Ademetionine 200 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden swelling of face, lips, or throat
- Difficulty breathing or swallowing
- Severe mood swings or thoughts of self-harm
- Yellowing of skin or eyes
- Severe abdominal pain or persistent vomiting
- Unusual bleeding or bruising
- Rapid heartbeat with fever and muscle twitching
If experiencing severe symptoms, call emergency services immediately.
What is intasam 200 mg tablet used for?
This medicine contains Ademetionine 200 mg, a naturally occurring compound that supports liver health, mood, and joint function. It is used for conditions like intrahepatic cholestasis, depression, and osteoarthritis. It works by donating methyl groups and boosting antioxidant levels.
- Generic Name: Ademetionine (200mg)
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 intasam 200 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एडेमेटियोनिन 200 मिलीग्राम युक्त है और मुख्य रूप से लिवर की समस्याओं जैसे इंट्राहेपेटिक कोलेस्टेसिस, अवसाद, और ऑस्टियोआर्थराइटिस के इलाज में उपयोग की जाती है। यह शरीर में मिथाइलेशन प्रक्रिया को सुधारती है और एंटीऑक्सीडेंट ग्लूटाथियोन के स्तर को बढ़ाती है। यह मूड को बेहतर बनाने और जोड़ों के दर्द को कम करने में मदद कर सकती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, पेट में असहजता, दस्त, कब्ज, और सिरदर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको एलर्जी, मूड में अचानक बदलाव, या आत्महत्या के विचार आते हैं, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अपनी मर्जी से खुराक न बढ़ाएं या घटाएं। अन्य दवाओं, विशेषकर एंटीडिप्रेसेंट और एमएओ इनहिबिटर के साथ लेने से पहले डॉक्टर से सलाह लें। शराब का सेवन न करें। यदि आपको बाइपोलर डिसऑर्डर या पार्किंसन रोग है, तो इस दवा का उपयोग सावधानी से करें। गर्भावस्था या स्तनपान के दौरान डॉक्टर की सलाह के बिना न लें।
💊 intasam 200 mg tablet Uses & Benefits
[{"condition":"Intrahepatic cholestasis","description":"This medicine helps improve bile flow and reduce liver enzyme levels in conditions where bile flow is impaired within the liver.","evidence":"Well-established"},{"condition":"Major depressive disorder","description":"Used as an adjunctive treatment to enhance the effects of standard antidepressants, possibly by increasing neurotransmitter levels.","evidence":"Moderate"},{"condition":"Osteoarthritis","description":"May provide pain relief and improve joint function, likely due to its anti-inflammatory and cartilage-protective effects.","evidence":"Moderate"},{"condition":"Fibromyalgia","description":"Sometimes used to reduce pain and fatigue, though evidence is limited and mixed.","evidence":"Limited"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Occasionally prescribed to prevent migraines, but evidence is not strong.","evidence":"Limited"},{"condition":"Attention deficit hyperactivity disorder (ADHD)","description":"Rarely used as an adjunct, but not standard practice.","evidence":"Limited"}]
Primary treatment for: Intrahepatic cholestasis
Also treats: Major depressive disorder, Osteoarthritis, Fibromyalgia
📋 Drug Information
| Generic Name(s) | Ademetionine (200mg) |
| Brand Name | intasam 200 mg tablet |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | VITAMINS MINERALS NUTRIENTS |
| Action Class | Hepatoprotectives |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ademetionine, the active ingredient in this medicine, functions primarily as a methyl donor in various biochemical reactions. It participates in the methylation of DNA, proteins, and lipids, which is crucial for cellular function. It also serves as a precursor for the synthesis of glutathione, a major antioxidant, and for the production of polyamines, which are involved in cell growth and differentiation. In the central nervous system, Ademetionine contributes to the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine by donating methyl groups. Additionally, it plays a role in the transsulfuration pathway, which helps regulate homocysteine levels. These combined actions support liver health, mood regulation, and joint function.
Mechanism Steps
💡 How to Take intasam 200 mg tablet
Strength: Ademetionine 200 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 200 mg to 400 mg per day, taken orally, often in divided doses. For liver conditions, the dose may be 200 mg twice daily. For depression, doses up to 800 mg per day have been used in clinical studies, but the optimal dose varies. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and adjust based on response and tolerability. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is established for renal impairment. Use with caution and monitor closely. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and monitor liver function. |
| Maximum Daily Dose | The maximum recommended daily dose is not well established. Doses up to 1600 mg per day have been used in clinical trials under medical supervision. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of intasam 200 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| SSRIs | Major | |
| Levodopa | Major | |
| Tricyclic antidepressants | Moderate | |
| Triptans | Moderate | |
| Tramadol | Moderate | |
| Antacids | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- SSRIs (e.g., fluoxetine, sertraline)
- Levodopa
⚡ Moderate Interactions
- Tricyclic antidepressants (e.g., amitriptyline)
- Triptans (e.g., sumatriptan)
- Tramadol
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol can increase the risk of liver damage and may worsen depression or anxiety. It can also interfere with the medicine's effectiveness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Ademetionine or any component of the tablet","Bipolar disorder (may precipitate mania)","Homocystinuria (unless under specialist supervision)","Use with MAO inhibitors"]
⚠️ Warnings & Precautions
["May trigger mania in patients with bipolar disorder.","Use with caution in patients with Parkinson's disease; may worsen symptoms.","May interact with serotonergic drugs; risk of serotonin syndrome.","Avoid alcohol consumption.","Not recommended during pregnancy or breastfeeding unless clearly needed.","May affect blood tests for homocysteine; inform your doctor."]
🤱 Lactation Safety
It is not known whether Ademetionine passes into breast milk. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
There is limited information on overdose with this medicine. If you suspect an overdose, seek immediate medical attention. Symptoms may include severe nausea, vomiting, diarrhea, and mood changes. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose without medical advice. Inform your doctor about all other medicines, supplements, and herbal products you are taking, especially antidepressants, MAO inhibitors, and levodopa, as interactions may occur. Avoid alcohol while taking this medicine because it can increase the risk of liver problems. If you have bipolar disorder, a history of mania, or Parkinson's disease, use this medicine only under close medical supervision. Do not use this medicine if you are pregnant or breastfeeding without consulting your doctor. Keep this medicine out of reach of children. Store it in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to side effects. Start with a lower dose and monitor closely for mood changes or dizziness.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. Safety is not established.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may affect methylation and homocysteine levels, which could influence recovery.
🦷 Dental Procedures
No specific precautions are required for dental procedures, but inform your dentist about all medicines you are taking.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience dizziness or fatigue, avoid strenuous exercise until you know how this medicine affects you. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It should not interfere with most desk jobs.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or allergic reactions, stop immediately and seek medical help.
📅 Long-Term Use Effects
Long-term use of this medicine is generally well tolerated. However, regular monitoring of liver function and mood may be advised. In rare cases, prolonged use may lead to elevated homocysteine levels. Periodic review with your doctor is recommended.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedEffective for depression alongside medication.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before any vaccination while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing schedule gradually under medical guidance. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take 1-2 weeks for liver symptoms and 2-4 weeks for mood or joint symptoms to improve.
A: It can interact with SSRIs and MAO inhibitors. Consult your doctor before combining.
A: Safety is not established. Use only if prescribed by your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for intasam 200 mg tablet
View AllAlternative brands with exact same active ingredient:
-
sampure 200mg tabletElder Pharmaceuticals Ltd ₹263.44 SAME PRICE
-
Adesam 200 TabletSun Pharmaceutical Industries Ltd ₹266.05 1% COSTLIER
-
Adenomac 200 TabletMacleods Pharmaceuticals Pvt Ltd ₹282.84 7.4% COSTLIER
-
S-Adimer TabletAspen Pharma ₹348.50 32.3% COSTLIER
-
metholor 200 tabletRacoon Pharmaceutical ₹364.60 38.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a stimulant.
Fact: It is not a stimulant; it is a naturally occurring compound that supports methylation and antioxidant processes. - Myth: It can cure depression on its own.
Fact: It may help as an adjunct, but it is not a standalone cure for depression. - Myth: It is safe to take with any medication.
Fact: It can interact with MAO inhibitors, SSRIs, and levodopa, so consult your doctor.
🔄 Alternative Options
Generic Alternatives
- Ademetionine 200 mg tablet (various manufacturers)
Brand Alternatives
- Samyr 200 mg tablet
- Heptral 200 mg tablet
- Transmetil 200 mg tablet