ig-cold syrup - Paracetamol (250mg) + Chlorpheniramine Maleate (2mg) medicine

IG-Cold Syrup: Complete Medicine Guide

No reviews yet
🏭 IGP Medventures Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 24, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for symptomatic relief of common cold and allergic rhinitis.
Reviewed by
SaathiMed Expert Panel | Oct 24, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of skin or eyes (jaundice)
  • Dark urine or pale stools
  • Severe abdominal pain
  • Difficulty breathing or swelling of face, lips, or throat
  • Unusual bruising or bleeding
  • Severe drowsiness or confusion
  • Persistent fever for more than 3 days

If experiencing severe symptoms, call emergency services immediately.

What is ig-cold syrup used for?

This medicine is a combination of Paracetamol and Chlorpheniramine Maleate used for temporary relief of common cold and allergy symptoms such as runny nose, sneezing, and fever. It works by reducing pain and fever and blocking histamine. It may cause drowsiness, so avoid driving. Do not exceed the recommended dose.

  • Generic Name: Paracetamol (250mg) + Chlorpheniramine Maleate (2mg)
  • Manufacturer: IGP Medventures Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ig-cold syrup के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल और क्लोरफेनिरामाइन मेलिएट का संयोजन है, जिसका उपयोग सर्दी-जुकाम, एलर्जी, बहती नाक, छींक, आंखों में पानी और हल्के बुखार के लक्षणों से राहत के लिए किया जाता है। यह दर्द और बुखार को कम करने और एलर्जी के लक्षणों को नियंत्रित करने में मदद करती है। इस दवा से नींद आ सकती है, इसलिए वाहन चलाने या मशीन चलाने से बचें। इसका उपयोग डॉक्टर की सलाह के अनुसार ही करें।

साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधली दृष्टि और जी मिचलाना शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन गंभीर एलर्जी प्रतिक्रिया, लीवर की क्षति, और रक्त विकार हो सकते हैं। यदि आपको पीलिया, गहरे रंग का पेशाब, गंभीर पेट दर्द, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अनुशंसित खुराक से अधिक न लें क्योंकि पैरासिटामोल की अधिक मात्रा से लीवर को नुकसान हो सकता है। इस दवा के साथ शराब न लें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। यदि आपको लीवर या गुर्दे की बीमारी, ग्लूकोमा, या पेशाब करने में कठिनाई है, तो डॉक्टर को बताएं। 5-7 दिनों से अधिक इसका उपयोग न करें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 ig-cold syrup Uses & Benefits

[{"condition":"Common cold","description":"Relieves symptoms such as runny nose, sneezing, watery eyes, mild fever, and body ache associated with the common cold.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Reduces sneezing, nasal itching, runny nose, and watery eyes caused by allergies.","evidence":"Well-established"},{"condition":"Flu-like symptoms","description":"Provides symptomatic relief from fever, headache, and muscle aches, along with antihistamine effects for respiratory symptoms.","evidence":"Well-established"}]

Off-label uses: []

Primary treatment for: Common cold

Also treats: Allergic rhinitis, Flu-like symptoms

📋 Drug Information

Generic Name(s)Paracetamol (250mg) + Chlorpheniramine Maleate (2mg)
Brand Nameig-cold syrup
ManufacturerIGP Medventures Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the bottle tightly closed.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Avoid alcohol while taking this medicine to prevent liver damage and excessive drowsiness.
3
Do not drive or operate heavy machinery until you know how this medicine affects you.
4
Do not exceed the recommended dose; too much Paracetamol can harm your liver.
5
Use this medicine for the shortest duration necessary, and consult a doctor if symptoms persist beyond 5-7 days.
6
Inform your doctor if you have liver or kidney disease, glaucoma, or difficulty urinating.
7
Keep out of reach of children and store in a cool, dry place.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Runny nose
This medicine is commonly used for this symptom.
Likely Use
✅
Sneezing
This medicine helps relieve sneezing due to allergies or cold.
Likely Use
✅
Fever
Paracetamol in this medicine reduces fever.
Likely Use
✅
Body ache
Paracetamol provides pain relief.
Likely Use
❌
Chest pain
This medicine is not for chest pain; seek immediate medical help.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Chlorpheniramine Maleate is also well absorbed after oral administration. Food may slightly delay absorption but does not significantly reduce the extent.
DistributionParacetamol distributes widely into body tissues. Chlorpheniramine distributes into body tissues and crosses the blood-brain barrier, which contributes to its sedative effects.
Protein BindingParacetamol: about 10-25% bound to plasma proteins. Chlorpheniramine: about 70% bound to plasma proteins.
MetabolismParacetamol is metabolized primarily in the liver via glucuronidation and sulfation, with a small fraction metabolized by CYP2E1 to a toxic intermediate (NAPQI) that is normally detoxified by glutathione. Chlorpheniramine is metabolized in the liver, primarily by CYP2D6 and other enzymes.
Half-LifeParacetamol: 2-3 hours in adults. Chlorpheniramine: 12-43 hours, with wide interindividual variation.
ExcretionParacetamol metabolites are excreted primarily in urine. Chlorpheniramine and its metabolites are excreted mainly in urine.
BioavailabilityParacetamol: approximately 80-100% after oral administration. Chlorpheniramine: approximately 25-50% due to first-pass metabolism.
Onset of ActionParacetamol: 30-60 minutes. Chlorpheniramine: 30-60 minutes.
Peak Plasma TimeParacetamol: 0.5-2 hours. Chlorpheniramine: 2-6 hours.
Duration of ActionParacetamol: 4-6 hours. Chlorpheniramine: 4-6 hours, but sedative effects may last longer.

How It Works

This medicine combines two active ingredients. Paracetamol acts primarily in the central nervous system to reduce pain and fever by inhibiting prostaglandin synthesis, though its exact mechanism is not fully understood. Chlorpheniramine Maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing allergic symptoms such as sneezing, runny nose, and watery eyes. It also has anticholinergic properties that contribute to dry mouth and drowsiness.

Mechanism Steps

1
Paracetamol central action: Paracetamol acts on the central nervous system to inhibit prostaglandin synthesis, thereby reducing pain and fever.
2
Chlorpheniramine H1 blockade: Chlorpheniramine Maleate blocks histamine H1 receptors, preventing histamine from causing sneezing, runny nose, and watery eyes.
3
Anticholinergic effect: Chlorpheniramine also has anticholinergic properties that reduce secretions and cause drowsiness.

💡 How to Take ig-cold syrup

Strength: Each 5 mL contains Paracetamol 250 mg and Chlorpheniramine Maleate 2 mg.

1Shake the bottle well before use.
2Use a measuring cup or spoon to measure the correct dose.
3Take orally, with or without food.
4Follow the prescribed dose and frequency.
5Do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose is 10 mL (2 teaspoons) every 4 to 6 hours as needed, not to exceed 4 doses (40 mL) in 24 hours. However, the dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose due to the risk of liver toxicity from Paracetamol.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may be more sensitive to the sedative and anticholinergic effects of Chlorpheniramine. Use with caution and consider lower doses. Consult a doctor for individualized dosing.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction or avoidance may be necessary. Consult a doctor.
Maximum Daily DoseFor adults: maximum 40 mL (1000 mg Paracetamol and 8 mg Chlorpheniramine) in 24 hours. Do not exceed.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of liver damage and drowsiness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ig-cold syrup

✅ Common Side Effects

Drowsiness (Common (10-20%))
Avoid driving or operating machinery. If persistent, consult your doctor.
Dry mouth (Common (5-10%))
Sip water or chew sugarless gum. Usually resolves on its own.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying position. Avoid alcohol.
Nausea (Uncommon (1-5%))
Take with food or milk to reduce stomach upset.
Blurred vision (Uncommon (1-5%))
Avoid tasks requiring clear vision until it resolves.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek immediate medical attention if you experience swelling of face, lips, tongue, or throat, difficulty breathing, or severe rash.
Liver damage (Paracetamol overdose) (Rare (<0.1%))
Seek immediate medical help if you notice yellowing of skin or eyes, dark urine, or severe abdominal pain.
Blood disorders (e.g., agranulocytosis, thrombocytopenia) (Very rare (<0.01%))
Report unusual bruising, bleeding, or signs of infection to your doctor immediately.

⚠️ Rare Side Effects

Agranulocytosis
Seek immediate medical attention if you develop fever, sore throat, or mouth ulcers.
Thrombocytopenia
Report unusual bleeding or bruising to your doctor.
Hepatotoxicity
Seek medical help if you experience jaundice, dark urine, or right upper abdominal pain.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Alcohol Major
MAOIs Major
Benzodiazepines Moderate
Tricyclic antidepressants Moderate
Fluoxetine Moderate
Antacids Minor
Cholestyramine Minor

🚨 Major Interactions

  • Warfarin
  • Alcohol
  • Monoamine oxidase inhibitors (MAOIs)

⚡ Moderate Interactions

  • CNS depressants (e.g., benzodiazepines, opioids, alcohol)
  • Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver toxicity from Paracetamol and enhances the sedative effects of Chlorpheniramine, which can impair your ability to drive or operate machinery.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Paracetamol, Chlorpheniramine, or any component","Severe liver disease or active liver disease","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","MAOI therapy within 14 days"]

⚠️ Warnings & Precautions

["Do not exceed recommended dose due to risk of liver damage.","Avoid alcohol while taking this medicine.","May cause drowsiness; avoid driving or operating machinery.","Use with caution in patients with glaucoma, urinary retention, or asthma.","Consult a doctor before use in pregnancy or breastfeeding.","Do not use for more than 5-7 days without medical advice."]

🤱 Lactation Safety

Paracetamol is considered safe during breastfeeding. Chlorpheniramine may pass into breast milk and cause drowsiness in the infant. Consult your doctor before use.

💊 Overdose Management

Overdose of Paracetamol can cause severe liver damage. Symptoms may include nausea, vomiting, abdominal pain, and jaundice. Seek immediate medical attention. The antidote N-acetylcysteine may be administered by a healthcare professional. Chlorpheniramine overdose may cause drowsiness, agitation, and anticholinergic effects. Treatment is supportive.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed. Do not exceed the recommended dose because the Paracetamol component can harm the liver in high doses. Avoid alcohol while taking this medicine as it increases the risk of liver damage and drowsiness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have liver or kidney disease, glaucoma, or difficulty urinating. Do not use this medicine for more than 5-7 days without consulting a doctor. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the sedative and anticholinergic effects of Chlorpheniramine. They may also be at higher risk of liver toxicity from Paracetamol. Use with caution and consider lower doses.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before taking this medicine. Paracetamol is generally considered safe, but Chlorpheniramine should be used with caution.

🏥 Post-Surgery Considerations

Consult your doctor before taking this medicine after surgery, as it may interact with other medications or affect recovery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may cause dry mouth and interact with other medications used during dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Stay hydrated by drinking plenty of fluids.
🥗
Get adequate rest to help your body recover.
😴
Use a humidifier to ease nasal congestion.
💧
Avoid exposure to allergens like dust and pollen.
🧘
Wash your hands frequently to prevent spreading infections.
🌞
Avoid smoking and secondhand smoke.

🏋️ Exercise Considerations

This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities requiring alertness until you know how it affects you.

🥗 Diet Recommendations

Drink warm fluids like soups and herbal teas.
Include vitamin C-rich foods like oranges and lemons.
Avoid cold drinks and ice cream.
Eat light, easily digestible meals.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness, which may affect your ability to drive or operate machinery. It is best to avoid these activities until you know how the medicine affects you. Inform your employer if your job requires alertness.

🛑 When to Stop This Medicine

Stop taking this medicine if your symptoms resolve or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time; consult your doctor for a tapering plan.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use of Paracetamol can increase the risk of liver damage, especially with high doses or alcohol consumption. Chlorpheniramine may cause tolerance and dependence. Regular monitoring of liver function may be needed if used for extended periods.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Saline nasal rinse

Helps clear nasal congestion without medication.

Evidence: Well-established
Steam inhalation

Can relieve nasal congestion and soothe airways.

Evidence: Limited
Antihistamine nasal sprays

Alternative for allergic rhinitis with fewer systemic side effects.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking it as prescribed, but adjust timing gradually. Check customs regulations for carrying medications. Do not leave it in a hot car.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with seasonal allergies
She experienced sneezing, runny nose, and itchy eyes every spring. Her doctor prescribed this medicine. She took it as directed and found significant relief within an hour. She noted mild drowsiness, so she took it at bedtime. She avoided driving after taking it.
💡 Lesson: Taking this medicine at bedtime can help manage drowsiness while providing relief from allergy symptoms.
👤 A 50-year-old man with common cold
He had a runny nose, mild fever, and body aches. He took this medicine every 6 hours as needed. His symptoms improved within two days. He made sure not to exceed the recommended dose and avoided alcohol.
💡 Lesson: Following the recommended dose and avoiding alcohol prevents complications like liver damage.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30-60 minutes after taking it.

Q: Can I take this medicine with other cold medicines?

A: Do not take with other medicines containing Paracetamol or antihistamines without consulting a doctor, as it may lead to overdose.

Q: Is it safe to take this medicine every day?

A: It is intended for short-term use. Consult a doctor if you need it for more than 5-7 days.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my liver?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for ig-cold syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure the common cold.
    Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection.
  • Myth: It is safe to take extra doses for faster relief.
    Fact: Taking more than the recommended dose can cause serious liver damage from Paracetamol.
  • Myth: This medicine is safe to take with alcohol.
    Fact: Alcohol increases the risk of liver damage and drowsiness. Avoid alcohol.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol + Chlorpheniramine Maleate syrup (generic)

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Paracetamol 250mg + Chlorpheniramine 2mg per 5mL","uses":"Cold, allergy symptoms","sedation":"Moderate"},{"medicine":"Paracetamol + Phenylephrine + Chlorpheniramine","composition":"Paracetamol 325mg + Phenylephrine 5mg + Chlorpheniramine 2mg","uses":"Cold with nasal congestion","sedation":"Moderate"}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory