Adic-K Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Severe injection site pain or numbness
If experiencing severe symptoms, call emergency services immediately.
What is integ d 75mg injection used for?
This medicine is a diclofenac injection used for short-term relief of moderate to severe acute pain and inflammation when oral therapy is not possible. It works by blocking COX enzymes and is given by a healthcare professional.
- Generic Name: Diclofenac (25mg/ml)
- Manufacturer: Megavision Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 integ d 75mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा डाइक्लोफेनाक सोडियम का इंजेक्शन है, जिसका उपयोग मध्यम से गंभीर दर्द और सूजन को कम करने के लिए किया जाता है। यह आमतौर पर सर्जरी के बाद, चोट लगने पर, गुर्दे की पथरी के दर्द में, और गठिया के तीव्र दौरे में दी जाती है। यह दवा सूजन पैदा करने वाले एंजाइमों को रोककर काम करती है। यह केवल डॉक्टर की देखरेख में ही दी जानी चाहिए और इसे खुद से नहीं लगाना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन लगाने की जगह पर दर्द, लालिमा या सूजन, मतली, उल्टी, दस्त, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट या आंतों में रक्तस्राव, गुर्दे की समस्या, हृदयाघात, स्ट्रोक, और गंभीर एलर्जी प्रतिक्रिया हो सकती है। यदि आपको काला मल, खून की उल्टी, सीने में दर्द, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इसे खुद से न लगाएं। अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं के बारे में बताएं, खासकर पेट के अल्सर, गुर्दे या लीवर की बीमारी, हृदय रोग, उच्च रक्तचाप, या अस्थमा। आप जो भी दवाएं ले रहे हैं, उनके बारे में डॉक्टर को बताएं। इस दवा के साथ शराब न लें। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर को बताएं।
💊 integ d 75mg injection Uses & Benefits
[{"condition":"Acute postoperative pain","description":"Provides rapid relief of moderate to severe pain following surgical procedures when oral intake is not possible.","evidence":"Well-established"},{"condition":"Acute musculoskeletal injury","description":"Reduces pain and inflammation in conditions such as sprains, strains, and fractures.","evidence":"Well-established"},{"condition":"Renal colic","description":"Effective in relieving the severe pain associated with kidney stones.","evidence":"Well-established"},{"condition":"Acute exacerbation of osteoarthritis or rheumatoid arthritis","description":"Used for short-term management of severe joint pain and swelling when oral therapy is inadequate.","evidence":"Well-established"},{"condition":"Biliary colic","description":"Helps alleviate pain from gallbladder contractions.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prevention of heterotopic ossification after hip surgery","description":"Sometimes used off-label to reduce abnormal bone formation after certain orthopedic procedures.","evidence":"Limited"},{"condition":"Acute migraine","description":"May be used off-label for rapid relief of migraine headache in emergency settings.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Postoperative pain, Musculoskeletal injuries, Renal colic, Osteoarthritis flare, Rheumatoid arthritis flare
📋 Drug Information
| Generic Name(s) | Diclofenac (25mg/ml) |
| Brand Name | integ d 75mg injection |
| Manufacturer | Megavision Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid) |
| Route of Administration | Parenteral (intramuscular or intravenous injection) |
| Storage | Store below 25°C (77°F). Do not freeze. Protect from light. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by reversibly inhibiting both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, thereby blocking the conversion of arachidonic acid into prostaglandins and thromboxanes. Prostaglandins are key mediators of pain, inflammation, and fever. By reducing their synthesis, this medicine produces analgesic, anti-inflammatory, and antipyretic effects. The inhibition is non-selective, which explains both its therapeutic actions and some of its side effects, particularly gastrointestinal and renal effects.
Mechanism Steps
💡 How to Take integ d 75mg injection
Strength: Injection: 25 mg/mL
Dosage Information
| Adult Dosage | The usual adult dose for acute pain is 25 mg to 75 mg given intramuscularly, and may be repeated every 6 to 8 hours as needed, not exceeding 150 mg per day. For intravenous administration, the dose is typically 25 mg to 75 mg infused over 30 minutes to 2 hours, repeated every 6 hours, with a maximum of 150 mg per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are at increased risk of gastrointestinal bleeding, renal impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | In patients with mild to moderate renal impairment, no dose adjustment is usually necessary, but caution is advised. In severe renal impairment (eGFR <30 mL/min), diclofenac is contraindicated. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, use with caution and consider lower doses. In severe hepatic impairment, diclofenac is contraindicated. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | 150 mg per day |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of integ d 75mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Major | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Cyclosporine | Moderate | |
| Digoxin | Minor |
🚨 Major Interactions
- Warfarin
- Aspirin
- Methotrexate
- Lithium
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Diuretics (e.g., furosemide)
- Corticosteroids
- SSRIs
- Cyclosporine
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine. Alcohol increases the risk of stomach bleeding, ulcers, and liver problems. It can also worsen dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or gastrointestinal bleeding","Severe heart failure","Severe renal impairment","Severe hepatic impairment","History of asthma, urticaria, or allergic reaction to aspirin or other NSAIDs","Third trimester of pregnancy","Coronary artery bypass graft (CABG) surgery perioperative period","Known hypersensitivity to diclofenac"]
⚠️ Warnings & Precautions
["Cardiovascular risk: NSAIDs may increase the risk of serious cardiovascular thrombotic events. Use the lowest effective dose for the shortest duration.","Gastrointestinal risk: NSAIDs can cause serious GI adverse events including bleeding, ulceration, and perforation. Use with caution in the elderly and those with a history of ulcer disease.","Renal effects: Long-term use may lead to kidney injury. Monitor renal function in at-risk patients.","Hepatic effects: Monitor liver enzymes in patients with liver disease or on prolonged therapy.","Bleeding risk: May inhibit platelet aggregation and prolong bleeding time. Use with caution in patients with bleeding disorders.","Injection site reactions: Ensure proper technique to avoid nerve damage, abscess, or tissue necrosis.","Not for intrathecal or epidural administration.","Avoid in patients with dehydration or hypovolemia."]
🤱 Lactation Safety
Diclofenac is excreted in breast milk in small amounts. It is generally considered compatible with breastfeeding, but consult your doctor before use.
💊 Overdose Management
Overdose of diclofenac injection may cause severe abdominal pain, nausea, vomiting, gastrointestinal bleeding, lethargy, drowsiness, and in severe cases, acute renal failure and seizures. There is no specific antidote. Treatment is supportive and symptomatic. Activated charcoal may be considered if ingestion occurred recently, but this is not applicable for injection. Hemodialysis is not effective in removing diclofenac. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
This medicine is usually given by a healthcare professional in a clinical setting. If you miss a scheduled dose, contact your doctor or nurse as soon as possible. Do not attempt to self-administer a missed dose. The dosing schedule will be adjusted by your healthcare provider.
Additional Safety Advice
This medicine must be given by a qualified healthcare professional using proper injection technique. Do not self-administer. Inform your doctor about all your medical conditions, especially stomach ulcers, kidney or liver problems, heart disease, high blood pressure, or asthma. Tell your doctor about all medicines you take, including blood thinners, steroids, antidepressants, and diuretics. Avoid alcohol while receiving this medicine. Do not use this medicine for more than the recommended duration unless directed by your doctor. Report any unusual symptoms such as black stools, severe abdominal pain, decreased urination, or swelling of the face or throat immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal function and blood pressure closely. Avoid concomitant use with other NSAIDs or anticoagulants.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Diclofenac may affect ovulation and is generally avoided during pregnancy, especially in the third trimester. Discuss alternative pain management options.
🏥 Post-Surgery Considerations
This medicine is often used for postoperative pain. It should be administered by a healthcare professional. Monitor for bleeding, infection at injection site, and renal function. Follow your surgeon's instructions regarding activity and wound care.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may increase bleeding risk during dental procedures. Your dentist may recommend postponing elective procedures or taking precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, avoid strenuous exercise or activities that could cause injury, especially if you have pain or inflammation. Gentle stretching and low-impact activities are generally safe, but consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. It is advisable to rest after receiving the injection and avoid demanding tasks until you feel fully alert. If your work involves physical labor, consult your doctor about when you can safely resume.
🛑 When to Stop This Medicine
This medicine is usually given for a short duration. Do not stop or extend the treatment without consulting your doctor. If you experience severe side effects, seek immediate medical attention. Your doctor will determine when to stop based on your condition and response to therapy.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to increased risks of gastrointestinal bleeding, kidney impairment, liver toxicity, and cardiovascular events. If long-term therapy is necessary, regular monitoring of renal and hepatic function, complete blood count, and blood pressure is required. Discuss with your doctor about alternative treatments for chronic pain.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedMay help reduce pain in some individuals.
Evidence: ModerateAlternative for localized pain with fewer systemic side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider that you are receiving this medicine.
📦 Storage Guide
✅ DO
Store below 25°C (77°F)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✅ DO
Keep out of reach of children
❌ DON'T
Do not use if solution is discolored or contains particles
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Keep it in a cool, dry place, and avoid exposing it to extreme temperatures. If traveling by air, pack it in your carry-on luggage to prevent loss or temperature fluctuations. Check the customs regulations of your destination country regarding injectable medications. It is advisable to carry a doctor's note explaining the medical necessity of the injection.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine typically starts relieving pain within 15 to 30 minutes after intramuscular injection.
A: The analgesic effect usually lasts 4 to 6 hours, but this can vary.
A: It is not recommended for patients with severe kidney disease. Your doctor will assess your kidney function before prescribing.
A: It is generally avoided in the third trimester. Consult your doctor if you are pregnant or planning pregnancy.
A: This medicine may cause dizziness or drowsiness. Avoid driving until you know how it affects you.
🤔 Common Patient Concerns
🔄 Substitutes for integ d 75mg injection
View AllAlternative brands with exact same active ingredient:
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diclonac 25mg/ml injectionLupin Ltd ₹3.75 58.3% CHEAPER
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Fenogesic 75mg InjectionTribhawan Injectables ₹3.75 58.3% CHEAPER
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aenafen 75mg injectionShawn & Co ₹4.22 53.1% CHEAPER
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dfn injectionParex Pharmaceuticals Pvt Ltd ₹4.22 53.1% CHEAPER
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lifogesic 25mg/ml injectionIntra Life ₹4.30 52.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Diclofenac injection is safer than oral diclofenac.
Fact: Both forms carry similar risks, including gastrointestinal and cardiovascular side effects. Injection is used when oral route is not feasible, not because it is safer. - Myth: You can self-administer diclofenac injection at home.
Fact: This medicine must be given by a trained healthcare professional due to risks of improper injection technique and serious allergic reactions. - Myth: Diclofenac injection can be used for long-term pain management.
Fact: It is intended for short-term use only. Long-term use increases the risk of serious side effects.
🔄 Alternative Options
Generic Alternatives
- Diclofenac sodium injection
Brand Alternatives
- Voveran injection
- Dynapar injection
- Zerodol injection