ivimax 1000 mg/500 mg injection - Cefotaxime (1000mg) + Sulbactam (500mg) medicine

Biotax SB 1000 mg/500 mg Injection: Complete Medicine Guide

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🏭 Vhb Life Sciences Inc 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or wheezing
  • Swelling of the face, lips, tongue, or throat
  • Severe or bloody diarrhea
  • Rash with fever or blistering
  • Decreased urine output or swelling in the legs
  • Yellowing of the skin or eyes
  • Unusual bleeding or bruising
  • Seizures

If experiencing severe symptoms, call emergency services immediately.

What is ivimax 1000 mg/500 mg injection used for?

This medicine is a combination antibiotic injection containing cefotaxime and sulbactam. It is used to treat serious bacterial infections. It works by killing bacteria and preventing them from producing enzymes that would destroy the antibiotic. It is given by a healthcare professional.

  • Generic Name: Cefotaxime (1000mg) + Sulbactam (500mg)
  • Manufacturer: Vhb Life Sciences Inc
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ivimax 1000 mg/500 mg injection के बारे में (Hindi Summary)

उपयोग: यह दवा सेफोटैक्साइम और सल्बैक्टम का संयोजन है, जिसका उपयोग गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह श्वसन तंत्र, मूत्र मार्ग, त्वचा, रक्त और अन्य अंगों के संक्रमण में प्रभावी है। यह इंजेक्शन के रूप में डॉक्टर या नर्स द्वारा दिया जाता है। यह वायरल संक्रमण जैसे सर्दी-जुकाम के लिए प्रभावी नहीं है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, लालिमा, दस्त, मतली, उल्टी, और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, सांस लेने में कठिनाई, चेहरे या गले में सूजन, और गंभीर दस्त हो सकते हैं। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा दी जानी चाहिए। इसे स्वयं न लगाएं। उपयोग से पहले अपने डॉक्टर को किसी भी एलर्जी, गुर्दे या यकृत की समस्या के बारे में बताएं। उपचार के दौरान डॉक्टर द्वारा बताई गई सावधानियों का पालन करें। बिना डॉक्टर की सलाह के दवा बंद न करें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 ivimax 1000 mg/500 mg injection Uses & Benefits

[{"condition":"Lower respiratory tract infections","description":"Used to treat community-acquired and hospital-acquired pneumonia, bronchitis, and other bacterial lung infections.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against complicated and uncomplicated urinary tract infections caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, abscesses, wound infections, and other bacterial skin infections.","evidence":"Well-established"},{"condition":"Bloodstream infections","description":"Used for bacteremia and sepsis caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Meningitis","description":"Cefotaxime is a preferred agent for bacterial meningitis in many age groups due to its CNS penetration.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Treats pelvic inflammatory disease, endometritis, and other infections of the female reproductive tract.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for peritonitis and intra-abdominal abscesses.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"May be used for osteomyelitis and septic arthritis caused by susceptible bacteria.","evidence":"Established"}]

Off-label uses: [{"condition":"Prophylaxis in surgical procedures","description":"Sometimes used before certain surgeries to prevent infection, though other agents are more commonly recommended.","evidence":"Limited"},{"condition":"Neutropenic fever","description":"May be used as part of empiric therapy in cancer patients with low white blood cell counts and fever.","evidence":"Limited"}]

Primary treatment for: Bacterial infections

Also treats: Pneumonia, Urinary tract infection, Cellulitis, Meningitis, Sepsis, Pelvic inflammatory disease

📋 Drug Information

Generic Name(s)Cefotaxime (1000mg) + Sulbactam (500mg)
Brand Nameivimax 1000 mg/500 mg injection
ManufacturerVhb Life Sciences Inc
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action Class
Route of AdministrationParenteral (intramuscular or intravenous)
StorageStore the unreconstituted powder at room temperature between 20°C and 25°C (68°F to 77°F). Protect from light and moisture. Once reconstituted, the solution should be used within the time specified by the manufacturer, typically within 1 hour for intravenous use or up to 24 hours if refrigerated. Follow the instructions provided by your healthcare facility.
Shelf LifeThe shelf life of the unreconstituted product is typically 24 to 36 months from the date of manufacture. Check the expiry date on the packaging. Do not use if expired.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always verify the patient's allergy history before administering this medicine, especially to penicillins and cephalosporins.
2
Reconstitute the powder with the recommended diluent and use within the specified time to maintain stability.
3
Monitor kidney function closely in elderly patients and those with pre-existing renal impairment.
4
Watch for signs of superinfection, such as oral thrush or vaginal yeast infections, during prolonged therapy.
5
Educate patients to report any severe or bloody diarrhea immediately, as it may indicate C. difficile infection.
6
Ensure the full course is completed as prescribed to prevent recurrence and resistance.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Fever with chills
This medicine is used for serious bacterial infections that can cause fever.
Likely Use
✅
Burning urination
It is effective for urinary tract infections.
Likely Use
❌
Common cold
This medicine is not effective against viral infections.
Not Primary
✅
Skin redness and swelling
It is used for skin and soft tissue infections.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is administered parenterally and is completely absorbed from the injection site into the bloodstream. It is not intended for oral administration.
DistributionCefotaxime and sulbactam distribute widely into body tissues and fluids, including the cerebrospinal fluid when the meninges are inflamed, achieving therapeutic concentrations in many sites of infection.
Protein BindingCefotaxime is approximately 30-50% bound to plasma proteins. Sulbactam is about 38% bound to plasma proteins.
MetabolismCefotaxime is partially metabolized in the liver to desacetylcefotaxime, which also has antibacterial activity. Sulbactam is largely metabolized to a lesser extent and is primarily excreted unchanged.
Half-LifeThe elimination half-life of cefotaxime is approximately 1 to 1.5 hours in adults with normal kidney function. Sulbactam has a half-life of about 1 hour. These half-lives are prolonged in patients with renal impairment.
ExcretionCefotaxime and its active metabolite desacetylcefotaxime are excreted primarily by the kidneys through glomerular filtration and tubular secretion. Sulbactam is also excreted mainly unchanged in the urine.
BioavailabilityBioavailability is 100% when administered intravenously. Intramuscular administration also provides high bioavailability, generally greater than 90%.
Onset of ActionThe onset of antibacterial action begins within 30 minutes to 1 hour after intravenous administration, with peak effects occurring shortly after infusion.
Peak Plasma TimePeak plasma concentrations are achieved immediately after intravenous injection and within 30 to 60 minutes after intramuscular injection.
Duration of ActionThe antibacterial effect typically lasts for 6 to 12 hours depending on the dose and the susceptibility of the infecting organism, which is why dosing is usually every 6 to 12 hours.

How It Works

Cefotaxime is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial lysis and death. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes produced by bacteria, thereby protecting cefotaxime from enzymatic degradation and extending its spectrum of activity against beta-lactamase-producing strains.

Mechanism Steps

1
Binding to penicillin-binding proteins: Cefotaxime binds to specific penicillin-binding proteins located in the bacterial cell wall, which are essential for cell wall synthesis.
2
Inhibition of cell wall cross-linking: This binding inhibits the transpeptidation reaction that cross-links peptidoglycan chains, weakening the bacterial cell wall.
3
Activation of autolysins: The disruption of cell wall synthesis leads to activation of bacterial autolytic enzymes that further degrade the cell wall.
4
Bacterial cell lysis: The weakened cell wall cannot withstand osmotic pressure, causing the bacterium to swell and burst, resulting in cell death.
5
Protection by sulbactam: Sulbactam binds to and inhibits beta-lactamase enzymes that would otherwise hydrolyze cefotaxime, ensuring cefotaxime remains active against beta-lactamase-producing bacteria.

💡 How to Take ivimax 1000 mg/500 mg injection

Strength: Each vial contains cefotaxime sodium equivalent to 1000 mg of cefotaxime and sulbactam sodium equivalent to 500 mg of sulbactam.

1This medicine is given by a healthcare professional as an intramuscular or intravenous injection.
2Do not attempt to self-administer this medicine.
3The injection site will be cleaned before administration.
4For intravenous use, the powder is reconstituted with sterile water or saline and may be given directly or diluted further.
5For intramuscular use, the powder is reconstituted with sterile water or a suitable diluent and injected into a large muscle.
6Report any pain, redness, or swelling at the injection site to your nurse or doctor.

Dosage Information

Adult DosageThe dose of this medicine is individualized by a qualified clinician based on the type and severity of infection, the patient's age, weight, kidney and liver function, and other factors. For many infections, a common adult dose is 1 to 2 grams of cefotaxime every 6 to 12 hours, but the exact dose and frequency must be determined by your doctor. The sulbactam component is fixed in a 2:1 ratio with cefotaxime. Do not self-administer; this medicine is given by a healthcare professional.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician. Doses are typically based on weight and the severity of infection, and must be determined by a qualified clinician.
Elderly DosageElderly patients may have reduced kidney function, which can affect the elimination of this medicine. Dose adjustment may be necessary based on kidney function. Your doctor will determine the appropriate dose.
Renal ImpairmentIn patients with kidney impairment, the dose and/or dosing interval of this medicine should be adjusted according to the degree of impairment. Your doctor will calculate the appropriate dose based on your creatinine clearance. Close monitoring of kidney function is recommended.
Hepatic ImpairmentNo specific dose adjustment is generally required for liver impairment alone, but caution is advised in patients with both liver and kidney disease. Your doctor will determine the appropriate dose.
Maximum Daily DoseThe maximum daily dose should not exceed 12 grams of cefotaxime per day, but the exact limit depends on the clinical situation and must be determined by a qualified clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

No specific food interactions
No restrictions
This medicine is given parenterally, so food does not affect its absorption.

⏰ What to Do If You Miss a Dose

📌 You miss a scheduled dose while in the hospital
→ Inform your nurse or doctor immediately.
💡 They will adjust the schedule and administer the dose as soon as possible.
📌 You are receiving treatment at home through a home healthcare service
→ Contact your healthcare provider as soon as you remember.
💡 Do not attempt to self-administer an extra dose.

⚠️ Side Effects of ivimax 1000 mg/500 mg injection

✅ Common Side Effects

Injection site pain (Common (5-10%))
Apply a cold compress to the site. Report if severe or persistent.
Diarrhea (Common (5-10%))
Stay hydrated. If diarrhea is severe or bloody, contact your doctor immediately.
Nausea (Common (5-10%))
Eat small, frequent meals. Inform your doctor if it persists.
Rash (Uncommon (1-5%))
Report to your doctor. If rash is accompanied by fever or swelling, seek immediate care.
Vomiting (Uncommon (1-5%))
Stay hydrated. Contact your doctor if vomiting is severe or persistent.

🚨 Serious Side Effects

Anaphylaxis (Rare (<0.1%))
Seek emergency medical attention immediately if you experience difficulty breathing, swelling of the face or throat, or a sudden drop in blood pressure.
Clostridioides difficile-associated diarrhea (Rare (<0.1%))
Contact your doctor if you develop severe, persistent, or bloody diarrhea, even weeks after treatment.
Severe skin reactions (e.g., Stevens-Johnson syndrome) (Rare (<0.1%))
Seek immediate medical attention if you notice a painful rash, blistering, or peeling skin.
Blood dyscrasias (e.g., neutropenia, thrombocytopenia) (Rare (<0.1%))
Report any unusual bruising, bleeding, or signs of infection to your doctor. Blood tests may be needed.
Nephrotoxicity (Rare (<0.1%))
Your doctor may monitor kidney function. Report decreased urine output or swelling.

⚠️ Rare Side Effects

Seizures
Seek emergency medical attention if seizures occur, especially in patients with kidney impairment.
Hepatitis
Report yellowing of skin or eyes, dark urine, or abdominal pain to your doctor immediately.
Interstitial nephritis
Seek medical attention if you experience fever, rash, and decreased urine output.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Gentamicin Major
Warfarin Major
Furosemide Moderate
Probenecid Moderate
Oral contraceptives Moderate
Methotrexate Minor

🚨 Major Interactions

  • Aminoglycosides (e.g., gentamicin)
  • Warfarin
  • Loop diuretics (e.g., furosemide)

⚡ Moderate Interactions

  • Probenecid
  • Oral contraceptives

🍷 Alcohol Interaction

Alcohol does not directly interact with this medicine, but it can worsen dehydration and gastrointestinal side effects. It is advisable to avoid alcohol during treatment, especially if you have an infection.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known severe allergy to cefotaxime, sulbactam, or other cephalosporins","Known severe allergy to penicillins (cross-reactivity possible)","Previous anaphylactic reaction to beta-lactam antibiotics"]

⚠️ Warnings & Precautions

["Use with caution in patients with kidney impairment; dose adjustment may be needed.","Use with caution in patients with liver disease.","May cause Clostridioides difficile-associated diarrhea; monitor for severe diarrhea.","Serious allergic reactions, including anaphylaxis, can occur. Discontinue immediately if suspected.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","May interfere with certain laboratory tests, such as urine glucose tests.","Not effective against viral infections.","Should be used only when a bacterial infection is confirmed or strongly suspected."]

🤱 Lactation Safety

Cefotaxime and sulbactam are excreted in human milk in low concentrations. The amount ingested by a nursing infant is usually small and unlikely to cause harm, but it may affect the infant's gut flora and lead to diarrhea or thrush. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose with this medicine is unlikely due to its parenteral administration in a healthcare setting. If overdose is suspected, treatment should be symptomatic and supportive. Cefotaxime and sulbactam can be removed by hemodialysis in cases of severe toxicity, especially in patients with renal failure.

⏰ Missed Dose

This medicine is administered by a healthcare professional, so missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer an extra dose.

Additional Safety Advice

General Safety

This medicine must only be administered by a healthcare professional. Before receiving it, inform your doctor about any allergies, especially to penicillins or cephalosporins, and about any kidney or liver problems you may have. Do not self-administer this injection. If you experience any signs of a severe allergic reaction, such as difficulty breathing, swelling of the face or throat, or a rapid heartbeat, seek emergency medical help immediately. Diarrhea that is severe or lasts after treatment may be a sign of a serious bowel infection and should be reported to your doctor. Your doctor may monitor your kidney and liver function, as well as your blood counts, during treatment. Do not skip doses or stop treatment early, even if you feel better, as this can lead to resistance and recurrence of the infection.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more likely to have reduced kidney function, which can affect the elimination of this medicine. Dose adjustment may be necessary. They may also be more susceptible to side effects such as confusion or seizures. Close monitoring is recommended.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is generally considered safe in pregnancy when needed, but the decision should be made with your healthcare provider.

🏥 Post-Surgery Considerations

This medicine may be used to treat or prevent infections after surgery. If you have recently had surgery, inform your surgeon and anesthesiologist about all medications you are taking, including this one.

🦷 Dental Procedures

Inform your dentist if you are receiving this medicine, as it may affect the choice of antibiotics for dental procedures or interact with other medications. Good oral hygiene is important during treatment.

💚 Lifestyle Tips for Better Results

🏃
Get plenty of rest to help your body fight the infection.
🥗
Stay well hydrated by drinking plenty of fluids.
😴
Eat a balanced diet to support your immune system.
💧
Practice good hand hygiene to prevent the spread of infection.
🧘
Avoid alcohol as it can worsen side effects and dehydration.
🌞
Complete the full course of treatment as prescribed.

🏋️ Exercise Considerations

While recovering from a serious infection, avoid strenuous exercise until you feel fully recovered. Light activity such as walking is fine, but consult your doctor before resuming intense workouts.

🥗 Diet Recommendations

Drink plenty of water and fluids.
Eat easily digestible foods if you have nausea or diarrhea.
Include probiotic-rich foods like yogurt if you experience diarrhea, but consult your doctor first.
Avoid spicy and greasy foods if you have stomach upset.

💼 Impact on Daily Work & Life

This medicine is given in a hospital or clinic, so you may need to take time off work during treatment. You should not drive or operate heavy machinery if you feel weak, dizzy, or unwell. Follow your doctor's advice regarding rest and return to work.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Stopping early can lead to recurrence of infection and antibiotic resistance. Your doctor will determine when to stop based on your clinical response and test results.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to antibiotic resistance, superinfections with fungi or resistant bacteria, and rarely, blood disorders or kidney problems. Prolonged therapy should be guided by clinical response and culture results. Regular monitoring of kidney function, liver function, and blood counts may be necessary.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Oral antibiotics

For mild infections, oral antibiotics may be used instead of injections.

Evidence: Well-established
Other injectable antibiotics

Depending on the bacteria and its susceptibility, other antibiotics like ceftriaxone or piperacillin-tazobactam may be used.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no specific vaccine interactions with this medicine. However, if you are due for any vaccinations, inform your doctor. Live vaccines should generally be avoided during acute infection.

📦 Storage Guide

✅ DO

Store the unreconstituted powder at room temperature (20-25°C)

❌ DON'T

Do not freeze the powder

✅ DO

Protect from light and moisture

❌ DON'T

Do not store in the bathroom

✅ DO

Use reconstituted solution within the recommended time

❌ DON'T

Do not use if the solution is cloudy or contains particles

✈️ Traveling with This Medicine

This medicine is given in a healthcare setting, so travel is not typically applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed, and declare it at customs if required. Consult your doctor before traveling if you are still on treatment.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 65-year-old man with diabetes and a urinary tract infection
He was admitted to the hospital with fever and burning urination. He was started on this medicine intravenously. His fever subsided within 48 hours, and his urine culture confirmed a susceptible bacterium. He completed a 7-day course and recovered fully. His kidney function was monitored throughout.
💡 Lesson: This medicine is effective for serious urinary tract infections, but kidney function should be monitored, especially in older adults with diabetes.
👤 A 30-year-old woman with a severe skin infection after a minor injury
She developed cellulitis on her leg that did not improve with oral antibiotics. She was given this medicine intravenously in the hospital. The redness and pain improved significantly within 3 days. She was discharged on oral antibiotics to complete the treatment.
💡 Lesson: For severe skin infections, intravenous antibiotics like this medicine can rapidly control the infection and prevent complications.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start feeling better within 24 to 48 hours after starting treatment, but it is important to complete the full course as prescribed.

Q: Can I take this medicine at home?

A: No, this medicine must be given by a healthcare professional in a clinical setting.

Q: What if I am allergic to penicillin?

A: Inform your doctor before receiving this medicine. There is a risk of cross-reactivity between penicillins and cephalosporins.

Q: Is this medicine safe during pregnancy?

A: It is generally considered safe when clearly needed, but you should consult your doctor to weigh the benefits and risks.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine if I am allergic to penicillin?
  • How long will I need to stay in the hospital?
  • Will this medicine affect my kidney function?
  • Can I breastfeed while on this medicine?
  • What should I do if I miss a dose?
  • Is it safe to take with other medications?

🔄 Substitutes for ivimax 1000 mg/500 mg injection

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure viral infections like the flu.
    Fact: This medicine is an antibiotic and is only effective against bacterial infections. It does not treat viral infections.
  • Myth: You can stop the injection once you feel better.
    Fact: You must complete the full course as prescribed by your doctor, even if you feel better, to prevent the infection from returning and to avoid antibiotic resistance.
  • Myth: This medicine is safe to self-administer at home.
    Fact: This medicine must be given by a healthcare professional in a clinical setting. Self-administration can be dangerous.

🔄 Alternative Options

Generic Alternatives

  • Cefotaxime + Sulbactam injection (generic)

Brand Alternatives

  • Biotax SB 1000 mg/500 mg injection

📊 Comparison with Similar Medicines

[{"medicine":"Cefotaxime + Sulbactam","class":"Third-generation cephalosporin + beta-lactamase inhibitor","route":"Parenteral","common_uses":"Respiratory, urinary, skin, bloodstream infections"},{"medicine":"Ceftriaxone + Sulbactam","class":"Third-generation cephalosporin + beta-lactamase inhibitor","route":"Parenteral","common_uses":"Similar to cefotaxime + sulbactam, but longer half-life"},{"medicine":"Cefoperazone + Sulbactam","class":"Third-generation cephalosporin + beta-lactamase inhibitor","route":"Parenteral","common_uses":"Similar spectrum, but more biliary excretion"}]

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