- Atorvastatin 20 mg + Aspirin 150 mg capsule (generic)