clopz 0.50mg tablet md - Clonazepam (0.50mg) medicine

clopz 0.50mg tablet md

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🏭 Snig Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 23, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is clopz 0.50mg tablet md used for?

This medicine contains Clonazepam (0.50mg) and is used to treat NEURO CNS. Enhances GABA-mediated inhibition by binding to benzodiazepine site on GABA-A receptors, increasing . Always consult your doctor before use.

  • Generic Name: Clonazepam
  • Manufacturer: Snig Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
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💊 clopz 0.50mg tablet md Uses & Benefits

Panic disorder, seizure disorders (e.g., Lennox-Gastaut syndrome, myoclonic seizures), anxiety disorders, REM sleep behavior disorder.

Off-label uses: Bipolar disorder (mania), restless legs syndrome, tinnitus, stiff-person syndrome.

📋 Drug Information

Generic Name(s)Clonazepam
Brand NameAnxipam
ManufacturerSnig Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassBenzodiazepines
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; peak plasma concentrations achieved within 1-4 hours.
DistributionWidely distributed throughout the body; crosses the blood-brain barrier and placenta.
Protein BindingApproximately 85% bound to plasma proteins.
MetabolismExtensively metabolized in the liver via CYP3A4 to inactive metabolites (mainly 7-aminoclonazepam).
Half-Life30-40 hours
ExcretionPrimarily renal excretion of metabolites; less than 2% excreted unchanged.
Bioavailability90%
Onset of Action30-60 minutes
Peak Plasma Time1-4 hours
Duration of Action6-12 hours (for single dose); longer with repeated dosing due to accumulation.

How It Works

Enhances GABA-mediated inhibition by binding to benzodiazepine site on GABA-A receptors, increasing chloride ion conductance.

Mechanism Steps

1Binds to benzodiazepine site on GABA-A receptor
2Increases affinity of GABA for the receptor
3Enhances chloride ion channel opening frequency
4Increases chloride ion influx
5Hyperpolarizes the neuron
6Reduces neuronal excitability

💡 How to Take clopz 0.50mg tablet md

Follow your doctor's prescription exactly.

⚠️ Side Effects of clopz 0.50mg tablet md

✅ Common Side Effects

Drowsiness
dizziness
ataxia
fatigue
somnolence
coordination impairment

🚨 Serious Side Effects

Respiratory depression
paradoxical reactions (agitation, aggression)
dependence
withdrawal seizures
suicidal ideation

⚠️ Rare Side Effects

Blood dyscrasias (thrombocytopenia)
hepatic dysfunction
hypersensitivity reactions
SIADH

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Alcohol Major Enhanced sedation and respiratory depression
Opioids Major Additive CNS depression, risk of respiratory depression
Ketoconazole Major Increased clonazepam levels due to CYP3A4 inhibition
Carbamazepine Moderate Decreased clonazepam levels due to CYP3A4 induction
Valproate Moderate Possible increased risk of absence seizures
Grapefruit juice Minor May increase clonazepam levels

🚨 Major Interactions

  • CNS depressants (e.g., alcohol, opioids, barbiturates)
  • CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)

⚡ Moderate Interactions

  • CYP3A4 inducers (e.g., carbamazepine, phenytoin)
  • Valproate

🍷 Alcohol Interaction

Additive CNS depression; avoid alcohol.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to benzodiazepines, severe hepatic impairment, narrow-angle glaucoma, respiratory insufficiency, myasthenia gravis.

🤱 Lactation Safety

Excreted in breast milk; avoid breastfeeding or use with caution.

💊 Overdose Management

Supportive care; flumazenil as antidote (use with caution due to risk of seizures).

⏰ Missed Dose

Take as soon as remembered unless close to next dose; do not double dose.

🔄 Substitutes for clopz 0.50mg tablet md

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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