Jeepam Plus 0.50mg/10mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or slow, shallow breathing
- Severe drowsiness or loss of consciousness
- Chest pain, fast or irregular heartbeat
- Seizures or convulsions
- Signs of allergic reaction such as rash, swelling of face, lips, or throat
- Confusion, hallucinations, or severe agitation
- Thoughts of self-harm or suicide
- Yellowing of skin or eyes, dark urine, or severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is jeepam plus 0.50mg/10mg tablet used for?
This medicine is a prescription combination of clonazepam 0.50 mg and escitalopram 10 mg used to treat anxiety and depression together. It works by calming the brain and increasing serotonin. It can cause drowsiness and dependence, so it must be taken exactly as prescribed and never stopped suddenly.
- Generic Name: Clonazepam (0.50mg) + Escitalopram Oxalate (10mg)
- Manufacturer: Jeen Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 jeepam plus 0.50mg/10mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोनाजेपम 0.50 मिलीग्राम और एस्सिटालोप्राम ऑक्सालेट 10 मिलीग्राम का संयोजन है। इसका उपयोग चिंता और अवसाद के इलाज के लिए किया जाता है। यह मस्तिष्क में शांति लाने और सेरोटोनिन के स्तर को बढ़ाने में मदद करती है। यह दवा केवल डॉक्टर के पर्चे पर ही ली जानी चाहिए। इसे अचानक बंद नहीं करना चाहिए क्योंकि इससे withdrawal के लक्षण हो सकते हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, थकान, मुँह सूखना, जी मिचलाना और पसीना आना शामिल हैं। कुछ लोगों को धुंधली दृष्टि, कब्ज या भूख में बदलाव हो सकता है। गंभीर दुष्प्रभावों में भ्रम, याददाश्त की समस्या, मांसपेशियों में कमजोरी और पेशाब करने में कठिनाई हो सकती है। यदि आपको एलर्जी, सांस लेने में कठिनाई, या दिल की धड़कन तेज होने जैसे लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें। शराब का सेवन बिल्कुल न करें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर को बताएं। नियमित रूप से डॉक्टर से मिलते रहें।
💊 jeepam plus 0.50mg/10mg tablet Uses & Benefits
- [{"condition":"Generalised anxiety disorder with depressive symptoms","description":"This combination is used when anxiety and depression occur together and have not improved enough with a single medicine.
- Clonazepam provides rapid anxiety relief while escitalopram treats the underlying depressive and anxiety symptoms over time.","evidence":"Established for the individual components; combination use is based on clinical practice and expert opinion."},{"condition":"Panic disorder with comorbid depression","description":"Clonazepam helps reduce the frequency and intensity of panic attacks, while escitalopram addresses the persistent low mood and worry that often accompany panic disorder.","evidence":"Established for the individual components; combination use is based on clinical practice."},{"condition":"Short-term management of severe anxiety","description":"In some cases, this medicine may be prescribed for a limited period to manage severe anxiety while an antidepressant takes full effect.
- Long-term use of the clonazepam component is generally avoided.","evidence":"Limited to short-term use; long-term combination therapy requires careful review."}]
Off-label uses: [{"condition":"Obsessive-compulsive disorder with anxiety","description":"Escitalopram is sometimes used for OCD, and clonazepam may be added short-term for severe anxiety, but this combination is not approved specifically for OCD.","evidence":"Limited"},{"condition":"Social anxiety disorder with depression","description":"The combination may be used off-label when social anxiety and depression coexist, but it is not a first-line approved treatment for this specific combination.","evidence":"Limited"}]
Primary treatment for: Generalised anxiety disorder with depressive symptoms
Also treats: Panic disorder, Major depressive disorder, Social anxiety disorder, Obsessive-compulsive disorder
📋 Drug Information
| Generic Name(s) | Clonazepam (0.50mg) + Escitalopram Oxalate (10mg) |
| Brand Name | jeepam plus 0.50mg/10mg tablet |
| Manufacturer | Jeen Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep in the original container, tightly closed, away from moisture and direct sunlight. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different but complementary mechanisms. Clonazepam enhances the inhibitory effect of gamma-aminobutyric acid at GABA-A receptors in the brain, which reduces excessive neuronal activity and produces calming, anxiolytic, and muscle-relaxant effects. Escitalopram oxalate selectively inhibits the reuptake of serotonin at the presynaptic membrane, increasing serotonin availability in the synaptic cleft. This leads to adaptive changes in serotonin receptors and improved mood regulation over time. Together, clonazepam provides rapid relief of anxiety and agitation, while escitalopram addresses the underlying depressive and anxiety symptoms with a delayed onset of several weeks.
Mechanism Steps
💡 How to Take jeepam plus 0.50mg/10mg tablet
Strength: Each tablet contains clonazepam 0.50 mg and escitalopram oxalate 10 mg. It is an immediate-release tablet for oral use.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once daily, preferably at the same time each day. The dose may be adjusted by your doctor based on your response and tolerability. The maximum recommended dose should not be exceeded. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Take this medicine exactly as prescribed. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Older adults are more sensitive to the effects of this medicine, especially drowsiness, dizziness, and low sodium levels. The starting dose should be lower, and the dose should be increased gradually only if needed and tolerated. Regular monitoring for falls, confusion, and electrolyte imbalances is recommended. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be necessary in patients with severe renal impairment. Clonazepam and escitalopram are excreted by the kidneys, and accumulation may occur. Consult your doctor for appropriate dose adjustment based on your kidney function. |
| Hepatic Impairment | Dose adjustment is recommended in patients with hepatic impairment because both clonazepam and escitalopram are metabolised in the liver. Use with caution and monitor for increased side effects. Consult your doctor for appropriate dose adjustment. |
| Maximum Daily Dose | The maximum daily dose of this medicine is one tablet (clonazepam 0.50 mg and escitalopram 10 mg) unless otherwise directed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of jeepam plus 0.50mg/10mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Opioids | Major | |
| Ketoconazole | Major | |
| Omeprazole | Major | |
| Warfarin | Moderate | |
| NSAIDs | Moderate | |
| Diuretics | Moderate | |
| Tricyclic antidepressants | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other central nervous system depressants (e.g., opioids, alcohol, barbiturates)
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP2C19 inhibitors (e.g., omeprazole, fluoxetine)
⚡ Moderate Interactions
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Anticoagulants (e.g., warfarin)
- Diuretics
- Tricyclic antidepressants
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol increases the sedative and central nervous system depressant effects of clonazepam, which can lead to severe drowsiness, respiratory depression, and impaired coordination. Alcohol can also worsen depression and anxiety, reducing the effectiveness of escitalopram. Combining alcohol with this medicine increases the risk of accidents, falls, and other injuries.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to clonazepam, escitalopram, or any component of this medicine","Severe liver disease","Narrow-angle glaucoma","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI","Myasthenia gravis","Severe respiratory insufficiency","Sleep apnoea syndrome","Pregnancy and breastfeeding unless clearly necessary and advised by a doctor"]
⚠️ Warnings & Precautions
["This medicine can cause dependence and withdrawal symptoms. Do not stop suddenly without medical supervision.","Avoid driving or operating heavy machinery until you know how this medicine affects you.","Do not consume alcohol while taking this medicine.","Use with caution in older adults due to increased risk of falls, confusion, and low sodium levels.","Inform your doctor if you have a history of substance abuse, liver disease, kidney disease, or heart problems.","This medicine may increase the risk of suicidal thoughts, especially in young adults. Report any unusual changes in mood or behaviour to your doctor immediately.","Do not share this medicine with others."]
🤱 Lactation Safety
Clonazepam and escitalopram are excreted in human breast milk. Breastfeeding while taking this medicine is not recommended because both components can cause sedation, poor feeding, and weight loss in the infant. Consult your doctor to discuss alternative options if you are breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, impaired coordination, slow or shallow breathing, fast or irregular heartbeat, and loss of consciousness. If you suspect an overdose, seek emergency medical help immediately. Treatment is supportive and may include activated charcoal, gastric lavage if within a short time of ingestion, and monitoring of vital signs. Flumazenil, a benzodiazepine antagonist, may be used with caution in cases of severe clonazepam toxicity, but it can precipitate seizures in dependent patients. There is no specific antidote for escitalopram overdose; management is supportive.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if it is less than half the dosing interval away. If more than half the dosing interval has passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, contact your doctor or pharmacist for guidance.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop suddenly, as this can cause withdrawal symptoms such as anxiety, insomnia, tremors, or seizures. Avoid alcohol completely while taking this medicine because it can increase drowsiness and impair your judgment. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep all follow-up appointments so your doctor can monitor your response and adjust the dose if needed. Store this medicine in its original container at room temperature, away from moisture and direct sunlight. Do not share this medicine with anyone else, even if they have similar symptoms. If you miss a dose, follow your doctor's instructions or the missed dose guidance provided with this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more sensitive to the sedative effects of clonazepam and the hyponatraemia risk of escitalopram. They are at higher risk of falls, confusion, and fractures. The starting dose should be lower, and regular monitoring of sodium levels and kidney function is advised. Avoid driving and other high-risk activities.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both clonazepam and escitalopram may pose risks to the fetus. Your doctor may recommend alternative treatments or a gradual dose reduction. Do not stop the medicine suddenly on your own.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine before any surgery. It can interact with anaesthetic agents and increase sedation. Your doctor may advise you to temporarily adjust or stop the medicine before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It can interact with sedatives or anaesthetics used in dentistry and increase drowsiness. Your dentist may take extra precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may affect your coordination. Avoid high-risk activities such as cycling, swimming alone, or using heavy gym equipment until you know how the medicine affects you. Light to moderate exercise is generally safe and beneficial for mood and anxiety.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and difficulty concentrating, which may affect your ability to drive, operate machinery, or perform tasks that require alertness. It may also affect your work performance initially. Inform your employer if your job involves safety-sensitive tasks. With time and dose adjustment, these effects may improve.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will decide when and how to stop based on your response and will gradually reduce the dose to prevent withdrawal symptoms. If you experience severe side effects or allergic reactions, seek immediate medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to tolerance, dependence, and withdrawal symptoms, especially from the clonazepam component. Escitalopram may cause sexual dysfunction, weight changes, and emotional blunting with prolonged use. Regular monitoring by your doctor is essential to assess the ongoing benefit and to adjust or taper the dose safely. Do not use this medicine for longer than prescribed without medical review.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
CBT is an effective non-drug treatment for anxiety and depression and can be used alongside or instead of medicine.
Evidence: Well-establishedThese practices can help reduce anxiety and improve mood.
Evidence: ModerateExercise has been shown to improve symptoms of depression and anxiety.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or exposure to extreme temperatures. If crossing time zones, consult your doctor about adjusting the timing of your dose. Store it at room temperature and away from direct sunlight. Check the customs regulations of your destination country regarding controlled medicines, as clonazepam may be regulated. Carry enough supply for your entire trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Clonazepam starts reducing anxiety within 30 to 60 minutes, but the antidepressant effect of escitalopram may take 1 to 2 weeks to begin and 4 to 6 weeks for full effect.
A: No, you should never stop this medicine suddenly. It can cause withdrawal symptoms such as anxiety, insomnia, tremors, and seizures. Your doctor will gradually reduce the dose.
A: This medicine can cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how it affects you.
A: No, alcohol should be completely avoided while taking this medicine because it increases sedation and impairs judgment.
A: If you miss a dose, take it as soon as you remember if it is less than half the dosing interval away. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is a sleeping pill.
Fact: This medicine is not a sleeping pill. It is a combination of an anti-anxiety medicine and an antidepressant used to treat anxiety and depression. - Myth: I can stop this medicine whenever I feel better.
Fact: You should never stop this medicine suddenly. It can cause withdrawal symptoms and worsen your condition. Always consult your doctor before stopping. - Myth: This medicine is addictive for everyone.
Fact: Clonazepam can cause dependence, especially with long-term use, but not everyone becomes addicted. It is important to use it exactly as prescribed and under medical supervision. - Myth: Taking this medicine means I am weak.
Fact: Taking medicine for anxiety and depression is a sign of strength and self-care. These are medical conditions that deserve proper treatment.
🔄 Alternative Options
Generic Alternatives
- Clonazepam 0.50 mg + Escitalopram 10 mg tablet
Brand Alternatives
- Jeepam Plus 0.50mg/10mg Tablet