Apotinib 400 Tablet (Imatinib Mesylate 400 mg): Comprehensive Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or chest pain
- Severe swelling of the face, lips, or throat
- Yellowing of the skin or eyes
- Dark urine or severe abdominal pain
- Unusual bleeding or bruising
- Fever, sore throat, or other signs of infection
- Rapid weight gain or swelling of the ankles or legs
- Severe skin rash with blisters or peeling
- Decreased urine output
- New or worsening cough or shortness of breath
If experiencing severe symptoms, call emergency services immediately.
What is imatova 400mg tablet used for?
This medicine is a targeted cancer therapy used to treat chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). It works by blocking abnormal proteins that drive cancer cell growth.
- Generic Name: Imatinib mesylate (400mg)
- Manufacturer: Neova Biogene Private Limited
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 imatova 400mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इमेटिनिब मेसिलेट 400 मिलीग्राम की एक ओरल टैबलेट है, जिसका उपयोग क्रोनिक मायलॉइड ल्यूकेमिया (सीएमएल) और गैस्ट्रोइंटेस्टाइनल स्ट्रोमल ट्यूमर (जीआईएसटी) जैसे कैंसर के इलाज के लिए किया जाता है। यह टाइरोसिन काइनेज इनहिबिटर नामक दवाओं के वर्ग में आती है, जो कैंसर कोशिकाओं में असामान्य प्रोटीन को रोककर उनकी वृद्धि को धीमा करती है। यह दवा डॉक्टर के परामर्श के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में शरीर में सूजन (आंखों, टखनों या पैरों के आसपास), मतली, उल्टी, दस्त, पेट दर्द, मांसपेशियों में ऐंठन, हड्डियों में दर्द, त्वचा पर दाने, थकान और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में गंभीर सूजन, लीवर की समस्या, रक्त कोशिकाओं की कमी, हृदय की समस्या या रक्तस्राव शामिल हो सकते हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों, विशेषकर हृदय, लीवर या गुर्दे की समस्याओं और किसी भी एलर्जी के बारे में बताएं। इस दवा को लेते समय गर्भवती न हों; उपचार के दौरान और बंद करने के कम से कम 14 दिन बाद तक प्रभावी गर्भनिरोधक का उपयोग करें। स्तनपान न कराएं। अंगूर और अंगूर के रस से बचें। इस दवा को भोजन के साथ और एक बड़े गिलास पानी के साथ लें। टैबलेट को पूरा निगलें; चबाएं या तोड़ें नहीं। यदि आप एक खुराक भूल जाते हैं, तो याद आते ही ले लें, लेकिन यदि अगली खुराक का समय हो गया है, तो छूटी हुई खुराक छोड़ दें और नियमित कार्यक्रम जारी रखें। दोहरी खुराक न लें। नियमित रक्त परीक्षण और जांच के लिए अपॉइंटमेंट रखें।
💊 imatova 400mg tablet Uses & Benefits
- [{"condition":"Chronic Myeloid Leukemia (CML)","description":"This medicine is used to treat newly diagnosed adult patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase.
- It is also used in accelerated phase or blast crisis.","evidence":"Well-established"},{"condition":"Gastrointestinal Stromal Tumors (GIST)","description":"This medicine is used to treat adult patients with Kit (CD117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumors.","evidence":"Well-established"},{"condition":"Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)","description":"This medicine is used to treat adult patients with myelodysplastic/myeloproliferative diseases associated with PDGFR gene rearrangements.","evidence":"Well-established"},{"condition":"Systemic Mastocytosis","description":"This medicine is used to treat adult patients with aggressive systemic mastocytosis without the D816V c-Kit mutation or with unknown mutational status.","evidence":"Well-established"},{"condition":"Hypereosinophilic Syndrome (HES) and/or Chronic Eosinophilic Leukemia (CEL)","description":"This medicine is used to treat adult patients with hypereosinophilic syndrome and/or chronic eosinophilic leukemia who have the FIP1L1-PDGFRα fusion kinase.","evidence":"Well-established"},{"condition":"Dermatofibrosarcoma Protuberans (DFSP)","description":"This medicine is used to treat adult patients with dermatofibrosarcoma protuberans.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)","description":"Sometimes used off-label in combination with chemotherapy for Ph+ ALL.","evidence":"Limited"},{"condition":"Desmoid tumors","description":"May be used off-label for progressive desmoid tumors.","evidence":"Limited"},{"condition":"Pulmonary arterial hypertension","description":"Rarely used off-label for pulmonary arterial hypertension.","evidence":"Limited"}]
Primary treatment for: Chronic Myeloid Leukemia (CML)
Also treats: Gastrointestinal Stromal Tumors (GIST), Myelodysplastic/Myeloproliferative Diseases, Systemic Mastocytosis, Hypereosinophilic Syndrome, Dermatofibrosarcoma Protuberans
📋 Drug Information
| Generic Name(s) | Imatinib mesylate (400mg) |
| Brand Name | imatova 400mg tablet |
| Manufacturer | Neova Biogene Private Limited |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed, away from moisture and heat. Do not refrigerate. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a tyrosine kinase inhibitor that works by blocking the activity of certain abnormal proteins that drive cancer cell growth. Specifically, it inhibits the BCR-ABL tyrosine kinase created by the Philadelphia chromosome abnormality in chronic myeloid leukemia. It also inhibits other tyrosine kinases such as c-Kit and platelet-derived growth factor receptor (PDGFR). By blocking these signals, it helps stop the growth and multiplication of cancer cells.
Mechanism Steps
💡 How to Take imatova 400mg tablet
Strength: 400 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose for chronic myeloid leukemia (CML) in chronic phase is 400 mg once daily. For accelerated phase or blast crisis, the dose may be increased to 600 mg once daily. For gastrointestinal stromal tumors (GIST), the recommended dose is 400 mg once daily. Doses may be adjusted based on response and toxicity. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients, but they may be more sensitive to side effects. Monitor closely. |
| Renal Impairment | No dose adjustment is required for patients with mild to moderate renal impairment. Use with caution in severe renal impairment. |
| Hepatic Impairment | Dose reduction is recommended for patients with severe hepatic impairment. For mild to moderate hepatic impairment, the starting dose should be reduced by 25%. |
| Maximum Daily Dose | 800 mg per day (in divided doses) for some indications, but typically 400-600 mg per day. Individualized by clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of imatova 400mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampin | Major | |
| Warfarin | Major | |
| Simvastatin | Moderate | |
| Grapefruit juice | Moderate | |
| Omeprazole | Moderate | |
| Acetaminophen | Major | |
| St. John's wort | Major | |
| Carbamazepine | Major | |
| Phenytoin | Major |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir)
- CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin, St. John's wort)
- Warfarin
- Acetaminophen (paracetamol)
⚡ Moderate Interactions
- Simvastatin
- Grapefruit juice
- Proton pump inhibitors (e.g., omeprazole)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and stomach bleeding. It is advisable to avoid or limit alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to imatinib or any component of the formulation","Pregnancy (unless benefit outweighs risk)","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine can cause severe fluid retention; monitor weight and report rapid weight gain.","Liver toxicity can occur; regular liver function tests are required.","Myelosuppression can occur; regular blood counts are needed.","Heart problems can occur; report chest pain or shortness of breath.","Severe skin reactions can occur; report rash immediately.","Tumor lysis syndrome can occur; ensure adequate hydration.","Avoid grapefruit and grapefruit juice.","Use effective contraception during treatment.","Do not breastfeed while taking this medicine.","Inform your doctor about all other medicines you are taking."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding is not recommended during treatment and for at least 14 days after stopping.
💊 Overdose Management
Overdose with this medicine may cause severe side effects such as fluid retention, liver toxicity, and low blood cell counts. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before starting this medicine, tell your doctor about all your medical conditions, especially heart, liver, or kidney problems, and any allergies. Inform your doctor about all other medicines, supplements, and herbal products you are taking, as many can interact with this medicine. Do not become pregnant while taking this medicine; use effective contraception during treatment and for at least 14 days after stopping. Do not breastfeed while taking this medicine. Avoid grapefruit and grapefruit juice, as they can increase the levels of this medicine in your body. Take this medicine with a meal and a large glass of water to reduce stomach upset. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Keep all appointments for blood tests and check-ups, as your doctor needs to monitor your response and side effects. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially fluid retention and heart problems. Close monitoring is recommended. Dose adjustments may be needed based on kidney and liver function.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. Effective contraception is required during treatment and for at least 14 days after stopping. This medicine may harm the unborn baby.
🏥 Post-Surgery Considerations
After surgery, your doctor will determine when it is safe to resume this medicine. It may affect wound healing and increase the risk of bleeding. Follow your surgeon's and oncologist's instructions carefully.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may increase the risk of bleeding and infection. Your dentist may recommend antibiotics or other precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience fatigue, muscle cramps, or fluid retention. Avoid strenuous exercise if you feel unwell. Consult your doctor before starting any new exercise program. Gentle activities like walking are usually safe and beneficial.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or fluid retention, which can affect your ability to drive or operate machinery. Avoid driving if you feel unwell. You may need to adjust your work schedule to accommodate rest periods and medical appointments. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping suddenly can cause the cancer to return. Your doctor will decide when it is appropriate to stop based on your response to treatment and overall health.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to persistent side effects such as fluid retention, fatigue, and muscle cramps. Regular monitoring of blood counts, liver function, and heart function is essential. Some patients may develop resistance to the medicine over time, requiring a change in treatment. It is important to attend all follow-up appointments and report any new or worsening symptoms.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Consider participating in clinical trials for new treatments.
Evidence: VariesMedicines like dasatinib or nilotinib may be options if resistance develops.
Evidence: Well-establishedA potential curative option for some patients with CML.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided while taking this medicine due to the risk of infection. Inactivated vaccines may be less effective. Consult your doctor before receiving any vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from moisture and heat. If crossing time zones, adjust the timing of your doses gradually in consultation with your doctor. Check customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The therapeutic effects of this medicine may take several weeks to become apparent. Your doctor will monitor your response with regular blood tests and imaging.
A: Yes, take this medicine with a meal and a large glass of water to reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: This medicine may cause harm to the unborn baby. It is not recommended during pregnancy unless the potential benefit justifies the risk. Use effective contraception during treatment.
A: It is advisable to avoid or limit alcohol while taking this medicine, as it may increase the risk of liver problems and stomach bleeding.
🤔 Common Patient Concerns
🔄 Substitutes for imatova 400mg tablet
View AllAlternative brands with exact same active ingredient:
-
resimat 400mg tabletResonance Laboratories Pvt Ltd ₹282.19 88.8% CHEAPER
-
mytinib 400 tabletMylan Pharmaceuticals Pvt Ltd ₹540.90 78.6% CHEAPER
-
admine 400 tabletAdley Formulations ₹750.00 70.3% CHEAPER
-
chemotinib 400mg tabletNeon Laboratories Ltd ₹1,057.50 58.2% CHEAPER
-
imatinib 400 tabletSun Pharmaceutical Industries Ltd ₹1,123.83 55.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure all cancers.
Fact: This medicine is only effective for specific types of cancer that have certain genetic mutations. It is not a cure for all cancers. - Myth: Once you start this medicine, you can stop whenever you feel better.
Fact: You must not stop this medicine without consulting your doctor. Stopping suddenly can cause the cancer to return. - Myth: This medicine has no side effects.
Fact: This medicine can cause side effects, some of which can be serious. Regular monitoring is required.
🔄 Alternative Options
Generic Alternatives
- Imatinib mesylate 400 mg tablet
Brand Alternatives
- Apotinib 400 tablet