A Lith 450mg Tablet SR: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe trembling or shaking of hands
- Confusion or difficulty concentrating
- Slurred speech
- Unsteady walking or loss of balance
- Blurred vision or ringing in the ears
- Severe nausea, vomiting, or diarrhoea
- Increased thirst and urination with weakness
- Seizures or loss of consciousness
If experiencing severe symptoms, call emergency services immediately.
What is intalith cr 450 tablet used for?
This medicine contains lithium carbonate, a mood stabilizer used to treat bipolar disorder. It helps reduce manic episodes and prevent mood swings. Regular blood tests are essential to monitor lithium levels and avoid toxicity.
- Generic Name: Lithium carbonate (450mg)
- Manufacturer: Intas Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 intalith cr 450 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लिथियम कार्बोनेट से बनी है और मुख्य रूप से बाइपोलर डिसऑर्डर (मूड स्विंग्स) के इलाज के लिए इस्तेमाल की जाती है। यह मानसिक स्थिति को स्थिर करने में मदद करती है और मैनिया (अत्यधिक उत्साह) और डिप्रेशन के दौरान मूड को संतुलित रखती है। यह दवा मूड स्विंग्स को कम करने और भविष्य में होने वाले एपिसोड को रोकने में मदद करती है। इसे डॉक्टर की सलाह के अनुसार ही लेना चाहिए और नियमित रूप से ब्लड टेस्ट करवाना जरूरी है।
साइड इफेक्ट्स: इस दवा के कुछ सामान्य दुष्प्रभाव हो सकते हैं जैसे हाथों में कंपन, ज्यादा प्यास लगना, बार-बार पेशाब आना, जी मिचलाना और दस्त। ये आमतौर पर शरीर के अनुकूल होने पर ठीक हो जाते हैं। कुछ गंभीर दुष्प्रभाव भी हो सकते हैं जैसे गंभीर कंपन, भ्रम, बोलने में कठिनाई, चलने में असंतुलन, धुंधली दृष्टि और कानों में घंटी बजना। अगर ऐसे लक्षण दिखें तो तुरंत डॉक्टर से मिलें। लंबे समय तक इस्तेमाल से थायरॉइड और किडनी पर असर पड़ सकता है, इसलिए नियमित जांच जरूरी है।
सुरक्षा सलाह: इस दवा को लेते समय सावधानी बरतें। डॉक्टर द्वारा बताई गई खुराक ही लें, खुद से दवा की मात्रा न बदलें। पर्याप्त पानी पिएं, खासकर गर्मी में या व्यायाम के दौरान। नमक का सेवन एक समान रखें, क्योंकि अचानक नमक कम या ज्यादा होने से लिथियम का स्तर प्रभावित हो सकता है। शराब से बचें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। नियमित रूप से ब्लड टेस्ट करवाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। दवा अचानक बंद न करें।
💊 intalith cr 450 tablet Uses & Benefits
[{"condition":"Bipolar disorder – acute mania","description":"This medicine is used to treat acute manic episodes in bipolar disorder, helping to reduce elevated mood, agitation, and impulsive behaviour.","evidence":"Well-established"},{"condition":"Bipolar disorder – maintenance","description":"This medicine is used long-term to prevent relapse of manic and depressive episodes in bipolar disorder.","evidence":"Well-established"},{"condition":"Treatment-resistant depression","description":"Sometimes used as an add-on treatment for major depressive disorder that has not responded to other antidepressants.","evidence":"Moderate"},{"condition":"Schizoaffective disorder","description":"May be used to stabilise mood in people with schizoaffective disorder, particularly those with manic symptoms.","evidence":"Limited"}]
Off-label uses: [{"condition":"Cluster headaches","description":"Lithium has been used off-label for the prevention of cluster headaches in some patients.","evidence":"Limited"},{"condition":"Impulse control disorders","description":"Occasionally prescribed off-label for aggressive behaviour or impulse control problems.","evidence":"Limited"}]
Primary treatment for: Bipolar disorder
Also treats: Treatment-resistant depression, Schizoaffective disorder
📋 Drug Information
| Generic Name(s) | Lithium carbonate (450mg) |
| Brand Name | intalith cr 450 tablet |
| Manufacturer | Intas Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Mood stabilizers |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Lithium is thought to exert its mood-stabilising effects through multiple actions on cellular signalling pathways in the brain. It inhibits enzymes such as inositol monophosphatase and glycogen synthase kinase-3, which are involved in neurotransmitter signalling and neuronal plasticity. This leads to a reduction in excessive dopamine and glutamate activity while enhancing GABAergic transmission. The overall effect is to dampen the extreme mood swings characteristic of bipolar disorder. Lithium also affects sodium transport across cell membranes, which may contribute to its side effects and toxicity.
Mechanism Steps
💡 How to Take intalith cr 450 tablet
Strength: Sustained-release tablet, 450 mg.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, age, weight, renal function, and response to treatment. For acute mania, a typical starting dose is 300 mg two to three times daily, with gradual increases to achieve a serum lithium level of 0.8 to 1.2 mmol/L. For maintenance, the target level is usually 0.6 to 1.0 mmol/L. Sustained-release tablets are often taken once or twice daily. Do not adjust the dose without medical supervision. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of lithium and are at higher risk of toxicity. Lower doses are often required, and renal function should be monitored closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, lithium clearance is reduced, and the dose must be adjusted. Regular monitoring of serum lithium levels and renal function is essential. In severe renal impairment, lithium is contraindicated. |
| Hepatic Impairment | No specific dose adjustment is required for hepatic impairment, as lithium is not metabolised by the liver. However, monitoring is advised. |
| Maximum Daily Dose | The maximum daily dose should not exceed the amount required to maintain serum lithium levels within the therapeutic range. Typically, doses above 1800 mg per day are rarely used. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of intalith cr 450 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Hydrochlorothiazide | Major | |
| Ibuprofen | Major | |
| Enalapril | Major | |
| Carbamazepine | Moderate | |
| Fluoxetine | Moderate | |
| Verapamil | Moderate | |
| Metronidazole | Moderate | |
| Sodium bicarbonate | Minor | |
| Caffeine | Minor | |
| Theophylline | Minor |
🚨 Major Interactions
- Diuretics (e.g., hydrochlorothiazide, furosemide)
- ACE inhibitors (e.g., enalapril, lisinopril)
- NSAIDs (e.g., ibuprofen, naproxen)
- Thiazide diuretics
⚡ Moderate Interactions
- Carbamazepine
- Calcium channel blockers (e.g., verapamil, diltiazem)
- SSRIs (e.g., fluoxetine, sertraline)
- Metronidazole
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can worsen side effects such as drowsiness and dizziness, and it can also affect lithium levels, increasing the risk of toxicity. Additionally, alcohol can destabilise mood, which counteracts the purpose of the medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe renal impairment","Severe cardiovascular disease","Severe dehydration or sodium depletion","Known hypersensitivity to lithium or any component of the formulation","Pregnancy, especially first trimester, unless absolutely necessary","Breastfeeding"]
⚠️ Warnings & Precautions
["Lithium has a narrow therapeutic index; regular blood monitoring is essential.","Dehydration from vomiting, diarrhoea, or excessive sweating can increase lithium levels and lead to toxicity.","Changes in salt intake can affect lithium levels; maintain a consistent diet.","Avoid alcohol and caffeine fluctuations.","Use with caution in elderly patients and those with renal or cardiac disease.","Do not stop this medicine abruptly without medical advice.","Inform your doctor if you develop an infection, fever, or any illness that may cause dehydration.","Lithium may impair driving or operating machinery, especially at higher doses."]
🤱 Lactation Safety
Lithium is excreted in breast milk and can reach levels in the infant that are significant. Breastfeeding is generally not recommended while taking this medicine. If breastfeeding is essential, the infant should be monitored closely for signs of lithium toxicity, and lithium levels in the infant's blood should be checked.
💊 Overdose Management
Overdose of lithium can be life-threatening. Symptoms of overdose include severe nausea, vomiting, diarrhoea, coarse tremor, confusion, slurred speech, blurred vision, ringing in the ears, unsteady gait, and in severe cases, seizures, coma, and cardiac arrhythmias. If you suspect an overdose, seek emergency medical help immediately. Treatment may include gastric lavage, intravenous fluids, and in severe cases, haemodialysis to remove lithium from the blood. Do not attempt to treat yourself.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
Safety is paramount when taking this medicine. Always take the exact dose prescribed by your doctor, and never adjust it on your own. Drink plenty of fluids, especially in hot weather or during exercise, to avoid dehydration, which can raise lithium levels. Maintain a consistent salt intake; sudden changes in salt consumption can affect lithium levels. Avoid alcohol, as it can worsen side effects and increase the risk of toxicity. Tell your doctor about all other medicines you are taking, including over-the-counter painkillers, diuretics, and blood pressure medicines, as many can interact with lithium. Regular blood tests to check lithium levels, kidney function, and thyroid function are essential. If you become pregnant or plan to become pregnant, speak to your doctor immediately. Do not stop this medicine abruptly, as this can cause your mood to become unstable. Keep all appointments with your healthcare team and report any new or worsening symptoms without delay.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to lithium and are at higher risk of toxicity. Lower doses are often required, and renal function should be monitored closely. Regular monitoring of serum lithium levels, kidney function, and thyroid function is essential.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine is not recommended during pregnancy unless the benefits clearly outweigh the risks. Your doctor may consider alternative treatments or adjust the dose. Effective contraception is advised while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine. Lithium can interact with anaesthetic agents and affect fluid balance. Close monitoring of lithium levels and renal function is advised before and after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. Lithium can cause dry mouth, which may increase the risk of dental problems. Maintain good oral hygiene and stay hydrated. No specific precautions are required for dental procedures, but your dentist should be aware of your medication.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is beneficial, but excessive sweating can lead to dehydration and increase lithium levels. Drink plenty of water before, during, and after exercise. Avoid strenuous activity in hot weather without adequate hydration. If you experience dizziness or weakness, stop and seek medical advice.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or tremor, which can affect your ability to drive or operate machinery. Avoid driving until you know how this medicine affects you. It is important to maintain a regular routine and take the medicine as prescribed to manage your condition effectively at work and in daily life.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping abruptly can cause a relapse of manic or depressive episodes. Your doctor will gradually reduce the dose if needed. If you experience severe side effects, contact your doctor immediately; they will decide whether to adjust or stop the medicine.
📅 Long-Term Use Effects
Long-term use of this medicine can affect the thyroid gland and kidneys. Regular monitoring of thyroid function, renal function, and serum lithium levels is essential. Some patients may develop hypothyroidism or renal impairment, which may require dose adjustment or additional treatment. Long-term use is generally safe when monitored appropriately, but regular follow-up with your healthcare provider is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine in managing bipolar disorder.
Evidence: Well-establishedRegular sleep, exercise, and stress management can help stabilise mood.
Evidence: ModerateValproate, lamotrigine, or atypical antipsychotics may be alternatives.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, if you develop a fever or infection after vaccination, inform your doctor, as dehydration can affect lithium levels.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. If crossing time zones, consult your doctor about adjusting the timing of doses. Store at room temperature and protect from extreme heat or moisture. Check customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The mood-stabilising effects may take several days to weeks to become noticeable. Acute manic symptoms may improve within 5 to 7 days, but full effect may take 2 to 3 weeks.
A: If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop this medicine abruptly. Stopping suddenly can cause your mood to become unstable. Always consult your doctor before making any changes.
A: This medicine is not recommended during pregnancy unless the benefits clearly outweigh the risks. It has been associated with an increased risk of congenital heart defects. Consult your doctor immediately if you are pregnant or planning to become pregnant.
🤔 Common Patient Concerns
🔄 Substitutes for intalith cr 450 tablet
View AllAlternative brands with exact same active ingredient:
-
alkalith 450mg tablet crAlkem Laboratories Ltd ₹16.41 63.1% CHEAPER
-
zecarb 450mg tablet srZeus Pharma ₹17.23 61.3% CHEAPER
-
a lith 450mg tablet srPifer Pharmaceuticals Pvt Ltd ₹19.69 55.8% CHEAPER
-
lithowel 450mg tablet crSigmund Promedica ₹21.34 52.1% CHEAPER
-
t lith 450mg tablet crTripada Biotec Pvt Ltd ₹22.27 50% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is addictive.
Fact: This medicine is not addictive, but it should not be stopped abruptly without medical advice. - Myth: This medicine will cure bipolar disorder.
Fact: This medicine helps manage symptoms but is not a cure. It must be taken regularly to be effective. - Myth: You can stop taking this medicine once you feel better.
Fact: Stopping suddenly can cause relapse. Always consult your doctor before making changes.
🔄 Alternative Options
Generic Alternatives
- Lithium carbonate 450 mg sustained-release tablets
Brand Alternatives
- A Lith 450mg Tablet SR