Anticox II Kid 100 mg/100 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Yellowing of the eyes or skin, or dark urine, which may indicate liver injury.
- Severe abdominal pain, especially in the right upper abdomen.
- Persistent vomiting or inability to keep down food or fluids.
- Unusual bruising or bleeding, which may indicate a blood disorder.
- Swelling of the face, lips, or throat, or difficulty breathing, which may be a sign of a severe allergic reaction.
- Confusion, hallucinations, or seizures.
- Decreased urine output or swelling in the legs.
- Fever with sore throat or mouth ulcers, which may indicate a blood disorder.
If experiencing severe symptoms, call emergency services immediately.
What is isocin - kid 100mg/100mg tablet used for?
This medicine is a combination of rifampicin and isoniazid used to treat tuberculosis. It works by killing the bacteria that cause tuberculosis. It must be taken exactly as prescribed, usually on an empty stomach, and the full course must be completed to prevent resistance.
- Generic Name: Rifampicin (100mg) + Isoniazid (100mg)
- Manufacturer: Zee Laboratories
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 isocin - kid 100mg/100mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा रिफैम्पिसिन और आइसोनियाजिड का संयोजन है, जिसका उपयोग तपेदिक (टीबी) के इलाज के लिए किया जाता है। यह बैक्टीरिया को मारकर संक्रमण को रोकती है। यह दवा आमतौर पर बच्चों और वजन के अनुसार दी जाती है। इसे डॉक्टर के निर्देशानुसार ही लें और पूरा कोर्स पूरा करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, पेट में असहजता, भूख न लगना और सिरदर्द शामिल हैं। रिफैम्पिसिन के कारण पेशाब, पसीना और थूक का रंग नारंगी-लाल हो सकता है, जो हानिरहित है। आइसोनियाजिड से हाथ-पैरों में झुनझुनी या सुन्नपन हो सकता है। गंभीर दुष्प्रभावों में लिवर की क्षति, पीलिया, और त्वचा पर गंभीर एलर्जी शामिल हैं। कोई भी गंभीर लक्षण दिखने पर तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर खाली पेट पानी के साथ। अगर पेट खराब होता है तो हल्के भोजन के साथ ले सकते हैं। इलाज बीच में न रोकें, वरना टीबी की दवा प्रतिरोधक हो सकती है। शराब बिल्कुल न पिएं क्योंकि इससे लिवर को नुकसान हो सकता है। अन्य दवाओं के बारे में डॉक्टर को बताएं, क्योंकि यह कई दवाओं के असर को कम कर सकती है। गर्भनिरोधक गोलियों का असर कम हो सकता है, इसलिए अतिरिक्त उपाय अपनाएं। आंखों या त्वचा का पीलापन, गहरे रंग का पेशाब, या लगातार उल्टी होने पर तुरंत डॉक्टर से संपर्क करें।
💊 isocin - kid 100mg/100mg tablet Uses & Benefits
[{"condition":"Drug-susceptible pulmonary tuberculosis","description":"Used as part of a multi-drug regimen to treat active tuberculosis infection in the lungs.","evidence":"Well-established"},{"condition":"Extrapulmonary tuberculosis","description":"Used in combination therapy for tuberculosis affecting lymph nodes, bones, joints, or other organs.","evidence":"Well-established"},{"condition":"Tuberculosis in children","description":"Weight-based dosing in pediatric patients as part of a complete antitubercular regimen.","evidence":"Well-established"},{"condition":"Latent tuberculosis infection","description":"Rifampicin plus isoniazid may be used in some latent tuberculosis regimens, but only under specialist guidance.","evidence":"Established in specific regimens"}]
Off-label uses: [{"condition":"Prophylaxis in close contacts of tuberculosis patients","description":"Sometimes used in selected contact-tracing protocols, but only according to local public health guidance.","evidence":"Limited and guideline-dependent"},{"condition":"Atypical mycobacterial infections","description":"Rifampicin-containing combinations may be used for some nontuberculous mycobacterial infections under specialist care.","evidence":"Limited"}]
Primary treatment for: Tuberculosis
Also treats: Extrapulmonary tuberculosis, Latent tuberculosis infection (in specific regimens)
📋 Drug Information
| Generic Name(s) | Rifampicin (100mg) + Isoniazid (100mg) |
| Brand Name | isocin - kid 100mg/100mg tablet |
| Manufacturer | Zee Laboratories |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep in the original container tightly closed. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | The World Health Organization recommends rifampicin and isoniazid as first-line antitubercular medicines for drug-susceptible tuberculosis. Fixed-dose combinations are endorsed to simplify treatment and reduce the risk of resistance. Treatment must follow national tuberculosis program guidelines. |
| ICMR Guideline | The Indian Council of Medical Research and the Revised National Tuberculosis Control Program recommend weight-based dosing of rifampicin and isoniazid for both adults and children. Fixed-dose combinations are preferred to improve adherence and prevent monotherapy. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antitubercular antibiotics with complementary mechanisms. Rifampicin binds to the beta subunit of bacterial DNA-dependent RNA polymerase, blocking RNA transcription and killing actively dividing Mycobacterium tuberculosis. Isoniazid is a prodrug activated by the bacterial enzyme KatG and then inhibits InhA, an enoyl-acyl carrier protein reductase, which prevents mycolic acid synthesis in the bacterial cell wall. The combination is bactericidal against susceptible mycobacteria and reduces the chance of resistance emerging during treatment.
Mechanism Steps
💡 How to Take isocin - kid 100mg/100mg tablet
Strength: Each tablet contains rifampicin 100 mg and isoniazid 100 mg in an immediate-release formulation.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, patient weight, age, and liver function. In adults, rifampicin is typically dosed at 10 mg/kg per day and isoniazid at 5 mg/kg per day, usually as part of a multi-drug regimen. This fixed-dose combination is primarily intended for weight-based pediatric dosing, but adults may receive it if the combination matches their prescribed regimen. Never adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is weight-based and must be determined by a qualified pediatrician or tuberculosis specialist. This 100 mg/100 mg tablet is commonly used in children as part of a complete antitubercular regimen. The dose is calculated according to the child's weight and the national tuberculosis program guidelines. Do not give this medicine to a child without a prescription and proper medical supervision. |
| Elderly Dosage | Elderly patients may be more susceptible to liver toxicity and drug interactions. The dose should be individualized by a clinician, and liver function should be monitored more frequently. No specific dose adjustment is established solely based on age. |
| Renal Impairment | Rifampicin and isoniazid are primarily metabolized by the liver, so dose adjustment is generally not required in mild to moderate kidney impairment. However, in severe kidney disease, monitoring is advised, and the dose may need to be individualized by a clinician. |
| Hepatic Impairment | This medicine should be used with extreme caution in patients with liver disease. Dose reduction or alternative regimens may be necessary, and liver function must be monitored closely. It is contraindicated in acute liver disease or severe hepatic impairment. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the patient's weight, age, and clinical condition. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of isocin - kid 100mg/100mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ritonavir | Major | |
| Warfarin | Major | |
| Oral contraceptives | Major | |
| Ketoconazole | Major | |
| Phenytoin | Major | |
| Paracetamol | Moderate | |
| Diazepam | Moderate | |
| Prednisolone | Moderate | |
| Metformin | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Ritonavir and other protease inhibitors
- Warfarin
- Oral contraceptives
- Ketoconazole and itraconazole
- Phenytoin
⚡ Moderate Interactions
- Paracetamol (acetaminophen)
- Diazepam
- Prednisolone
- Metformin
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both rifampicin and isoniazid can cause liver injury, and alcohol significantly increases this risk. Alcohol may also worsen the peripheral neuropathy caused by isoniazid.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to rifampicin, isoniazid, or any component of this medicine","Acute liver disease or severe hepatic impairment","Previous drug-induced hepatitis from rifampicin or isoniazid","Concurrent use with certain antiretroviral drugs such as ritonavir-boosted protease inhibitors","Acute porphyria"]
⚠️ Warnings & Precautions
["This medicine can cause serious liver injury. Report yellowing of eyes or skin, dark urine, or abdominal pain immediately.","Rifampicin may cause harmless orange-red discoloration of body fluids. This is not a sign of bleeding.","Use effective non-hormonal contraception during treatment, as this medicine reduces the effectiveness of hormonal contraceptives.","Avoid alcohol completely during treatment to reduce the risk of liver damage.","Patients with diabetes, malnutrition, or alcohol use disorder may need pyridoxine supplementation to prevent peripheral neuropathy.","This medicine can interact with many other drugs. Always inform your doctor about all medicines you are taking.","Do not stop treatment early, even if you feel better, as this can lead to drug-resistant tuberculosis."]
🤱 Lactation Safety
Both rifampicin and isoniazid pass into breast milk in small amounts. Breastfeeding is generally considered safe while taking this medicine, but the infant should be monitored for jaundice or unusual drowsiness. Pyridoxine supplementation may be recommended for the breastfeeding mother and infant.
💊 Overdose Management
Overdose of this medicine can cause severe nausea, vomiting, abdominal pain, and liver injury. In case of suspected overdose, seek emergency medical care immediately. Treatment is supportive, and there is no specific antidote. Activated charcoal may be given if the patient presents early. Liver function should be monitored closely.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your doctor for guidance.
Additional Safety Advice
Take this medicine exactly as prescribed, usually on an empty stomach with a full glass of water, but if it upsets your stomach, you may take it with a light meal. Do not skip doses or stop treatment early, because incomplete treatment can lead to drug-resistant tuberculosis. Avoid alcohol completely while taking this medicine, as alcohol increases the risk of liver damage. Tell your doctor about all other medicines you take, including oral contraceptives, blood thinners, diabetes medicines, and antiretroviral drugs, because rifampicin can reduce their effectiveness. Use a non-hormonal or additional contraceptive method during treatment. Report any yellowing of the eyes or skin, dark urine, persistent nausea, or unusual tiredness immediately. Keep all follow-up appointments for liver function tests and sputum checks.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of liver toxicity and drug interactions. Liver function should be monitored more frequently, and the dose should be individualized by a clinician. Watch for signs of confusion or falls, which may be related to side effects or drug interactions.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss your tuberculosis treatment with your doctor before conception. Rifampicin and isoniazid are generally considered safe during pregnancy when clinically indicated, but specialist supervision is required. Effective contraception should be used during treatment, as this medicine can reduce the effectiveness of hormonal contraceptives.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. Rifampicin can interact with anesthetic agents and other medications used during surgery. Your doctor may need to adjust your treatment or monitor you more closely.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Rifampicin can interact with some antibiotics and anesthetics. Good oral hygiene is important, and you should report any mouth ulcers or unusual bleeding to your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine, but listen to your body and rest when tired. Avoid strenuous exercise if you feel weak or have fever. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Most people can continue their daily activities while taking this medicine. However, if you experience dizziness, fatigue, or nausea, avoid driving or operating heavy machinery until you know how the medicine affects you. Inform your employer about your treatment if you work in a healthcare or crowded setting.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping early can lead to treatment failure and drug-resistant tuberculosis. If you experience severe side effects, contact your doctor immediately; they may adjust your treatment. Only stop if your doctor advises you to do so.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well tolerated when monitored appropriately. The main concern is liver toxicity, which can occur at any time but is more common in the first few months. Regular liver function tests are essential. Peripheral neuropathy from isoniazid can be prevented with pyridoxine supplementation. Completing the full course is crucial to prevent relapse and drug resistance.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A healthcare worker observes the patient taking each dose to ensure adherence and improve outcomes.
Evidence: Well-establishedAdequate nutrition helps improve immune function and treatment outcomes in tuberculosis.
Evidence: Well-establishedVitamin B6 is given to prevent peripheral neuropathy caused by isoniazid.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, live vaccines should be avoided during treatment for tuberculosis unless approved by your doctor. The BCG vaccine is used for prevention, not treatment, and is not given during active tuberculosis treatment.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Store at room temperature and away from direct sunlight. If crossing time zones, continue taking the medicine at the same interval as prescribed, but consult your doctor for specific advice. Check customs regulations for carrying prescription medicines into your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within a few weeks, but the full course of treatment usually lasts 6 months or longer. It is important to complete the entire course as prescribed.
A: It is best taken on an empty stomach, but if it upsets your stomach, you may take it with a light meal. Avoid high-fat meals as they can reduce absorption.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, alcohol should be completely avoided because it increases the risk of serious liver damage.
A: Yes, this medicine is commonly used in children, but the dose must be determined by a pediatrician based on the child's weight.
🤔 Common Patient Concerns
🔄 Substitutes for isocin - kid 100mg/100mg tablet
View AllAlternative brands with exact same active ingredient:
-
osorifa plus kid tabletOsho Pharma Pvt Ltd ₹11.54 15.1% CHEAPER
-
isorif kid tabletSbp Healthcare Pvt Ltd ₹13.13 3.4% CHEAPER
-
Rinex Kid TabletHamax Pharmaceuticals ₹13.13 3.4% CHEAPER
-
Recox 100mg/100mg TabletJarson Pharmaceuticals ₹13.13 3.4% CHEAPER
-
nkt kid 100mg/100mg tabletAsian Pharmaceuticals Pvt Ltd ₹14.00 3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Tuberculosis treatment can be stopped once symptoms improve.
Fact: Treatment must be completed for the full prescribed duration, even if you feel better, to prevent relapse and drug resistance. - Myth: Orange-red urine means the medicine is not working.
Fact: Orange-red discoloration of urine and other body fluids is a harmless and expected effect of rifampicin. - Myth: This medicine can be taken with alcohol.
Fact: Alcohol should be completely avoided because it increases the risk of serious liver damage. - Myth: Tuberculosis is hereditary.
Fact: Tuberculosis is an infectious disease caused by bacteria, not a hereditary condition.
🔄 Alternative Options
Generic Alternatives
- Rifampicin and Isoniazid fixed-dose combination
Brand Alternatives
- Anticox II Kid 100 mg/100 mg Tablet