ivabid cv 3.125 tablet - Carvedilol (3.125mg) + Ivabradine (5mg) medicine

Ivabrad C 3.125mg/5mg Tablet: Complete Medicine Guide

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🏭 Abbott Healthcare Private Limited 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 25, 2026
🤰 Pregnancy Category Not established from the available information. Use in pregnancy only if clearly needed and after consulting a doctor. Both carvedilol and ivabradine may harm the fetus. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for the individual components in heart failure; limited for the fixed-dose combination.
Reviewed by
SaathiMed Expert Panel | Oct 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
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When to Call Your Doctor IMMEDIATELY

  • Severe dizziness or fainting
  • Very slow heart rate (below 50 beats per minute)
  • Chest pain or difficulty breathing
  • Sudden weight gain or swelling in legs
  • Blurred vision or visual disturbances that persist
  • Yellowing of skin or eyes
  • Severe allergic reaction (swelling of face, lips, throat)

If experiencing severe symptoms, call emergency services immediately.

What is ivabid cv 3.125 tablet used for?

This medicine is a combination of carvedilol and ivabradine used to treat chronic heart failure with reduced ejection fraction. It works by slowing the heart rate and reducing the heart's workload, improving symptoms and reducing hospitalizations.

  • Generic Name: Carvedilol (3.125mg) + Ivabradine (5mg)
  • Manufacturer: Abbott Healthcare Private Limited
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ivabid cv 3.125 tablet के बारे में (Hindi Summary)

उपयोग: यह दवा कैर्वेडिलोल और आइवाब्राडीन का संयोजन है, जिसका उपयोग पुरानी हृदय विफलता (क्रोनिक हार्ट फेल्योर) के इलाज में किया जाता है। यह हृदय की गति को धीमा करती है और हृदय पर दबाव कम करती है, जिससे सांस लेने में आसानी होती है और थकान कम होती है। यह दवा केवल हृदय रोग विशेषज्ञ की सलाह से ही लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, थकान, सिरदर्द, और निम्न रक्तचाप शामिल हैं। कुछ रोगियों को धुंधली दृष्टि या अस्थायी दृष्टि विकार हो सकते हैं। गंभीर दुष्प्रभावों में बहुत धीमी हृदय गति, हृदय ब्लॉक, और हृदय विफलता का बिगड़ना शामिल है। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को हमेशा अपने डॉक्टर के निर्देशानुसार ही लें। इसे अचानक बंद न करें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो। शराब से बचें क्योंकि इससे चक्कर और निम्न रक्तचाप बढ़ सकता है। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। नियमित रूप से हृदय गति और रक्तचाप की जांच कराएं।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 ivabid cv 3.125 tablet Uses & Benefits

[{"condition":"Chronic heart failure with reduced ejection fraction","description":"Used in patients with stable chronic heart failure and left ventricular ejection fraction ≤35% who remain symptomatic despite optimal standard therapy, including beta-blockers, and who have a heart rate ≥70 beats per minute.","evidence":"Well-established"},{"condition":"Heart rate control in chronic heart failure","description":"The ivabradine component specifically lowers elevated resting heart rate, which is associated with worse outcomes in heart failure.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Inappropriate sinus tachycardia","description":"Ivabradine, a component of this medicine, is sometimes used off-label to reduce heart rate in patients with inappropriate sinus tachycardia, but the combination with carvedilol is not standard for this indication.","evidence":"Limited"},{"condition":"Stable angina pectoris","description":"Ivabradine alone is approved for stable angina in some regions, but the fixed-dose combination with carvedilol is not typically used for this purpose.","evidence":"Limited"}]

Primary treatment for: Chronic heart failure with reduced ejection fraction

Also treats: Coronary artery disease, Hypertension, Arrhythmias

📋 Drug Information

Generic Name(s)Carvedilol (3.125mg) + Ivabradine (5mg)
Brand Nameivabid cv 3.125 tablet
ManufacturerAbbott Healthcare Private Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always start this medicine at a low dose and titrate slowly based on heart rate and blood pressure.
2
Monitor resting heart rate regularly; aim for a target heart rate as advised by your cardiologist.
3
Take the medicine with food to improve absorption and reduce gastrointestinal side effects.
4
Do not stop this medicine abruptly; taper gradually under medical supervision.
5
Educate patients about the importance of reporting symptoms like dizziness, fainting, or visual changes.
6
Check renal and hepatic function periodically, especially in elderly patients.
7
Avoid concomitant use with CYP3A4 inhibitors and heart rate-lowering drugs.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic heart failure with reduced ejection fraction
This medicine is commonly prescribed for this condition.
Likely Use
❌
High blood pressure
This medicine is not a primary blood pressure medicine, though carvedilol has some effect.
Not Primary
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionCarvedilol is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring 1 to 2 hours after oral administration. Food slows the rate but not the extent of absorption. Ivabradine is also rapidly absorbed, with peak plasma levels reached about 1 hour after oral intake. Food delays absorption by about 1 hour but does not significantly affect bioavailability.
DistributionCarvedilol is highly lipophilic and distributes widely into tissues, including the heart, lungs, and central nervous system. It is approximately 98% bound to plasma proteins. Ivabradine is moderately bound to plasma proteins (about 70%) and has a volume of distribution of approximately 100 liters in healthy volunteers.
Protein BindingCarvedilol: approximately 98% bound to plasma proteins, primarily albumin. Ivabradine: approximately 70% bound to plasma proteins.
MetabolismCarvedilol is extensively metabolized in the liver, primarily by CYP2D6 and CYP2C9 enzymes, with some involvement of CYP3A4, CYP1A2, and CYP2E1. Its metabolites are mainly excreted in bile. Ivabradine is metabolized in the liver and intestines by CYP3A4 to an active N-desmethylated metabolite. Both parent drug and metabolite are eliminated via feces and urine.
Half-LifeCarvedilol: approximately 7 to 10 hours. Ivabradine: approximately 11 hours (effective half-life).
ExcretionCarvedilol is excreted mainly via bile into feces, with less than 2% excreted unchanged in urine. Ivabradine and its metabolites are excreted in feces (about 70%) and urine (about 30%).
BioavailabilityCarvedilol: approximately 25% to 35% due to first-pass metabolism. Ivabradine: approximately 40% due to first-pass metabolism.
Onset of ActionCarvedilol: heart rate reduction begins within 1 to 2 hours after oral dose. Ivabradine: heart rate reduction is evident within 1 to 2 hours, with peak effect at about 3 to 4 hours.
Peak Plasma TimeCarvedilol: 1 to 2 hours. Ivabradine: approximately 1 hour.
Duration of ActionCarvedilol: approximately 12 to 24 hours depending on dose and formulation. Ivabradine: approximately 12 hours for heart rate reduction.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Carvedilol is a non-selective beta-adrenergic blocker and alpha-1 adrenergic blocker. It reduces heart rate, blood pressure, and myocardial contractility by blocking beta-1 receptors in the heart, and causes vasodilation by blocking alpha-1 receptors in blood vessels. Ivabradine selectively inhibits the If (funny) current in the sinoatrial node, which is responsible for the spontaneous depolarization that initiates each heartbeat. By inhibiting this current, ivabradine slows the heart rate without affecting myocardial contractility or blood pressure. Together, these agents reduce cardiac workload, improve diastolic filling time, and enhance cardiac efficiency in heart failure.

Mechanism Steps

1
Carvedilol blocks beta-adrenergic receptors: Carvedilol binds to beta-1 receptors in the heart, reducing heart rate and contractility, and to beta-2 receptors in the lungs and blood vessels.
2
Carvedilol blocks alpha-1 adrenergic receptors: This leads to vasodilation, reducing peripheral vascular resistance and lowering blood pressure.
3
Ivabradine inhibits the If current: Ivabradine enters the sinoatrial node cells and blocks HCN channels, slowing the spontaneous depolarization rate and reducing heart rate.
4
Combined effect on cardiac workload: The reduced heart rate and blood pressure decrease myocardial oxygen demand and improve coronary perfusion, benefiting patients with heart failure.

💡 How to Take ivabid cv 3.125 tablet

Strength: Tablet containing Carvedilol 3.125 mg and Ivabradine 5 mg.

1Take this medicine with food to reduce stomach upset and improve absorption.
2Swallow the tablet whole with a glass of water. Do not crush or chew.
3Take it at the same times each day, preferably morning and evening.
4Do not stop taking this medicine suddenly without consulting your doctor.
5If you miss a dose, follow the missed dose instructions.
6Keep a record of your heart rate and blood pressure if advised by your doctor.

Dosage Information

Adult DosageThe dose of this medicine must be individualized by a qualified clinician based on the patient's condition, heart rate, blood pressure, and renal and hepatic function. Typically, treatment is started with a low dose and gradually increased over weeks. The usual starting dose is one tablet twice daily with food. The maximum recommended dose is one tablet twice daily, but your doctor may adjust based on your response. Never change the dose without consulting your doctor.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially bradycardia and hypotension. Dose should be started low and titrated slowly with close monitoring.
Renal ImpairmentIn patients with severe renal impairment (creatinine clearance <15 mL/min), this medicine is contraindicated. In moderate renal impairment, dose adjustment may be needed. Consult your doctor.
Hepatic ImpairmentThis medicine is contraindicated in severe hepatic impairment. In mild to moderate hepatic impairment, dose reduction and close monitoring are required. Consult your doctor.
Maximum Daily DoseThe maximum daily dose is one tablet twice daily (total daily dose: carvedilol 6.25 mg + ivabradine 10 mg). However, the exact maximum dose must be determined by your cardiologist.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and improves absorption.
Grapefruit juice
Avoid
May increase ivabradine levels and risk of bradycardia.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ivabid cv 3.125 tablet

✅ Common Side Effects

Dizziness (Common (5-10%))
Rise slowly from sitting or lying positions. Avoid driving if dizzy. Consult doctor if persistent.
Fatigue (Common (5-10%))
Ensure adequate rest. If severe or worsening, contact your doctor.
Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if severe or persistent.
Low blood pressure (Common (5-10%))
Monitor blood pressure regularly. Report symptoms like fainting or lightheadedness to your doctor.
Blurred vision or visual disturbances (Common (5-10%))
Usually occurs in the first few months. If persistent or severe, consult your doctor.

🚨 Serious Side Effects

Severe bradycardia (very slow heart rate) (Uncommon (0.1-1%))
Seek immediate medical attention if you experience fainting, severe dizziness, or confusion.
Heart block (Rare (<0.1%))
Requires immediate medical evaluation. Symptoms include fainting, palpitations, or chest pain.
Worsening heart failure (Uncommon (0.1-1%))
Contact your doctor if you experience increased shortness of breath, swelling, or fatigue.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Call emergency services immediately if you have swelling of face, lips, throat, or difficulty breathing.

⚠️ Rare Side Effects

Lupus-like syndrome
Report joint pain, rash, or fever to your doctor.
Psoriasis-like rash
Consult a dermatologist if skin changes occur.
Severe liver injury
Seek medical attention if you notice yellowing of eyes or skin, dark urine, or severe abdominal pain.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Verapamil Major
Diltiazem Major
Ketoconazole Major
Clarithromycin Major
Fluoxetine Major
Digoxin Moderate
Clonidine Moderate
Insulin Moderate
Antacids Minor
NSAIDs Minor

🚨 Major Interactions

  • Verapamil, diltiazem, and other heart rate-lowering drugs
  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)

⚡ Moderate Interactions

  • Digoxin
  • Clonidine
  • Insulin and oral antidiabetics

🍷 Alcohol Interaction

Alcohol may enhance the blood pressure-lowering and dizziness effects of this medicine. It is advisable to avoid or limit alcohol consumption while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Severe bradycardia (heart rate

⚠️ Warnings & Precautions

["Do not stop this medicine abruptly; withdrawal may worsen heart failure or cause arrhythmias.","Use with caution in patients with asthma or COPD due to beta-blocking effects of carvedilol.","May mask symptoms of hypoglycemia in diabetic patients.","Avoid in patients with severe hypotension or uncontrolled hypertension.","Use with caution in patients with peripheral vascular disease.","May cause visual disturbances; avoid driving if affected.","Not recommended for children and adolescents.","Elderly patients may be more sensitive to side effects."]

🤱 Lactation Safety

Not established from the available information. Carvedilol is excreted in breast milk. Ivabradine is also likely to be excreted in breast milk. Breastfeeding is not recommended while taking this medicine.

💊 Overdose Management

Overdose may cause severe bradycardia, hypotension, heart failure, and bronchospasm. Treatment is supportive and symptomatic. If overdose is suspected, seek immediate medical attention. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor heart rate, blood pressure, and cardiac rhythm. Use atropine for bradycardia, and inotropic agents or glucagon for severe hypotension. Dialysis is not effective for removing carvedilol or ivabradine.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Always take this medicine exactly as prescribed by your cardiologist. Do not change the dose or stop taking it suddenly. Take it with food to reduce stomach upset and improve absorption. Avoid alcohol, as it can worsen dizziness and low blood pressure. Do not drive or operate heavy machinery until you know how this medicine affects you. Keep all follow-up appointments for heart rate, blood pressure, and kidney function monitoring. Inform your doctor if you become pregnant, plan to become pregnant, or are breastfeeding. Tell all your healthcare providers that you are taking this medicine, especially before any surgery or dental procedure.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more prone to bradycardia, hypotension, and dizziness. Start with a low dose and titrate slowly. Monitor renal and hepatic function regularly.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy. If you are planning pregnancy, consult your doctor to discuss alternative treatments. Use effective contraception while taking this medicine.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect heart rate and blood pressure during surgery. Your doctor may advise temporary dose adjustments.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It may cause dry mouth or dizziness during dental procedures. Local anesthetics with epinephrine should be used with caution.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce strain on your heart.
🥗
Engage in regular low-impact exercise like walking or swimming, as advised by your doctor.
😴
Follow a heart-healthy diet low in salt and saturated fats.
💧
Avoid smoking and limit alcohol consumption.
🧘
Get adequate sleep and manage stress through relaxation techniques.
🌞
Monitor your heart rate and blood pressure regularly at home if advised.

🏋️ Exercise Considerations

Avoid strenuous exercise until you know how this medicine affects you. It may cause dizziness or slow heart rate during exercise. Always warm up and cool down gradually. Consult your doctor before starting any new exercise program.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.
Reduce salt intake to manage blood pressure.
Avoid grapefruit juice.
Eat plenty of fruits and vegetables.
Stay well hydrated unless advised otherwise.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or visual disturbances, especially when starting treatment. Avoid driving or operating heavy machinery until you know how it affects you. Most patients can continue their normal activities once stabilized.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects or your condition changes, your doctor may adjust or stop the medicine gradually.

📅 Long-Term Use Effects

Long-term use of this medicine is generally safe and beneficial for heart failure patients. Regular monitoring of heart rate, blood pressure, renal and hepatic function is required. Some patients may develop tolerance or worsening heart failure, requiring dose adjustment. Do not stop the medicine without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Beta-blocker alone (e.g., metoprolol, bisoprolol)

Standard therapy for heart failure; may be used if ivabradine is not tolerated.

Evidence: Well-established
Ivabradine alone

Used when beta-blockers are contraindicated or not tolerated.

Evidence: Well-established
Device therapy (e.g., CRT, ICD)

May be considered in eligible patients with heart failure.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, patients with heart failure should receive annual influenza and pneumococcal vaccinations as advised by their doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from moisture. If traveling across time zones, consult your doctor about adjusting dosing times. Carry enough supply for the entire trip plus extra in case of delays. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 62-year-old man with chronic heart failure and a heart rate of 82 bpm despite beta-blocker therapy.
He was started on this medicine by his cardiologist. After 4 weeks, his heart rate reduced to 68 bpm, and he noticed significant improvement in his exercise tolerance. He initially experienced mild dizziness, which resolved after a few days. He emphasized taking the medicine with breakfast and dinner.
💡 Lesson: Gradual titration and consistent administration with food improve tolerability and outcomes.
👤 A 55-year-old woman with heart failure and reduced ejection fraction who was hesitant to add another medicine.
She was concerned about side effects but agreed to try this medicine under close supervision. Over 3 months, her symptoms improved, and she was able to walk further without shortness of breath. She reported occasional blurred vision, which her doctor monitored and eventually resolved.
💡 Lesson: Close monitoring and patient education are key to managing side effects and ensuring adherence.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts reducing heart rate within 1-2 hours, but full benefits on symptoms and heart function may take several weeks to months.

Q: Can I stop taking this medicine if I feel better?

A: No, you should never stop this medicine suddenly. Always consult your doctor before making any changes.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for ivabid cv 3.125 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be stopped once you feel better.
    Fact: No, this medicine must be continued as prescribed. Stopping suddenly can worsen heart failure.
  • Myth: This medicine is a cure for heart failure.
    Fact: This medicine helps manage symptoms and improves outcomes but does not cure heart failure.
  • Myth: You can take this medicine without food.
    Fact: It is best taken with food to improve absorption and reduce stomach upset.

🔄 Alternative Options

Generic Alternatives

  • Carvedilol + Ivabradine fixed-dose combination (generic)

📊 Comparison with Similar Medicines

[{"medicine":"Carvedilol alone","difference":"Does not contain ivabradine; may not reduce heart rate as effectively in some patients."},{"medicine":"Ivabradine alone","difference":"Does not contain carvedilol; lacks beta-blocking and alpha-blocking effects."},{"medicine":"Metoprolol + Ivabradine","difference":"Metoprolol is a beta-1 selective blocker; different side effect profile."}]

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