bioside 100mg injection - Etoposide (100mg) medicine

bioside 100mg injection - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Neova Biogene Private Limited ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jul 2, 2026
โš ๏ธ Hepatotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jul 02, 2026

What is bioside 100mg injection used for?

Actitop 100mg Injection (Etoposide) is used to treat ANTI NEOPLASTICS. It contains Etoposide (100mg), which Inhibits topoisomerase II, causing DNA strand breaks and cell cycle arrest in S . Always consult your doctor before use. Take as prescribed.

  • Generic Name: Etoposide
  • Manufacturer: Neova Biogene Private Limited
  • Form: Allopathy
  • Pregnancy Category: D
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

๐Ÿ’Š bioside 100mg injection Uses & Benefits

Small cell lung cancer, testicular cancer, lymphoma, leukemia, ovarian cancer.

Off-label uses: Gestational trophoblastic disease, Ewing sarcoma, brain tumors.

๐Ÿ“‹ Drug Information

Generic Name(s)Etoposide
Brand NameActitop 100mg Injection
ManufacturerNeova Biogene Private Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassAlkaloids-cytotoxic agents
Route of AdministrationIntravenous infusion
StorageStore at 20-25ยฐC; protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous administration results in complete bioavailability.
DistributionWidely distributed; crosses blood-brain barrier to a limited extent.
Protein BindingApproximately 94-97% bound to plasma proteins.
MetabolismHepatic metabolism via CYP3A4 and glucuronidation.
Half-Life4-11 hours (terminal half-life).
ExcretionRenal excretion (40-60% as unchanged drug) and biliary excretion.
Bioavailability100% (intravenous).
Onset of ActionRapid (within minutes).
Peak Plasma TimeAt end of infusion.
Duration of ActionVariable, typically 24-48 hours.

How It Works

Inhibits topoisomerase II, causing DNA strand breaks and cell cycle arrest in S and G2 phases.

Mechanism Steps

1Etoposide binds to topoisomerase II and DNA, forming a stable complex.
2Prevents religation of DNA strands, causing double-strand breaks.
3Accumulation of DNA breaks leads to cell cycle arrest in S and G2 phases.

๐Ÿ’ก How to Take bioside 100mg injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of bioside 100mg injection

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Alopecia
  • Myelosuppression
  • Mucositis

๐Ÿšจ Serious Side Effects

  • Severe myelosuppression
  • Hypersensitivity reactions
  • Hepatotoxicity
  • Secondary leukemia

โš ๏ธ Rare Side Effects

  • Interstitial pneumonitis
  • Cardiotoxicity
  • Peripheral neuropathy

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Cyclosporine Major Increased immunosuppression and nephrotoxicity
Cisplatin Major Enhanced myelosuppression
Methotrexate Major Increased toxicity
Phenytoin Moderate Decreased etoposide efficacy
Azole antifungals Moderate Increased etoposide levels
Protease inhibitors Moderate Increased etoposide toxicity
Corticosteroids Minor Possible increased immunosuppression
Calcium channel blockers Minor Possible increased etoposide levels

๐Ÿšจ Major Interactions

  • Warfarin
  • Cyclosporine
  • Cisplatin
  • Methotrexate

โšก Moderate Interactions

  • Phenytoin
  • Antifungals (azole)
  • Protease inhibitors

โ„น๏ธ Minor Interactions

  • Corticosteroids
  • Calcium channel blockers

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

Avoid alcohol due to increased hepatotoxicity risk.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to etoposide; severe hepatic impairment; severe bone marrow suppression; pregnancy.

๐Ÿ“Š Monitoring Parameters

Complete blood count, liver function tests, renal function tests, blood pressure.

๐Ÿคฑ Lactation Safety

Contraindicated; excreted in breast milk.

๐Ÿ’Š Overdose Management

Supportive care; monitor bone marrow function; consider hematopoietic growth factors.

โฐ Missed Dose

Administer as soon as remembered; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jul 02, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for bioside 100mg injection

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Alternative brands with exact same active ingredient (Etoposide (100mg)):

Medical Note: Always consult your doctor before switching medications.

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