imprin 75mg tablet - Imipramine (75mg) medicine

Antipres 75mg Tablet (Imipramine): Complete Medicine Guide

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🏭 Osho Pharma Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 26, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for depression and bedwetting; moderate for other uses.
Reviewed by
SaathiMed Expert Panel | Sep 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Thoughts of harming yourself or others
  • Irregular heartbeat or palpitations
  • Severe chest pain or difficulty breathing
  • Fainting or severe dizziness
  • Yellowing of skin or eyes
  • Severe allergic reaction (rash, swelling, difficulty breathing)
  • Seizures

If experiencing severe symptoms, call emergency services immediately.

What is imprin 75mg tablet used for?

This medicine is a tricyclic antidepressant used to treat depression, bedwetting in children, and certain anxiety disorders. It works by increasing serotonin and norepinephrine in the brain. It is taken orally, usually 75 mg per day initially, and must be used under medical supervision.

  • Generic Name: Imipramine (75mg)
  • Manufacturer: Osho Pharma Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 imprin 75mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा इमिप्रामाइन नामक सक्रिय तत्व से बनी है, जो एक ट्राइसाइक्लिक एंटीडिप्रेसेंट है। इसका उपयोग अवसाद (डिप्रेशन), बच्चों में बिस्तर गीला करने (नॉक्टर्नल एन्यूरिसिस), और कुछ चिंता विकारों के इलाज के लिए किया जाता है। यह मस्तिष्क में सेरोटोनिन और नॉरएपिनेफ्रिन के स्तर को बढ़ाकर काम करती है, जिससे मूड, नींद और ऊर्जा में सुधार होता है। यह 75 मिलीग्राम की गोली के रूप में उपलब्ध है और मुंह से ली जाती है। इस दवा को डॉक्टर के निर्देशानुसार ही लें और अचानक बंद न करें।

साइड इफेक्ट्स: आम दुष्प्रभावों में मुंह सूखना, नींद आना, चक्कर आना, कब्ज, धुंधली दृष्टि और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, गंभीर एलर्जी प्रतिक्रिया, और युवाओं में आत्महत्या के विचार शामिल हो सकते हैं। यदि आपको बेहोशी, सीने में दर्द, या पेशाब करने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अचानक बंद न करें। शराब और अन्य नींद लाने वाली दवाओं से बचें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या मशीनरी चलाने से बचें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं, विशेष रूप से MAO इनहिबिटर, रक्त पतला करने वाली दवाएं, और अन्य एंटीडिप्रेसेंट। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 imprin 75mg tablet Uses & Benefits

[{"condition":"Major depressive disorder","description":"This medicine is used to relieve symptoms of depression such as sadness, loss of interest, and sleep disturbances.","evidence":"Well-established"},{"condition":"Nocturnal enuresis (bedwetting) in children","description":"This medicine can help reduce bedwetting episodes in children over 6 years old.","evidence":"Well-established"},{"condition":"Panic disorder","description":"This medicine may reduce the frequency and severity of panic attacks.","evidence":"Moderate"},{"condition":"Chronic pain syndromes","description":"This medicine is sometimes used to manage neuropathic pain and other chronic pain conditions.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"This medicine may be prescribed off-label to prevent migraines.","evidence":"Limited"},{"condition":"Bulimia nervosa","description":"This medicine has been studied for reducing binge-eating episodes.","evidence":"Limited"}]

Primary treatment for: Major depressive disorder

Also treats: Nocturnal enuresis, Panic disorder, Chronic pain

📋 Drug Information

Generic Name(s)Imipramine (75mg)
Brand Nameimprin 75mg tablet
ManufacturerOsho Pharma Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassTricyclic antidepressants
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at bedtime if it makes you drowsy during the day.
2
Do not stop this medicine suddenly; your doctor will taper the dose gradually.
3
Inform your doctor if you experience any changes in mood, especially worsening depression or suicidal thoughts.
4
Avoid alcohol and recreational drugs while taking this medicine.
5
Keep all follow-up appointments to monitor your response and side effects.
6
Use sugar-free gum or candies to relieve dry mouth.
7
Increase fiber and fluids in your diet to prevent constipation.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Persistent sadness or loss of interest
This medicine is commonly prescribed for depression.
Likely Use
✅
Bedwetting in children
This medicine is used for nocturnal enuresis.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is well absorbed from the gastrointestinal tract after oral administration.
DistributionThis medicine is widely distributed throughout the body and crosses the blood-brain barrier.
Protein BindingThis medicine is approximately 90% bound to plasma proteins.
MetabolismThis medicine is metabolized in the liver primarily by CYP2D6, CYP1A2, and CYP3A4 enzymes into active and inactive metabolites.
Half-LifeThe elimination half-life of this medicine ranges from 6 to 20 hours.
ExcretionThis medicine and its metabolites are primarily excreted in the urine.
BioavailabilityThe oral bioavailability of this medicine is approximately 30-50% due to first-pass metabolism.
Onset of ActionThe antidepressant effects of this medicine may take 2 to 4 weeks to become noticeable.
Peak Plasma TimePeak plasma concentrations of this medicine are reached within 1 to 2 hours after oral administration.
Duration of ActionThe effects of a single dose of this medicine last for about 24 hours.

How It Works

This medicine works by blocking the reuptake of serotonin and norepinephrine in the brain, which increases their availability in the synaptic cleft. It also has anticholinergic, antihistaminic, and alpha-adrenergic blocking effects. These actions contribute to its antidepressant and other therapeutic effects.

Mechanism Steps

1
Inhibition of serotonin reuptake: This medicine blocks the serotonin transporter, leading to increased serotonin in the synapse.
2
Inhibition of norepinephrine reuptake: This medicine blocks the norepinephrine transporter, increasing norepinephrine levels.
3
Antagonism of muscarinic receptors: This medicine blocks acetylcholine at muscarinic receptors, causing dry mouth, constipation, and blurred vision.
4
Antagonism of histamine H1 receptors: This medicine blocks histamine, leading to sedation and weight gain.
5
Antagonism of alpha1-adrenergic receptors: This medicine blocks alpha1 receptors, which can cause dizziness and orthostatic hypotension.

💡 How to Take imprin 75mg tablet

Strength: Imipramine 75 mg immediate-release tablet

1Take this medicine by mouth with or without food.
2Swallow the tablet whole with a glass of water.
3Take it at the same time each day to maintain consistent levels.
4If it causes drowsiness, take it at bedtime.
5Do not crush, chew, or break the tablet unless instructed by your doctor.

Dosage Information

Adult DosageThe usual starting dose for depression is 75 mg per day in divided doses, which may be increased gradually up to 150-200 mg per day. For bedwetting in children, doses are lower and based on age and weight. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients should start at a lower dose, typically 25-50 mg per day, and increase gradually. Close monitoring for side effects is recommended.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is 200 mg for adults, but this may vary based on indication and patient factors. Always follow your doctor's prescription.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of imprin 75mg tablet

✅ Common Side Effects

Dry mouth (Common (10-30%))
Sip water, chew sugar-free gum, or use saliva substitutes. Consult doctor if severe.
Drowsiness (Common (10-30%))
Avoid driving or operating machinery until you know how it affects you. Take at bedtime if advised.
Constipation (Common (10-30%))
Increase fiber and fluid intake. Consult doctor if persistent.
Blurred vision (Common (10-30%))
Usually temporary. Consult doctor if persistent.
Weight gain (Common (10-30%))
Monitor diet and exercise. Consult doctor if concerned.

🚨 Serious Side Effects

Cardiac arrhythmias (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations, fainting, or chest pain.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you have rash, swelling, or difficulty breathing.
Increased suicidal thoughts (Uncommon (0.1-1%))
Contact doctor immediately if you have thoughts of self-harm.
Seizures (Rare (<0.1%))
Seek immediate medical attention.

⚠️ Rare Side Effects

Blood dyscrasias
Report unusual bruising or bleeding to doctor.
Liver toxicity
Report yellowing of skin or eyes to doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAO inhibitors Major
SSRIs Major
Antiarrhythmics Major
CNS depressants Moderate
Anticholinergics Moderate
Sympathomimetics Moderate
Cimetidine Minor
Oral contraceptives Minor

🚨 Major Interactions

  • MAO inhibitors
  • SSRIs
  • Antiarrhythmics (e.g., quinidine)

⚡ Moderate Interactions

  • CNS depressants (e.g., alcohol, benzodiazepines)
  • Anticholinergics
  • Sympathomimetics

🍷 Alcohol Interaction

Alcohol can increase the sedative effects of this medicine and impair judgment. Avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to imipramine or other tricyclic antidepressants","Concurrent use with MAO inhibitors","Acute recovery phase after myocardial infarction","Uncontrolled glaucoma","Urinary retention","Severe liver disease"]

⚠️ Warnings & Precautions

["May increase risk of suicidal thoughts in children, adolescents, and young adults.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not stop abruptly; taper gradually under medical supervision.","Use with caution in elderly patients due to increased risk of falls and confusion.","May worsen symptoms of psychosis or bipolar disorder."]

🤱 Lactation Safety

This medicine passes into breast milk and may cause drowsiness in the infant. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose of this medicine can be life-threatening. Symptoms include irregular heartbeat, seizures, coma, and difficulty breathing. Seek emergency medical help immediately. Treatment is supportive and may include activated charcoal, sodium bicarbonate for cardiac toxicity, and intensive monitoring.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed. Do not stop suddenly without medical advice. Avoid alcohol and other central nervous system depressants. Use caution when driving or operating machinery until you know how this medicine affects you. Inform your doctor about all other medications you are taking, especially MAO inhibitors, blood thinners, and other antidepressants. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, confusion, and falls. Start at a lower dose and monitor closely.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor. This medicine may be continued if needed, but close monitoring is required. Do not stop suddenly without medical advice.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect blood pressure and heart rate.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine, as it can cause dry mouth and may interact with certain dental anesthetics.

💚 Lifestyle Tips for Better Results

🏃
Maintain a regular sleep schedule.
🥗
Engage in regular physical activity as tolerated.
😴
Eat a balanced diet rich in fruits and vegetables.
💧
Avoid alcohol and illicit drugs.
🧘
Practice stress-reduction techniques like meditation or deep breathing.
🌞
Stay connected with friends and family for emotional support.

🏋️ Exercise Considerations

This medicine may cause drowsiness or dizziness. Avoid strenuous exercise or activities requiring alertness until you know how it affects you.

🥗 Diet Recommendations

Include fiber-rich foods to prevent constipation.
Stay well hydrated to reduce dry mouth.
Limit caffeine as it may increase anxiety or insomnia.
Avoid grapefruit and grapefruit juice.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness, dizziness, or blurred vision, which can affect your ability to drive or operate machinery. It is advisable to avoid these activities until you know how the medicine affects you. Discuss with your employer if you need accommodations.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects or your condition worsens, contact your doctor immediately. Your doctor will decide if and how to taper the dose.

📅 Long-Term Use Effects

Long-term use of this medicine may require periodic monitoring of heart, liver, and kidney function. It may also cause weight gain and sexual dysfunction. Regular follow-up with your doctor is important to adjust the dose and manage side effects.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Cognitive behavioral therapy (CBT)

Can be used alone or with medicine for depression and anxiety.

Evidence: Well-established
Bladder training

For bedwetting, behavioral techniques can complement medicine.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. If traveling across time zones, adjust the timing of your doses gradually to match your new schedule. Store it in a cool, dry place away from direct sunlight. Check customs regulations for controlled substances before traveling internationally.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with major depression
She started this medicine at 75 mg daily. After 3 weeks, her mood improved significantly, and she was able to return to work. She experienced dry mouth and drowsiness initially, which decreased over time. She emphasizes the importance of taking it regularly and not stopping suddenly.
💡 Lesson: Consistent use and patience are key; side effects often improve with time.
👤 A 7-year-old boy with nocturnal enuresis
He was prescribed this medicine for bedwetting. After 2 weeks, the frequency of bedwetting reduced from nightly to once a week. His parents were advised to give the medicine at bedtime and to monitor for any side effects. The boy experienced mild drowsiness in the morning, which resolved after adjusting the dose.
💡 Lesson: This medicine can be effective for bedwetting in children, but dose adjustment and monitoring are important.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: It may take 2 to 4 weeks to see full antidepressant effects. For bedwetting, improvement may be seen within 1-2 weeks.

Q: Can I stop this medicine suddenly?

A: No, stopping suddenly can cause withdrawal symptoms. Your doctor will taper the dose gradually.

Q: Is this medicine safe during pregnancy?

A: Consult your doctor. It may be used if the benefits outweigh the risks, but close monitoring is needed.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for imprin 75mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is addictive.
    Fact: This medicine is not addictive in the traditional sense, but it can cause dependence and withdrawal symptoms if stopped abruptly.
  • Myth: This medicine works immediately.
    Fact: It may take 2 to 4 weeks to see full antidepressant effects.

🔄 Alternative Options

Generic Alternatives

  • Imipramine hydrochloride

Brand Alternatives

  • Antipres 75mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Imipramine","class":"Tricyclic antidepressant","main_use":"Depression, bedwetting","sedation":"Moderate","anticholinergic":"High"},{"medicine":"Amitriptyline","class":"Tricyclic antidepressant","main_use":"Depression, neuropathic pain","sedation":"High","anticholinergic":"High"},{"medicine":"Nortriptyline","class":"Tricyclic antidepressant","main_use":"Depression","sedation":"Moderate","anticholinergic":"Moderate"}]

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