Axifur 750mg Injection (Cefuroxime): A Comprehensive Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat.
- Severe, watery, or bloody diarrhoea.
- Rash with blistering or peeling of the skin.
- Unusual bleeding or bruising.
- Decreased urine output or swelling in the legs.
- Seizures or confusion.
- Yellowing of the skin or eyes.
If experiencing severe symptoms, call emergency services immediately.
What is iviroxime 750mg injection used for?
This medicine is a cefuroxime injection, a second-generation cephalosporin antibiotic used to treat serious bacterial infections. It works by breaking down the bacterial cell wall, leading to bacterial death. It is given by a healthcare professional and is effective against a wide range of bacteria.
- Generic Name: Cefuroxime (750mg)
- Manufacturer: Vhb Life Sciences Inc
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 iviroxime 750mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफुरोक्साइम नामक एंटीबायोटिक का इंजेक्शन है, जिसका उपयोग गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र, मूत्र मार्ग, त्वचा, हड्डियों और जोड़ों के संक्रमण, मेनिनजाइटिस और गोनोरिया के इलाज में प्रभावी है। यह सर्जरी से पहले संक्रमण को रोकने के लिए भी दिया जाता है। यह दवा केवल डॉक्टर या नर्स द्वारा अस्पताल या क्लिनिक में ही दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन लगाने की जगह पर दर्द, लालिमा या सूजन, दस्त, जी मिचलाना, उल्टी और हल्के दाने शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, गंभीर त्वचा प्रतिक्रिया, आंतों का संक्रमण और रक्त कोशिकाओं में कमी हो सकती है। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या क्लिनिक में प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इससे पहले कि आपको यह दवा दी जाए, अपने डॉक्टर को बताएं कि आपको किसी भी एंटीबायोटिक से एलर्जी है या नहीं, या आपको गुर्दे या यकृत की कोई समस्या है या नहीं। अपनी सभी दवाओं के बारे में डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। इलाज के दौरान शराब न पिएं। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें।
💊 iviroxime 750mg injection Uses & Benefits
[{"condition":"Lower respiratory tract infections","description":"Used to treat community-acquired pneumonia, acute exacerbations of chronic bronchitis, and other bacterial lung infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated and uncomplicated urinary tract infections, including pyelonephritis, when caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, wound infections, and abscesses caused by susceptible Gram-positive and Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"Used in the management of osteomyelitis and septic arthritis, often as part of a broader treatment plan.","evidence":"Well-established"},{"condition":"Meningitis","description":"Effective in treating bacterial meningitis caused by susceptible strains of Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae.","evidence":"Well-established"},{"condition":"Gonorrhoea","description":"Used as an alternative treatment for uncomplicated gonorrhoea caused by susceptible strains of Neisseria gonorrhoeae.","evidence":"Well-established"},{"condition":"Surgical prophylaxis","description":"Administered before certain surgical procedures to reduce the risk of postoperative infections.","evidence":"Well-established"},{"condition":"Septicaemia","description":"Used in the treatment of bloodstream infections caused by susceptible bacteria.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Lyme disease","description":"Sometimes used as an alternative to other antibiotics for early Lyme disease, though not a first-line agent.","evidence":"Limited"},{"condition":"Prophylaxis in dental procedures","description":"Occasionally used in patients at high risk of infective endocarditis, but not routinely recommended.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin and soft tissue infections, Bone and joint infections, Meningitis, Gonorrhoea, Septicaemia
📋 Drug Information
| Generic Name(s) | Cefuroxime (750mg) |
| Brand Name | iviroxime 750mg injection |
| Manufacturer | Vhb Life Sciences Inc |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporins: 2nd generation |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store the unreconstituted powder at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light. After reconstitution, the solution should be used within the time specified by the manufacturer, typically within 1 hour if stored at room temperature, or up to 24 hours if refrigerated. Do not freeze. |
| Shelf Life | The shelf life of the unreconstituted powder is typically 24 to 36 months from the date of manufacture. Check the expiry date on the packaging. Once reconstituted, use within the recommended time frame. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting bacterial cell wall synthesis. It binds to specific penicillin-binding proteins located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains. This weakens the cell wall and leads to bacterial cell lysis and death. It is bactericidal against a wide range of Gram-positive and Gram-negative bacteria.
Mechanism Steps
💡 How to Take iviroxime 750mg injection
Strength: 750 mg powder for solution for injection.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the type and severity of infection, the patient's age, weight, and kidney function. For adults with normal kidney function, typical doses range from 750 mg to 1.5 g every 6 to 8 hours, administered intravenously or intramuscularly. For uncomplicated gonorrhoea, a single 1.5 g intramuscular dose (divided into two sites) is often used. For surgical prophylaxis, a single 1.5 g intravenous dose is given 30 to 60 minutes before the procedure. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Doses are typically weight-based and must be determined by a qualified clinician. |
| Elderly Dosage | Elderly patients may have reduced kidney function, which can increase the risk of side effects. The dose should be adjusted based on renal function. Close monitoring is advised. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, the dose and/or dosing interval must be adjusted. For creatinine clearance between 10 and 20 mL/min, the usual dose may be given every 12 hours. For creatinine clearance less than 10 mL/min, the usual dose may be given every 24 hours. Patients on hemodialysis should receive an additional dose after dialysis. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | No specific dosage adjustment is required for patients with hepatic impairment alone, as the drug is primarily excreted unchanged by the kidneys. However, if both hepatic and renal impairment are present, dose adjustment may be necessary. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose should not exceed 6 g per day in adults with normal renal function, but the exact maximum is determined by the clinician based on the indication and patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of iviroxime 750mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Gentamicin | Major | |
| Furosemide | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Tetracycline | Moderate | |
| Chloramphenicol | Moderate | |
| Antacids | Minor | |
| Food | Minor | |
| Alcohol | Moderate |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin)
- Loop diuretics (e.g., furosemide)
- Warfarin
- Probenecid
⚡ Moderate Interactions
- Oral contraceptives
- Bacteriostatic antibiotics (e.g., tetracyclines, chloramphenicol)
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. Alcohol can worsen side effects such as nausea, vomiting, and diarrhoea, and may increase the risk of liver problems. It is best to abstain from alcohol until the treatment course is completed and you have recovered.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to cefuroxime or any other cephalosporin.","Previous severe allergic reaction to penicillins or other beta-lactam antibiotics.","Use in patients with a history of anaphylaxis to beta-lactams."]
⚠️ Warnings & Precautions
["Before starting this medicine, inform your doctor about any allergies to antibiotics.","Use with caution in patients with kidney impairment; dose adjustment may be needed.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","May cause Clostridium difficile-associated diarrhoea; report persistent diarrhoea.","May interfere with certain laboratory tests, such as urine glucose tests and Coombs test.","Do not use this medicine for viral infections as it is ineffective.","Ensure adequate hydration during treatment."]
🤱 Lactation Safety
This medicine is excreted in human breast milk in low concentrations. It is generally considered safe during breastfeeding, but caution is advised. Monitor the infant for diarrhoea, thrush, or rash. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
Overdose with this medicine can cause symptoms such as nausea, vomiting, abdominal pain, and seizures, especially in patients with renal impairment. There is no specific antidote. Treatment is supportive and symptomatic. In cases of severe overdose, hemodialysis may be considered to remove the drug from the bloodstream. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
This medicine is administered by a healthcare professional, so missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer a double dose to catch up. The dosing schedule will be adjusted by your healthcare provider.
Additional Safety Advice
This medicine is for hospital or clinic use only and must be administered by a trained healthcare professional. Before receiving this medicine, tell your doctor if you have ever had an allergic reaction to any antibiotic, especially penicillins or cephalosporins, or if you have kidney problems, liver disease, or a history of colitis. Inform your doctor about all other medicines you are taking, including blood thinners, diuretics, and oral contraceptives. Do not attempt to self-administer this injection. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits with your doctor. Avoid alcohol during treatment as it may worsen side effects. Complete the full course as prescribed, even if you feel better, to prevent the infection from returning.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of side effects. The dose may need to be adjusted based on renal function. Close monitoring for signs of toxicity is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is generally considered safe in pregnancy when clearly needed, but the benefits and risks should be weighed.
🏥 Post-Surgery Considerations
This medicine is often used before surgery to prevent infection. After surgery, if you are prescribed this medicine, it is important to complete the course to prevent postoperative infections. Follow your surgeon's instructions carefully.
🦷 Dental Procedures
If you are scheduled for a dental procedure, inform your dentist if you are receiving this medicine. In some cases, antibiotic prophylaxis may be needed for certain dental procedures, but this medicine is not routinely used for that purpose.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or weak. Avoid strenuous exercise until you have fully recovered. Light activities like walking are fine if you feel up to it. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you may need to take time off work or arrange for transportation. You may experience fatigue or dizziness, so avoid driving or operating heavy machinery until you know how the medicine affects you. Discuss your work schedule with your employer and doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Even if you feel better, you must complete the full course to ensure the infection is fully treated. If you experience severe side effects, your doctor may decide to stop the medicine and switch to an alternative. Always consult your healthcare provider before discontinuing treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is not common, as it is typically used for short courses. Prolonged use may increase the risk of antibiotic resistance, superinfections, and rare blood or kidney problems. If long-term therapy is necessary, regular monitoring of kidney function, blood counts, and liver function may be required. Always follow your doctor's advice regarding the duration of treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For less severe infections, oral antibiotics may be used instead of injections.
Evidence: Well-establishedIf allergic to cephalosporins, other classes such as macrolides or fluoroquinolones may be considered.
Evidence: Well-establishedRest, hydration, and fever control can complement antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are due for a vaccine, inform your doctor, as the timing may need to be adjusted based on your infection and treatment.
📦 Storage Guide
✅ DO
Store the unreconstituted powder at room temperature (15-30°C).
❌ DON'T
Do not freeze the powder or the reconstituted solution.
✅ DO
Protect the powder from light.
❌ DON'T
Do not use if the powder is discolored or the packaging is damaged.
✅ DO
Use the reconstituted solution within the recommended time (usually 1 hour at room temperature or 24 hours if refrigerated).
❌ DON'T
Do not store reconstituted solution for longer than recommended.
✈️ Traveling with This Medicine
If you are traveling and need to continue this medicine, carry it in its original packaging with the prescription label. Keep a copy of your prescription with you. Since this medicine is given by injection, you will need to arrange for a healthcare professional to administer it at your destination. Store it at room temperature and protect it from light. Check with the airline and local authorities about carrying injectable medicines. Always carry a doctor's note explaining your medical condition and the need for this medicine.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours after starting treatment, but it is important to complete the full course as prescribed.
A: No, this medicine must be administered by a healthcare professional in a hospital or clinic setting.
A: Report any side effects to your doctor or nurse immediately. Mild side effects like nausea or diarrhoea may resolve on their own, but severe symptoms require medical attention.
A: This medicine can be used in children, but the dose is determined by a pediatrician based on weight and kidney function.
A: No, you must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance.
🤔 Common Patient Concerns
🔄 Substitutes for iviroxime 750mg injection
View AllAlternative brands with exact same active ingredient:
-
bacticef o kid tabletPrayas Pharmaceuticals ₹34.80 62.5% CHEAPER
-
c-roxim 750mg injectionTroikaa Pharmaceuticals Ltd ₹52.73 43.2% CHEAPER
-
bacticef o syrupPrayas Pharmaceuticals ₹58.59 36.9% CHEAPER
-
cefuroxime sodium 750mg injectionSun Pharmaceutical Industries Ltd ₹77.34 16.7% CHEAPER
-
Sanroxime 750mg InjectionSanjeevani Bio-Tech Pvt Ltd ₹78.75 15.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine is an antibiotic and is ineffective against viruses, including the common cold. - Myth: You can stop this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine is safe to self-administer.
Fact: This medicine must be given by a healthcare professional. Self-administration can be dangerous. - Myth: This medicine is the same as penicillin.
Fact: This medicine is a cephalosporin, which is a different class of antibiotic, though both are beta-lactams. Allergic cross-reactivity is possible.
🔄 Alternative Options
Generic Alternatives
- Cefuroxime sodium
Brand Alternatives
- Axifur 750mg injection