Dapasach S 10mg/100mg Tablet: A Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Nausea, vomiting, abdominal pain, deep rapid breathing, or fruity-smelling breath (possible ketoacidosis).
- Severe pain, redness, or swelling in the genital or perineal area with fever (possible Fournier's gangrene).
- High fever, chills, severe flank pain, or blood in urine (possible severe urinary tract infection).
- Severe abdominal pain radiating to the back, with or without vomiting (possible pancreatitis).
- Swelling of the face, lips, tongue, or throat, or difficulty breathing (possible angioedema or anaphylaxis).
- Signs of dehydration such as dizziness, lightheadedness, or decreased urine output.
- Yellowing of skin or eyes, or severe fatigue (possible liver problem).
If experiencing severe symptoms, call emergency services immediately.
What is istavel d 10/100 tablet used for?
This medicine is a combination of dapagliflozin 10 mg and sitagliptin 100 mg used to treat type 2 diabetes. It works by helping the kidneys remove excess sugar and by increasing insulin release after meals. It is taken once daily orally, with or without food, as prescribed by your doctor.
- Generic Name: Dapagliflozin (10mg) + Sitagliptin (100mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 istavel d 10/100 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डैपाग्लिफ्लोज़िन 10 मिलीग्राम और सिटाग्लिप्टिन 100 मिलीग्राम का संयोजन है, जिसका उपयोग टाइप 2 मधुमेह (डायबिटीज) के इलाज के लिए किया जाता है। यह रक्त शर्करा को नियंत्रित करने में मदद करती है। यह गुर्दे से अतिरिक्त शर्करा को बाहर निकालती है और भोजन के बाद इंसुलिन के स्राव को बढ़ाती है। यह दवा उन वयस्कों के लिए है जिनका रक्त शर्करा आहार, व्यायाम और अन्य दवाओं से नियंत्रित नहीं हो पाता। इसे डॉक्टर के परामर्श से ही लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में जननांग फंगल संक्रमण, मूत्र मार्ग संक्रमण, सिरदर्द, नाक बंद होना, गले में खराश और पेट में हल्की परेशानी शामिल हैं। गंभीर दुष्प्रभावों में डायबिटिक कीटोएसिडोसिस, गंभीर मूत्र संक्रमण, अग्नाशयशोथ, गंभीर जोड़ों का दर्द और त्वचा पर छाले शामिल हो सकते हैं। यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर पेट दर्द हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपने आप डोज न बदलें और न ही दवा बंद करें। दिन भर पर्याप्त पानी पिएं ताकि निर्जलीकरण से बचा जा सके। निजी स्वच्छता का ध्यान रखें। रक्त शर्करा की नियमित जांच करें। गुर्दे या लीवर की समस्या हो तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान इस दवा का उपयोग न करें। शराब का सेवन न करें।
💊 istavel d 10/100 tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Used as an add-on therapy to diet and exercise to improve glycemic control in adults whose blood sugar is not adequately controlled with metformin or other single agents.","evidence":"Well-established"},{"condition":"Type 2 diabetes with cardiovascular risk","description":"The dapagliflozin component may reduce the risk of hospitalization for heart failure in patients with type 2 diabetes and established cardiovascular disease or multiple risk factors.","evidence":"Well-established"},{"condition":"Type 2 diabetes with chronic kidney disease","description":"Dapagliflozin may slow the progression of kidney disease in patients with type 2 diabetes and diabetic nephropathy, when used as part of a comprehensive treatment plan.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Weight management in type 2 diabetes","description":"Dapagliflozin can cause modest weight loss, and this combination may be used off-label to support weight reduction in obese patients with type 2 diabetes.","evidence":"Limited"},{"condition":"Non-alcoholic fatty liver disease (NAFLD)","description":"Some small studies suggest SGLT2 inhibitors and DPP-4 inhibitors may improve liver enzymes in NAFLD, but this is not an approved indication.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Heart failure, Chronic kidney disease, Obesity
📋 Drug Information
| Generic Name(s) | Dapagliflozin (10mg) + Sitagliptin (100mg) |
| Brand Name | istavel d 10/100 tablet |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place. Keep the tablets in their original blister pack or container to protect from moisture and light. Do not refrigerate. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends SGLT2 inhibitors and DPP-4 inhibitors as second-line or third-line agents for type 2 diabetes in certain patients, but specific recommendations vary. Consult your doctor for personalized advice. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines for type 2 diabetes management include SGLT2 inhibitors and DPP-4 inhibitors as options for add-on therapy. The choice depends on individual patient factors. Consult your doctor for guidance. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct but complementary mechanisms. Dapagliflozin inhibits sodium-glucose co-transporter 2 (SGLT2) in the proximal tubules of the kidney, reducing glucose reabsorption and increasing urinary glucose excretion, which lowers blood glucose independently of insulin. Sitagliptin inhibits the enzyme dipeptidyl peptidase-4 (DPP-4), which normally breaks down incretin hormones such as GLP-1 and GIP. By inhibiting DPP-4, sitagliptin increases the levels of these hormones, leading to enhanced glucose-dependent insulin secretion from pancreatic beta cells and reduced glucagon release from alpha cells. Together, these actions improve fasting and postprandial blood glucose control with a low risk of hypoglycemia when used alone.
Mechanism Steps
💡 How to Take istavel d 10/100 tablet
Strength: Tablet containing dapagliflozin 10 mg and sitagliptin 100 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally once daily, preferably in the morning with or without food. The dose is fixed as dapagliflozin 10 mg and sitagliptin 100 mg per tablet. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially regarding dehydration, low blood pressure, and kidney function. Dose selection should be cautious, and kidney function should be monitored regularly. No specific dose adjustment is recommended solely based on age, but individualization is essential. |
| Renal Impairment | For patients with mild renal impairment (eGFR 60-89 mL/min/1.73 m2), no dose adjustment is needed. For moderate renal impairment (eGFR 45-59 mL/min/1.73 m2), no dose adjustment is needed, but monitor kidney function closely. For eGFR 30-44 mL/min/1.73 m2, dapagliflozin can be used but sitagliptin dose should be reduced to 50 mg once daily; however, this fixed-dose combination is not suitable for such dose reduction. For eGFR less than 30 mL/min/1.73 m2, this medicine is not recommended. Consult your doctor for appropriate alternatives. |
| Hepatic Impairment | No dose adjustment is needed for mild to moderate hepatic impairment. For severe hepatic impairment, sitagliptin should be used with caution, and dapagliflozin has not been studied. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | One tablet (dapagliflozin 10 mg and sitagliptin 100 mg) once daily. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of istavel d 10/100 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Insulin | Major | |
| Sulfonylureas | Major | |
| Diuretics | Major | |
| NSAIDs | Moderate | |
| ACE inhibitors | Moderate | |
| ARBs | Moderate | |
| Beta-blockers | Moderate | |
| Digoxin | Minor | |
| Alcohol | Minor | |
| Cationic drugs (e.g., metformin) | Moderate |
🚨 Major Interactions
- Insulin or sulfonylureas
- Diuretics
- Cationic drugs (e.g., metformin, digoxin)
⚡ Moderate Interactions
- NSAIDs
- ACE inhibitors or ARBs
- Beta-blockers
🍷 Alcohol Interaction
Alcohol may increase the risk of lactic acidosis and hypoglycemia when taken with this medicine. It is advisable to limit or avoid alcohol consumption while on this medicine, especially if you have liver or kidney problems.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to dapagliflozin, sitagliptin, or any component of the formulation","Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR less than 30 mL/min/1.73 m2) for the dapagliflozin component","Active bladder or genital infection","History of pancreatitis","Pregnancy and breastfeeding"]
⚠️ Warnings & Precautions
["Risk of diabetic ketoacidosis, which can occur even with normal blood sugar levels. Seek immediate medical attention if you experience symptoms.","Risk of severe urinary tract infections and genital fungal infections. Maintain good hygiene and report symptoms promptly.","Risk of dehydration and low blood pressure. Stay well hydrated, especially in hot weather or during exercise.","Risk of hypoglycemia when used with insulin or sulfonylureas. Monitor blood sugar closely.","Risk of acute kidney injury. Monitor kidney function, especially if you have existing kidney disease or take diuretics or NSAIDs.","Risk of Fournier's gangrene, a rare but life-threatening infection. Seek emergency care for severe genital pain, redness, or swelling.","Do not use in patients with type 1 diabetes or diabetic ketoacidosis.","May cause slight increase in LDL cholesterol. Monitor lipid profile.","Avoid alcohol consumption due to increased risk of lactic acidosis and hypoglycemia.","Inform your doctor if you are scheduled for surgery, as this medicine may need to be temporarily stopped."]
🤱 Lactation Safety
It is not known whether dapagliflozin or sitagliptin pass into breast milk. Because of the potential for serious adverse reactions in breastfed infants, this medicine is not recommended during breastfeeding. Consult your doctor for alternative treatments.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of suspected overdose, seek immediate medical attention. Treatment should be supportive and symptomatic, including monitoring of vital signs, blood glucose, and kidney function. Hemodialysis may be considered for sitagliptin removal, but dapagliflozin is not significantly removed by dialysis.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop it on your own. Stay well hydrated throughout the day to prevent dehydration and low blood pressure. Maintain good genital and urinary hygiene to reduce the risk of infections. Check your blood sugar regularly as advised and keep a record. Inform your doctor if you have kidney or liver problems, or if you are scheduled for surgery. Avoid excessive alcohol because it can increase the risk of lactic acidosis and low blood sugar. Do not use this medicine if you are pregnant or planning pregnancy without consulting your doctor. Keep this medicine out of reach of children and store it in its original packaging.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to dehydration, low blood pressure, and kidney impairment while taking this medicine. Regular monitoring of kidney function, blood pressure, and hydration status is recommended. Dose adjustment may be needed based on kidney function. Falls risk may increase if dizziness occurs.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative, such as insulin, before conception. Good blood sugar control before and during pregnancy is crucial for the health of both mother and baby.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily stopped before surgery due to the risk of ketoacidosis and dehydration. Inform your surgeon and anesthesiologist that you are taking this medicine. Your doctor will advise when to restart it after surgery, usually once you are eating and drinking normally and kidney function is stable.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It is generally safe to continue, but if you are having a procedure that requires fasting or sedation, your doctor may advise adjusting the dose. Maintain good oral hygiene and monitor for any signs of infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is encouraged while taking this medicine, but be cautious about dehydration. Drink plenty of water before, during, and after exercise. If you experience dizziness, weakness, or signs of low blood sugar, stop exercising and seek medical advice. Avoid strenuous exercise in hot weather without proper hydration.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or lightheadedness in some people, especially if dehydrated. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue your daily activities, but take precautions if you feel unwell. Inform your employer if you have diabetes and need regular breaks for meals and medication.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects such as ketoacidosis, severe infection, or allergic reaction, seek immediate medical attention and your doctor may advise stopping the medicine. If you become pregnant, contact your doctor to switch to a safer alternative. Always follow your doctor's guidance regarding discontinuation.
📅 Long-Term Use Effects
Long-term use of this medicine can help maintain blood sugar control and reduce the risk of diabetes-related complications, including heart and kidney disease. Regular monitoring of kidney function, blood sugar, and HbA1c is necessary. Some patients may experience persistent genital fungal infections or urinary tract infections. Weight loss may occur initially but usually stabilizes. Long-term safety data for the combination are limited, but individual components have been used for many years. Always follow your doctor's advice for regular check-ups.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the cornerstone of diabetes management and can complement or reduce the need for medication.
Evidence: Well-establishedMetformin, sulfonylureas, or other SGLT2 or DPP-4 inhibitors may be alternatives based on individual factors.
Evidence: Well-establishedMay be needed if oral agents fail to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, people with diabetes are at higher risk of infections, so ensure you are up to date with recommended vaccinations, including influenza and pneumococcal vaccines. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate
✅ DO
Keep in original blister pack or container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, continue taking your dose at the same local time as usual, but consult your doctor if you need to adjust the timing. Carry enough supply for your entire trip and consider a letter from your doctor if traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within the first day, but maximum effects on HbA1c may take 1 to 3 months. Continue taking it as prescribed and monitor your blood sugar regularly.
A: Yes, but your doctor may need to adjust the doses of other medicines, especially insulin or sulfonylureas, to avoid low blood sugar. Always inform your doctor about all medicines you take.
A: This medicine may need dose adjustment or may not be suitable for people with severe kidney disease. Your doctor will monitor your kidney function and decide if it is right for you.
A: This medicine is not recommended during pregnancy. If you are pregnant or planning to become pregnant, consult your doctor immediately for alternative treatment.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for istavel d 10/100 tablet
View AllAlternative brands with exact same active ingredient:
-
sitacip d 10mg/100mg tabletCipla Ltd ₹175.31 46.7% CHEAPER
-
sitafirst d 10mg/100mg tabletAkned Healthcare Pvt. Ltd. ₹182.81 44.4% CHEAPER
-
udapa-s 10/100 tabletUSV Ltd ₹185.63 43.6% CHEAPER
-
dapasach s 10mg/100mg tabletCipla Ltd ₹192.84 41.4% CHEAPER
-
sidacor 10mg/100mg tabletEris Lifesciences Ltd ₹206.25 37.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. It must be continued along with diet and exercise. - Myth: This medicine is safe for everyone with diabetes.
Fact: It is not suitable for people with type 1 diabetes, severe kidney disease, or during pregnancy. Always consult a doctor. - Myth: You can stop this medicine once your sugar levels are normal.
Fact: Stopping this medicine without medical advice can cause blood sugar to rise again. Always consult your doctor before stopping. - Myth: This medicine causes weight gain.
Fact: This medicine is more likely to cause mild weight loss or no weight change, unlike some other diabetes medicines.
🔄 Alternative Options
Generic Alternatives
- Dapagliflozin + Sitagliptin generic
Brand Alternatives
- Dapasach S 10mg/100mg Tablet