Alzoset 0.25mg/25mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe drowsiness or difficulty breathing
- Irregular heartbeat or palpitations
- Seizures or convulsions
- Severe allergic reaction (swelling of face, lips, tongue, or throat)
- Yellowing of skin or eyes (jaundice)
- Unusual bleeding or bruising
- Confusion or hallucinations
- Suicidal thoughts or behavior
If experiencing severe symptoms, call emergency services immediately.
What is imprax 0.25 mg/25 mg tablet used for?
This medicine is a combination of alprazolam (a benzodiazepine) and imipramine (a tricyclic antidepressant) used for anxiety with depression. It is a controlled prescription drug that can cause dependence and serious side effects. It must only be taken under medical supervision.
- Generic Name: Alprazolam (0.25mg) + Imipramine (25mg)
- Manufacturer: Consern Pharma Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 imprax 0.25 mg/25 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एल्प्राजोलम और इमिप्रामाइन का संयोजन है, जिसका उपयोग चिंता और अवसाद के इलाज के लिए किया जाता है। यह चिंता को कम करने और मूड को बेहतर बनाने में मदद करती है। यह केवल डॉक्टर के पर्चे पर ही मिलती है और इसका सेवन डॉक्टर की सलाह के अनुसार ही करना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, कब्ज, और धुंधली दृष्टि शामिल हैं। गंभीर दुष्प्रभावों में तेज दिल की धड़कन, दौरे, और एलर्जी की प्रतिक्रिया शामिल हो सकती है। कोई भी गंभीर लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें। शराब का सेवन न करें। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको पता न चल जाए कि यह दवा आप पर कैसा असर करती है। अपनी सभी दवाओं के बारे में डॉक्टर को बताएं।
💊 imprax 0.25 mg/25 mg tablet Uses & Benefits
[{"condition":"Anxiety with depressive symptoms","description":"Used for short-term relief of anxiety that occurs together with depression, when other treatments have not worked.","evidence":"Limited"},{"condition":"Panic disorder with agoraphobia","description":"May be prescribed for panic attacks and avoidance behavior, but only under specialist care.","evidence":"Limited"},{"condition":"Chronic pain syndromes with anxiety","description":"Sometimes used for pain conditions like fibromyalgia or neuropathic pain when anxiety is a major component.","evidence":"Limited"}]
Off-label uses: [{"condition":"Insomnia with anxiety","description":"Occasionally prescribed off-label for short-term sleep problems related to anxiety.","evidence":"Limited"},{"condition":"Irritable bowel syndrome with anxiety","description":"Rarely used off-label for IBS symptoms when anxiety is prominent.","evidence":"Limited"}]
Primary treatment for: Anxiety with depressive symptoms
Also treats: Panic disorder, Chronic pain syndromes with anxiety, Insomnia with anxiety
📋 Drug Information
| Generic Name(s) | Alprazolam (0.25mg) + Imipramine (25mg) |
| Brand Name | imprax 0.25 mg/25 mg tablet |
| Manufacturer | Consern Pharma Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct light. Keep in the original container, tightly closed. Do not store in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture. Do not use after the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Alprazolam enhances the inhibitory effect of gamma-aminobutyric acid at GABA-A receptors, leading to sedation, anxiety relief, and muscle relaxation. Imipramine blocks the reuptake of serotonin and norepinephrine in the brain, which increases their availability and helps improve mood and reduce anxiety over time. The combination provides rapid anxiety relief from alprazolam and longer-term mood stabilization from imipramine.
Mechanism Steps
💡 How to Take imprax 0.25 mg/25 mg tablet
Strength: Tablet containing alprazolam 0.25 mg and imipramine 25 mg.
Dosage Information
| Adult Dosage | The usual starting dose for adults is one tablet taken orally one to three times daily, depending on the condition being treated and the patient's response. The dose may be gradually increased by the doctor. The maximum daily dose should not exceed what is prescribed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concurrent medications. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of this medicine. Start with a lower dose and titrate slowly. Monitor for increased sedation, confusion, falls, and cardiac effects. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be needed in patients with severe renal impairment. Monitor renal function and adjust dose as prescribed by a qualified clinician. |
| Hepatic Impairment | Dose adjustment is recommended in patients with hepatic impairment. Start with a lower dose and titrate slowly. Monitor liver function tests. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is determined by the prescribing doctor based on the patient's condition and response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of imprax 0.25 mg/25 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| CNS depressants | Major | |
| CYP3A4 inhibitors | Major | |
| CYP2D6 inhibitors | Major | |
| Antihypertensives | Moderate | |
| Anticholinergics | Moderate | |
| Thyroid medications | Moderate | |
| Cimetidine | Minor | |
| Oral contraceptives | Minor | |
| Grapefruit juice | Moderate |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- CNS depressants (alcohol, opioids, barbiturates, benzodiazepines)
- CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin, ritonavir)
- CYP2D6 inhibitors (fluoxetine, paroxetine, quinidine)
⚡ Moderate Interactions
- Antihypertensives
- Anticholinergics (benztropine, diphenhydramine)
- Thyroid medications
🍷 Alcohol Interaction
Do not drink alcohol while taking this medicine. Alcohol increases the sedative effects of alprazolam and imipramine, which can lead to severe drowsiness, impaired breathing, and dangerous drops in blood pressure. It also increases the risk of falls, accidents, and liver problems.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to alprazolam, imipramine, or any component of the formulation","Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI","Acute narrow-angle glaucoma","Severe respiratory insufficiency","Severe liver disease","Acute myocardial infarction or recent heart attack","Pregnancy and breastfeeding","Children under 18 years of age"]
⚠️ Warnings & Precautions
["This medicine can cause dependence and withdrawal symptoms. Do not stop suddenly.","May impair mental and physical abilities required for driving or operating machinery.","Avoid alcohol and other CNS depressants.","Use with caution in elderly patients due to increased risk of falls and confusion.","May worsen depression and increase suicidal thoughts. Monitor closely.","Can cause anticholinergic effects such as dry mouth, constipation, and urinary retention.","May cause orthostatic hypotension. Rise slowly from sitting or lying positions.","Do not use in patients with untreated narrow-angle glaucoma.","Use with caution in patients with a history of seizures.","May affect blood sugar levels in diabetic patients. Monitor glucose."]
🤱 Lactation Safety
Alprazolam and imipramine are excreted in breast milk. Breastfeeding is not recommended while taking this medicine because it may cause sedation, poor feeding, and developmental effects in the infant. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine can be life-threatening. Symptoms include extreme drowsiness, confusion, coma, respiratory depression, irregular heartbeat, and seizures. If you suspect an overdose, call emergency services immediately. Treatment is supportive and may include activated charcoal, gastric lavage, intravenous fluids, and medications to control seizures and arrhythmias. There is no specific antidote for alprazolam, but flumazenil may be used with caution. Imipramine overdose may require sodium bicarbonate for cardiac toxicity.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you miss multiple doses, contact your doctor for guidance.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not crush, chew, or break the tablet unless your doctor tells you to. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not drink alcohol while taking this medicine. Do not stop this medicine suddenly, as it can cause withdrawal symptoms. Keep all follow-up appointments and tell your doctor about all other medicines you take. Store this medicine in a secure place away from children and pets.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine. They are at higher risk of sedation, confusion, falls, and cardiac arrhythmias. Start with a lower dose and titrate slowly. Regular monitoring of renal, hepatic, and cardiac function is recommended. Avoid using this medicine for long periods in the elderly.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning to become pregnant. Both alprazolam and imipramine may harm the fetus. If you are planning pregnancy, consult your doctor to discuss alternative treatments. Use effective contraception while taking this medicine. If you become pregnant, contact your doctor immediately.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It can interact with anesthetic agents and increase the risk of complications. Your doctor may advise you to stop the medicine temporarily before surgery. Do not stop it on your own.
🦷 Dental Procedures
Tell your dentist that you are taking this medicine before any dental procedure. It can interact with local anesthetics and sedatives used in dentistry. Your dentist may need to adjust the medications used. Do not stop this medicine without consulting your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may affect your coordination. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. Light to moderate exercise is generally safe, but consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and impaired concentration, which may affect your ability to work, drive, or operate machinery. It is advisable to avoid these activities until you know how the medicine affects you. Discuss with your employer if you need accommodations. Do not make important decisions while starting this medicine.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will gradually reduce the dose to prevent withdrawal symptoms. If you experience severe side effects or your condition worsens, contact your doctor immediately. Stopping abruptly can cause anxiety, insomnia, seizures, and other serious withdrawal effects.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to dependence, tolerance, and withdrawal symptoms. It may also cause cognitive impairment, memory problems, and increased risk of falls, especially in the elderly. Regular monitoring of liver, kidney, and heart function is recommended. Periodic review of the need for continued treatment is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A talking therapy that can help manage anxiety and depression without medication.
Evidence: Well-establishedAlternative antidepressants with a better safety profile for long-term use.
Evidence: Well-establishedCan complement medical treatment for anxiety and depression.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking. Live vaccines should be avoided if you have a weakened immune system, but this medicine does not typically cause immunosuppression.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not share with others
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Check the laws of your destination country regarding controlled substances. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, adjust dosing times gradually in consultation with your doctor. Do not pack it in checked baggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Alprazolam starts working within 30 to 60 minutes, providing rapid anxiety relief. Imipramine may take 1 to 3 weeks to show full antidepressant effects.
A: No, stopping suddenly can cause withdrawal symptoms such as anxiety, insomnia, and seizures. Always taper under medical supervision.
A: Yes, alprazolam can cause dependence. This medicine should be used for the shortest duration possible and only under medical supervision.
A: Avoid alcohol, driving, and operating heavy machinery until you know how the medicine affects you. Also avoid grapefruit juice.
A: This medicine is not recommended during pregnancy as it may harm the fetus. Consult your doctor immediately if you are pregnant or planning to become pregnant.
🤔 Common Patient Concerns
🔄 Substitutes for imprax 0.25 mg/25 mg tablet
View AllAlternative brands with exact same active ingredient:
-
impress a 0.25 mg/25 mg tabletA N Pharmacia ₹9.06 66.7% CHEAPER
-
deplam 0.25 mg/25 mg tabletMankind Pharma Ltd ₹15.23 44% CHEAPER
-
Finezol IM 0.25mg/25mg TabletFinecure Pharmaceuticals Ltd. ₹16.80 38.2% CHEAPER
-
depsolam 0.25 mg/25 mg tabletPacific Drugs & Chemicals ₹19.00 30.1% CHEAPER
-
alzoset 0.25mg/25mg tabletBaxter India Pvt Ltd ₹25.00 8.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for long-term use without any risk.
Fact: This medicine can cause dependence and withdrawal. It is usually prescribed for short-term use and requires regular monitoring. - Myth: I can stop this medicine whenever I want.
Fact: Stopping suddenly can cause withdrawal symptoms such as anxiety, insomnia, and seizures. Always taper under medical supervision. - Myth: This medicine is a sleeping pill.
Fact: It is not a primary sleeping pill. It is used for anxiety and depression, though it may cause drowsiness as a side effect. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol increases the sedative effects and can cause dangerous respiratory depression. Avoid alcohol completely.
🔄 Alternative Options
Generic Alternatives
- Alprazolam 0.25 mg tablet
- Imipramine 25 mg tablet
Brand Alternatives
- Alzoset 0.25mg/25mg tablet