Infen MR 25mg/4mg Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is infen mr 25mg/4mg tablet used for?
This medicine is a combination of Ketoprofen (an NSAID) and Thiocolchicoside (a muscle relaxant) used for short-term relief of acute musculoskeletal pain associated with muscle spasm. It reduces pain, inflammation, and muscle spasm. It should be taken with food and only as prescribed by a doctor.
- Generic Name: Ketoprofen (25mg) + Thiocolchicoside (4mg)
- Manufacturer: Emcure Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 infen mr 25mg/4mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा कीटोप्रोफेन और थायोकोलचिकोसाइड का संयोजन है। यह मांसपेशियों में ऐंठन और दर्द के इलाज के लिए इस्तेमाल की जाती है। यह दर्द, सूजन और मांसपेशियों की ऐंठन को कम करने में मदद करती है। यह आमतौर पर कमर दर्द, गर्दन दर्द, मोच और खिंचाव के लिए दी जाती है। यह दवा केवल डॉक्टर के परामर्श से ही लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, पेट दर्द, अपच, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, गुर्दे की समस्या, यकृत की क्षति और एलर्जी प्रतिक्रिया शामिल हो सकते हैं। यदि आपको काला मल, खून की उल्टी, तेज पेट दर्द, सांस लेने में कठिनाई, या चेहरे पर सूजन हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को भोजन के साथ लें ताकि पेट में जलन न हो। शराब और अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आपको नींद या चक्कर आते हैं तो वाहन न चलाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। 7 दिनों से अधिक इसका उपयोग न करें। बच्चों की पहुंच से दूर रखें।
💊 infen mr 25mg/4mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"Short-term relief of pain and spasm in conditions such as acute low back pain, neck pain, and myofascial pain syndrome.","evidence":"Well-established for short-term use"},{"condition":"Post-traumatic pain and inflammation" class="semantic-link" title="Medicines for swelling">swelling","description":"Used after sprains, strains, and soft tissue injuries to reduce pain, inflammation, and associated muscle spasm.","evidence":"Well-established for short-term use"},{"condition":"Post-operative pain with spasm","description":"May be used for short-term management of pain and muscle spasm after certain surgical procedures.","evidence":"Limited to short-term use under medical supervision"}]
Off-label uses: [{"condition":"Tension-type headache with muscle spasm","description":"Sometimes prescribed off-label when headache is associated with significant neck muscle spasm.","evidence":"Limited"},{"condition":"Dysmenorrhea with pelvic muscle spasm","description":"Rarely used off-label for painful menstrual cramps with associated muscle spasm.","evidence":"Limited"}]
Primary treatment for: Acute musculoskeletal pain with muscle spasm
Also treats: Low back pain, Neck pain, Myofascial pain syndrome, Sprains and strains, Post-operative pain
📋 Drug Information
| Generic Name(s) | Ketoprofen (25mg) + Thiocolchicoside (4mg) |
| Brand Name | infen mr 25mg/4mg tablet |
| Manufacturer | Emcure Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Ketoprofen is a non-selective NSAID that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing prostaglandin synthesis and thereby decreasing pain, inflammation, and fever. Thiocolchicoside is a centrally acting muscle relaxant that acts as a GABA-A receptor agonist, enhancing inhibitory neurotransmission in the spinal cord and brainstem, which reduces muscle spasm and associated pain.
Mechanism Steps
💡 How to Take infen mr 25mg/4mg tablet
Strength: Each tablet contains Ketoprofen 25 mg and Thiocolchicoside 4 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally one to two times daily, preferably with food, or as directed by your doctor. The dose and duration depend on the condition being treated, your age, weight, kidney and liver function, and response to treatment. Do not exceed the prescribed dose. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding, kidney problems, and cardiovascular events. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose reduction may be necessary. Consult your doctor for individualized dosing. Avoid in severe renal impairment. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose reduction may be necessary. Consult your doctor for individualized dosing. Avoid in severe hepatic impairment. |
| Maximum Daily Dose | The maximum recommended daily dose is 2 tablets (50 mg Ketoprofen + 8 mg Thiocolchicoside) per day, unless otherwise directed by your doctor. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of infen mr 25mg/4mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors/ARBs | Moderate | |
| Diuretics | Moderate | |
| SSRIs | Moderate | |
| Beta-blockers | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Other NSAIDs (e.g., ibuprofen, naproxen, aspirin)
- Corticosteroids
- Methotrexate
- Lithium
⚡ Moderate Interactions
- ACE inhibitors and ARBs
- Diuretics
- SSRIs
- Beta-blockers
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Both Ketoprofen and alcohol can irritate the stomach lining and increase the risk of gastrointestinal bleeding. Alcohol may also increase the risk of liver toxicity and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to Ketoprofen, Thiocolchicoside, or any component of the formulation","Active peptic ulcer or history of recurrent peptic ulcers","Severe heart failure","Severe kidney disease","Severe liver disease","Third trimester of pregnancy","Children under 18 years of age (safety not established)","Patients with asthma, urticaria, or allergic reactions to aspirin or other NSAIDs"]
⚠️ Warnings & Precautions
["Take with food to reduce stomach upset.","Avoid alcohol and other NSAIDs.","Do not drive or operate machinery if you feel drowsy or dizzy.","Use with caution in elderly patients due to increased risk of side effects.","Monitor kidney and liver function during prolonged use.","Do not use for more than 7 days without medical advice.","Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart disease, or asthma.","Stop use and consult doctor if you experience signs of allergic reaction, bleeding, or severe abdominal pain."]
🤱 Lactation Safety
Not established from the available information. Ketoprofen may pass into breast milk. Thiocolchicoside excretion in breast milk is not known. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose may cause severe nausea, vomiting, abdominal pain, drowsiness, and gastrointestinal bleeding. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine with food or milk to reduce stomach irritation. Do not exceed the prescribed dose or duration. Avoid alcohol and other NSAIDs while taking this medicine. Do not drive or operate heavy machinery if you feel drowsy or dizzy. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart disease, high blood pressure, or asthma. Do not take this medicine for more than 7 days without medical advice. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney injury, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney and liver function regularly. Avoid in patients with severe kidney or liver disease.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for alternative treatments. If you become pregnant while taking this medicine, stop it and inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine may be used for short-term pain management after surgery, but only under medical supervision. It may increase bleeding risk, so inform your surgeon if you are taking it before any surgery. Do not take it without your doctor's advice after surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase bleeding risk. Your dentist may advise you to stop it temporarily before certain procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, especially if you have muscle spasm or pain. Gentle stretching and low-impact activities may be beneficial. Consult your doctor or physiotherapist before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food. Most people can continue their daily activities with caution.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as gastrointestinal bleeding, allergic reactions, kidney or liver problems, or if your symptoms do not improve within 7 days. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to increased risk of gastrointestinal bleeding, kidney injury, liver toxicity, and cardiovascular events. If long-term use is necessary, regular monitoring of kidney and liver function, blood counts, and blood pressure is advised. Consult your doctor for alternative treatments if pain persists.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and muscle spasm.
Evidence: Well-establishedHelps relieve muscle spasm and pain.
Evidence: Well-establishedMay help with pain relief in some patients.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There are no known interactions between this medicine and vaccines. Consult your doctor for specific advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight and moisture. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines. Keep enough supply for your trip and carry it in your hand luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Ketoprofen starts relieving pain within 30 to 60 minutes. The muscle relaxant effect may take a few hours to become noticeable. Full benefit may take 1-2 days.
A: Yes, take it with food or milk to reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is not recommended during pregnancy, especially in the third trimester. Consult your doctor if you are pregnant or planning pregnancy.
A: Do not take other NSAIDs or painkillers without consulting your doctor, as it may increase the risk of side effects.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken long-term for chronic pain.
Fact: This medicine is intended for short-term use only. Long-term use increases the risk of serious side effects and should be avoided unless specifically prescribed by a doctor. - Myth: This medicine is safe to take without a prescription.
Fact: This medicine is a prescription drug. It should only be taken under medical supervision. - Myth: Taking this medicine with alcohol is safe.
Fact: Alcohol increases the risk of gastrointestinal bleeding and liver toxicity. Avoid alcohol while taking this medicine.
🔄 Alternative Options
Generic Alternatives
- Ketoprofen 25 mg + Thiocolchicoside 4 mg tablet (generic)
Brand Alternatives
- Infen MR 25mg/4mg Tablet