IntoFlox-O Oral Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Numbness or tingling in hands or feet
- Seizures or convulsions
If experiencing severe symptoms, call emergency services immediately.
What is intoflox-o oral suspension used for?
This medicine is a combination antibiotic containing Ofloxacin and Metronidazole, used to treat infectious diarrhea, amebic dysentery, and other mixed bacterial and protozoal infections. It works by killing the microorganisms causing the infection.
- Generic Name: Ofloxacin (100mg) + Metronidazole (200mg)
- Manufacturer: Integrated Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 intoflox-o oral suspension के बारे में (Hindi Summary)
उपयोग: यह दवा ओफ्लोक्सासिन और मेट्रोनिडाजोल का संयोजन है, जिसका उपयोग संक्रामक दस्त, अमीबिक पेचिश, और अन्य मिश्रित बैक्टीरियल और प्रोटोज़ोअल संक्रमणों के इलाज के लिए किया जाता है। यह संक्रमण पैदा करने वाले सूक्ष्मजीवों को मारकर काम करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, धातु जैसा स्वाद, सिरदर्द और चक्कर आना शामिल हैं। गंभीर दुष्प्रभावों में टेंडन टूटना, तंत्रिका क्षति, दौरे और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। उपचार के दौरान और अंतिम खुराक के 48 घंटे बाद तक शराब का सेवन बिल्कुल न करें। पर्याप्त पानी पिएं। एंटासिड, आयरन या जिंक सप्लीमेंट इस दवा से 2 घंटे पहले या बाद में न लें। यदि आपको चक्कर आते हैं तो वाहन चलाने से बचें।
💊 intoflox-o oral suspension Uses & Benefits
[{"condition":"Infectious diarrhea","description":"Treats diarrhea caused by susceptible bacteria and protozoa, including mixed infections.","evidence":"Well-established"},{"condition":"Amebic dysentery","description":"Effective against Entamoeba histolytica, a common cause of bloody diarrhea.","evidence":"Well-established"},{"condition":"Giardiasis","description":"Used to treat Giardia lamblia infection, which causes prolonged diarrhea and malabsorption.","evidence":"Well-established"},{"condition":"Bacterial vaginosis","description":"Sometimes prescribed when anaerobic bacteria are involved, though not first-line.","evidence":"Limited"},{"condition":"Pelvic inflammatory disease","description":"May be used as part of combination therapy for PID caused by mixed aerobic and anaerobic bacteria.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Diverticulitis","description":"Occasionally used in mild cases, but not standard first-line therapy.","evidence":"Limited"},{"condition":"Small intestinal bacterial overgrowth (SIBO)","description":"Sometimes prescribed when other antibiotics are ineffective.","evidence":"Limited"}]
Primary treatment for: Infectious diarrhea
Also treats: Amebic dysentery, Giardiasis, Bacterial vaginosis, Pelvic inflammatory disease
📋 Drug Information
| Generic Name(s) | Ofloxacin (100mg) + Metronidazole (200mg) |
| Brand Name | intoflox-o oral suspension |
| Manufacturer | Integrated Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the bottle tightly closed. Do not freeze. Shake well before each use. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antibiotics with complementary mechanisms. Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair, leading to bacterial cell death. Metronidazole enters anaerobic organisms and is reduced to reactive intermediates that damage DNA, causing strand breakage and inhibiting nucleic acid synthesis. Together, they cover a broad spectrum of aerobic and anaerobic bacteria and certain protozoa.
Mechanism Steps
💡 How to Take intoflox-o oral suspension
Strength: Each 5 mL of oral suspension contains Ofloxacin 100 mg and Metronidazole 200 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 mL to 10 mL (containing Ofloxacin 100 mg and Metronidazole 200 mg per 5 mL) taken orally twice daily, or as directed by your physician. The exact dose and duration depend on the type and severity of infection, your kidney and liver function, and your response to treatment. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function and are at higher risk of side effects, especially tendon rupture and central nervous system effects. Dose adjustment may be necessary based on renal function. Use with caution and monitor closely. |
| Renal Impairment | In patients with renal impairment (creatinine clearance <50 mL/min), the dose of Ofloxacin should be reduced. Metronidazole dose may also need adjustment in severe renal impairment. Consult your doctor for specific dosing recommendations based on your kidney function. |
| Hepatic Impairment | In patients with severe liver disease, Metronidazole metabolism may be prolonged, requiring dose reduction. Ofloxacin does not require significant hepatic adjustment. Monitor liver function and consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 20 mL (Ofloxacin 400 mg and Metronidazole 800 mg) per day, but this must be confirmed by your physician based on your condition. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of intoflox-o oral suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Theophylline | Major | |
| Antacids | Major | |
| Alcohol | Major | |
| Cimetidine | Moderate | |
| Cyclosporine | Moderate | |
| Phenytoin | Moderate | |
| Lithium | Moderate | |
| Caffeine | Minor | |
| Sucralfate | Minor |
🚨 Major Interactions
- Warfarin
- Theophylline
- Antacids, iron, zinc
- Alcohol
⚡ Moderate Interactions
- Cimetidine
- Cyclosporine
- Phenytoin
- Lithium
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Metronidazole can cause a disulfiram-like reaction with alcohol, leading to flushing, severe nausea, vomiting, headache, and rapid heart rate. Additionally, alcohol may worsen dizziness and drowsiness caused by Ofloxacin.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Ofloxacin, Metronidazole, or any other quinolone or nitroimidazole antibiotics.","History of tendon disorders associated with fluoroquinolone use.","Myasthenia gravis (may worsen muscle weakness).","Pregnancy and breastfeeding.","Severe renal impairment (dose adjustment required, may be contraindicated).","Use of disulfiram within the past two weeks."]
⚠️ Warnings & Precautions
["Fluoroquinolones, including Ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions, including tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects. Reserve for patients with no alternative treatment options.","Metronidazole may cause a disulfiram-like reaction with alcohol. Avoid alcohol during and for 48 hours after therapy.","May cause dizziness and drowsiness. Avoid driving or operating machinery until you know how it affects you.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi. Monitor for superinfections.","Use with caution in patients with epilepsy or other seizure disorders.","May exacerbate symptoms of myasthenia gravis.","Avoid excessive sunlight and use sunscreen due to photosensitivity risk.","Do not use in children under 18 years unless specifically prescribed by a pediatrician."]
🤱 Lactation Safety
Both Ofloxacin and Metronidazole are excreted in breast milk. Ofloxacin may cause serious adverse reactions in nursing infants. Metronidazole may also pass into breast milk. Breastfeeding is not recommended while taking this medicine. Consult your doctor for safe alternatives.
💊 Overdose Management
Overdose may cause nausea, vomiting, dizziness, and potentially seizures. There is no specific antidote. Treatment is supportive and symptomatic. Maintain adequate hydration and monitor vital signs. In case of accidental overdose, seek immediate medical attention or contact a poison control center.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Avoid alcohol completely during treatment and for at least 48 hours after the last dose to prevent a disulfiram-like reaction. Stay well hydrated. Do not take antacids, iron, or zinc supplements within 2 hours of this medicine, as they can reduce its absorption. Inform your doctor if you have kidney or liver problems, or if you are pregnant or breastfeeding. Avoid driving or operating heavy machinery if you experience dizziness.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, kidney impairment, and central nervous system effects. Dose adjustment based on renal function is often necessary. Monitor closely for side effects.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for use during pregnancy or when planning pregnancy. If you are trying to conceive, consult your doctor for alternative antibiotics. Both Ofloxacin and Metronidazole may harm the developing fetus.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon that you are taking this medicine. It may interact with anesthetics and other medications. Your doctor may advise you to stop it before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with certain antibiotics or anesthetics used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, as it may increase the risk of tendon rupture. Light activities like walking are generally safe if you feel up to it.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness and drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take rest if you have severe diarrhea or fatigue.
🛑 When to Stop This Medicine
Do not stop taking this medicine before completing the full course, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience serious side effects, contact your doctor immediately; they may advise you to stop.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to bacterial resistance, superinfections, and rare but serious effects like peripheral neuropathy or tendon damage. It should only be used for the prescribed duration. Regular monitoring of kidney and liver function may be required if prolonged therapy is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Essential for managing dehydration from diarrhea.
Evidence: Well-establishedMay help restore gut flora and reduce diarrhea duration.
Evidence: ModerateRecommended in children with diarrhea to reduce severity and duration.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the effectiveness of live bacterial vaccines like typhoid vaccine. Avoid taking live vaccines during treatment and for several days after. Consult your doctor for specific timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Shake well before each use
❌ DON'T
Do not use if the suspension appears discolored or has particles
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. Store at room temperature and protect from light. If crossing time zones, adjust dosing times gradually to maintain even intervals. Check local customs regulations for carrying antibiotics.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24-48 hours, but it is important to complete the full course as prescribed.
A: Yes, taking it with food helps reduce stomach upset.
A: Avoid alcohol, antacids, iron, and zinc supplements within 2 hours of this medicine.
A: No, this medicine is not recommended during pregnancy. Consult your doctor for alternatives.
🤔 Common Patient Concerns
🔄 Substitutes for intoflox-o oral suspension
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhea.
Fact: It is only effective against specific bacterial and protozoal infections. Viral diarrhea will not respond. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course to prevent recurrence and resistance. - Myth: It is safe to drink alcohol while on this medicine.
Fact: Alcohol can cause a severe reaction with Metronidazole. Avoid completely.
🔄 Alternative Options
Generic Alternatives
- Ofloxacin + Metronidazole oral suspension (generic)
Brand Alternatives
- IntoFlox-O
- Oflox-M
- Metrogyl-O
- Ofloxacin-Metronidazole combination products