Human Mixtard 50 Injection: A Comprehensive Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe hypoglycemia (confusion, seizures, loss of consciousness)
- Signs of severe allergic reaction (rash, swelling, difficulty breathing)
- Persistent hyperglycemia with ketones in urine
- Injection site infection (redness, swelling, pus)
- Unexplained weight loss or extreme fatigue
- Blurred vision or eye pain
If experiencing severe symptoms, call emergency services immediately.
What is insucare m 50 injection 40iu/ml used for?
This medicine is a premixed insulin injection containing 50% intermediate-acting insulin isophane and 50% rapid-acting human soluble insulin. It is used to treat diabetes mellitus by lowering blood sugar levels. It is injected subcutaneously, usually twice daily before meals, and the dose is individualized by a doctor.
- Generic Name: Insulin Isophane/NPH (50%) + Human Insulin/Soluble Insulin (50%)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 insucare m 50 injection 40iu/ml के बारे में (Hindi Summary)
उपयोग: यह दवा मधुमेह (डायबिटीज) के इलाज के लिए इस्तेमाल की जाती है। यह एक प्रीमिक्स इंसुलिन इंजेक्शन है जिसमें 50% इंटरमीडिएट-एक्टिंग इंसुलिन और 50% रैपिड-एक्टिंग इंसुलिन होता है। यह रक्त शर्करा के स्तर को नियंत्रित करने में मदद करती है। इसे त्वचा के नीचे इंजेक्शन द्वारा लगाया जाता है, आमतौर पर भोजन से 30 मिनट पहले दिन में दो बार। इसका उपयोग टाइप 1 और टाइप 2 डायबिटीज वाले मरीजों में किया जाता है।
साइड इफेक्ट्स: इस दवा के सबसे आम दुष्प्रभावों में हाइपोग्लाइसीमिया (कम रक्त शर्करा) शामिल है, जिससे कंपकंपी, पसीना, भ्रम और भूख लग सकती है। इंजेक्शन लगाने की जगह पर लालिमा, सूजन या खुजली हो सकती है। कभी-कभी वजन बढ़ सकता है। गंभीर दुष्प्रभावों में गंभीर हाइपोग्लाइसीमिया, एलर्जी प्रतिक्रिया और पोटेशियम की कमी शामिल है। यदि आपको कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: अपने रक्त शर्करा की नियमित जांच करें। इंसुलिन पेन या सुई किसी के साथ साझा न करें। इंजेक्शन की जगह बदल-बदल कर लगाएं। इस दवा को फ्रिज में 2°C से 8°C के बीच रखें, जमने न दें। उपयोग में लाए जा रहे पेन को कमरे के तापमान पर 28 दिनों तक रखा जा सकता है। धूप से बचाएं। बीमारी, तनाव या आहार में बदलाव के दौरान रक्त शर्करा की निगरानी बढ़ाएं। हाइपोग्लाइसीमिया के लिए हमेशा ग्लूकोज साथ रखें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 insucare m 50 injection 40iu/ml Uses & Benefits
[{"condition":"Type 1 Diabetes Mellitus","description":"Used as part of a regimen to provide both mealtime and basal insulin coverage in patients with type 1 diabetes who require insulin for survival.","evidence":"Well-established"},{"condition":"Type 2 Diabetes Mellitus","description":"Used in patients with type 2 diabetes who have inadequate glycemic control on oral agents or other insulins, providing a premixed option for mealtime and basal coverage.","evidence":"Well-established"},{"condition":"Gestational Diabetes","description":"May be prescribed during pregnancy when oral agents are insufficient and insulin therapy is required to control blood glucose.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Diabetes Mellitus
Also treats: Type 1 Diabetes, Type 2 Diabetes, Gestational Diabetes
📋 Drug Information
| Generic Name(s) | Insulin Isophane/NPH (50%) + Human Insulin/Soluble Insulin (50%) |
| Brand Name | insucare m 50 injection 40iu/ml |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Parenteral (subcutaneous injection) |
| Storage | Store unused pens in the refrigerator between 2°C and 8°C. Do not freeze. In-use pens can be stored at room temperature (below 30°C) for up to 28 days. Protect from direct sunlight and heat. |
| Shelf Life | 24 months from the date of manufacture when stored under recommended conditions. |
| WHO Guideline | Insulin is recommended by the World Health Organization for the treatment of diabetes when oral agents are insufficient or contraindicated. Premixed insulins are included in the WHO Model List of Essential Medicines. |
| ICMR Guideline | The Indian Council of Medical Research recommends insulin therapy for patients with type 1 diabetes and for type 2 diabetes patients who do not achieve glycemic targets with oral agents. Premixed insulins are an option for those requiring both basal and prandial coverage. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to insulin receptors on the surface of cells, primarily in the liver, muscle, and adipose tissue. The soluble insulin component acts rapidly to facilitate glucose uptake into cells and inhibit hepatic glucose production, while the isophane component provides a slower, more prolonged release of insulin to maintain basal insulin levels. This dual action helps lower blood glucose levels by promoting cellular glucose uptake, inhibiting glucose production in the liver, and slowing the absorption of glucose from the gastrointestinal tract.
Mechanism Steps
💡 How to Take insucare m 50 injection 40iu/ml
Strength: Injection, 40 IU/mL (premixed 50% isophane and 50% soluble insulin)
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and must be determined by a qualified clinician based on your blood glucose levels, diet, and activity. It is typically injected subcutaneously 30 minutes before a meal, usually twice daily. The starting dose may be calculated based on body weight and adjusted according to response. Never change your dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of insulin and may require lower doses. Renal function should be monitored, and dose adjustments made accordingly. Close monitoring of blood glucose is recommended. |
| Renal Impairment | In patients with renal impairment, insulin requirements may be reduced due to decreased clearance. Dose adjustments should be made based on blood glucose monitoring and clinical response. |
| Hepatic Impairment | In patients with hepatic impairment, insulin metabolism may be altered, and dose adjustments may be necessary. Monitor blood glucose closely. |
| Maximum Daily Dose | The maximum daily dose is individualized and determined by the clinician based on the patient's needs. There is no fixed maximum; it depends on blood glucose control. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of insucare m 50 injection 40iu/ml
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Beta-blockers | Major | |
| Corticosteroids | Major | |
| Oral antidiabetic agents | Major | |
| Thiazide diuretics | Moderate | |
| ACE inhibitors | Moderate | |
| Alcohol | Moderate | |
| Thyroid hormones | Minor | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Oral antidiabetic agents
- Beta-blockers
- Corticosteroids
⚡ Moderate Interactions
- Thiazide diuretics
- ACE inhibitors
- Alcohol
🍷 Alcohol Interaction
Alcohol can cause unpredictable changes in blood glucose levels and may increase the risk of hypoglycemia, especially if consumed on an empty stomach. It is advisable to limit alcohol intake and monitor blood glucose closely if you choose to drink.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypoglycemia","Hypersensitivity to insulin or any excipient","Diabetic ketoacidosis (requires rapid-acting insulin)"]
⚠️ Warnings & Precautions
["Never share insulin pens or needles.","Do not use if the solution is cloudy or discolored (for clear insulins); however, this premixed insulin is normally cloudy.","Rotate injection sites to prevent lipodystrophy.","Monitor blood glucose regularly and carry glucose for hypoglycemia.","Adjust dose during illness, stress, or changes in diet or exercise.","Use with caution in patients with renal or hepatic impairment.","Avoid driving or operating machinery if hypoglycemic."]
🤱 Lactation Safety
Insulin is safe to use during breastfeeding. It is a large protein and is not excreted in breast milk in significant amounts. However, monitor blood glucose and consult a doctor for any concerns.
💊 Overdose Management
Overdose of this medicine can cause severe hypoglycemia. If conscious, administer fast-acting glucose orally. If unconscious, call emergency services immediately; glucagon may be administered if available. Intravenous glucose may be required in a hospital setting. Monitor blood glucose and potassium levels closely.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. Monitor your blood glucose more frequently and consult your doctor if unsure.
Additional Safety Advice
Always check your blood sugar levels regularly as advised by your doctor. Never share your insulin pen or needles with anyone else, as this can transmit infections. Rotate injection sites within the same area to prevent lipodystrophy. Do not use this medicine if it appears cloudy or has particles; however, this premixed insulin is naturally cloudy, so gently roll the pen between your hands to mix it before use. Do not shake it vigorously. Store unused pens in the refrigerator and in-use pens at room temperature, away from direct sunlight. Do not freeze this medicine. If you are sick, under stress, or changing your diet or exercise routine, your insulin requirements may change, so monitor your blood sugar more frequently and consult your doctor. Always carry a source of fast-acting sugar, such as glucose tablets or candy, to treat hypoglycemia. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not drive or operate heavy machinery if you experience symptoms of low blood sugar.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to insulin and have reduced renal function, increasing the risk of hypoglycemia. Lower doses and close monitoring are recommended.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor to optimize blood sugar control before conception. Insulin is safe during pregnancy, but doses may need adjustment.
🏥 Post-Surgery Considerations
After surgery, blood sugar levels can be unstable. Close monitoring and dose adjustments are necessary. Inform your surgical team about your insulin regimen.
🦷 Dental Procedures
Inform your dentist about your diabetes and insulin use. Dental procedures can affect blood sugar; monitor levels and adjust insulin as needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar and increase the risk of hypoglycemia. Monitor your blood sugar before, during, and after exercise. You may need to adjust your insulin dose or consume extra carbohydrates. Consult your doctor for personalized advice.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may affect your ability to drive or operate machinery if you experience hypoglycemia. Always check your blood sugar before driving and keep glucose within reach. Inform your employer about your condition and treatment in case of emergencies.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping insulin suddenly can lead to severe hyperglycemia and diabetic ketoacidosis. Your doctor will advise if and when to adjust or stop treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is essential for managing diabetes and preventing complications such as neuropathy, nephropathy, and retinopathy. However, it requires regular monitoring of blood glucose, HbA1c, and kidney function. Prolonged use can lead to weight gain and injection site changes. Regular follow-up with your healthcare provider is necessary to adjust the dose and manage any side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Continuous subcutaneous insulin infusion can be an alternative for some patients.
Evidence: Well-establishedBasal-bolus regimen may provide more flexibility.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, illness can affect blood sugar control, so monitor closely if you receive any vaccine.
📦 Storage Guide
✅ DO
Store unused pens in the refrigerator (2°C to 8°C)
❌ DON'T
Do not freeze
✅ DO
Store in-use pens at room temperature (below 30°C) for up to 28 days
❌ DON'T
Do not expose to direct sunlight or heat
✅ DO
Keep in original packaging
❌ DON'T
Do not transfer to unmarked containers
✈️ Traveling with This Medicine
When traveling, carry your insulin in its original packaging with a prescription copy. Keep it in a cool bag or refrigerator if possible; do not freeze. For air travel, keep insulin in your carry-on luggage, as checked baggage may freeze. Be prepared for time zone changes by adjusting injection times in consultation with your doctor. Carry a medical alert card and enough supplies for the trip. Check customs regulations for carrying needles and insulin.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 minutes of injection, peaks in 2 to 12 hours, and lasts up to 24 hours.
A: Insulin is considered safe during pregnancy when clinically indicated. Consult your doctor for proper management.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Insulin is addictive.
Fact: Insulin is a hormone that your body needs. It is not addictive; it is essential for survival in type 1 diabetes and often necessary in type 2 diabetes. - Myth: Taking insulin means your diabetes is very severe.
Fact: Insulin is simply a treatment option. Many people with type 2 diabetes need insulin to achieve good control, and it does not mean they have failed other treatments. - Myth: Insulin causes blindness and kidney failure.
Fact: Poorly controlled diabetes causes these complications. Insulin helps control blood sugar and reduces the risk of complications.
🔄 Alternative Options
Brand Alternatives
- Human Mixtard 50 Injection 40IU/ml