Augtax 1000 mg/500 mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing, swelling of face, lips, or throat, or a sudden drop in blood pressure.
- Severe, persistent, or bloody diarrhea that may be accompanied by fever or abdominal cramps.
- Seizures, confusion, or unusual movements, especially in patients with kidney problems.
- Widespread rash, blistering, or peeling of the skin.
- Unusual bruising or bleeding, or signs of infection such as persistent fever.
- Decreased urine output, swelling in legs, or flank pain.
If experiencing severe symptoms, call emergency services immediately.
What is cefup 1000 mg/500 mg injection used for?
This medicine is a combination antibiotic injection containing cefotaxime and sulbactam. It is used to treat serious bacterial infections in hospitals. It works by killing bacteria and blocking their defense enzymes. It is given intravenously by a healthcare professional.
- Generic Name: Cefotaxime + Sulbactam
- Manufacturer: Sanat Products Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cefup 1000 mg/500 mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफोटैक्साइम और सल्बैक्टम का संयोजन है, जिसे गंभीर जीवाणु संक्रमणों के इलाज के लिए नस के माध्यम से दिया जाता है। यह निमोनिया, मेनिनजाइटिस, सेप्सिस, मूत्र पथ के संक्रमण, त्वचा संक्रमण और पेट के अंदर के संक्रमण के इलाज में उपयोग किया जाता है। यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा ही दी जानी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, दस्त, मतली, उल्टी, दाने और हल्का बुखार शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी की प्रतिक्रिया, गंभीर दस्त, दौरे और रक्त विकार हो सकते हैं। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल अस्पताल में प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इससे पहले कि आपको यह दवा दी जाए, अपने डॉक्टर को अपनी सभी एलर्जी, गुर्दे या यकृत की समस्याओं के बारे में बताएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर को सूचित करें। इलाज के दौरान कोई भी नया लक्षण होने पर तुरंत डॉक्टर को बताएं।
💊 cefup 1000 mg/500 mg injection Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used to treat moderate to severe bacterial pneumonia caused by susceptible organisms such as Streptococcus pneumoniae and Haemophilus influenzae.","evidence":"Well-established"},{"condition":"Bacterial meningitis","description":"Effective against common causes of bacterial meningitis including Neisseria meningitidis and Streptococcus pneumoniae when used at appropriate doses.","evidence":"Well-established"},{"condition":"Sepsis and bloodstream infections","description":"Used empirically for serious systemic infections until culture results guide therapy.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Treats pyelonephritis and other complicated UTIs caused by susceptible Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for cellulitis, abscesses, and wound infections when intravenous therapy is needed.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Covers common enteric Gram-negative bacteria and some anaerobes in conditions like peritonitis and intra-abdominal abscess.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Used for pelvic inflammatory disease and postpartum infections caused by susceptible bacteria.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prophylaxis in certain surgical procedures","description":"Sometimes used off-label for surgical prophylaxis in patients allergic to standard agents, though not a first-line choice.","evidence":"Limited"},{"condition":"Bone and joint infections","description":"Occasionally used for osteomyelitis or septic arthritis when susceptible organisms are identified, but requires specialist guidance.","evidence":"Limited"}]
Primary treatment for: Bacterial infections caused by susceptible organisms
Also treats: Pneumonia, Meningitis, Sepsis, Urinary tract infections, Skin infections, Intra-abdominal infections
📋 Drug Information
| Generic Name(s) | Cefotaxime + Sulbactam |
| Brand Name | Augtax 1000 mg/500 mg Injection |
| Manufacturer | Sanat Products Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) injection or infusion. It may be given as a slow IV push over 3-5 minutes or as an IV infusion over 20-30 minutes after dilution |
| Storage | Store the dry powder at room temperature (15-30°C) in a dry place, protected from light. Once reconstituted, the solution should be used immediately or stored as directed by the manufacturer (usually refrigerated and used within 24 hours). Do not freeze. |
| Shelf Life | The shelf life of the dry powder is typically 24 months from the date of manufacture. Once reconstituted, use within the time specified by the manufacturer, usually within 24 hours if refrigerated. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Cefotaxime, the primary active component, is a third-generation cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This binding prevents the cross-linking of peptidoglycan strands, leading to weakened cell walls and bacterial lysis. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes produced by bacteria, protecting cefotaxime from enzymatic degradation and extending its spectrum against beta-lactamase-producing strains. Together, they provide broad-spectrum bactericidal activity.
Mechanism Steps
💡 How to Take cefup 1000 mg/500 mg injection
Strength: Each vial contains cefotaxime sodium equivalent to 1000 mg cefotaxime and sulbactam sodium equivalent to 500 mg sulbactam. It is a sterile powder for injection.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1.5 g (1000 mg cefotaxime + 500 mg sulbactam) administered intravenously every 6 to 8 hours. For severe infections, the dose may be increased to every 6 hours. The maximum daily dose should not exceed 12 g of cefotaxime. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific combination. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can prolong the half-life of cefotaxime and sulbactam. Dose adjustment based on creatinine clearance is recommended. Monitor renal function closely. |
| Renal Impairment | In patients with renal impairment, the dose and/or dosing interval must be adjusted. For creatinine clearance 20-40 mL/min, the usual dose may be given every 8-12 hours. For creatinine clearance 5-20 mL/min, every 12-24 hours. For creatinine clearance <5 mL/min, every 24 hours. Monitor renal function and adjust accordingly. |
| Hepatic Impairment | No specific dose adjustment is required for hepatic impairment alone, but caution is advised in patients with combined hepatic and renal impairment. Monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is 12 g of cefotaxime (which would correspond to 6 g of sulbactam in this combination) in divided doses. Do not exceed this without specialist guidance. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cefup 1000 mg/500 mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | |
| Loop diuretics | Major | |
| Warfarin | Major | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Methotrexate | Minor |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin, tobramycin)
- Loop diuretics (e.g., furosemide)
- Warfarin
⚡ Moderate Interactions
- Probenecid
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol does not directly interact with this medicine, but alcohol can worsen dehydration and may increase the risk of certain side effects like nausea and dizziness. It is advisable to avoid alcohol during treatment, especially if you have an infection.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to cefotaxime, sulbactam, or other cephalosporins","Known severe allergy to penicillins (cross-reactivity possible)","Previous anaphylactic reaction to beta-lactam antibiotics"]
⚠️ Warnings & Precautions
["Use with caution in patients with penicillin allergy due to potential cross-reactivity.","Dose adjustment is required in patients with renal impairment to avoid accumulation and toxicity.","Prolonged use may lead to superinfection with resistant bacteria or fungi.","May cause Clostridioides difficile-associated diarrhea; monitor for severe diarrhea.","Safety and effectiveness in pediatric patients have not been fully established for this combination; use only under specialist guidance.","Contains sodium; consider sodium intake in patients on a low-sodium diet."]
🤱 Lactation Safety
Cefotaxime is excreted in human milk in low concentrations. Sulbactam is also excreted in breast milk. Caution is advised when administering to a nursing mother. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose can cause severe neurological symptoms including seizures, especially in patients with renal impairment. Treatment is supportive and symptomatic. Hemodialysis may be considered to remove cefotaxime from the blood in severe cases. There is no specific antidote. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a hospital or clinic. If you miss a scheduled dose, inform your nurse or doctor immediately. They will determine the appropriate action. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must be given only by a trained healthcare professional in a hospital or clinic setting. Before receiving this medicine, tell your doctor about all your allergies, especially to antibiotics, and about any kidney or liver problems. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Do not attempt to self-administer this injection. While receiving this medicine, report any new symptoms such as severe diarrhea, skin rash, difficulty breathing, or swelling of the face and throat immediately. Your doctor may monitor your kidney function, liver function, and blood counts during treatment. Do not stop treatment early even if you feel better, because incomplete treatment can lead to resistant infections.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the risk of side effects. Dose adjustment based on creatinine clearance is important. Monitor for confusion or seizures.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor. This medicine is generally considered safe in pregnancy when needed, but use only under medical supervision.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent surgical site infections. Follow your surgeon's instructions regarding wound care and signs of infection.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. It may be used for prophylaxis in certain dental procedures for patients at risk of infective endocarditis, but this is decided by your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during treatment, especially if you have fever or feel weak. Light activity like walking is fine if you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You will likely need to be in the hospital for administration of this medicine, so work may be affected. Once discharged, you may feel tired for a few days. Avoid driving or operating machinery if you feel dizzy or weak.
🛑 When to Stop This Medicine
Do not stop this medicine without your doctor's advice. It is usually stopped when the infection is cured or when your doctor decides to switch to oral antibiotics. Stopping early can lead to recurrence and resistance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, superinfections, and rarely, blood dyscrasias or liver enzyme elevations. Prolonged therapy should be guided by culture results and clinical response. Regular monitoring of renal and hepatic function is advised for extended use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used once the infection is controlled and you can take oral medicines.
Evidence: Well-establishedDepending on culture results, a different antibiotic may be more appropriate.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, antibiotics may reduce the effectiveness of live bacterial vaccines like typhoid vaccine. Consult your doctor about vaccination timing.
📦 Storage Guide
✅ DO
Store the dry powder at room temperature (15-30°C) in a dry place.
❌ DON'T
Do not freeze the dry powder.
✅ DO
Use reconstituted solution immediately or refrigerate and use within 24 hours.
❌ DON'T
Do not use reconstituted solution if it is cloudy or contains particles.
✅ DO
Keep in original packaging until use.
❌ DON'T
Do not transfer to unmarked containers.
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting, so travel is not applicable. If you are traveling after treatment, carry a copy of your prescription and discharge summary. Store any remaining medication as directed. For international travel, check customs regulations regarding injectable antibiotics.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: Report any side effects to your doctor immediately, especially severe diarrhea, rash, or difficulty breathing.
🤔 Common Patient Concerns
🔄 Substitutes for cefup 1000 mg/500 mg injection
View AllAlternative brands with exact same active ingredient:
-
effimax plus 1000 mg/500 mg injectionAbbott ₹29.80 9.2% CHEAPER
-
sultax 1000 mg/500 mg injectionIpca Laboratories Ltd ₹32.55 0.9% CHEAPER
-
osotax-s 1000mg/500mg injectionOsper Formulations Pvt Ltd ₹32.59 0.7% CHEAPER
-
Taxtam 1000 mg/500 mg InjectionOrchid Chemicals & Pharmaceuticals Ltd ₹32.80 0.1% CHEAPER
-
lupitax s 1000 mg/500 mg injectionLupin Ltd ₹38.26 16.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is ineffective against viruses. - Myth: You can stop the injection once you feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and resistance, even if you feel better. - Myth: This medicine is safe to self-administer at home.
Fact: This medicine must be given by a healthcare professional in a medical setting due to risks of serious side effects.
🔄 Alternative Options
Generic Alternatives
- Cefotaxime + Sulbactam injection (generic versions may be available)
Brand Alternatives
- Augtax 1000 mg/500 mg injection