c-roxim 750mg injection - Cefuroxime (750mg) medicine

Axotil 750 Injection: Complete Medicine Guide

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🏭 Troikaa Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 17, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Oct 17, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or swelling of the face, lips, or throat
  • Severe or bloody diarrhea
  • Widespread rash with blisters or peeling skin
  • Seizures or confusion
  • Decreased urine output or swelling in the legs
  • Yellowing of the skin or eyes
  • Persistent high fever despite treatment

If experiencing severe symptoms, call emergency services immediately.

What is c-roxim 750mg injection used for?

This medicine is a cefuroxime injection used to treat serious bacterial infections. It works by killing bacteria and is given by a healthcare professional.

  • Generic Name: Cefuroxime
  • Manufacturer: Troikaa Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 c-roxim 750mg injection के बारे में (Hindi Summary)

उपयोग: यह दवा सेफुरोक्साइम नामक एंटीबायोटिक का इंजेक्शन है, जिसका उपयोग बैक्टीरिया से होने वाले संक्रमणों के इलाज के लिए किया जाता है। यह निमोनिया, मूत्र मार्ग संक्रमण, त्वचा और मांसपेशियों के संक्रमण, हड्डियों के संक्रमण और कुछ यौन संचारित रोगों के इलाज में प्रभावी है। यह दवा बैक्टीरिया की कोशिका भित्ति को तोड़कर उन्हें मार देती है। यह दवा केवल डॉक्टर के निर्देशानुसार और स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन वाली जगह पर दर्द, लालिमा या सूजन, दस्त, जी मिचलाना, उल्टी और हल्के दाने शामिल हैं। कभी-कभी लिवर एंजाइम बढ़ सकते हैं या खून की जांच में बदलाव दिख सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, सांस लेने में कठिनाई, चेहरे या गले में सूजन, गंभीर दस्त, या त्वचा पर फफोले जैसे लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इंजेक्शन लगवाने से पहले अपने डॉक्टर को सेफुरोक्साइम, पेनिसिलिन या किसी अन्य एंटीबायोटिक से एलर्जी, और गुर्दे या लिवर की समस्याओं के बारे में जरूर बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। इलाज के दौरान शराब न पिएं। डॉक्टर द्वारा बताई गई पूरी अवधि तक दवा लें, भले ही आप बेहतर महसूस करें। कोई भी नया लक्षण दिखने पर तुरंत डॉक्टर को बताएं।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 c-roxim 750mg injection Uses & Benefits

[{"condition":"Lower respiratory tract infections","description":"Used to treat community-acquired pneumonia and acute exacerbations of chronic bronchitis caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against many urinary tract infections, including pyelonephritis, when caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for cellulitis, wound infections, and abscesses caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"May be used for osteomyelitis and septic arthritis as part of a broader treatment plan.","evidence":"Well-established"},{"condition":"Gonorrhea","description":"Used as an alternative treatment for uncomplicated gonorrhea caused by susceptible strains of Neisseria gonorrhoeae.","evidence":"Established"},{"condition":"Surgical prophylaxis","description":"Given before certain surgical procedures to reduce the risk of postoperative infection.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Lyme disease","description":"Sometimes used off-label for early Lyme disease in patients who cannot take other recommended antibiotics.","evidence":"Limited"},{"condition":"Prophylaxis in dental procedures","description":"Occasionally considered off-label for preventing infection in high-risk patients undergoing dental work, but not routinely recommended.","evidence":"Limited"}]

Primary treatment for: Bacterial infections caused by susceptible organisms.

Also treats: Pneumonia, Bronchitis, Urinary tract infection, Cellulitis, Osteomyelitis, Gonorrhea

📋 Drug Information

Generic Name(s)Cefuroxime
Brand NameAltacef 500 Tablet
ManufacturerTroikaa Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassCephalosporins: 2nd generation
Route of AdministrationParenteral (intravenous or intramuscular injection). This medicine is not for oral use
StorageStore the unreconstituted powder at room temperature between 15°C and 30°C, away from light and moisture. After reconstitution, the solution should be used within the time specified by the manufacturer, typically within a few hours if kept at room temperature or up to 24 hours if refrigerated. Follow the instructions provided with the product.
Shelf LifeThe shelf life of the unreconstituted powder is typically 24 to 36 months from the date of manufacture. Check the expiry date on the packaging. Do not use if expired.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always reconstitute and administer this medicine according to the manufacturer's instructions.
2
Monitor kidney function before and during treatment, especially in elderly patients or those on other nephrotoxic drugs.
3
Ask patients about any history of penicillin or cephalosporin allergy before administering the first dose.
4
Watch for signs of Clostridioides difficile infection if diarrhea develops during or after treatment.
5
Ensure the full course is completed to prevent relapse and resistance.
6
Consider dose adjustment in patients with renal impairment based on creatinine clearance.
7
Educate patients about the importance of reporting any rash, breathing difficulty, or severe diarrhea immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Fever with cough and difficulty breathing
This medicine is commonly prescribed for bacterial pneumonia.
Likely Use
✅
Burning sensation during urination
This medicine may be used for urinary tract infections.
Likely Use
❌
Runny nose and sneezing
This medicine is not effective against viral infections like the common cold.
Not Primary
✅
Red, swollen, painful skin area
This medicine may be used for skin and soft tissue infections.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is given by injection and is therefore completely absorbed into the bloodstream. The route of administration is parenteral, not oral.
DistributionCefuroxime distributes widely into body tissues and fluids, including the lungs, skin, bone, synovial fluid, and cerebrospinal fluid when the meninges are inflamed. It crosses the placenta and is present in breast milk in small amounts.
Protein BindingCefuroxime is approximately 33% to 50% bound to plasma proteins.
MetabolismCefuroxime is not significantly metabolized in the body and is excreted largely unchanged.
Half-LifeThe elimination half-life is approximately 1 to 2 hours in adults with normal kidney function. It is prolonged in patients with renal impairment.
ExcretionThis medicine is excreted primarily unchanged by the kidneys through glomerular filtration and tubular secretion. Dose adjustment is required in patients with reduced kidney function.
BioavailabilityBioavailability is 100% when given intravenously. Intramuscular administration provides slightly lower but still high bioavailability.
Onset of ActionThe onset of action is rapid, typically within 30 to 60 minutes after intravenous administration, as blood levels rise quickly.
Peak Plasma TimePeak plasma concentrations are reached at the end of an intravenous infusion or within 15 to 60 minutes after intramuscular injection.
Duration of ActionThe duration of action is approximately 6 to 8 hours for most susceptible bacteria, which is why dosing is usually every 6 to 8 hours.

How It Works

This medicine works by binding to specific penicillin-binding proteins located inside the bacterial cell wall. This binding blocks the final step of cell wall synthesis, known as cross-linking of peptidoglycan strands. Without a properly cross-linked cell wall, the bacterium cannot maintain its shape and internal pressure, leading to cell lysis and death. Because human cells do not have a cell wall, this medicine is selectively toxic to bacteria.

Mechanism Steps

1
Binding to penicillin-binding proteins: This medicine binds to penicillin-binding proteins on the inner surface of the bacterial cell wall.
2
Inhibition of cell wall cross-linking: The binding prevents the cross-linking of peptidoglycan chains, which are essential for the strength of the bacterial cell wall.
3
Activation of autolysins: The weakened cell wall triggers bacterial enzymes called autolysins, which further break down the cell wall.
4
Bacterial cell lysis and death: The bacterium can no longer withstand osmotic pressure and bursts, resulting in its death.

💡 How to Take c-roxim 750mg injection

Strength: This product is a sterile powder for injection containing 750 mg of cefuroxime per vial. It must be reconstituted before use according to the manufacturer's instructions.

1This medicine is given by a healthcare professional as an intravenous or intramuscular injection.
2Do not attempt to self-administer this medicine at home.
3The injection site will be cleaned before administration.
4Report any pain, swelling, or redness at the injection site to your nurse or doctor.
5Follow your doctor's instructions for the duration of treatment.
6Complete the full course even if you feel better.

Dosage Information

Adult DosageThe dose of this medicine must be individualized by a qualified clinician based on the type and severity of infection, the patient's age, weight, kidney and liver function, and other factors. For many infections, a common adult dose is 750 mg to 1.5 g given every 6 to 8 hours by intravenous or intramuscular injection. For uncomplicated gonorrhea, a single 1.5 g intramuscular dose may be used. For surgical prophylaxis, a single 1.5 g dose is often given before the procedure. Do not self-administer; this medicine must be given by a healthcare professional.
Pediatric DosagePediatric dosing is not established from available information for this specific product. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may have reduced kidney function, which can increase the levels of this medicine in the body. Dose adjustment may be necessary based on kidney function. Your doctor will determine the appropriate dose.
Renal ImpairmentIn patients with kidney impairment, the dose and dosing interval must be adjusted according to the degree of renal impairment. Your doctor will calculate the appropriate dose based on your creatinine clearance. Close monitoring is advised.
Hepatic ImpairmentNo specific dose adjustment is required for liver impairment alone, as cefuroxime is not significantly metabolized by the liver. However, if both liver and kidney impairment are present, dose adjustment may be needed.
Maximum Daily DoseThe maximum daily dose should not exceed the dose recommended by your doctor. For serious infections, doses up to 3 g every 6 hours (12 g per day) have been used in adults with normal kidney function, but such high doses require close medical supervision.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

Alcohol
Avoid
May worsen nausea, dizziness, and stomach upset.
General food
No restrictions
This medicine is given by injection, so food does not affect its absorption.

⏰ What to Do If You Miss a Dose

📌 You miss a scheduled dose
→ Contact your healthcare provider as soon as possible.
💡 Do not attempt to self-administer a double dose.
📌 You are unsure about the next dose
→ Call your doctor or nurse for guidance.
💡 They will advise you on the correct timing for the next dose.

⚠️ Side Effects of c-roxim 750mg injection

✅ Common Side Effects

Injection site pain or inflammation (Common (1-10%))
Apply a cold compress if advised by your nurse. Report severe pain or swelling to your doctor.
Diarrhea (Common (1-10%))
Stay hydrated. If diarrhea is severe or contains blood, contact your doctor immediately.
Nausea (Common (1-10%))
Eat small, bland meals. Inform your doctor if nausea persists.
Rash (Uncommon (0.1-1%))
Report any rash to your doctor. Stop the medicine and seek urgent care if the rash spreads or is accompanied by fever.
Elevated liver enzymes (Uncommon (0.1-1%))
This is usually detected on blood tests and often resolves without treatment. Your doctor may monitor your liver function.

🚨 Serious Side Effects

Anaphylaxis (Rare (<0.1%))
Seek emergency medical attention immediately if you experience difficulty breathing, swelling of the face or throat, or a sudden drop in blood pressure.
Clostridioides difficile-associated diarrhea (Rare (<0.1%))
Contact your doctor if you develop severe, persistent diarrhea, abdominal pain, or fever. Do not treat with over-the-counter anti-diarrheal medicines without medical advice.
Stevens-Johnson syndrome (Very rare (<0.01%))
Seek immediate medical care if you develop a painful rash, blisters, or peeling skin, especially with fever.
Seizures (Rare (<0.1%))
This is more likely in patients with kidney impairment. Seek emergency care if a seizure occurs.
Severe blood disorders (Very rare (<0.01%))
Report unusual bruising, bleeding, or signs of infection such as persistent fever. Blood tests may be needed.

⚠️ Rare Side Effects

Interstitial nephritis
Hemolytic anemia
Aplastic anemia
Toxic epidermal necrolysis
Encephalopathy
Hepatic cholestasis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Gentamicin Major
Furosemide Major
Probenecid Moderate
Oral contraceptives Moderate
Antacids Minor
Food Minor
Alcohol Moderate
Methotrexate Moderate
Chloramphenicol Moderate

🚨 Major Interactions

  • Aminoglycosides (e.g., gentamicin)
  • Loop diuretics (e.g., furosemide)
  • Warfarin

⚡ Moderate Interactions

  • Probenecid
  • Oral contraceptives

🍷 Alcohol Interaction

Alcohol should be avoided while receiving this medicine because it can increase the risk of nausea, vomiting, and dizziness. It may also worsen dehydration if diarrhea occurs.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known severe allergy to cefuroxime or other cephalosporins","Previous severe immediate allergic reaction to penicillins","Use of live bacterial vaccines during treatment"]

⚠️ Warnings & Precautions

["Before starting this medicine, inform your doctor about any allergies to antibiotics.","Use with caution in patients with kidney impairment; dose adjustment may be needed.","Prolonged use may lead to overgrowth of non-susceptible organisms, including Candida.","If severe diarrhea occurs, consider Clostridioides difficile infection and seek medical advice.","This medicine may interfere with some blood tests, such as Coombs test and urine glucose tests.","Do not use this medicine for viral infections; it will not help.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]

🤱 Lactation Safety

Cefuroxime passes into breast milk in small amounts. It is generally considered compatible with breastfeeding, but monitor the infant for diarrhea, thrush, or rash. Consult your doctor before use.

💊 Overdose Management

Overdose with this medicine can cause brain irritation leading to seizures, especially in patients with kidney impairment. Treatment is supportive and symptomatic. In case of overdose, seek immediate medical attention. Hemodialysis may help remove cefuroxime from the blood in severe cases.

⏰ Missed Dose

If you miss a dose of this medicine, contact your healthcare provider as soon as possible. Do not attempt to self-administer a double dose. Your doctor will advise you on the next step based on your dosing schedule.

Additional Safety Advice

General Safety

This medicine must only be given by a qualified healthcare professional. Before receiving it, tell your doctor about any allergy to cephalosporins, penicillins, or other antibiotics, and about any kidney or liver problems. Do not attempt to inject this medicine yourself. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor so that the benefits and risks can be discussed. Avoid alcohol during treatment because it may worsen nausea and dizziness. Complete the full course prescribed by your doctor, even if you feel better after the first dose, to reduce the risk of resistant bacteria. Report any new symptoms, especially severe diarrhea, rash, or breathing difficulty, without delay.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more likely to have reduced kidney function, which can lead to higher blood levels of this medicine and an increased risk of side effects. Dose adjustment based on kidney function is often necessary. Close monitoring for side effects is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, discuss with your doctor before starting this medicine. Cefuroxime is generally considered safe in pregnancy when needed, but your doctor will weigh the benefits and risks. If you become pregnant while on this medicine, inform your doctor immediately.

🏥 Post-Surgery Considerations

This medicine is sometimes used before, during, or after surgery to prevent or treat infections. If you have recently had surgery, your doctor will determine if this medicine is appropriate for you. Follow all postoperative instructions carefully.

🦷 Dental Procedures

If you are scheduled for a dental procedure while receiving this medicine, inform your dentist. In some cases, your doctor may recommend adjusting the timing of your dose. This medicine is not routinely used for dental prophylaxis unless you have a specific heart condition that requires it.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help your kidneys flush out the medicine.
🥗
Get plenty of rest to support your immune system while fighting the infection.
😴
Eat a balanced diet rich in fruits and vegetables to aid recovery.
💧
Practice good hand hygiene to prevent the spread of infection.
🧘
Avoid close contact with people who are sick while you are recovering.
🌞
Complete the full course of treatment even if you feel better.

🏋️ Exercise Considerations

While receiving this medicine, you may feel tired or weak. Avoid strenuous exercise until you have recovered from the infection. Light activities like walking are fine if you feel up to it. Consult your doctor before resuming intense workouts.

🥗 Diet Recommendations

Drink plenty of water and fluids.
Include probiotic-rich foods like yogurt if you experience diarrhea, but consult your doctor first.
Eat small, frequent meals if you have nausea.
Avoid alcohol during treatment.
Include foods rich in vitamin C and zinc to support healing.

💼 Impact on Daily Work & Life

You may need to take time off work or school while receiving this medicine, especially if you are hospitalized. You may feel tired or dizzy, so avoid driving or operating heavy machinery until you feel fully recovered. Follow your doctor's advice about when to return to normal activities.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Stopping early can allow the infection to return and may lead to antibiotic resistance. Your doctor will determine when the course is complete. If you experience severe side effects, contact your doctor immediately; they will decide whether to stop or change the treatment.

📅 Long-Term Use Effects

Long-term use of this medicine is not common because it is usually given for a short course. Prolonged use may increase the risk of antibiotic resistance, fungal overgrowth, and Clostridioides difficile infection. Regular monitoring of kidney and liver function may be needed if used for extended periods. Always follow your doctor's instructions and do not use it for longer than prescribed.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Oral antibiotics

For mild infections, oral antibiotics may be used instead of injections. However, this depends on the type and severity of the infection.

Evidence: Well-established
Other injectable antibiotics

Depending on the bacteria causing the infection, other antibiotics such as ceftriaxone or cefazolin may be used.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine may reduce the effectiveness of live bacterial vaccines, such as the typhoid vaccine. Avoid receiving live vaccines during treatment and for a short period after. Inactivated vaccines are generally safe to receive. Consult your doctor for specific advice.

📦 Storage Guide

✅ DO

Store the unreconstituted powder at room temperature (15-30°C).

❌ DON'T

Do not freeze the powder.

✅ DO

Keep the vial in its original carton to protect from light.

❌ DON'T

Do not store in direct sunlight or in a bathroom cabinet.

✅ DO

Use the reconstituted solution within the time specified by the manufacturer.

❌ DON'T

Do not use the solution if it is cloudy or contains particles.

✈️ Traveling with This Medicine

If you need to travel while receiving this medicine, carry it in its original packaging with the prescription label clearly visible. Carry a copy of your prescription and a letter from your doctor explaining the medical need for the injection. Since this medicine is given by a healthcare professional, arrange for administration at a clinic or hospital at your destination. Store the unreconstituted powder at room temperature, away from direct sunlight and moisture. If you are crossing time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for carrying injectable medicines across borders.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old man with community-acquired pneumonia
He was admitted to the hospital with high fever and difficulty breathing. He was started on this medicine intravenously. Within 48 hours, his fever subsided and his breathing improved. He completed a 7-day course and recovered fully. He reported mild diarrhea during treatment, which resolved after the course ended.
💡 Lesson: This medicine can be highly effective for serious bacterial infections when given promptly and appropriately. Mild side effects like diarrhea are common but usually temporary.
👤 A 32-year-old woman with a complicated urinary tract infection
She had a history of kidney stones and developed a severe urinary tract infection. She was treated with this medicine by injection for 5 days, followed by oral antibiotics. Her symptoms resolved completely. She was advised to increase her water intake to prevent future infections.
💡 Lesson: Injectable antibiotics like this medicine are useful for serious infections that may not respond to oral antibiotics. Staying hydrated is important for urinary tract health.

💬 Questions Patients Often Ask

Q: How long does it take for this medicine to work?

A: You may start to feel better within 24 to 48 hours after starting treatment, but it is important to complete the full course prescribed by your doctor.

Q: Can I take this medicine at home?

A: No, this medicine must be given by a healthcare professional in a clinic or hospital setting.

Q: What should I do if I experience side effects?

A: Report any side effects to your doctor immediately. Mild side effects like nausea or diarrhea may resolve on their own, but severe symptoms require urgent medical attention.

Q: Is this medicine safe during pregnancy?

A: This medicine is generally considered safe during pregnancy when clearly needed, but you should always consult your doctor to weigh the benefits and risks.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine if I am allergic to penicillin?
  • How long will I need to stay in the hospital for this injection?
  • Will this medicine affect my kidney function?
  • Can I breastfeed while receiving this medicine?
  • What should I do if I miss a dose?
  • Can I drink alcohol while on this medicine?

🔄 Substitutes for c-roxim 750mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure viral infections like the flu.
    Fact: This medicine only works against bacterial infections. It is not effective against viruses.
  • Myth: You can stop this medicine as soon as you feel better.
    Fact: You must complete the full course prescribed by your doctor to prevent the infection from returning and to reduce the risk of antibiotic resistance.
  • Myth: This medicine is safe to self-administer at home.
    Fact: This medicine must be given by a trained healthcare professional. Self-administration can be dangerous.

🔄 Alternative Options

Generic Alternatives

  • Cefuroxime injection (generic)

Brand Alternatives

  • Axotil 750 injection

📊 Comparison with Similar Medicines

[{"medicine":"Cefuroxime injection","class":"Second-generation cephalosporin","route":"Parenteral","common_use":"Respiratory, urinary, skin infections"},{"medicine":"Ceftriaxone injection","class":"Third-generation cephalosporin","route":"Parenteral","common_use":"Meningitis, gonorrhea, pneumonia"},{"medicine":"Cefazolin injection","class":"First-generation cephalosporin","route":"Parenteral","common_use":"Surgical prophylaxis, skin infections"}]

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