Holoxan Uromitexan 200mg/1gm Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in urine or painful urination
- Fever, chills, or signs of infection
- Unusual bleeding or bruising
- Confusion, drowsiness, or hallucinations
- Chest pain or difficulty breathing
- Decreased urine output or swelling
- Severe abdominal pain
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is ifomid m 1g injection used for?
This medicine is a combination of ifosfamide, a chemotherapy drug, and mesna, a protective agent that prevents bladder damage. It is given intravenously by a healthcare professional to treat certain cancers, including testicular cancer and sarcomas. Mesna helps reduce the risk of hemorrhagic cystitis, a serious side effect of ifosfamide.
- Generic Name: Mesna (200mg) + Ifosfamide (1gm)
- Manufacturer: United Biotech Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ifomid m 1g injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक विशेष कीमोथेरेपी उपचार है जिसका उपयोग कुछ प्रकार के कैंसर के इलाज के लिए किया जाता है, जैसे कि टेस्टिकुलर कैंसर, सॉफ्ट टिश्यू सारकोमा, और कुछ लिम्फोमा। इसमें इफोस्फामाइड नामक कीमोथेरेपी दवा और मेसना नामक एक सुरक्षात्मक दवा शामिल है। मेसना मूत्राशय को इफोस्फामाइड के कारण होने वाले गंभीर नुकसान से बचाती है। यह दवा केवल अस्पताल या कैंसर क्लिनिक में एक स्वास्थ्य पेशेवर द्वारा नस के माध्यम से दी जाती है। इसे घर पर स्वयं न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, भूख न लगना, बालों का झड़ना और थकान शामिल हैं। गंभीर दुष्प्रभावों में मूत्र में रक्त आना, दर्दनाक पेशाब, बुखार, संक्रमण, भ्रम, और गुर्दे की समस्या शामिल हो सकती है। यदि आपको कोई भी गंभीर लक्षण दिखाई दे, तो तुरंत चिकित्सकीय सहायता लें।
सुरक्षा सलाह: यह दवा केवल एक योग्य स्वास्थ्य पेशेवर द्वारा नियंत्रित चिकित्सा सेटिंग में दी जानी चाहिए। उपचार के दौरान खूब पानी पिएं। मूत्र में रक्त, दर्द या पेशाब में जलन होने पर तुरंत डॉक्टर को बताएं। संक्रमण से बचें और हाथों की स्वच्छता बनाए रखें। गर्भवती होने या स्तनपान कराने की स्थिति में डॉक्टर को सूचित करें। उपचार के दौरान और बाद में गर्भनिरोधक का उपयोग करें। शराब से बचें।
💊 ifomid m 1g injection Uses & Benefits
[{"condition":"Testicular cancer","description":"This medicine is used as part of combination chemotherapy regimens to treat germ cell tumors of the testis, often in patients with advanced disease.","evidence":"Well-established"},{"condition":"Soft tissue sarcoma","description":"It is effective in treating various soft tissue sarcomas, including synovial sarcoma and leiomyosarcoma, often in combination with other agents.","evidence":"Well-established"},{"condition":"Non-Hodgkin lymphoma","description":"Used in some salvage chemotherapy regimens for relapsed or refractory non-Hodgkin lymphoma.","evidence":"Moderate"},{"condition":"Ewing sarcoma","description":"Part of multi-agent chemotherapy for Ewing sarcoma, a type of bone cancer that mainly affects children and young adults.","evidence":"Well-established"},{"condition":"Osteosarcoma","description":"Sometimes included in chemotherapy protocols for osteosarcoma, especially in metastatic or recurrent settings.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Small cell lung cancer","description":"Occasionally used off-label in combination regimens for extensive-stage small cell lung cancer.","evidence":"Limited"},{"condition":"Ovarian cancer","description":"Rarely used off-label for platinum-resistant ovarian cancer in some institutional protocols.","evidence":"Limited"}]
Primary treatment for: Cancer (various types)
Also treats: Testicular cancer, Soft tissue sarcoma, Ewing sarcoma, Non-Hodgkin lymphoma, Osteosarcoma
📋 Drug Information
| Generic Name(s) | Mesna (200mg) + Ifosfamide (1gm) |
| Brand Name | ifomid m 1g injection |
| Manufacturer | United Biotech Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store this medicine in its original packaging at room temperature, between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Do not freeze. Keep out of reach of children. Once reconstituted or diluted, the solution should be used immediately or stored as directed by the manufacturer. Follow institutional guidelines for handling and disposal of cytotoxic drugs. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture when stored as directed. Check the expiry date on the packaging before use. Do not use if the expiry date has passed. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ifosfamide is a prodrug that requires activation by liver enzymes to form its active metabolite, which then acts as an alkylating agent. It attaches alkyl groups to DNA, causing cross-linking of DNA strands and preventing cancer cells from replicating. Mesna is not an anti-cancer drug; it works by providing a sulfhydryl group that binds to acrolein, a toxic metabolite of ifosfamide excreted in urine. This binding inactivates acrolein, protecting the bladder lining from damage.
Mechanism Steps
💡 How to Take ifomid m 1g injection
Strength: This medicine is supplied as a kit containing ifosfamide 1g injection and mesna 200mg injection. The exact strength and combination may vary. Always check the label.
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and depends on the specific cancer being treated, the patient's body surface area, kidney function, and overall health. It is usually given as part of a combination chemotherapy regimen. A common regimen may involve ifosfamide given intravenously over several hours, with mesna given at the same time and repeated after the ifosfamide infusion to protect the bladder. The exact dose and schedule must be determined by a qualified oncologist. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist for dosing in children. |
| Elderly Dosage | Elderly patients may be more susceptible to the toxic effects of this medicine, especially bone marrow suppression, kidney toxicity, and neurotoxicity. Doses may need to be reduced based on kidney function and overall health. Close monitoring is required. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Ifosfamide is excreted by the kidneys, and dose reduction is necessary in patients with renal impairment. The dose should be adjusted based on creatinine clearance. In patients with severe renal impairment, this medicine is contraindicated. Close monitoring of renal function is essential. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | Ifosfamide is metabolized in the liver, and dose reduction may be necessary in patients with hepatic impairment. Close monitoring of liver function is required. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the specific treatment protocol. It should not exceed the dose determined by the treating oncologist. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ifomid m 1g injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Cisplatin | Major | |
| Live vaccines | Major | |
| Rifampin | Major | |
| Ketoconazole | Major | |
| Allopurinol | Moderate | |
| Amphotericin B | Moderate | |
| Aminoglycosides | Moderate | |
| Ondansetron | Minor | |
| Grapefruit | Moderate |
🚨 Major Interactions
- Warfarin
- Cisplatin
- Live vaccines
- CYP3A4 inducers (e.g., rifampin, phenytoin)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
⚡ Moderate Interactions
- Allopurinol
- Amphotericin B
- Aminoglycosides
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. Alcohol can worsen nausea, vomiting, and fatigue, and may increase the risk of liver toxicity. It can also exacerbate central nervous system side effects such as drowsiness and confusion.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ifosfamide, mesna, or any component of the formulation","Severe bone marrow suppression","Active infection","Severe renal impairment","Severe hepatic impairment","Pregnancy","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine should only be administered by experienced oncology professionals.","Hemorrhagic cystitis can occur; mesna is given to reduce this risk. Adequate hydration is essential.","Bone marrow suppression is common; monitor blood counts regularly.","Neurotoxicity can occur; monitor for confusion, drowsiness, or hallucinations.","Renal toxicity can occur; monitor kidney function and maintain hydration.","Avoid live vaccines during treatment.","Use effective contraception during and after treatment.","Do not breastfeed during treatment.","May cause infertility; discuss fertility preservation before treatment.","May increase risk of secondary cancers."]
🤱 Lactation Safety
It is not known whether ifosfamide or mesna are excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment and for at least 1 month after the last dose.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. Overdose may cause severe bone marrow suppression, hemorrhagic cystitis, and neurotoxicity. Management should be supportive and symptomatic, including close monitoring of blood counts, renal function, and neurological status. Mesna may be continued to protect the bladder. In case of overdose, contact a poison control center or emergency department immediately.
⏰ Missed Dose
This medicine is given by a healthcare professional in a clinical setting. If you miss an appointment for your dose, contact your oncology team as soon as possible to reschedule. Do not attempt to self-administer this medicine at home.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a controlled medical setting. Do not attempt to administer it yourself. Before each dose, your doctor will check your blood counts, kidney function, and urine to ensure it is safe for you to receive treatment. You will likely receive fluids and mesna along with ifosfamide to help protect your bladder. Drink plenty of fluids as advised by your nurse or doctor to help flush your bladder. Report any blood in your urine, painful urination, or lower abdominal pain immediately. Avoid contact with people who have infections, and practice good hand hygiene because your immune system may be weakened. Do not receive any live vaccines while on this medicine. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Use effective contraception during treatment and for some time after, as this medicine can harm an unborn baby. Avoid alcohol while on this medicine as it can worsen side effects. Keep all appointments for blood tests and follow-up visits.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially bone marrow suppression, kidney toxicity, and neurotoxicity. Doses may need to be reduced, and monitoring should be more frequent.
🤰 Pregnancy Planning (TTC)
This medicine can cause harm to an unborn baby. Women should use effective contraception during treatment and for at least 6 months after the last dose. Men should also use contraception for at least 6 months after treatment. Discuss pregnancy planning with your doctor before starting treatment.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your doctor. This medicine can affect wound healing and increase the risk of bleeding. Your doctor will decide the appropriate timing for treatment after surgery.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine. It can increase the risk of bleeding and infection. Dental procedures may need to be postponed until your blood counts recover. Consult your oncologist before any dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise may need to be modified during treatment due to fatigue and increased risk of bleeding. Avoid contact sports or activities that could cause injury. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, drowsiness, and confusion, which can affect your ability to work or drive. Avoid driving or operating heavy machinery until you know how this medicine affects you. You may need to take time off work during treatment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your oncologist. Treatment is usually continued for a specific number of cycles. If you experience severe side effects, your doctor may adjust or stop treatment. Always follow your doctor's instructions.
📅 Long-Term Use Effects
Long-term effects of this medicine may include infertility, increased risk of secondary cancers, and chronic kidney problems. Regular follow-up with your oncologist is essential to monitor for these effects. Some patients may experience persistent fatigue or neuropathy. Discuss any long-term concerns with your healthcare team.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the cancer type, other chemotherapy drugs or combinations may be used.
Evidence: Well-establishedFor some cancers, targeted therapies may be an option.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine due to the risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a hospital or clinic setting, so travel is not applicable for self-administration. If you are traveling to receive treatment, carry a copy of your prescription and medical records. Ensure that your treatment schedule is coordinated with your healthcare team. Store the medicine as directed by the manufacturer. Check customs regulations for carrying cytotoxic drugs.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The anti-cancer effects begin after the first dose, but it may take weeks or months to see a response. Your doctor will monitor your progress with scans and tests.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: Contact your doctor immediately. Blood in urine can be a sign of hemorrhagic cystitis, a serious side effect.
🤔 Common Patient Concerns
🔄 Substitutes for ifomid m 1g injection
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is given only by intravenous infusion in a hospital or clinic setting. - Myth: Mesna is a chemotherapy drug.
Fact: Mesna is not a chemotherapy drug; it is a protective agent that prevents bladder damage caused by ifosfamide. - Myth: You can stop this medicine when you feel better.
Fact: Treatment must be completed as prescribed by your oncologist. Stopping early can reduce effectiveness.
🔄 Alternative Options
Generic Alternatives
- Ifosfamide injection
- Mesna injection
Brand Alternatives
- Holoxan Uromitexan 200mg/1gm Injection