jaizzy 50mg capsule - Diacerein (50mg) medicine

Artifit 50mg Capsule (Diacerein): Complete Medicine Guide

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🏭 Aamorb Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
⚠️ Hepatotoxicity Risk 🤰 Pregnancy Category Not established from the available information. Diacerein is not recommended during pregnancy unless clearly needed and prescribed by a doctor. Animal studies have shown some evidence of harm to the fetus, but there are no adequate human studies. Consult your doctor if you are pregnant or planning to become pregnant. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate. Several clinical trials support the use of diacerein in osteoarthritis, but results are mixed. It is considered a slow-acting drug for osteoarthritis with moderate evidence.
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Yellowing of skin or eyes
  • Dark urine
  • Severe diarrhea with dehydration
  • Swelling of face, lips, or throat
  • Difficulty breathing
  • Chest pain
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is jaizzy 50mg capsule used for?

This medicine contains Diacerein 50mg, a slow-acting drug for osteoarthritis. It works by reducing inflammation and protecting cartilage. It is taken orally with food, usually once or twice daily. It may cause loose stools and diarrhea. It is not for immediate pain relief and takes weeks to show effect.

  • Generic Name: Diacerein (50mg)
  • Manufacturer: Aamorb Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 jaizzy 50mg capsule के बारे में (Hindi Summary)

उपयोग: यह दवा डायसेरिन 50 मिलीग्राम कैप्सूल है, जिसका उपयोग ऑस्टियोआर्थराइटिस (जोड़ों की गठिया) के इलाज में किया जाता है। यह जोड़ों के दर्द, सूजन और अकड़न को कम करने में मदद करती है। यह दवा धीरे-धीरे काम करती है और इसे कम से कम 2-4 हफ्तों तक नियमित रूप से लेना पड़ता है। यह दवा कार्टिलेज को नुकसान से बचाने में भी मदद करती है। इसे हमेशा भोजन के साथ लें ताकि पेट की परेशानी कम हो। इस दवा को डॉक्टर की सलाह के बिना न लें और न ही बंद करें।

साइड इफेक्ट्स: इस दवा के सबसे आम दुष्प्रभाव पेट से जुड़े होते हैं, जैसे दस्त, पतला मल, पेट दर्द और जी मिचलाना। ये आमतौर पर हल्के होते हैं और कुछ दिनों में ठीक हो जाते हैं। कभी-कभी पेशाब का रंग गहरा पीला या भूरा हो सकता है, जो हानिकारक नहीं है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको लगातार गंभीर दस्त, आंखों या त्वचा का पीलापन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को हमेशा भोजन के साथ या खाने के तुरंत बाद लें ताकि पेट की परेशानी और दस्त कम हो। कैप्सूल को पूरा निगलें, चबाएं नहीं। इस दवा के साथ शराब न पिएं क्योंकि इससे लीवर की समस्या और पेट में bleeding का खतरा बढ़ सकता है। अगर आपको लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर की सलाह के बिना यह दवा न लें। बच्चों को यह दवा न दें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 jaizzy 50mg capsule Uses & Benefits

[{"condition":"Osteoarthritis of the knee","description":"Reduces pain, improves joint function, and slows cartilage degradation in knee osteoarthritis.","evidence":"Well-established"},{"condition":"Osteoarthritis of the hip","description":"Helps alleviate pain and stiffness in hip osteoarthritis, improving mobility.","evidence":"Well-established"},{"condition":"Osteoarthritis of the hand","description":"May reduce pain and improve hand function in patients with hand osteoarthritis.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Chronic low back pain","description":"Sometimes prescribed off-label for chronic low back pain with degenerative changes, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Osteoarthritis

Also treats: Knee osteoarthritis, Hip osteoarthritis, Hand osteoarthritis

📋 Drug Information

Generic Name(s)Diacerein (50mg)
Brand Namejaizzy 50mg capsule
ManufacturerAamorb Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassProteoglycan synthesis Stimulator
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the capsules in their original container, tightly closed. Do not refrigerate unless specified. Keep out of reach of children and pets.
Shelf Life24 months from the date of manufacture, or as indicated on the packaging. Do not use after the expiry date printed on the pack.
WHO GuidelineNot established from the available information. The World Health Organization does not have specific guidelines for diacerein. Treatment should follow local clinical guidelines for osteoarthritis.
ICMR GuidelineNot established from the available information. The Indian Council of Medical Research (ICMR) does not have specific guidelines for diacerein. Consult Indian clinical practice guidelines for osteoarthritis management.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food to minimize stomach upset and diarrhea.
2
Stay well hydrated throughout the day, especially if you experience loose stools.
3
Avoid alcohol completely while taking this medicine to prevent liver damage.
4
Do not expect immediate pain relief; this medicine takes 2-4 weeks to show effect.
5
Report any yellowing of eyes or skin, dark urine, or severe abdominal pain immediately.
6
Do not stop this medicine abruptly without consulting your doctor.
7
Inform your doctor if you have a history of liver or kidney disease before starting this medicine.
8
Take the capsule whole; do not crush or chew it.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Chronic joint pain
This medicine is commonly prescribed for osteoarthritis.
Likely Use
Joint stiffness
This medicine helps reduce stiffness in osteoarthritis.
Likely Use
Fever
This medicine is not a fever reducer.
Not Primary
Acute injury pain
This medicine is not for acute pain relief.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDiacerein is absorbed from the gastrointestinal tract after oral administration. It undergoes extensive first-pass metabolism in the liver, where it is converted to its active metabolite, rhein. The bioavailability of diacerein is relatively low due to this first-pass effect. Food does not significantly affect the absorption of diacerein, but taking it with food may reduce gastrointestinal side effects.
DistributionAfter absorption and conversion to rhein, the active metabolite is widely distributed in the body. It shows a high affinity for joint tissues, including cartilage and synovium, which is where it exerts its therapeutic effects. Protein binding of rhein is high, primarily to albumin.
Protein BindingRhein, the active metabolite of diacerein, is approximately 99% bound to plasma proteins, mainly albumin.
MetabolismDiacerein is extensively metabolized in the liver via first-pass metabolism. It is converted to its active metabolite, rhein, through deacetylation. Rhein undergoes further phase II metabolism, including glucuronidation and sulfation, to form inactive conjugates.
Half-LifeThe elimination half-life of rhein, the active metabolite, is approximately 4 to 5 hours after oral administration of diacerein.
ExcretionDiacerein and its metabolites are primarily excreted through the kidneys. About 30-60% of a dose is excreted in urine as rhein and its conjugates, while a smaller portion is eliminated in feces. Renal impairment can prolong the elimination of rhein.
BioavailabilityThe oral bioavailability of diacerein is approximately 30-50% due to extensive first-pass metabolism. The active metabolite, rhein, reaches peak plasma concentrations within 2-3 hours.
Onset of ActionThe onset of action of this medicine is gradual. It may take 2 to 4 weeks of regular use before noticeable improvement in pain and joint function occurs. Maximum benefits are typically seen after 6 to 12 weeks of continuous therapy.
Peak Plasma TimePeak plasma concentration of the active metabolite, rhein, is reached approximately 2 to 3 hours after oral administration of diacerein.
Duration of ActionThe therapeutic effect of this medicine is long-lasting with continued use. Once steady-state levels are achieved, the beneficial effects on pain and joint function persist as long as the medicine is taken regularly. The duration of action per dose is not clearly defined, but the medicine is usually taken once or twice daily.

How It Works

This medicine works by inhibiting the activity of interleukin-1 beta (IL-1β), a key cytokine that drives inflammation and cartilage breakdown in osteoarthritis. By blocking IL-1β, it reduces the production of matrix metalloproteinases and other enzymes that degrade cartilage. This leads to decreased inflammation, less pain, and slowed progression of joint damage. Unlike traditional NSAIDs, this medicine does not directly inhibit cyclooxygenase enzymes, so it has less immediate pain-relieving effect but may offer long-term cartilage protection.

Mechanism Steps

1
Inhibition of IL-1β production: This medicine reduces the synthesis and release of interleukin-1 beta from activated synovial cells and chondrocytes.
2
Reduction of cartilage-degrading enzymes: By lowering IL-1β levels, it decreases the production of matrix metalloproteinases (MMPs) such as collagenase, which break down cartilage matrix.
3
Stimulation of cartilage repair: This medicine promotes the synthesis of transforming growth factor-beta (TGF-β) and cartilage matrix components, aiding in cartilage repair.
4
Anti-inflammatory effect: Overall, these actions reduce joint inflammation, pain, and stiffness, leading to improved joint function over time.

💡 How to Take jaizzy 50mg capsule

Strength: Diacerein 50 mg immediate-release capsule

1Take this medicine exactly as prescribed by your doctor.
2Swallow the capsule whole with a glass of water.
3Take it with food or immediately after a meal to reduce stomach upset.
4Do not crush, chew, or open the capsule.
5Take it at the same time each day to maintain consistent levels.
6If you miss a dose, follow the missed dose instructions.
7Do not stop taking this medicine without consulting your doctor.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 50 mg taken once or twice daily, preferably with meals. The exact dose and duration of treatment must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to therapy. Do not self-adjust the dose. It may take several weeks to see full benefits. Always follow your doctor's prescription.
Pediatric DosagePediatric dosing is not established from available information. This medicine is not recommended for children and adolescents under 18 years of age. Consult a pediatrician for alternative treatments.
Elderly DosageElderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially gastrointestinal side effects like diarrhea. Dose adjustment may be necessary based on renal and hepatic function. Regular monitoring is advised. Consult your doctor for appropriate dosing.
Renal ImpairmentIn patients with mild renal impairment (creatinine clearance 60-89 mL/min), no dose adjustment is usually needed. In moderate renal impairment (creatinine clearance 30-59 mL/min), dose reduction may be considered. This medicine is contraindicated in severe renal impairment (creatinine clearance <30 mL/min). Consult your doctor for individualized dosing.
Hepatic ImpairmentThis medicine is contraindicated in patients with severe hepatic impairment. In mild to moderate hepatic impairment, use with caution and monitor liver function tests regularly. Dose adjustment may be necessary. Consult your doctor for guidance.
Maximum Daily DoseThe maximum recommended daily dose is 100 mg (50 mg twice daily). Do not exceed this dose unless directed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With meals
Take with food
Reduces stomach upset and diarrhea.
Alcohol
Avoid
Increases risk of liver damage and stomach bleeding.
High-fat meals
Take with caution
May increase gastrointestinal side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of jaizzy 50mg capsule

✅ Common Side Effects

Diarrhea (Common (10-30%))
Stay hydrated and take the medicine with food. If diarrhea persists or becomes severe, consult your doctor.
Loose stools (Common (10-20%))
Usually resolves on its own. Taking with food may help. Consult doctor if it continues.
Abdominal pain (Common (5-10%))
Take with meals. If pain is severe or persistent, contact your doctor.
Nausea (Common (5-10%))
Take with food. Avoid fatty or spicy meals. Consult doctor if it persists.
Dark urine (Common (5-10%))
This is a harmless effect of the medicine. No action needed unless other symptoms occur.

🚨 Serious Side Effects

Severe diarrhea with dehydration (Uncommon (1-2%))
Stop the medicine and seek immediate medical attention if you have severe diarrhea, weakness, or dizziness.
Liver toxicity (hepatitis) (Rare (<0.1%))
Seek immediate medical help if you notice yellowing of eyes or skin, dark urine, or severe abdominal pain.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Call emergency services if you experience swelling of face, lips, throat, difficulty breathing, or widespread rash.

⚠️ Rare Side Effects

Skin rash or itching
Consult your doctor if rash appears. Discontinue if severe.
Headache
Usually resolves. Consult doctor if persistent.
Dizziness
Avoid driving if dizzy. Consult doctor if it continues.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Methotrexate Major
Furosemide Moderate
Antidiabetic drugs Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Hepatotoxic drugs (e.g., methotrexate, isoniazid)

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide)
  • Antidiabetic drugs

🍷 Alcohol Interaction

Avoid consuming alcohol while taking this medicine. Alcohol can increase the risk of liver damage and may worsen gastrointestinal side effects such as diarrhea and stomach pain. It may also increase the risk of stomach bleeding. If you consume alcohol regularly, discuss this with your doctor before starting this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity or allergy to diacerein or any component of the formulation","Inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease)","Severe liver disease or active liver disease","Severe kidney disease (creatinine clearance

⚠️ Warnings & Precautions

["Take with food to reduce gastrointestinal side effects.","Avoid alcohol consumption during treatment.","Monitor liver function tests regularly.","Use with caution in patients with mild to moderate renal impairment.","Discontinue if severe diarrhea occurs and consult a doctor.","Inform your doctor if you have a history of liver or kidney disease.","Do not use for immediate pain relief; it works slowly.","Not recommended for children and adolescents."]

🤱 Lactation Safety

It is not known whether diacerein or its metabolites are excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother. Consult your doctor before breastfeeding.

💊 Overdose Management

There is no specific antidote for diacerein overdose. In case of overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Induce vomiting if the patient is conscious and within a short time of ingestion, but only under medical supervision. Monitor vital signs, liver and kidney function, and electrolytes. Severe diarrhea may lead to dehydration and electrolyte imbalance, requiring intravenous fluids.

⏰ Missed Dose

If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.

Additional Safety Advice

General Safety

Always take this medicine with food or immediately after a meal to reduce the chance of stomach upset and diarrhea. Do not crush or chew the capsule; swallow it whole with a glass of water. Avoid drinking alcohol while taking this medicine because it can increase the risk of liver problems and stomach bleeding. Inform your doctor if you have a history of liver disease, kidney disease, or inflammatory bowel disease before starting this medicine. Your doctor may want to check your liver function tests before and during treatment. Do not take this medicine for longer than prescribed without consulting your doctor. If you are pregnant, planning to become pregnant, or breastfeeding, tell your doctor before taking this medicine. Keep this medicine out of reach of children. Do not share this medicine with others, even if they have similar symptoms.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to gastrointestinal side effects and electrolyte imbalances from diarrhea. Dose adjustment may be needed based on renal and hepatic function. Regular monitoring is advised.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy or when planning pregnancy. If you are trying to conceive, consult your doctor to discuss alternative treatments. Use effective contraception while taking this medicine.

🏥 Post-Surgery Considerations

Consult your doctor before resuming this medicine after surgery. It may interact with other medications or affect healing. Your doctor will advise when it is safe to restart.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. It may increase bleeding risk if combined with certain medications. No specific precautions are usually needed, but consult your doctor.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints.
🥗
Engage in low-impact exercises like swimming or cycling.
😴
Practice good posture and body mechanics.
💧
Include anti-inflammatory foods like omega-3 rich fish, fruits, and vegetables.
🧘
Get adequate sleep to aid recovery.
🌞
Use hot or cold compresses for joint pain relief.
🚭
Avoid prolonged standing or repetitive joint movements.

🏋️ Exercise Considerations

While taking this medicine, you can continue low-impact exercises as tolerated. Avoid high-impact activities that strain joints. If you experience increased pain or swelling, stop and consult your doctor. Physical therapy may be beneficial.

🥗 Diet Recommendations

Include omega-3 rich foods like salmon, flaxseeds, and walnuts.
Reduce intake of processed and fried foods.
Eat plenty of fruits and vegetables rich in antioxidants.
Stay well hydrated to prevent dehydration from diarrhea.
Limit sugar and refined carbohydrates.

💼 Impact on Daily Work & Life

This medicine may cause dizziness in some people. Avoid driving or operating heavy machinery if you feel dizzy. Otherwise, it should not significantly affect your daily work. Take it with food to minimize stomach issues.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects like persistent diarrhea, liver symptoms, or allergic reactions, stop immediately and seek medical help. Your doctor may adjust the dose or switch to another medicine.

📅 Long-Term Use Effects

Long-term use of this medicine may be necessary for chronic osteoarthritis. Regular monitoring of liver and kidney function is advised. Some patients may experience persistent gastrointestinal effects. The medicine may help slow cartilage damage over time. Do not use for longer than prescribed without medical supervision. Periodic review with your doctor is essential to assess benefits and risks.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve joint function.

Evidence: Well-established
Weight loss

Reduces joint stress and improves osteoarthritis symptoms.

Evidence: Well-established
Glucosamine and chondroitin

Dietary supplements that may help with joint health, but evidence is mixed.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information. There are no known interactions between this medicine and vaccines. However, consult your doctor before any vaccination while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking it at your usual times, but adjust gradually if needed. Keep it in your carry-on luggage to avoid loss. Check customs regulations for carrying prescription medicines. Carry enough supply for your entire trip.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old woman with knee osteoarthritis
She had been suffering from knee pain for years and found little relief from painkillers. Her doctor prescribed this medicine. After 3 weeks of taking it with food, she noticed reduced stiffness and could walk longer distances. She experienced mild loose stools initially, which resolved after a week.
💡 Lesson: Consistent use with food and patience are key, as this medicine works slowly but effectively.
👤 A 62-year-old man with hip osteoarthritis
He started this medicine after his hip pain limited his daily activities. He was advised to take it twice daily with meals. After 6 weeks, his pain significantly decreased, and he could climb stairs without support. He also incorporated swimming into his routine.
💡 Lesson: Combining this medicine with lifestyle modifications like low-impact exercise enhances overall joint health.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine is a slow-acting drug. It may take 2 to 4 weeks to notice improvement, and maximum benefits may take 6 to 12 weeks.

Q: Can I take this medicine with other painkillers?

A: Consult your doctor before combining with other painkillers, especially NSAIDs, as interactions may occur.

Q: What should I do if I experience diarrhea?

A: Mild diarrhea is common and usually resolves. Stay hydrated. If diarrhea is severe or persistent, contact your doctor.

Q: Is this medicine safe for my liver?

A: This medicine can rarely cause liver problems. Your doctor may monitor liver function tests. Report any symptoms like yellowing of eyes or skin.

Q: Can I stop taking this medicine when I feel better?

A: Do not stop without consulting your doctor. Stopping abruptly may worsen symptoms.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe during pregnancy?
  • How long does it take to work?

🔄 Substitutes for jaizzy 50mg capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine provides immediate pain relief.
    Fact: This medicine is a slow-acting drug and may take 2-4 weeks to show noticeable effects. It is not for immediate pain relief.
  • Myth: This medicine can cure osteoarthritis completely.
    Fact: This medicine helps manage symptoms and may slow cartilage damage, but it does not cure osteoarthritis.
  • Myth: You can stop this medicine once pain improves.
    Fact: Do not stop without consulting your doctor. Stopping abruptly may worsen symptoms.

🔄 Alternative Options

Generic Alternatives

  • Diacerein 50mg capsule

Brand Alternatives

  • Artifit 50mg capsule
  • Dycerin 50mg capsule
  • Zolter 50mg capsule
  • Cartishine 50mg capsule

📊 Comparison with Similar Medicines

[{"medicine":"Diacerein","class":"SYSADOA","onset":"Slow (2-4 weeks)","main_use":"Osteoarthritis","common_side_effects":"Diarrhea, loose stools"},{"medicine":"Ibuprofen","class":"NSAID","onset":"Fast (30-60 minutes)","main_use":"Pain and inflammation","common_side_effects":"Stomach upset, ulcers"},{"medicine":"Paracetamol","class":"Analgesic","onset":"Fast (30-60 minutes)","main_use":"Pain and fever","common_side_effects":"Liver toxicity in overdose"}]

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