inmecin 50mg Capsule (Indomethacin 50mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or black tarry stools
- Vomiting blood or material that looks like coffee grounds
- Severe abdominal pain that does not go away
- Chest pain, shortness of breath, or difficulty breathing
- Sudden swelling of face, lips, tongue, or throat
- Yellowing of skin or eyes, dark urine, or severe tiredness
- Decreased urine output or sudden swelling in legs
- Severe headache with visual changes or confusion
- Unusual bruising or bleeding from gums or nose
- Rash with blisters or peeling skin
If experiencing severe symptoms, call emergency services immediately.
What is inmeth suppositories used for?
This medicine is a strong prescription NSAID containing indomethacin 50 mg. It is used for severe inflammatory conditions like rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout, and acute musculoskeletal pain. It works by blocking COX enzymes and reducing prostaglandins. It must be taken with food, avoided with alcohol, and used only under a doctor's supervision because of risks of stomach bleeding, kidney problems, and heart problems.
- Generic Name: Indomethacin (50mg)
- Manufacturer: Hetero Healthcare Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 inmeth suppositories के बारे में (Hindi Summary)
उपयोग: यह दवा इंडोमेथासिन 50 मिलीग्राम कैप्सूल एक मजबूत प्रिस्क्रिप्शन दर्द निवारक और सूजन कम करने वाली दवा है। इसका उपयोग रूमेटॉइड अर्थराइटिस, ऑस्टियोआर्थराइटिस, एंकिलोज़िंग स्पॉन्डिलाइटिस, गाउट के तीव्र दौरे और चोट के बाद होने वाले तेज दर्द और सूजन के इलाज के लिए किया जाता है। यह शरीर में प्रोस्टाग्लैंडिन नामक रसायन को कम करके दर्द और सूजन को कम करती है। यह दवा केवल डॉक्टर की सलाह से ही लेनी चाहिए। इसे खाने के साथ या दूध के साथ लें ताकि पेट में जलन न हो। शराब के साथ इसका सेवन बिल्कुल न करें। पेट में अल्सर, गंभीर किडनी या लिवर की बीमारी, दिल की विफलता या एस्पिरिन से एलर्जी वाले लोगों को यह दवा नहीं लेनी चाहिए। गर्भावस्था में विशेष रूप से अंतिम तीन महीनों में इससे बचना चाहिए।
साइड इफेक्ट्स: इस दवा के सबसे आम दुष्प्रभाव पेट और आंतों से जुड़े होते हैं। कई लोगों को मतली, उल्टी, सीने में जलन, अपच, पेट दर्द, दस्त या कब्ज हो सकती है। कुछ लोगों को सिरदर्द, चक्कर आना, नींद आना या कान में घंटी बजने जैसी आवाज महसूस हो सकती है। गंभीर दुष्प्रभाव कम होते हैं लेकिन तुरंत ध्यान देने योग्य होते हैं। इस दवा से पेट या आंत में खून आना, अल्सर या छेद हो सकता है, खासकर बुजुर्गों में या स्टेरॉयड या खून पतला करने वाली दवाओं के साथ। यह रक्तचाप बढ़ा सकती है, शरीर में पानी जमा कर सकती है और दिल की विफलता को बिगाड़ सकती है। किडनी की समस्या, पेशाब कम आना और पैरों में सूजन हो सकती है। दुर्लभ मामलों में त्वचा पर गंभीर प्रतिक्रिया, लिवर की क्षति, अस्थमा का दौरा और खून की बीमारियाँ हो सकती हैं।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। कैप्सूल को पूरा निगलें और एक गिलास पानी के साथ लें। इसे खाने या दूध के साथ लें ताकि पेट में जलन न हो। कैप्सूल को चबाएं या तोड़ें नहीं। बताई गई मात्रा से ज्यादा न लें और डॉक्टर की सलाह से ज्यादा समय तक न लें। इस दवा के साथ शराब बिल्कुल न पिएं क्योंकि इससे पेट में खून आने का खतरा बढ़ जाता है। दूसरी दर्द निवारक दवाएं, जैसे आइबुप्रोफेन, नैप्रोक्सन या एस्पिरिन, डॉक्टर से पूछे बिना न लें। अगर आपको दिल की बीमारी, उच्च रक्तचाप, किडनी या लिवर की समस्या, अस्थमा या पेट में अल्सर की history है तो डॉक्टर को बताएं। गर्भावस्था, गर्भधारण की योजना या स्तनपान के दौरान डॉक्टर से सलाह लें। अगर चक्कर या नींद आए तो गाड़ी न चलाएं और मशीन न चलाएं। दवा को ठंडी, सूखी जगह पर धूप से दूर और बच्चों की पहुंच से दूर रखें।
💊 inmeth suppositories Uses & Benefits
[{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness in rheumatoid arthritis, helping improve daily function.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"Relieves pain and improves mobility in osteoarthritis of the knee, hip, and hand.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps control pain and inflammation of the spine and sacroiliac joints in ankylosing spondylitis.","evidence":"Well-established"},{"condition":"Acute gouty arthritis","description":"Used to reduce severe pain and inflammation during acute gout attacks.","evidence":"Well-established"},{"condition":"Acute musculoskeletal pain","description":"Prescribed for short-term relief of pain and swelling after injuries, sprains, and strains.","evidence":"Well-established"},{"condition":"Patent ductus arteriosus in premature infants","description":"Used in hospital settings to close a patent ductus arteriosus in premature babies.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine and other headaches","description":"Sometimes used off-label for acute migraine attacks or certain headache disorders.","evidence":"Limited"},{"condition":"Pericarditis","description":"Occasionally used off-label to reduce inflammation in pericarditis.","evidence":"Limited"},{"condition":"Bursitis and tendinitis","description":"May be used off-label for short-term relief of inflammatory bursitis or tendinitis.","evidence":"Limited"}]
Primary treatment for: Inflammatory arthritis and acute musculoskeletal pain
Also treats: Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis, Acute gouty arthritis, Acute musculoskeletal pain, Patent ductus arteriosus in premature infants
📋 Drug Information
| Generic Name(s) | Indomethacin (50mg) |
| Brand Name | inmeth suppositories |
| Manufacturer | Hetero Healthcare Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a cool, dry place. Protect from direct sunlight and moisture. Keep the capsules in their original container, tightly closed. Do not refrigerate unless specifically instructed. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by reversibly inhibiting the cyclooxygenase enzymes, mainly COX-1 and COX-2. These enzymes convert arachidonic acid into prostaglandins and thromboxane. By blocking this step, the medicine reduces prostaglandins that sensitize pain nerves, cause blood vessel dilation, and promote swelling and fever. The anti-inflammatory effect is stronger than that of many other NSAIDs, which is why it is used for severe inflammatory conditions. It also affects platelet function by reducing thromboxane A2, which can increase bleeding risk. Because it blocks both COX-1 and COX-2, it can irritate the stomach lining and affect kidney blood flow.
Mechanism Steps
💡 How to Take inmeth suppositories
Strength: Immediate-release oral capsule containing indomethacin 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 25 mg to 50 mg taken two to three times a day with food, depending on the condition being treated. For acute gout, a higher starting dose may be used for a short time. For arthritis, the dose is often adjusted to the lowest effective amount. The maximum daily dose is usually 200 mg, but your doctor may prescribe a different dose based on your condition, age, weight, kidney and liver function, and other medicines you take. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information for general use. This medicine is used in premature infants for patent ductus arteriosus only in hospital settings under specialist care. For children and adolescents, consult a pediatrician for appropriate dosing and alternatives. |
| Elderly Dosage | Elderly patients above 65 years are more sensitive to the side effects of this medicine, especially stomach bleeding, kidney problems, and heart problems. The lowest effective dose should be used for the shortest possible time. Doctors may prescribe a lower dose and monitor kidney function, blood pressure, and blood counts more closely. Consult your doctor for the right dose. |
| Renal Impairment | This medicine should be used with caution in people with kidney problems. In mild to moderate kidney impairment, the dose may need to be reduced. In severe kidney disease, this medicine is usually avoided. Kidney function should be monitored regularly. Consult your doctor for dose adjustment. |
| Hepatic Impairment | This medicine should be used with caution in people with liver problems. In mild to moderate liver impairment, the dose may need to be reduced. In severe liver disease, this medicine is usually avoided. Liver function should be monitored regularly. Consult your doctor for dose adjustment. |
| Maximum Daily Dose | The maximum recommended daily dose is 200 mg, but the exact limit depends on the condition and your doctor's advice. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of inmeth suppositories
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Ibuprofen | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Corticosteroids | Major | |
| SSRIs | Moderate | |
| Digoxin | Moderate |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Aspirin and other NSAIDs
- Corticosteroids
- Methotrexate
- Lithium
- ACE inhibitors and angiotensin receptor blockers
- Diuretics
⚡ Moderate Interactions
- Beta blockers
- Cyclosporine
- Digoxin
- SSRIs
- Tacrolimus
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both alcohol and this medicine irritate the stomach lining and increase the risk of stomach ulcers and serious bleeding. Alcohol can also add to dizziness and drowsiness. If you drink alcohol regularly, tell your doctor before starting this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active stomach or intestinal ulcer or bleeding","History of asthma, hives, or allergic reaction to aspirin or other NSAIDs","Severe kidney disease","Severe liver disease","Uncontrolled heart failure","Third trimester of pregnancy","Breastfeeding without medical advice","Children below 14 years for general pain and inflammation, unless specifically prescribed","Recent coronary artery bypass graft surgery"]
⚠️ Warnings & Precautions
["Take this medicine with food or milk to reduce stomach upset.","Avoid alcohol completely while taking this medicine.","Do not take other NSAIDs or painkillers without asking your doctor.","Tell your doctor if you have heart disease, high blood pressure, kidney or liver problems, or asthma.","This medicine may cause dizziness or drowsiness. Avoid driving or operating machinery until you know how it affects you.","Long-term use increases the risk of stomach bleeding, kidney problems, and heart problems.","Do not stop or change the dose without consulting your doctor.","Keep all follow-up appointments and blood tests as advised.","Store the capsules in a cool, dry place away from direct sunlight and out of reach of children."]
🤱 Lactation Safety
This medicine passes into breast milk in small amounts. It is generally not recommended during breastfeeding because of the risk of serious side effects in the baby, including bleeding and kidney problems. If it must be used, the lowest effective dose should be taken for the shortest time, and the baby should be monitored. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of this medicine can cause severe nausea, vomiting, stomach pain, bleeding, headache, dizziness, drowsiness, ringing in the ears, and in severe cases, seizures, kidney failure, and coma. If you suspect an overdose, contact your doctor or go to the nearest emergency department immediately. Do not try to vomit unless told to do so by a medical professional. Treatment is supportive and may include activated charcoal, stomach lavage, and management of symptoms. Bring the medicine container with you to the hospital.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure what to do, contact your doctor or pharmacist.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Swallow the capsule whole with a full glass of water and take it with food or milk to reduce stomach upset. Do not crush, chew, or open the capsule. Do not take more than the prescribed dose or use it for longer than advised. Avoid alcohol completely while taking this medicine because it increases the risk of stomach bleeding. Do not take other painkillers, especially other NSAIDs like ibuprofen, naproxen, or aspirin, without asking your doctor. Tell your doctor if you have heart disease, high blood pressure, kidney or liver problems, asthma, or a history of stomach ulcers. If you are pregnant, planning pregnancy, or breastfeeding, inform your doctor before using this medicine. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Keep all follow-up appointments and blood tests as advised. Store the capsules in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients above 65 years are at higher risk of serious side effects from this medicine, especially stomach bleeding, kidney problems, heart problems, and confusion. The lowest effective dose should be used for the shortest possible time. Doctors may monitor blood pressure, kidney function, liver function, and blood counts more closely. Elderly patients should also be careful about dizziness and falls. Consult your doctor for the right dose and monitoring plan.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before taking this medicine. This medicine should be avoided during pregnancy, especially in the third trimester, because it can cause premature closure of the ductus arteriosus in the baby and may affect labor. If you become pregnant while taking this medicine, contact your doctor immediately. Do not start or stop any medicine without medical advice.
🏥 Post-Surgery Considerations
This medicine may be used after some surgeries for pain and inflammation, but it is contraindicated for peri-operative pain in coronary artery bypass graft surgery. It can increase bleeding risk and affect kidney function after surgery. Always inform your surgeon and anesthesiologist that you are taking this medicine. Do not take it after surgery unless specifically prescribed by your doctor.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. This medicine can increase bleeding risk, so your dentist may need to take extra precautions. It may also interact with painkillers or antibiotics used after dental work. Do not stop the medicine on your own; ask your doctor or dentist for advice.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel better and be tempted to do more activity, but you should still avoid high-impact or strenuous exercises that can stress your joints. Low-impact activities like swimming, cycling, and gentle walking are usually safer. If you feel dizzy or drowsy, avoid exercise until you know how the medicine affects you. Always warm up before exercise and stop if you feel pain. Consult your doctor or physiotherapist before starting any new exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people, which can affect your ability to drive or operate heavy machinery. Avoid driving or using machinery until you know how this medicine affects you. If your work involves physical strain, discuss with your doctor about modifications. The medicine can reduce pain and improve function, which may help you work more comfortably, but you should still follow safety precautions and avoid overexertion.
🛑 When to Stop This Medicine
Do not stop this medicine suddenly without consulting your doctor, especially if you have been taking it for a long time. Your doctor will decide when and how to stop based on your condition and response. If you experience serious side effects such as stomach bleeding, severe allergic reaction, kidney problems, or heart symptoms, stop the medicine and seek immediate medical help. Always ask your doctor before stopping or changing the dose.
📅 Long-Term Use Effects
Long-term use of this medicine increases the risk of serious stomach problems, including ulcers and bleeding, kidney problems, high blood pressure, fluid retention, and heart problems such as heart attack and stroke. It can also cause liver injury and blood disorders in rare cases. Regular monitoring of blood pressure, kidney function, liver function, and blood counts is needed during long-term use. The lowest effective dose should be used for the shortest possible time. Your doctor will review the need for continuing this medicine regularly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedMay provide local pain relief with fewer stomach side effects for some conditions.
Evidence: Well-establishedCan help reduce pain and stiffness in joints and muscles.
Evidence: Well-establishedCan reduce joint stress and improve overall function in arthritis.
Evidence: Well-establishedMay help some people with chronic pain, but evidence is mixed.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, if you are due for any vaccination, inform your doctor that you are taking this medicine. Live vaccines should generally be avoided if you are on medicines that suppress the immune system, but this medicine is not a major immunosuppressant. Follow your doctor's advice regarding vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container, tightly closed
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children and pets
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Keep a copy of your prescription and a doctor's note with you, especially for international travel. Store the capsules in a cool, dry place away from direct sunlight and moisture. If you are crossing time zones, continue taking your doses at the same intervals as prescribed, but adjust gradually if your doctor advises. Do not leave the medicine in a hot car or checked luggage. Check the customs rules of your destination country for prescription medicines. Carry enough supply for your entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief usually begins within 30 minutes to 1 hour after taking the capsule. The full anti-inflammatory effect may take a few days to weeks, depending on your condition.
A: No. This medicine should be taken with food or milk to reduce stomach upset and irritation.
A: No. Alcohol should be completely avoided because it greatly increases the risk of stomach bleeding and ulcers.
A: This medicine should be avoided during pregnancy, especially in the third trimester, unless your doctor decides the benefit clearly outweighs the risk. Consult your doctor before use.
A: Do not take other NSAIDs or painkillers without asking your doctor. Combining them increases the risk of stomach ulcers, bleeding, and kidney problems.
A: If you remember within half the dosing interval, take the missed dose. If it is almost time for the next dose, skip it and continue your regular schedule. Do not double dose.
A: Yes, this medicine can raise blood pressure and cause fluid retention. Your doctor may monitor your blood pressure regularly, especially if you have high blood pressure.
A: Yes, especially in elderly patients, people with existing kidney disease, heart failure, or dehydration, and those taking diuretics or blood pressure medicines. Kidney function should be monitored.
🤔 Common Patient Concerns
🔄 Substitutes for inmeth suppositories
View AllAlternative brands with exact same active ingredient:
-
artisid 50mg capsuleSun Pharmaceutical Industries Ltd ₹31.08 92.2% CHEAPER
-
inmecin 50mg capsuleSterkem Pharma Pvt Ltd ₹72.19 81.9% CHEAPER
-
inmecin 50mg tabletSterkem Pharma Pvt Ltd ₹80.00 79.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a simple painkiller for everyday aches.
Fact: This medicine is a strong prescription NSAID meant for specific inflammatory conditions, not for minor aches or routine fever. - Myth: It is safe to take this medicine for months without monitoring.
Fact: Long-term use requires regular monitoring of blood pressure, kidney function, liver function, and blood counts because of serious risks. - Myth: Taking this medicine with alcohol is fine.
Fact: Alcohol greatly increases the risk of stomach bleeding and ulcers and should be completely avoided. - Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food or milk to reduce stomach upset and irritation. - Myth: If one capsule does not work, taking two will work faster.
Fact: Taking more than the prescribed dose increases the risk of serious side effects and does not improve safety. Always follow your doctor's dose.
🔄 Alternative Options
Generic Alternatives
- Indomethacin 50 mg capsule
Brand Alternatives
- inmecin 50mg capsule