Propofol 10mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe difficulty breathing or apnoea
- Profound or persistent hypotension
- Signs of propofol infusion syndrome: metabolic acidosis, muscle pain, dark urine, or cardiac arrhythmias
- Signs of anaphylaxis: rash, swelling of face or throat, difficulty breathing
- Seizures or involuntary muscle movements
- Chest pain or palpitations
- Severe pain or swelling at the injection site
If experiencing severe symptoms, call emergency services immediately.
What is indifol 100 injection used for?
This medicine is a rapid-acting intravenous anaesthetic used for induction and maintenance of general anaesthesia and for procedural sedation in monitored medical settings. It works by enhancing the inhibitory effects of GABA in the brain, causing sedation and hypnosis within seconds. It must only be administered by trained healthcare professionals.
- Generic Name: Propofol (10mg)
- Manufacturer: Varenyam Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 indifol 100 injection के बारे में (Hindi Summary)
उपयोग: यह दवा प्रोपोफोल का एक इंजेक्शन है जिसका उपयोग अस्पताल में संज्ञाहरण (एनेस्थीसिया) शुरू करने और बनाए रखने के लिए किया जाता है। इसका उपयोग एंडोस्कोपी, कोलोनोस्कोपी जैसी प्रक्रियाओं के दौरान बेहोशी और शांति के लिए भी किया जाता है। यह दवा बहुत तेजी से असर करती है और मरीज को कुछ ही सेकंड में बेहोश कर देती है। यह केवल प्रशिक्षित डॉक्टर या एनेस्थेसियोलॉजिस्ट द्वारा ही दी जानी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन की जगह पर दर्द, कम रक्तचाप, धीमी हृदय गति, और सांस लेने में कठिनाई शामिल हैं। कुछ मरीजों को मतली, उल्टी, सिरदर्द और चक्कर आ सकते हैं। गंभीर दुष्प्रभावों में गहरी सांस की कमी, गंभीर निम्न रक्तचाप, और दुर्लभ रूप से प्रोपोफोल इन्फ्यूजन सिंड्रोम हो सकता है। चूंकि यह दवा निगरानी में दी जाती है, इसलिए अधिकांश दुष्प्रभावों का तुरंत पता लगाया और इलाज किया जा सकता है।
सुरक्षा सलाह: यह दवा केवल अस्पताल में प्रशिक्षित डॉक्टर द्वारा ही दी जानी चाहिए। इस दवा को देने के दौरान हृदय गति, रक्तचाप, ऑक्सीजन स्तर और सांस की निगरानी लगातार की जानी चाहिए। इस दवा को लेने के बाद कम से कम 24 घंटे तक वाहन न चलाएं और मशीनरी संचालित न करें। शराब का सेवन कम से कम 24 घंटे तक न करें। अपने डॉक्टर को सभी दवाओं के बारे में बताएं जो आप ले रहे हैं। यदि आपको प्रोपोफोल, अंडा या सोया से एलर्जी है तो यह दवा न लें।
💊 indifol 100 injection Uses & Benefits
[{"condition":"Induction of general anaesthesia","description":"This medicine is used to rapidly induce unconsciousness before surgery or other procedures requiring general anaesthesia.","evidence":"Well-established"},{"condition":"Maintenance of general anaesthesia","description":"Continuous infusion or repeated boluses maintain anaesthetic depth during surgical procedures.","evidence":"Well-established"},{"condition":"Procedural sedation","description":"Used for sedation during diagnostic or therapeutic procedures such as endoscopy, colonoscopy, and cardioversion in monitored settings.","evidence":"Well-established"},{"condition":"Intensive care unit sedation","description":"Administered as a continuous infusion for sedation of mechanically ventilated patients in the ICU.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Refractory status epilepticus","description":"Sometimes used as a third-line agent for refractory seizures in intensive care settings.","evidence":"Limited"},{"condition":"Treatment-resistant depression","description":"Investigated as an adjunct in anaesthetic doses for rapid mood improvement, but not standard practice.","evidence":"Limited"}]
Primary treatment for: Anaesthesia and procedural sedation
Also treats: Intensive care unit sedation, Endoscopy and colonoscopy sedation, Cardioversion sedation
📋 Drug Information
| Generic Name(s) | Propofol (10mg) |
| Brand Name | indifol 100 injection |
| Manufacturer | Varenyam Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | General anaesthetic agents |
| Route of Administration | Parenteral (intravenous) |
| Storage | Store at controlled room temperature between 20°C and 25°C (68°F to 77°F). Do not freeze. Protect from light. Keep the vial in the outer carton until use. Do not use if the emulsion appears separated or discoloured. Once opened, use immediately and discard any unused portion after 6 hours. |
| Shelf Life | 24 months from the date of manufacture, unless otherwise specified on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Propofol enhances the inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA) at the GABA-A receptor complex in the central nervous system. By binding to a site distinct from the benzodiazepine site, it increases the frequency and duration of chloride channel opening, leading to hyperpolarisation of neurons and depression of the central nervous system. This results in hypnosis, amnesia, and sedation. At higher concentrations, it may also affect other ion channels, but the primary anaesthetic effect is through GABA-A potentiation.
Mechanism Steps
💡 How to Take indifol 100 injection
Strength: Injection: 10 mg per mL (1% w/v) in a 20 mL vial, containing 200 mg of propofol per vial.
Dosage Information
| Adult Dosage | For induction of anaesthesia, a typical adult dose is 1.5 to 2.5 mg per kg given intravenously, but the dose must be individualized by a qualified clinician based on indication, age, weight, and renal and hepatic function. For maintenance, a continuous infusion of 4 to 12 mg per kg per hour is commonly used. For procedural sedation, smaller incremental doses of 0.5 to 1 mg per kg may be given. Elderly or debilitated patients require lower doses. This information is for educational reference only and does not replace clinical judgement. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or pediatric anaesthesiologist for appropriate dosing. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the effects of this medicine and may require lower doses. A reduction of 20-50% in the induction dose is often recommended, and maintenance infusion rates should be titrated carefully. Close monitoring of blood pressure and respiratory function is essential. |
| Renal Impairment | No specific dose adjustment is generally required for renal impairment, but caution is advised. Monitor renal function during prolonged infusions. This medicine is not removed by dialysis to a significant extent. |
| Hepatic Impairment | Dose reduction may be necessary in patients with severe hepatic impairment because propofol is metabolised in the liver. Titrate carefully and monitor clinical response. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the clinical situation. For maintenance of anaesthesia, doses up to 12 mg per kg per hour are commonly used, but higher doses may be used for short periods under close supervision. Prolonged high-dose infusions should be avoided due to the risk of propofol infusion syndrome. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of indifol 100 injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Morphine | Major | |
| Midazolam | Major | |
| Fentanyl | Major | |
| Metoprolol | Moderate | |
| Valproate | Moderate | |
| Alcohol | Major | |
| Theophylline | Minor | |
| Ketamine | Minor | |
| Lidocaine | Minor | |
| Atropine | Minor |
🚨 Major Interactions
- Opioids (e.g., morphine, fentanyl)
- Benzodiazepines (e.g., midazolam, diazepam)
- Antihypertensives and beta-blockers
⚡ Moderate Interactions
- CNS depressants (e.g., alcohol, barbiturates)
- Valproate
🍷 Alcohol Interaction
Alcohol should be avoided for at least 24 hours after receiving this medicine because it can enhance the sedative and respiratory depressant effects, increasing the risk of profound sedation, respiratory failure, and delayed recovery. Patients should not consume alcohol while still experiencing any residual sedation.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to propofol or any component of the formulation","Allergy to egg or soy protein (due to lipid emulsion)","Severe cardiovascular disease or hypovolaemia (relative)","Increased intracranial pressure (relative, use with caution)","Disorders of lipid metabolism (relative)","Pregnancy for elective procedures (relative)"]
⚠️ Warnings & Precautions
["This medicine must only be administered by trained personnel in a monitored setting with resuscitation equipment available.","Continuous monitoring of respiratory and cardiovascular function is mandatory.","Use with caution in elderly, debilitated, or hypovolaemic patients due to increased risk of hypotension.","Prolonged infusion at high doses can cause propofol infusion syndrome; monitor for metabolic acidosis, rhabdomyolysis, and cardiac failure.","Avoid in patients with a history of epilepsy unless benefits outweigh risks, as it may lower seizure threshold.","Do not use if the emulsion appears separated or discoloured.","Strict aseptic technique is required; discard any unused portion after 6 hours.","Patients should not drive or operate machinery for at least 24 hours after administration."]
🤱 Lactation Safety
Propofol is excreted in breast milk in small amounts. The amount is likely too small to be harmful, but because the medicine is given in a controlled setting, breastfeeding can usually be resumed once the mother is fully alert and stable, typically within a few hours. Consult your doctor for specific guidance.
💊 Overdose Management
Overdose of this medicine can cause profound central nervous system depression, respiratory depression, apnoea, and cardiovascular collapse. Management is supportive and symptomatic. Maintain a patent airway, provide assisted ventilation with oxygen, and support blood pressure with fluids and vasopressors if needed. There is no specific antidote. Continuous monitoring of vital signs and appropriate supportive care in an intensive care setting are essential until the patient recovers.
⏰ Missed Dose
This medicine is administered by healthcare professionals in a controlled setting, so missed doses are not applicable. If a scheduled dose is missed during a continuous infusion, the clinical team will adjust the infusion rate as needed.
Additional Safety Advice
This medicine must only be administered by a qualified anaesthesiologist or trained clinician in a facility with full resuscitation equipment. Continuous monitoring of heart rate, blood pressure, oxygen saturation, and respiratory function is essential throughout the procedure and during recovery. Strict aseptic technique must be followed when drawing up the medicine, and the vial should be discarded if contamination is suspected. Patients should not drive, operate machinery, or make important decisions for at least 24 hours after receiving this medicine. Alcohol and other central nervous system depressants should be avoided for at least 24 hours. Inform your doctor about all medicines you take, especially sedatives, opioids, and blood pressure medicines. Do not use this medicine if you have a known allergy to propofol, egg, or soy.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine and may require lower doses. A reduction of 20-50% in the induction dose is often recommended. Close monitoring of blood pressure, heart rate, and respiratory function is essential. Recovery may be slower, and the risk of hypotension and bradycardia is higher.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, inform your doctor before receiving this medicine. It should be used during pregnancy only if clearly needed, and elective procedures should be postponed until after delivery. Discuss the risks and benefits with your healthcare provider.
🏥 Post-Surgery Considerations
After surgery involving this medicine, you will be monitored in a recovery area until you are fully awake and stable. You may experience drowsiness, nausea, or dizziness. Follow your surgeon's instructions regarding activity, diet, and medications. Do not drive or operate machinery for at least 24 hours.
🦷 Dental Procedures
This medicine may be used for sedation during complex dental procedures in a hospital setting. Inform your dentist and anaesthesiologist about all your medical conditions and medications. You will need someone to accompany you home and should not drive for 24 hours.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities requiring coordination for at least 24 hours after receiving this medicine, as residual sedation and dizziness may impair your ability to perform these safely.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine causes profound sedation and impairs coordination and judgement. You should not return to work, drive, or operate machinery for at least 24 hours after receiving it. Plan to take the day off and arrange for transportation. Most people feel back to normal within a day, but some may experience lingering drowsiness.
🛑 When to Stop This Medicine
This medicine is stopped by the healthcare professional once the procedure is complete or the desired level of sedation is achieved. Patients do not self-administer or stop this medicine. If you experience any unusual symptoms after the procedure, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term effects of this medicine are not well established for single or short-term use. Prolonged infusions, especially at high doses, can lead to propofol infusion syndrome, which may cause metabolic acidosis, rhabdomyolysis, and cardiac failure. Regular monitoring of electrolytes, creatine kinase, and acid-base status is recommended during prolonged infusions. There is no evidence of long-term cognitive impairment after standard clinical use, but recovery may be slower in elderly patients.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can be used as an alternative to general anaesthesia for certain procedures, avoiding systemic effects.
Evidence: Well-establishedEtomidate or ketamine may be used in patients where propofol is contraindicated.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, elective procedures requiring anaesthesia should be scheduled when the patient is not acutely ill. Follow your doctor's advice regarding vaccination timing.
📦 Storage Guide
✅ DO
Store at controlled room temperature between 20°C and 25°C.
❌ DON'T
Do not freeze.
✅ DO
Keep the vial in the outer carton to protect from light.
❌ DON'T
Do not use if the emulsion appears separated or discoloured.
✅ DO
Use immediately after opening and discard any unused portion after 6 hours.
❌ DON'T
Do not store opened vials for later use.
✈️ Traveling with This Medicine
This medicine is administered only in a hospital setting, so travel advice is not applicable. If you are travelling after a procedure involving this medicine, ensure you are fully recovered and accompanied by a responsible adult. Do not drive or travel alone for at least 24 hours. Carry a copy of your prescription and medical records if you need to seek medical care while travelling.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine works within 30-60 seconds after intravenous injection.
A: No, this medicine induces unconsciousness or deep sedation, so you will not be aware during the procedure.
A: No, you must not drive for at least 24 hours after receiving this medicine. Arrange for someone else to drive you home.
A: Pediatric dosing is not established from available information. Consult a pediatrician or pediatric anaesthesiologist.
A: No, avoid alcohol for at least 24 hours as it can enhance the sedative effects and increase the risk of respiratory depression.
🤔 Common Patient Concerns
🔄 Substitutes for indifol 100 injection
View AllAlternative brands with exact same active ingredient:
-
hypro 10mg injectionCelon Laboratories Ltd ₹121.15 37.4% COSTLIER
-
rapifol 10mg injectionSun Pharmaceutical Industries Ltd ₹130.00 47.4% COSTLIER
-
mct rof injectionNeon Laboratories Ltd ₹146.25 65.8% COSTLIER
-
troypofol 10mg injectionTroikaa Pharmaceuticals Ltd ₹146.69 66.3% COSTLIER
-
zyfol 10mg injectionThemis Medicare Ltd ₹146.72 66.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used at home for sleep.
Fact: This medicine is a powerful anaesthetic and must only be used in a hospital setting under close supervision. - Myth: This medicine is safe for everyone.
Fact: It is contraindicated in people with allergies to propofol, egg, or soy, and in certain other conditions. - Myth: You can drive immediately after receiving this medicine.
Fact: You must not drive or operate machinery for at least 24 hours after receiving this medicine.
🔄 Alternative Options
Generic Alternatives
- Propofol 10 mg/mL injection
Brand Alternatives
- Hypro 10mg injection