Azaprin Tablet (Azathioprine 50mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever, chills, or sore throat that may indicate infection.
- Unusual bleeding or bruising.
- Severe abdominal pain, especially upper abdominal pain radiating to the back.
- Yellowing of the skin or eyes, dark urine, or pale stools.
- Shortness of breath, chest pain, or swelling of the face, lips, or throat.
- Severe fatigue or paleness.
- New or changing skin lesions.
If experiencing severe symptoms, call emergency services immediately.
What is imoprine tablet used for?
Azathioprine is an immunosuppressant used to prevent organ rejection after kidney transplants and to treat autoimmune diseases like rheumatoid arthritis and Crohn's disease. It works by suppressing the immune system and requires regular blood tests to monitor for side effects.
- Generic Name: Azathioprine (50mg)
- Manufacturer: Canixa Life Sciences Pvt
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 imoprine tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एज़ाथियोप्रिन एक इम्यूनोसप्रेसेंट है जिसका उपयोग अंग प्रत्यारोपण के बाद शरीर की प्रतिरक्षा प्रणाली को दबाने के लिए किया जाता है। यह रूमेटॉइड आर्थराइटिस, क्रोहन रोग, अल्सरेटिव कोलाइटिस और ल्यूपस जैसी ऑटोइम्यून बीमारियों के इलाज में भी प्रयोग किया जाता है। यह दवा लक्षणों को कम करने में मदद करती है लेकिन इसमें कुछ हफ्तों से लेकर महीनों तक का समय लग सकता है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें और नियमित रक्त परीक्षण करवाते रहें।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, भूख न लगना और पेट की परेशानी शामिल हैं। गंभीर दुष्प्रभावों में संक्रमण का खतरा बढ़ना, असामान्य रक्तस्राव या चोट लगना, और लीवर की समस्या के लक्षण जैसे त्वचा या आंखों का पीला पड़ना शामिल हैं। दुर्लभ मामलों में अग्न्याशय की सूजन हो सकती है जिसमें पेट में तेज दर्द होता है। लंबे समय तक उपयोग से कुछ प्रकार के कैंसर का खतरा बढ़ सकता है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को शुरू करने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, खासकर लीवर या किडनी की बीमारी, संक्रमण, या लेश-निहान सिंड्रोम। इस दवा के सेवन के दौरान लाइव वैक्सीन न लगवाएं। संक्रमण वाले लोगों के संपर्क से बचें। त्वचा कैंसर के खतरे को कम करने के लिए सनस्क्रीन और सुरक्षात्मक कपड़े पहनें। गर्भवती न हों; पुरुष और महिला दोनों को इलाज के दौरान और बाद में प्रभावी गर्भनिरोधक का उपयोग करना चाहिए। स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। डॉक्टर की सलाह के बिना दवा बंद न करें। नियमित रक्त परीक्षण करवाते रहें। शराब से बचें क्योंकि इससे लीवर की समस्या बढ़ सकती है।
💊 imoprine tablet Uses & Benefits
[{"condition":"Kidney transplant rejection prevention","description":"Used as part of immunosuppressive therapy to prevent the body from rejecting a transplanted kidney.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Helps reduce joint inflammation and damage in patients with moderate to severe rheumatoid arthritis who have not responded to other treatments.","evidence":"Well-established"},{"condition":"Crohn's disease","description":"Used to maintain remission and reduce steroid dependence in patients with moderate to severe Crohn's disease.","evidence":"Well-established"},{"condition":"Ulcerative colitis","description":"Helps maintain remission in patients with ulcerative colitis who are dependent on steroids or have not responded to other therapies.","evidence":"Well-established"},{"condition":"Systemic lupus erythematosus","description":"Sometimes used as a steroid-sparing agent in patients with severe lupus.","evidence":"Moderate"},{"condition":"Myasthenia gravis","description":"Used as an immunosuppressant to improve muscle strength in patients with myasthenia gravis.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Multiple sclerosis","description":"Occasionally used off-label to reduce relapses in multiple sclerosis.","evidence":"Limited"},{"condition":"Behçet's disease","description":"May be used off-label for severe Behçet's disease with eye or nervous system involvement.","evidence":"Limited"},{"condition":"Atopic dermatitis","description":"Rarely used off-label for severe atopic dermatitis unresponsive to other treatments.","evidence":"Limited"}]
Primary treatment for: Organ transplant rejection
Also treats: Rheumatoid arthritis, Crohn's disease, Ulcerative colitis, Systemic lupus erythematosus, Myasthenia gravis
📋 Drug Information
| Generic Name(s) | Azathioprine (50mg) |
| Brand Name | imoprine tablet |
| Manufacturer | Canixa Life Sciences Pvt |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Immunosuppressant- Purine analogs |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Azathioprine is a prodrug that is converted in the body to 6-mercaptopurine and then to active metabolites. These metabolites interfere with the synthesis of DNA and RNA by inhibiting purine metabolism. This action primarily affects rapidly dividing cells, especially lymphocytes, which are key players in the immune response. By suppressing the proliferation of these immune cells, azathioprine reduces the immune system's ability to attack transplanted organs or healthy tissues in autoimmune diseases. The full effect takes weeks to months because it affects the production of new immune cells rather than immediately neutralizing existing ones.
Mechanism Steps
💡 How to Take imoprine tablet
Strength: Azathioprine 50 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and depends on the condition being treated, your response to therapy, and your kidney and liver function. For transplant patients, a typical starting dose is 3 to 5 mg per kg of body weight per day, taken as a single daily dose. For rheumatoid arthritis, the starting dose is often 1 mg per kg per day, which may be increased after 6 to 8 weeks. For inflammatory bowel disease, the dose is usually 1.5 to 2.5 mg per kg per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Regular blood tests are essential to monitor for side effects and adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of azathioprine, especially bone marrow suppression. Doses should be used with caution and renal function should be monitored. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, azathioprine should be used with caution. Dose reduction may be necessary. Monitor renal function closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with hepatic impairment, azathioprine should be used with caution. Dose reduction may be necessary. Monitor liver function closely. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the indication and patient factors. It should not exceed the dose recommended by your clinician. Typically, doses above 5 mg per kg per day are not recommended. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of imoprine tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Allopurinol | Major | |
| Warfarin | Major | |
| Live vaccines | Major | |
| ACE inhibitors | Major | |
| Methotrexate | Moderate | |
| Aminosalicylates | Moderate | |
| Ribavirin | Moderate | |
| Antacids | Minor | |
| Corticosteroids | Minor |
🚨 Major Interactions
- Allopurinol
- Warfarin
- Live vaccines
- ACE inhibitors
⚡ Moderate Interactions
- Methotrexate
- Aminosalicylates (e.g., mesalamine, sulfasalazine)
- Ribavirin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase the risk of liver damage and may worsen gastrointestinal side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to azathioprine or any component of the formulation.","Previous treatment with alkylating agents (e.g., cyclophosphamide, chlorambucil) may increase risk of neoplasia.","Pregnancy, especially in transplant patients, unless the benefit outweighs the risk.","Breastfeeding.","Severe liver disease.","Severe bone marrow suppression.","Active serious infections."]
⚠️ Warnings & Precautions
["Immunosuppression may increase susceptibility to infections. Monitor for signs of infection.","Increased risk of malignancies, particularly skin cancer and lymphoma, especially with long-term use.","Bone marrow suppression can occur; monitor blood counts regularly.","Hepatotoxicity may occur; monitor liver function.","Avoid live vaccines during therapy.","May cause fetal harm; use effective contraception during treatment.","Not recommended for patients with Lesch-Nyhan syndrome.","Use with caution in patients with renal or hepatic impairment.","May interact with allopurinol, requiring dose reduction.","Patients should be advised to use sun protection."]
🤱 Lactation Safety
Azathioprine is excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
Overdose of azathioprine can cause severe bone marrow suppression, leading to infections and bleeding. There is no specific antidote. Treatment is supportive and may include blood transfusions, antibiotics, and hospitalization. If overdose is suspected, seek immediate medical attention.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before starting this medicine, tell your doctor about all your medical conditions, especially liver or kidney disease, infections, or if you have a condition called Lesch-Nyhan syndrome. You should not receive live vaccines while taking this medicine. Avoid close contact with people who have infections. Use sunscreen and protective clothing to reduce the risk of skin cancer. Do not become pregnant while taking this medicine; use effective contraception for both men and women during treatment and for a period after. If you are breastfeeding, consult your doctor as this medicine may pass into breast milk. Do not stop taking this medicine suddenly without your doctor's advice. Keep all appointments for blood tests to monitor your blood counts and liver function. Avoid alcohol as it may increase the risk of liver problems. Inform any healthcare provider you see that you are taking this medicine, especially before surgery or dental work.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of azathioprine, especially bone marrow suppression and infections. Doses should be used with caution, and renal function should be monitored. Regular blood tests are essential.
🤰 Pregnancy Planning (TTC)
Azathioprine may cause fetal harm. Both men and women should use effective contraception during treatment and for a period after. If you are planning pregnancy, consult your doctor to discuss risks and alternatives. Do not become pregnant without medical advice.
🏥 Post-Surgery Considerations
After surgery, continue taking azathioprine as prescribed unless your doctor advises otherwise. Inform your surgeon and anesthesiologist that you are on this medicine, as it may affect wound healing and infection risk.
🦷 Dental Procedures
Inform your dentist that you are taking azathioprine before any dental procedure. You may be at increased risk of infection and bleeding. Your dentist may recommend antibiotics or other precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may be more prone to infections and fatigue. Avoid strenuous exercise if you feel unwell. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also increase your risk of infections, so take precautions in crowded places or if your work involves close contact with sick individuals.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or plan to become pregnant, discuss with your doctor who may adjust or change your treatment.
📅 Long-Term Use Effects
Long-term use of azathioprine increases the risk of infections, bone marrow suppression, and certain cancers, especially skin cancer and lymphoma. Regular monitoring of blood counts, liver function, and skin examinations is essential. The risk of these effects increases with higher doses and longer duration of therapy. Your doctor will periodically assess the benefit-risk balance and may adjust the dose or consider alternative treatments.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedAnti-inflammatory diet may help manage autoimmune conditions.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with azathioprine and for at least 3 months after discontinuation. Inactivated vaccines are generally safe but may be less effective due to immunosuppression. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry your azathioprine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue taking your dose at the same interval as prescribed; consult your doctor if unsure. Check customs regulations for controlled substances; azathioprine is not a controlled substance but carry documentation to avoid delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take several weeks to months to see the full effect. Continue taking it as prescribed and attend regular follow-ups.
A: Avoid alcohol, live vaccines, and close contact with people who have infections. Use sun protection.
A: No, do not stop without consulting your doctor. Stopping suddenly can worsen your condition.
🤔 Common Patient Concerns
🔄 Substitutes for imoprine tablet
View AllAlternative brands with exact same active ingredient:
-
davaindia azathioprine 50mg tabletDavaindia Generic Pharmacy ₹30.00 73.3% CHEAPER
-
imuzat 50mg tabletElder Pharmaceuticals Ltd ₹55.12 51% CHEAPER
-
azithioprine 50mg tabletAlkem Laboratories Ltd ₹58.50 48% CHEAPER
-
a pin 50mg tabletParry Pharma Pvt Ltd ₹60.00 46.7% CHEAPER
-
transimune 50mg tabletTroikaa Pharmaceuticals Ltd ₹67.26 40.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Azathioprine is a painkiller.
Fact: Azathioprine is not a painkiller; it is an immunosuppressant that reduces immune system activity. - Myth: Azathioprine works immediately.
Fact: It can take several weeks to months to see the full effect. - Myth: Azathioprine is safe to take without monitoring.
Fact: Regular blood tests are essential to monitor for serious side effects.
🔄 Alternative Options
Generic Alternatives
- Azathioprine 50 mg tablet (various manufacturers)
Brand Alternatives
- Azaprin tablet