Bren PX 400mg/250mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
- Severe skin rash with blisters or peeling
If experiencing severe symptoms, call emergency services immediately.
What is bren px 400mg/250mg/32.5mg tablet used for?
This medicine is a combination of ibuprofen and paracetamol used for short-term relief of acute pain, inflammation, and fever. It works by reducing pain and swelling. Take it with food to avoid stomach upset. Do not exceed 3 tablets in 24 hours.
- Generic Name: Ibuprofen + Paracetamol
- Manufacturer: Kopran Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bren px 400mg/250mg/32.5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इबुप्रोफेन और पैरासिटामोल का संयोजन है, जिसका उपयोग दर्द, सूजन और बुखार के अल्पकालिक उपचार के लिए किया जाता है। यह मांसपेशियों के दर्द, दांत दर्द, सिरदर्द, मासिक धर्म के दर्द और सर्जरी के बाद के दर्द में राहत देती है। इसे भोजन के साथ लेना चाहिए ताकि पेट में जलन न हो। इसका उपयोग डॉक्टर की सलाह के बिना 3 दिन से अधिक नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, जलन और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें पेट में गंभीर दर्द, काला या खूनी मल, खून की उल्टी, एलर्जी की प्रतिक्रिया, सांस लेने में कठिनाई और पेशाब कम आना शामिल हो सकते हैं। यदि आपको कोई भी गंभीर लक्षण दिखे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन या दूध के साथ लें। इस दवा के साथ शराब न लें। यदि आपको पेट के अल्सर, गुर्दे की बीमारी, लीवर की बीमारी, हृदय रोग या अस्थमा है, तो डॉक्टर को बताएं। गर्भवती महिलाओं को इस दवा से बचना चाहिए। बच्चों को डॉक्टर की सलाह के बिना न दें।
💊 bren px 400mg/250mg/32.5mg tablet Uses & Benefits
[{"condition":"Acute musculoskeletal pain","description":"Relieves pain and inflammation in muscles, joints, and soft tissues, such as sprains, strains, and back pain.","evidence":"Well-established"},{"condition":"Dental pain","description":"Provides relief from toothache and pain after dental procedures.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after surgery.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever by acting on the hypothalamus.","evidence":"Well-established"},{"condition":"Headache","description":"Relieves tension headaches and mild migraines.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes used off-label for preventing migraines, but evidence is limited.","evidence":"Limited"},{"condition":"Osteoarthritis","description":"May be used for short-term relief of osteoarthritis pain, but not for long-term management due to risks.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Fever, Dental pain, Musculoskeletal pain, Post-operative pain, Dysmenorrhea
📋 Drug Information
| Generic Name(s) | Ibuprofen + Paracetamol |
| Brand Name | Adiflam Plus 400 mg/500 mg Tablet |
| Manufacturer | Kopran Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms of action. Ibuprofen is a non-steroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), leading to decreased synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol acts primarily in the central nervous system, where it inhibits prostaglandin synthesis and may also activate descending serotonergic pathways, producing analgesia and antipyresis. The combination provides additive pain relief and anti-inflammatory effects.
Mechanism Steps
💡 How to Take bren px 400mg/250mg/32.5mg tablet
Strength: Tablet containing Ibuprofen 400 mg and Paracetamol 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally every 6 to 8 hours as needed for pain and fever. Do not exceed 3 tablets in 24 hours. The maximum daily dose should not exceed 1200 mg of ibuprofen and 750 mg of paracetamol from this combination. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not take for more than 3 days for fever or 5 days for pain without consulting a doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are at increased risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Consult a doctor before taking this medicine. |
| Renal Impairment | Use with caution in patients with kidney disease. Dose adjustment may be needed. Consult a doctor before taking this medicine. |
| Hepatic Impairment | Use with caution in patients with liver disease. Dose adjustment may be needed. Consult a doctor before taking this medicine. |
| Maximum Daily Dose | Maximum daily dose: 3 tablets in 24 hours. Do not exceed 1200 mg of ibuprofen and 750 mg of paracetamol per day from this combination. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bren px 400mg/250mg/32.5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| ACE inhibitors | Major | |
| Diuretics | Major | |
| Lithium | Moderate | |
| Methotrexate | Moderate | |
| SSRIs | Moderate | |
| Anticoagulants | Moderate | |
| Zidovudine | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., aspirin, naproxen)
- Corticosteroids
- ACE inhibitors and ARBs
- Diuretics
⚡ Moderate Interactions
- Lithium
- Methotrexate
- SSRIs
- Anticoagulants (e.g., apixaban, rivaroxaban)
- Zidovudine
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can worsen liver damage, especially with paracetamol.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ibuprofen, paracetamol, or any other ingredients.","History of asthma, urticaria, or allergic reaction after taking aspirin or other NSAIDs.","Active or history of recurrent peptic ulcer or gastrointestinal bleeding.","Severe heart failure, severe kidney disease, or severe liver disease.","Third trimester of pregnancy.","Children under 12 years of age (unless directed by a doctor).","Concurrent use with other NSAIDs or paracetamol-containing products."]
⚠️ Warnings & Precautions
["Take with food or milk to reduce stomach upset.","Do not exceed the recommended dose or duration of treatment.","Avoid alcohol while taking this medicine.","Do not use with other NSAIDs or paracetamol-containing products.","Consult your doctor if you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Long-term use may increase the risk of heart attack, stroke, and kidney problems.","Stop use and consult a doctor if you experience signs of gastrointestinal bleeding, allergic reaction, or liver problems."]
🤱 Lactation Safety
Ibuprofen and paracetamol are excreted in breast milk in small amounts. Short-term use is generally considered safe during breastfeeding. However, consult your doctor before taking this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage due to paracetamol and gastrointestinal bleeding, kidney failure, and central nervous system effects due to ibuprofen. If you suspect an overdose, seek immediate medical attention. Treatment includes activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine, as it can increase the risk of stomach bleeding and liver damage. Do not take other medicines containing paracetamol or NSAIDs without consulting your doctor, as this can lead to overdose. If you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or asthma, inform your doctor before taking this medicine. Pregnant women should avoid this medicine, especially during the last three months of pregnancy. Breastfeeding mothers should consult their doctor before use. Keep this medicine out of reach of children. Store it at room temperature, away from direct sunlight and moisture. Do not use it after the expiry date.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events. Use the lowest effective dose for the shortest duration. Consult a doctor before taking this medicine.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like ibuprofen may affect ovulation and are generally avoided during pregnancy, especially in the third trimester.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but consult your surgeon before taking it, as it can increase the risk of bleeding.
🦷 Dental Procedures
This medicine can be used for dental pain, but inform your dentist if you are taking it before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain while taking this medicine. Listen to your body and rest if needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve after 3 days for fever or 5 days for pain, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney problems, liver damage, and cardiovascular events such as heart attack and stroke. It is not recommended for long-term use unless directed by a doctor. Regular monitoring of kidney and liver function may be needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help reduce pain and inflammation.
Evidence: LimitedMay provide pain relief for some conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking it as prescribed, but do not exceed the maximum daily dose. Check local customs regulations regarding carrying medicines. Always keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 minutes to 1 hour after taking it.
A: It is best to take it with food or milk to reduce the risk of stomach upset.
A: Do not take more than 3 tablets in 24 hours.
A: Consult your doctor before taking this medicine during pregnancy, especially in the third trimester.
A: Do not take it with other NSAIDs or paracetamol-containing products without consulting your doctor.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe to take on an empty stomach.
Fact: It should be taken with food to reduce the risk of stomach upset and bleeding. - Myth: This medicine can be taken long-term for chronic pain.
Fact: Long-term use increases the risk of serious side effects. Use only for short-term relief unless directed by a doctor. - Myth: This medicine is safe to take with other painkillers.
Fact: Taking it with other NSAIDs or paracetamol-containing products can lead to overdose and serious side effects.
🔄 Alternative Options
Generic Alternatives
- Ibuprofen 400 mg + Paracetamol 250 mg tablet