Gastobid Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Involuntary movements of face, tongue, or limbs
- High fever with muscle rigidity and confusion
- Severe allergic reaction with swelling of face or throat
- Irregular heartbeat or palpitations
- Yellowing of skin or eyes
- Severe abdominal pain or blood in stool
- Difficulty urinating or severe constipation
If experiencing severe symptoms, call emergency services immediately.
What is Isorez 5mg/1mg Tablet used for?
This medicine is a combination of isopropamide (an anticholinergic) and trifluoperazine (an antipsychotic) used to treat irritable bowel syndrome and other gastrointestinal disorders with anxiety. It works by reducing stomach acid, slowing gut movement, and calming the mind. It is taken by mouth, usually two to three times daily, and must be prescribed by a doctor.
- Generic Name: Isopropamide (5mg) + Trifluoperazine (1mg)
- Manufacturer: Dellwich Healthcare LLP
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Isorez 5mg/1mg Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इरिटेबल बाउल सिंड्रोम (IBS), पेप्टिक अल्सर और पेट से जुड़ी चिंता वाले विकारों के इलाज में इस्तेमाल की जाती है। यह पेट में एसिड को कम करती है, आंतों की ऐंठन को शांत करती है और मन को शांत करने में मदद करती है। यह मल्टी-डोज़ टैबलेट है और इसे डॉक्टर के निर्देशानुसार ही लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मुँह सूखना, धुंधली दृष्टि, कब्ज, नींद आना और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में अनैच्छिक मांसपेशीय हलचल, गंभीर एलर्जी, अनियमित दिल की धड़कन और न्यूरोलेप्टिक मैलिग्नेंट सिंड्रोम शामिल हैं। अगर आपको असामान्य लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गोली को चबाएं नहीं, पूरा निगलें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। शराब न पिएं। अगर आपको ग्लूकोमा, प्रोस्टेट की समस्या, लीवर की बीमारी या दिल की धड़कन की समस्या है तो डॉक्टर को बताएं। दवा अचानक बंद न करें।
💊 Isorez 5mg/1mg Tablet Uses & Benefits
[{"condition":"Irritable bowel syndrome (IBS)","description":"Helps relieve abdominal pain, bloating, and altered bowel habits by reducing gut spasm and anxiety.","evidence":"Moderate"},{"condition":"Peptic ulcer disease","description":"Reduces gastric acid secretion and relieves pain associated with ulcers.","evidence":"Limited"},{"condition":"Functional dyspepsia","description":"May improve symptoms of upper abdominal discomfort and early satiety.","evidence":"Limited"},{"condition":"Anxiety-associated gastrointestinal disorders","description":"The trifluoperazine component helps reduce anxiety that exacerbates gut symptoms.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Nausea and vomiting","description":"Sometimes used off-label for nausea due to trifluoperazine's antiemetic properties.","evidence":"Limited"},{"condition":"Chronic abdominal pain","description":"May be prescribed off-label for persistent abdominal pain not responding to other treatments.","evidence":"Limited"}]
Primary treatment for: Irritable bowel syndrome
Also treats: Peptic ulcer disease, Functional dyspepsia, Anxiety-associated gastrointestinal disorders
📋 Drug Information
| Generic Name(s) | Isopropamide (5mg) + Trifluoperazine (1mg) |
| Brand Name | Isorez 5mg/1mg Tablet |
| Manufacturer | Dellwich Healthcare LLP |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Isopropamide blocks muscarinic acetylcholine receptors in the gastrointestinal tract, reducing acid secretion, slowing motility, and decreasing spasms. Trifluoperazine blocks dopamine D2 receptors in the brain, which helps reduce anxiety, nausea, and vomiting. The combination targets both the physical and psychological components of gastrointestinal disorders.
Mechanism Steps
💡 How to Take Isorez 5mg/1mg Tablet
Strength: Tablet: Isopropamide 5 mg + Trifluoperazine 1 mg
Dosage Information
| Adult Dosage | The usual adult dose is one tablet two to three times daily, taken with or without food. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, and renal and hepatic function. Do not self-adjust the dose. Follow your doctor's instructions carefully. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine. Start with a lower dose and titrate slowly. Monitor for confusion, falls, and extrapyramidal symptoms. |
| Renal Impairment | Use with caution in renal impairment. Dose adjustment may be necessary. Consult your doctor. |
| Hepatic Impairment | Use with caution in hepatic impairment. Dose adjustment may be necessary. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose is not established from available information. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Isorez 5mg/1mg Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| CNS depressants | Major | |
| Anticholinergics | Major | |
| Levodopa | Moderate | |
| Antihypertensives | Moderate | |
| Antacids | Moderate | |
| Caffeine | Minor | |
| Smoking | Minor |
🚨 Major Interactions
- MAO inhibitors
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
- Anticholinergic drugs (e.g., antihistamines, tricyclic antidepressants)
⚡ Moderate Interactions
- Levodopa
- Antihypertensives
- Antacids
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase sedation, dizziness, and impair your ability to think clearly. It may also worsen anticholinergic side effects like dry mouth and constipation.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to isopropamide or trifluoperazine","Glaucoma","Prostatic hypertrophy or urinary retention","Severe liver disease","Parkinson's disease","Blood dyscrasias","Comatose states","Children under 12 years"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol and other CNS depressants.","Use with caution in elderly patients due to increased risk of falls and confusion.","May cause anticholinergic effects; use with caution in patients with glaucoma or prostate enlargement.","Do not stop abruptly; taper gradually under medical supervision.","May impair temperature regulation; avoid extreme heat.","Use with caution in patients with cardiovascular disease.","May increase risk of seizures in predisposed individuals."]
🤱 Lactation Safety
Not established from the available information. Trifluoperazine may pass into breast milk and cause drowsiness in the infant. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe anticholinergic effects (dry mouth, flushing, tachycardia, urinary retention), sedation, coma, and extrapyramidal symptoms. Seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and ECG.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush or chew the tablet; swallow it whole with water. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it can cause drowsiness. Do not drink alcohol while taking this medicine, as it can increase sedation and impair your ability to think clearly. Inform your doctor if you have glaucoma, prostate problems, liver disease, or heart rhythm disorders. Do not stop this medicine suddenly without consulting your doctor, as withdrawal symptoms may occur. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and anticholinergic effects. Start with a lower dose and monitor for confusion, falls, and urinary retention. Regular review of the need for continued therapy is advised.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for alternative treatments. If you become pregnant while taking this medicine, contact your doctor immediately.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist about this medicine before surgery. It may interact with anesthetic agents and increase the risk of complications. Your doctor may advise stopping it before surgery.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. It can cause dry mouth and increase the risk of dental problems. It may also interact with sedatives used in dentistry.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise until you know how this medicine affects you, as it can cause drowsiness and dizziness. Light activities like walking are generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive or operate machinery. It may also cause dry mouth and blurred vision, which can interfere with fine tasks. Adjust your work schedule if needed and inform your employer if your job involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Do not stop this medicine suddenly without consulting your doctor. Abrupt withdrawal can cause nausea, vomiting, insomnia, and agitation. Your doctor will gradually taper the dose. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use may increase the risk of tardive dyskinesia, metabolic changes, and anticholinergic effects. Regular monitoring of liver function, blood counts, and mental status is recommended. Periodic review of the need for continued therapy is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps manage anxiety and gut symptoms without medication.
Evidence: Well-establishedCan reduce IBS symptoms.
Evidence: ModerateMay improve gut health and reduce symptoms.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, inform your doctor about this medicine before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing times gradually under medical advice. Check customs regulations for controlled substances. Keep a list of your medicines with you at all times.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may notice some relief within a few hours, but full effects on IBS and anxiety may take 1-2 weeks.
A: Inform your doctor about all medicines you take, as this medicine can interact with many drugs.
A: Take it as soon as you remember, but skip if it's almost time for the next dose. Do not double dose.
A: This medicine can cause drowsiness. Avoid driving until you know how it affects you.
🤔 Common Patient Concerns
🔄 Substitutes for Isorez 5mg/1mg Tablet
View AllAlternative brands with exact same active ingredient:
-
gastobid tabletThrift Pharmaceuticals ₹19.69 35.7% CHEAPER
-
spascol 5mg/1mg tabletVilco Laboratories Pvt Ltd ₹20.63 32.6% CHEAPER
-
stelabid 5mg/1mg tabletCorona Remedies Pvt Ltd ₹45.00 47.1% COSTLIER
-
stelbid tabletCorona Remedies Pvt Ltd ₹63.66 108% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Gastobid Tablet is a simple antacid.
Fact: It is a combination of an anticholinergic and an antipsychotic, not a simple antacid. - Myth: You can stop taking it whenever you feel better.
Fact: It should be tapered gradually under medical supervision to avoid withdrawal symptoms. - Myth: It is safe to drive after taking this medicine.
Fact: It can cause drowsiness; avoid driving until you know how it affects you.
🔄 Alternative Options
Generic Alternatives
- Isopropamide + Trifluoperazine combination tablets from other manufacturers
Brand Alternatives
- Gastobid Tablet