Apomatine Syrup (Metoclopramide 5mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Uncontrollable muscle spasms or stiffness, especially in the neck, face, or tongue.
- High fever with muscle rigidity and confusion.
- Difficulty breathing or swelling of the face, lips, or throat.
- Irregular heartbeat or palpitations.
- Severe abdominal pain or blood in vomit or stool.
- Yellowing of the skin or eyes.
- Decreased urine output.
If experiencing severe symptoms, call emergency services immediately.
What is johnlee metoclopramide injection used for?
This medicine is a syrup containing metoclopramide 5 mg per 5 mL. It is used to treat nausea, vomiting, and slow stomach emptying. It works by blocking dopamine receptors and speeding up stomach emptying. It is available by prescription only.
- Generic Name: Metoclopramide (5mg)
- Manufacturer: Johnlee Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 johnlee metoclopramide injection के बारे में (Hindi Summary)
उपयोग: यह दवा मतली, उल्टी और पेट की धीमी गति से खाली होने की समस्या के इलाज के लिए इस्तेमाल की जाती है। यह पेट और आंतों की गति को तेज करती है और मतली को कम करती है। यह डायबिटीज से जुड़े गैस्ट्रोपैरेसिस और एसिड रिफ्लक्स में भी मदद कर सकती है। यह सिरप के रूप में उपलब्ध है और इसे डॉक्टर के निर्देशानुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, बेचैनी, थकान, सिरदर्द और चक्कर आना शामिल हैं। कुछ मामलों में मांसपेशियों में अकड़न, ऐंठन या असामान्य हरकतें हो सकती हैं, जो गंभीर हो सकती हैं। अगर ऐसा कुछ हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसकी मात्रा न बढ़ाएं। इस दवा को लेने के बाद नींद आ सकती है, इसलिए गाड़ी चलाने या मशीन चलाने से बचें। शराब का सेवन न करें। अगर आपको किडनी, लीवर, मिर्गी या पार्किंसन रोग है तो डॉक्टर को बताएं। बच्चों को यह दवा बिना डॉक्टर की सलाह के न दें।
💊 johnlee metoclopramide injection Uses & Benefits
[{"condition":"Nausea and vomiting","description":"This medicine is used to relieve nausea and vomiting from various causes, including chemotherapy, radiotherapy, and surgery.","evidence":"Well-established"},{"condition":"Diabetic gastroparesis","description":"It helps improve stomach emptying in patients with diabetes who have delayed gastric emptying.","evidence":"Well-established"},{"condition":"Gastroesophageal reflux disease (GERD)","description":"It may be used to reduce heartburn and acid reflux by speeding up stomach emptying.","evidence":"Moderate"},{"condition":"Migraine-associated nausea","description":"It can help relieve nausea that occurs with migraines.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Lactation stimulation","description":"Sometimes used off-label to increase breast milk production, but this is not recommended due to potential side effects in the infant.","evidence":"Limited"},{"condition":"Nausea in pregnancy","description":"May be prescribed off-label for severe morning sickness, but only under close medical supervision.","evidence":"Limited"}]
Primary treatment for: Nausea and vomiting
Also treats: Diabetic gastroparesis, Gastroesophageal reflux disease, Migraine-associated nausea
📋 Drug Information
| Generic Name(s) | Metoclopramide (5mg) |
| Brand Name | johnlee metoclopramide injection |
| Manufacturer | Johnlee Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Dopamine (D2) receptor antagonist-Prokinetic agent |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the bottle tightly closed. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by blocking dopamine receptors in the brain and in the gastrointestinal tract. It also has serotonin receptor antagonist properties and enhances the action of acetylcholine. By blocking dopamine D2 receptors in the chemoreceptor trigger zone, it reduces nausea and vomiting. In the stomach and intestines, it increases the strength and frequency of contractions while relaxing the pyloric sphincter, which speeds up gastric emptying.
Mechanism Steps
💡 How to Take johnlee metoclopramide injection
Strength: Each 5 mL of syrup contains 5 mg of metoclopramide.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine for nausea and vomiting is 10 mg to 15 mg taken up to three times daily, 30 minutes before meals. For diabetic gastroparesis, the dose may be 10 mg four times daily, 30 minutes before meals and at bedtime. The maximum recommended dose is 45 mg per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the side effects of this medicine, especially extrapyramidal symptoms and tardive dyskinesia. The dose should be reduced, and the medicine should be used for the shortest possible duration. Consult a doctor for appropriate dosing. |
| Renal Impairment | In patients with severe kidney impairment (creatinine clearance less than 30 mL/min), the dose should be reduced by 50% or the dosing interval extended. Consult a doctor for dose adjustment. |
| Hepatic Impairment | In patients with severe liver impairment, the dose should be reduced and used with caution. Consult a doctor for dose adjustment. |
| Maximum Daily Dose | 45 mg per day for adults. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of johnlee metoclopramide injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Antipsychotics | Major | |
| Levodopa | Major | |
| CNS depressants | Moderate | |
| Anticholinergics | Moderate | |
| Digoxin | Moderate | |
| Paracetamol | Minor | |
| Ibuprofen | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Antipsychotics (e.g., haloperidol, risperidone)
- Levodopa
⚡ Moderate Interactions
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
- Anticholinergic drugs (e.g., atropine, benztropine)
- Digoxin
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine, as it can increase drowsiness, dizziness, and the risk of other side effects. Alcohol may also worsen the underlying condition.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to metoclopramide or any component of the formulation.","Gastrointestinal obstruction, perforation, or bleeding.","Pheochromocytoma.","Epilepsy.","Parkinson's disease.","History of tardive dyskinesia or dystonic reactions to drugs.","Children below 1 year of age (risk of extrapyramidal symptoms)."]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Use with caution in patients with kidney or liver impairment; dose adjustment may be needed.","May cause extrapyramidal symptoms, especially in children and elderly; discontinue if these occur.","Long-term use may cause tardive dyskinesia; use for the shortest duration possible.","May increase prolactin levels; monitor in patients with breast cancer.","Use with caution in patients with heart failure or hypertension."]
🤱 Lactation Safety
This medicine is excreted in breast milk and may cause side effects in the nursing infant, such as drowsiness, restlessness, or abnormal muscle movements. It is generally not recommended during breastfeeding. Consult your doctor for alternative options.
💊 Overdose Management
Overdose may cause drowsiness, confusion, extrapyramidal symptoms, and cardiac arrhythmias. If overdose is suspected, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1 hour of ingestion. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness. Avoid drinking alcohol while taking this medicine, as it can increase drowsiness and other side effects. Inform your doctor if you have kidney or liver disease, epilepsy, Parkinson's disease, or any heart condition. Do not use this medicine for longer than recommended without medical supervision. Keep out of reach of children. If you are pregnant or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of extrapyramidal symptoms and tardive dyskinesia. Use the lowest effective dose for the shortest duration. Monitor closely for any abnormal movements.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed. Discuss alternative treatments if possible.
🏥 Post-Surgery Considerations
This medicine may be used to treat nausea and vomiting after surgery. It should be used with caution in patients who have had gastrointestinal surgery, as it may increase the risk of complications.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with certain medications used during dental procedures. It may also cause dry mouth, which can affect dental health.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise immediately after taking this medicine, as it may cause dizziness or drowsiness. Light activities are fine, but listen to your body and rest if you feel unwell.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause restlessness, which can interfere with concentration.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience abnormal muscle movements, severe drowsiness, or any signs of an allergic reaction. Do not stop suddenly without consulting your doctor if you have been taking it for a long time.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of tardive dyskinesia, a potentially irreversible movement disorder. It may also cause elevated prolactin levels, leading to breast enlargement or milk production. Regular monitoring for movement disorders is recommended. Use for the shortest duration possible.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Eating small, frequent meals and avoiding trigger foods can help manage nausea and gastroparesis.
Evidence: Well-establishedMay help reduce nausea and vomiting in some patients.
Evidence: ModerateNatural remedy that may help with mild nausea.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions between this medicine and vaccines are known. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from light and moisture. If traveling across time zones, adjust dosing times gradually to match your new schedule. Check customs regulations for carrying prescription medicines. Keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after oral administration.
A: It can interact with several medicines, including MAOIs, antipsychotics, and levodopa. Always inform your doctor about all medicines you are taking.
A: It should be used during pregnancy only if clearly needed. Consult your doctor to weigh the benefits and risks.
🤔 Common Patient Concerns
🔄 Substitutes for johnlee metoclopramide injection
View AllAlternative brands with exact same active ingredient:
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esmet 5mg injectionSPM Drugs Pvt Ltd ₹2.34 52% CHEAPER
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metaclop 5mg injectionInd Swift Laboratories Ltd ₹5.63 15.4% COSTLIER
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peridon 5mg injectionWockhardt Ltd ₹6.73 37.9% COSTLIER
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metotid 5mg syrupBiological E Ltd ₹7.50 53.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use.
Fact: This medicine is not recommended for long-term use due to the risk of tardive dyskinesia. It should be used for the shortest duration possible. - Myth: This medicine can be taken for any type of stomach upset.
Fact: This medicine is specifically for nausea, vomiting, and delayed gastric emptying. It is not effective for all types of stomach upset. - Myth: This medicine is safe for infants.
Fact: This medicine is contraindicated in children below 1 year of age due to the risk of serious extrapyramidal symptoms.
🔄 Alternative Options
Generic Alternatives
- Metoclopramide syrup 5 mg/5 mL
Brand Alternatives
- Apomatine syrup