Ifomid M 400mg/2gm Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in urine or painful urination
- Fever or chills
- Unusual bleeding or bruising
- Severe confusion or hallucinations
- Decreased urine output
- Yellowing of skin or eyes
- Chest pain or shortness of breath
If experiencing severe symptoms, call emergency services immediately.
What is ifomid m 400mg/2gm injection used for?
This medicine is a combination of ifosfamide, a chemotherapy drug, and mesna, a protective agent. It is used to treat certain cancers such as testicular cancer and soft tissue sarcoma. It is given intravenously by a healthcare professional.
- Generic Name: Mesna (400mg) + Ifosfamide (2gm)
- Manufacturer: United Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ifomid m 400mg/2gm injection के बारे में (Hindi Summary)
उपयोग: यह दवा इफोस्फामाइड और मेसना का संयोजन है, जिसका उपयोग कुछ प्रकार के कैंसर जैसे टेस्टिकुलर कैंसर, सॉफ्ट टिश्यू सारकोमा और कुछ लिम्फोमा के इलाज के लिए किया जाता है। यह एक कीमोथेरेपी दवा है जो कैंसर कोशिकाओं को बढ़ने से रोकती है। मेसना मूत्राशय को नुकसान से बचाने के लिए दिया जाता है। यह दवा केवल अस्पताल में डॉक्टर की देखरेख में इंजेक्शन के रूप में दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, भूख न लगना, बालों का झड़ना और थकान शामिल हैं। गंभीर दुष्प्रभावों में हड्डी मज्जा का दमन, मूत्राशय में रक्तस्राव, गुर्दे की क्षति और तंत्रिका तंत्र की समस्याएं शामिल हैं। कोई भी असामान्य लक्षण तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा अस्पताल या क्लिनिक में ही दी जानी चाहिए। इसे स्वयं न लें। अपने डॉक्टर को सभी अन्य दवाओं के बारे में बताएं। पर्याप्त पानी पिएं। संक्रमण से बचें। उपचार के दौरान गर्भधारण न करें। स्तनपान न कराएं। नियमित रक्त और मूत्र परीक्षण कराएं।
💊 ifomid m 400mg/2gm injection Uses & Benefits
[{"condition":"Testicular cancer","description":"Used as part of combination chemotherapy regimens for germ cell testicular tumors.","evidence":"Well-established"},{"condition":"Soft tissue sarcoma","description":"Effective in treating various soft tissue sarcomas, often in combination with other agents.","evidence":"Well-established"},{"condition":"Non-Hodgkin lymphoma","description":"Used in some salvage chemotherapy regimens for lymphomas.","evidence":"Established"},{"condition":"Ovarian cancer","description":"Sometimes used in combination chemotherapy for ovarian cancer.","evidence":"Limited"},{"condition":"Small cell lung cancer","description":"May be used in combination regimens for small cell lung cancer.","evidence":"Limited"}]
Off-label uses: [{"condition":"Ewing sarcoma","description":"Sometimes used off-label in combination chemotherapy for Ewing sarcoma.","evidence":"Limited"},{"condition":"Osteosarcoma","description":"Occasionally used off-label in certain osteosarcoma treatment protocols.","evidence":"Limited"}]
Primary treatment for: Cancer
Also treats: Testicular cancer, Soft tissue sarcoma, Non-Hodgkin lymphoma, Ovarian cancer, Small cell lung cancer
📋 Drug Information
| Generic Name(s) | Mesna (400mg) + Ifosfamide (2gm) |
| Brand Name | ifomid m 400mg/2gm injection |
| Manufacturer | United Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store at room temperature (15-30°C). Protect from light. Do not freeze. Keep in original packaging. |
| Shelf Life | Not established from the available information. Refer to the product label. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ifosfamide is a prodrug that requires activation by liver enzymes to form its active metabolite, which then acts as an alkylating agent. It cross-links DNA strands, preventing cell division and leading to cancer cell death. Mesna works by binding to acrolein, a toxic metabolite of ifosfamide that causes bladder irritation, thereby protecting the urinary tract.
Mechanism Steps
💡 How to Take ifomid m 400mg/2gm injection
Strength: Injection: Mesna 400 mg and Ifosfamide 2 gm per vial.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the specific cancer being treated, the patient's body surface area, kidney and liver function, and other factors. It is typically given as an intravenous infusion over several hours. Common regimens may involve doses of ifosfamide ranging from 1.2 to 2.5 g/m² per day for several days, repeated every 3 to 4 weeks. Mesna is given at a dose of 20% of the ifosfamide dose at the time of ifosfamide administration, and then at 40% of the ifosfamide dose at 4 and 8 hours after ifosfamide. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more susceptible to side effects, especially kidney and bone marrow toxicity. Dose adjustments may be necessary based on kidney and liver function. Individualize by a qualified clinician. |
| Renal Impairment | Dose reduction may be necessary in patients with kidney impairment. Monitor kidney function closely. Individualize by a qualified clinician. |
| Hepatic Impairment | Dose reduction may be necessary in patients with liver impairment. Monitor liver function closely. Individualize by a qualified clinician. |
| Maximum Daily Dose | Not established from the available information. Doses are individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ifomid m 400mg/2gm injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Live vaccines | Major | |
| Aminoglycosides | Major | |
| Amphotericin B | Major | |
| Rifampin | Moderate | |
| Phenytoin | Moderate | |
| Ketoconazole | Moderate | |
| Clarithromycin | Moderate | |
| Ondansetron | Minor | |
| Grapefruit | Moderate |
🚨 Major Interactions
- Warfarin
- Live vaccines
- Nephrotoxic drugs (e.g., aminoglycosides, amphotericin B)
⚡ Moderate Interactions
- CYP3A4 inducers (e.g., rifampin, phenytoin)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine, as it may increase the risk of liver toxicity and worsen nausea and vomiting.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ifosfamide or mesna","Severe bone marrow suppression","Active infection","Severe kidney impairment","Severe liver impairment","Pregnancy","Breastfeeding"]
⚠️ Warnings & Precautions
["Administer only under supervision of an oncologist.","Ensure adequate hydration and frequent voiding to reduce bladder toxicity.","Mesna must be given with ifosfamide to prevent hemorrhagic cystitis.","Monitor blood counts closely; dose adjustments may be needed.","Avoid live vaccines during treatment.","Use effective contraception during and after treatment.","May cause drowsiness or confusion; avoid driving or operating machinery until effects are known.","Report any signs of infection, bleeding, or urinary symptoms immediately."]
🤱 Lactation Safety
Not established from the available information. Breastfeeding is not recommended during treatment and for a period after.
💊 Overdose Management
Overdose of ifosfamide can cause severe bone marrow suppression, hemorrhagic cystitis, and central nervous system toxicity. There is no specific antidote. Management is supportive, including hydration, mesna administration, and blood product transfusions as needed. Contact a poison control center or emergency services immediately.
⏰ Missed Dose
This medicine is administered by healthcare professionals in a clinical setting. If a scheduled dose is missed, contact your healthcare provider immediately to reschedule. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be administered only by a qualified healthcare professional in a hospital or clinic setting. Do not attempt to self-administer. Inform your doctor about all other medicines, supplements, and herbal products you are taking, as many can interact. Drink plenty of fluids as advised to help protect your bladder. Avoid contact with people who have infections. Use effective contraception during treatment and for a period after, as this medicine can harm an unborn baby. Do not breastfeed while receiving this medicine. Regular blood tests and urine tests are necessary to monitor for side effects. Report any unusual symptoms promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially kidney and bone marrow toxicity. Close monitoring and dose adjustments may be necessary.
🤰 Pregnancy Planning (TTC)
This medicine can cause harm to an unborn baby. Use effective contraception during treatment and for at least 6 months after. Discuss fertility preservation options before starting treatment if you plan to have children in the future.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your doctor. This medicine can affect wound healing and increase the risk of infection. Your doctor will decide the appropriate timing for treatment.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine. It can increase the risk of bleeding and infection. Your dentist may recommend postponing non-urgent dental work until your blood counts recover.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Consult your doctor before starting any exercise program. Fatigue is common, so balance activity with rest. Avoid strenuous activities if you have low blood counts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may experience fatigue, nausea, and increased risk of infection, which can affect your ability to work. Discuss with your employer about flexible hours or remote work options. Avoid operating heavy machinery if you feel drowsy or confused.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your oncologist. Treatment duration is determined by your doctor based on your response and side effects. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term effects may include kidney damage, infertility, and an increased risk of secondary cancers. Regular follow-up with your oncologist is essential to monitor for these effects. Some side effects may persist or appear months to years after treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the cancer type, other chemotherapy drugs or combinations may be used.
Evidence: Well-establishedFor some cancers, targeted drugs may be an option.
Evidence: Established for specific cancers💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Avoid live vaccines during treatment and for a period after, as your immune system may be weakened. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original packaging
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a hospital or clinic setting, so travel is not applicable for self-administration. If you are traveling for treatment, carry your prescription and medical records. Ensure you have a copy of your treatment plan. Discuss any travel plans with your oncologist in advance.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects of this medicine are not immediate. It works over time to damage cancer cells. Your doctor will monitor your response with regular tests.
A: This medicine can cause drowsiness or confusion. Avoid driving or operating machinery until you know how it affects you.
A: No, this medicine can harm an unborn baby. Use effective contraception during treatment and for a period after. Consult your doctor if you are pregnant or planning pregnancy.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Ifosfamide is safe to take at home.
Fact: Ifosfamide must be administered by a healthcare professional in a clinical setting. - Myth: Mesna is a chemotherapy drug.
Fact: Mesna is a protective agent that helps prevent bladder toxicity caused by ifosfamide. - Myth: Ifosfamide does not cause hair loss.
Fact: Hair loss is a common side effect of ifosfamide.