Zerodol-MR Tablet: Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Severe dizziness or fainting
- Rapid heartbeat or palpitations
If experiencing severe symptoms, call emergency services immediately.
What is iramol tz 100mg/2mg tablet used for?
This medicine is a combination of Aceclofenac (100 mg) and Tizanidine (2 mg) used for short-term relief of painful musculoskeletal conditions associated with muscle spasm. It works by reducing pain and inflammation and relaxing muscles. It should be taken with food and avoided in people with stomach ulcers, severe kidney or liver disease, or those allergic to any component.
- Generic Name: Aceclofenac (100mg) + Tizanidine (2mg)
- Manufacturer: Kiama Lifesciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 iramol tz 100mg/2mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एसिटोक्लोफेनाक 100 मिलीग्राम और टिज़ानिडीन 2 मिलीग्राम का संयोजन है। इसका उपयोग मांसपेशियों में दर्द, सूजन और ऐंठन के इलाज के लिए किया जाता है। यह दर्द और सूजन को कम करने के साथ-साथ मांसपेशियों को आराम देती है। यह पीठ दर्द, गर्दन दर्द, मोच और अन्य मस्कुलोस्केलेटल समस्याओं में राहत देती है। इसे डॉक्टर के निर्देशानुसार भोजन के साथ लेना चाहिए। इस दवा को बिना डॉक्टर की सलाह के लंबे समय तक नहीं लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, सिरदर्द, चक्कर आना, नींद आना, मुंह सूखना और थकान शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में गंभीर दर्द, काला मल, खून की उल्टी, एलर्जी प्रतिक्रिया, सांस लेने में कठिनाई, पीलिया और कम पेशाब आना शामिल हो सकते हैं। इन लक्षणों को नजरअंदाज न करें और तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब न लें। गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। यदि आपको पेट अल्सर, किडनी या लिवर की बीमारी, हृदय रोग या अस्थमा है तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 iramol tz 100mg/2mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain with spasm","description":"Relieves pain and reduces muscle spasm in conditions like back pain, neck pain, and sprains.","evidence":"Well-established"},{"condition":"Post-operative pain and spasm","description":"Used short-term after surgery to manage pain and muscle spasm.","evidence":"Moderate"},{"condition":"Osteoarthritis flare-up","description":"Provides symptomatic relief of pain and inflammation in osteoarthritis, especially when associated with muscle spasm.","evidence":"Moderate"},{"condition":"Rheumatoid arthritis","description":"May be used as an adjunct for short-term symptom relief, but not as a disease-modifying agent.","evidence":"Limited"}]
Off-label uses: [{"condition":"Tension headache","description":"Sometimes prescribed off-label for tension-type headaches with muscle spasm.","evidence":"Limited"},{"condition":"Fibromyalgia","description":"May be used off-label for short-term relief of muscle pain and spasm in fibromyalgia.","evidence":"Limited"}]
Primary treatment for: Musculoskeletal pain with muscle spasm
Also treats: Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis, Acute back pain, Neck pain, Sprains and strains
📋 Drug Information
| Generic Name(s) | Aceclofenac (100mg) + Tizanidine (2mg) |
| Brand Name | iramol tz 100mg/2mg tablet |
| Manufacturer | Kiama Lifesciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Aceclofenac is a non-steroidal anti-inflammatory drug that inhibits the cyclooxygenase (COX) enzymes, leading to decreased production of prostaglandins, which are mediators of pain and inflammation. Tizanidine is a centrally acting alpha-2 adrenergic agonist that reduces the release of excitatory neurotransmitters from spinal interneurons, thereby decreasing muscle tone and spasm. Together, they provide relief from both pain and muscle spasm.
Mechanism Steps
💡 How to Take iramol tz 100mg/2mg tablet
Strength: Tablet containing Aceclofenac 100 mg and Tizanidine 2 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, preferably with food. The exact dose and duration depend on the condition being treated, its severity, and your response to therapy. Do not exceed the recommended dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially drowsiness, dizziness, and kidney effects. Use with caution. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with kidney impairment. Dose reduction may be necessary. Avoid in severe renal impairment (eGFR <30 mL/min). Consult your doctor for dose adjustment. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Dose reduction may be necessary. Avoid in severe hepatic impairment. Consult your doctor for dose adjustment. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets (300 mg aceclofenac and 6 mg tizanidine) per day. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of iramol tz 100mg/2mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ciprofloxacin | Major | |
| Fluvoxamine | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| Antihypertensives | Moderate | |
| CNS depressants | Moderate | |
| Oral contraceptives | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, naproxen)
- Ciprofloxacin
- Fluvoxamine
- Methotrexate
⚡ Moderate Interactions
- Antihypertensives
- CNS depressants (e.g., benzodiazepines, opioids)
- Oral contraceptives
- Diuretics
- Lithium
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding and ulcers due to the NSAID component, and it can enhance the sedative effects of tizanidine, leading to excessive drowsiness, dizziness, and impaired coordination. This can increase the risk of accidents and falls.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or history of recurrent ulcers","Severe heart failure","Severe kidney disease (eGFR
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol consumption.","Take with food to reduce stomach upset.","Do not use for longer than prescribed without medical advice.","Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart disease, or asthma.","May increase risk of cardiovascular events with long-term use.","Do not take other NSAIDs or pain relievers without consulting your doctor.","Use with caution in the elderly due to increased risk of side effects.","May cause low blood pressure; rise slowly from sitting or lying position.","Do not stop abruptly if you have been taking tizanidine for a long time; taper gradually."]
🤱 Lactation Safety
Not established from the available information. Aceclofenac and tizanidine may pass into breast milk. Consult your doctor before using this medicine while breastfeeding. Alternative options may be preferred.
💊 Overdose Management
Overdose may cause severe drowsiness, dizziness, slow heart rate, low blood pressure, nausea, vomiting, and stomach pain. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach irritation. Avoid alcohol while taking this medicine as it can increase drowsiness and the risk of stomach bleeding. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart disease, or asthma. Do not take other NSAIDs or pain relievers without consulting your doctor. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medicine. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat. Do not use after the expiry date.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients (above 65 years) are at higher risk of side effects such as gastrointestinal bleeding, kidney impairment, and drowsiness. Use with caution and lower doses may be required. Regular monitoring of kidney and liver function is advised. Avoid driving or operating machinery if drowsy.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs may affect ovulation and are not recommended during pregnancy, especially in the third trimester. Tizanidine is also not recommended. Discuss alternative treatment options with your doctor.
🏥 Post-Surgery Considerations
This medicine may be used short-term after surgery to manage pain and muscle spasm. However, it may increase the risk of bleeding and kidney problems. Inform your surgeon and anesthesiologist about all medicines you are taking. Follow your doctor's instructions carefully regarding dose and duration.
🦷 Dental Procedures
If you are scheduled for dental work, inform your dentist that you are taking this medicine. It may increase the risk of bleeding during procedures. Your dentist may advise you to stop the medicine temporarily before surgery. Do not stop without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel drowsy or dizzy. Avoid high-impact or strenuous exercises until you know how the medicine affects you. Gentle stretching and low-impact activities like walking or swimming are generally safe. Consult your physiotherapist for a tailored exercise plan.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause stomach upset; taking it with food can help. Inform your employer if your job requires alertness. Most people can continue their daily activities with caution.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach bleeding, allergic reactions, or signs of liver or kidney problems. Do not stop abruptly if you have been taking it for a long time; your doctor may advise a gradual taper to avoid withdrawal symptoms. Always follow your doctor's instructions regarding the duration of treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Regular monitoring of kidney and liver function, blood pressure, and signs of bleeding is recommended. It is not intended for long-term use without medical supervision. Consult your doctor regularly to assess the need for continued therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve muscle strength and flexibility.
Evidence: Well-establishedApplying heat or cold packs can help relieve muscle spasm and pain.
Evidence: ModerateMay provide pain relief for some musculoskeletal conditions.
Evidence: LimitedGentle yoga and stretching can improve flexibility and reduce muscle tension.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking. It is generally safe to receive vaccines while on this medicine, but consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust dosing times gradually as advised by your doctor. Check local customs regulations regarding prescription medicines. Always carry enough supply for your trip and a few extra days in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 30 to 60 minutes after taking the tablet. The muscle relaxant effect may be noticed within 1 to 2 hours.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine may cause drowsiness and dizziness. Avoid driving or operating heavy machinery until you know how it affects you.
A: Do not stop abruptly without consulting your doctor, especially if you have been taking it for a long time. Your doctor may advise a gradual taper.
🤔 Common Patient Concerns
🔄 Substitutes for iramol tz 100mg/2mg tablet
View AllAlternative brands with exact same active ingredient:
-
accetiz 100 mg/2 mg tabletGeno Pharmaceuticals Ltd ₹37.50 36.5% CHEAPER
-
solo mr 100mg/2mg tabletDaksh Pharma Pvt Ltd ₹45.00 23.8% CHEAPER
-
starnac tz 100mg/2mg tabletInvision Medi Sciences Pvt Ltd ₹45.94 22.2% CHEAPER
-
starmoto-tz 100mg/2mg tabletMinova Life Sciences Pvt Ltd ₹45.94 22.2% CHEAPER
-
zofen-t 100mg/2mg tabletZodak Healthcare ₹48.00 18.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of pain.
Fact: This medicine is specifically for musculoskeletal pain with muscle spasm. It is not effective for all types of pain and should only be used as prescribed. - Myth: It is safe to take this medicine long-term without monitoring.
Fact: Long-term use can increase the risk of stomach bleeding, kidney problems, and cardiovascular events. Regular monitoring is required. - Myth: You can drink alcohol while taking this medicine.
Fact: Alcohol increases the risk of stomach bleeding and drowsiness. It should be avoided. - Myth: This medicine is safe during pregnancy.
Fact: This medicine is not recommended during pregnancy, especially in the third trimester, unless clearly needed and prescribed by a doctor. - Myth: You can stop this medicine abruptly without any issues.
Fact: Abrupt discontinuation of tizanidine can cause rebound hypertension and other withdrawal symptoms. Always consult your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Aceclofenac + Tizanidine
Brand Alternatives
- Zerodol-MR
- Hifenac-MR
- Acenac-MR