ibusoft 400mg tablet - Dexibuprofen (400mg) medicine

Ibusoft 400mg Tablet: Comprehensive Guide to Uses, Side Effects, and Safety

No reviews yet
🏭 Emcure Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 24, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not established from the available information. However, NSAIDs like dexibuprofen are generally avoided in the third trimester due to risk of premature closure of the ductus arteriosus and other complications. Use in the first and second trimester should be only if clearly needed and after consulting a doctor. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Oct 24, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bleeding or bruising
  • Severe skin rash with blisters or peeling

If experiencing severe symptoms, call emergency services immediately.

What is ibusoft 400mg tablet used for?

This medicine is an NSAID containing dexibuprofen 400 mg, used to relieve pain and inflammation in conditions like arthritis, musculoskeletal pain, and menstrual cramps. It works by inhibiting COX-2 enzymes. Take it with food to reduce stomach upset, and avoid alcohol. Do not exceed 1200 mg per day.

  • Generic Name: Dexibuprofen (400mg)
  • Manufacturer: Emcure Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ibusoft 400mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डेक्सिबुप्रोफेन 400 मिलीग्राम युक्त एक तत्काल रिलीज टैबलेट है, जिसका उपयोग दर्द और सूजन को कम करने के लिए किया जाता है। यह ऑस्टियोआर्थराइटिस, रुमेटॉइड आर्थराइटिस, एंकिलोजिंग स्पॉन्डिलाइटिस, तीव्र मस्कुलोस्केलेटल दर्द और मासिक धर्म के दर्द में प्रभावी है। यह शरीर में प्रोस्टाग्लैंडिन नामक रसायनों के उत्पादन को कम करके काम करती है, जो दर्द और सूजन का कारण बनते हैं। इसे भोजन के साथ लेना चाहिए ताकि पेट में जलन न हो। इस दवा को डॉक्टर की सलाह के बिना न लें और न ही अधिक मात्रा में लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सीने में जलन, दस्त, कब्ज, सिरदर्द, चक्कर आना और दाने शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें पेट या आंतों में रक्तस्राव, गुर्दे की समस्या, यकृत की समस्या, गंभीर त्वचा प्रतिक्रियाएं और हृदय संबंधी घटनाएं शामिल हो सकती हैं। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, पेशाब में कमी, त्वचा या आंखों का पीलापन, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक से अधिक न लें। इसे भोजन के साथ या बाद में पानी के साथ लें। अन्य NSAIDs जैसे एस्पिरिन, आइबुप्रोफेन के साथ न लें। शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ सकता है। यदि आपको पेट के अल्सर, हृदय रोग, गुर्दे या यकृत की बीमारी है, तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बिना डॉक्टर की सलाह के 7 दिनों से अधिक न लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 ibusoft 400mg tablet Uses & Benefits

[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Helps alleviate back pain and stiffness associated with ankylosing spondylitis.","evidence":"Well-established"},{"condition":"Acute musculoskeletal pain","description":"Provides relief from acute pain due to strains, sprains, and other soft tissue injuries.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label to prevent migraines, but evidence is limited.","evidence":"Limited"},{"condition":"Postoperative pain","description":"May be used off-label for short-term management of postoperative pain.","evidence":"Limited"}]

Primary treatment for: Osteoarthritis

Also treats: Rheumatoid arthritis, Ankylosing spondylitis, Acute musculoskeletal pain, Primary dysmenorrhea

📋 Drug Information

Generic Name(s)Dexibuprofen (400mg)
Brand Nameibusoft 400mg tablet
ManufacturerEmcure Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassNSAID's- Non-Selective COX 1&2 Inhibitors (propionic acid)
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food or milk to minimize stomach irritation.
2
Use the lowest effective dose for the shortest duration necessary to control symptoms.
3
Avoid taking this medicine with other NSAIDs, including over-the-counter pain relievers.
4
Monitor for signs of gastrointestinal bleeding, such as black stools or vomiting blood.
5
If you have high blood pressure, heart disease, or kidney disease, use this medicine with caution and under medical supervision.
6
Do not use this medicine for more than 7 days for pain relief without consulting your doctor.
7
Inform your doctor if you are taking blood thinners, corticosteroids, or antidepressants.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic joint pain
This medicine is commonly prescribed for this.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Menstrual cramps
This medicine is effective for primary dysmenorrhea.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDexibuprofen is rapidly absorbed from the gastrointestinal tract after oral administration. The absorption is not significantly affected by food, but taking it with food may delay the time to peak concentration.
DistributionDexibuprofen is highly bound to plasma proteins, primarily albumin. It distributes into synovial fluid, which is important for its anti-inflammatory effect in joints.
Protein BindingApproximately 99% bound to plasma proteins.
MetabolismDexibuprofen is extensively metabolized in the liver, primarily by cytochrome P450 enzymes, mainly CYP2C9. The main metabolites are hydroxylated and carboxylated derivatives, which are pharmacologically inactive.
Half-LifeThe elimination half-life of dexibuprofen is approximately 2 to 3 hours.
ExcretionMetabolites are excreted primarily in the urine (about 90%) and to a lesser extent in the feces. Less than 1% is excreted unchanged.
BioavailabilityThe oral bioavailability of dexibuprofen is approximately 80-90%.
Onset of ActionPain relief typically begins within 30 to 60 minutes after oral administration.
Peak Plasma TimePeak plasma concentrations are reached approximately 1.5 to 2 hours after oral administration on an empty stomach; with food, it may be delayed to 2 to 3 hours.
Duration of ActionThe analgesic effect lasts approximately 4 to 6 hours, but the anti-inflammatory effect may persist longer with regular dosing.

How It Works

This medicine works by reversibly inhibiting the cyclooxygenase (COX) enzymes, with a preference for COX-2 over COX-1. By inhibiting COX-2, it reduces the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. This leads to analgesic, anti-inflammatory, and antipyretic effects. The preferential COX-2 inhibition may result in a lower risk of gastrointestinal side effects compared to non-selective NSAIDs, but it does not eliminate the risk entirely.

Mechanism Steps

1
Inhibition of COX-2: This medicine selectively binds to and inhibits the COX-2 enzyme, reducing the conversion of arachidonic acid to prostaglandin H2.
2
Reduced prostaglandin synthesis: Decreased production of prostaglandins, which are key mediators of pain, inflammation, and fever.
3
Analgesic and anti-inflammatory effects: The reduction in prostaglandins leads to decreased pain perception and reduced inflammation at the site of injury or disease.
4
Antipyretic effect: Prostaglandin reduction in the hypothalamus leads to lowering of elevated body temperature.

💡 How to Take ibusoft 400mg tablet

Strength: 400 mg immediate-release tablet.

1Take the tablet with a full glass of water.
2Swallow the tablet whole; do not crush or chew.
3Take with or immediately after food to reduce stomach upset.
4Follow the prescribed dose and frequency exactly.
5Do not take more than the recommended dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 200 mg to 400 mg taken orally two to three times daily, depending on the severity of the condition and the patient's response. The maximum recommended daily dose is 1200 mg. For osteoarthritis and rheumatoid arthritis, the typical dose is 400 mg two to three times daily. For acute pain, a starting dose of 400 mg may be used, followed by 200 mg every 4-6 hours as needed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially gastrointestinal and kidney side effects. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function.
Renal ImpairmentIn patients with mild to moderate renal impairment, no dose adjustment is usually necessary, but caution is advised. In severe renal impairment, this medicine is contraindicated. Dose must be individualized by a qualified clinician based on renal function.
Hepatic ImpairmentIn patients with mild to moderate hepatic impairment, no dose adjustment is usually necessary, but caution is advised. In severe hepatic impairment, this medicine is contraindicated. Dose must be individualized by a qualified clinician based on hepatic function.
Maximum Daily Dose1200 mg per day.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Increases risk of gastrointestinal bleeding.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ibusoft 400mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce nausea. If it persists, consult your doctor.
Abdominal pain (Common (5-10%))
Take with food. If pain is severe or persistent, contact your doctor.
Heartburn (Common (5-10%))
Avoid lying down immediately after taking. Use antacids if needed, but consult your doctor.
Headache (Common (5-10%))
Usually resolves on its own. If severe, consult your doctor.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how this medicine affects you.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black or tarry stools, vomiting blood, or severe abdominal pain.
Kidney impairment (Rare (<0.1%))
Report decreased urine output, swelling of legs, or fatigue to your doctor immediately.
Liver toxicity (Rare (<0.1%))
Seek medical help if you experience yellowing of skin or eyes, dark urine, or severe fatigue.
Severe skin reactions (Very rare (<0.01%))
Stop the medicine and seek immediate medical attention if you develop a rash with blisters, peeling skin, or fever.
Cardiovascular events (Rare (<0.1%))
Seek emergency care if you experience chest pain, shortness of breath, or weakness in one side of the body.

⚠️ Rare Side Effects

Aseptic meningitis
Seek immediate medical attention if you experience severe headache, stiff neck, fever, and sensitivity to light.
Pancreatitis
Seek medical help if you have severe upper abdominal pain that radiates to your back.
Hepatitis
Report symptoms like jaundice, dark urine, or right upper abdominal pain to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Aspirin Major
Other NSAIDs Major
Methotrexate Major
Lithium Major
ACE inhibitors Moderate
Diuretics Moderate
Corticosteroids Moderate
SSRIs Moderate
Antacids Minor

🚨 Major Interactions

  • Warfarin
  • Aspirin
  • Other NSAIDs
  • Methotrexate
  • Lithium

⚡ Moderate Interactions

  • ACE inhibitors
  • Diuretics
  • Corticosteroids
  • SSRIs

🍷 Alcohol Interaction

Avoid consuming alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding and ulcers, and may also increase the risk of liver damage.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to dexibuprofen, ibuprofen, or other NSAIDs","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs","Active peptic ulcer or gastrointestinal bleeding","Severe heart failure","Severe liver impairment","Severe kidney impairment","Third trimester of pregnancy","Coronary artery bypass graft (CABG) surgery perioperative period"]

⚠️ Warnings & Precautions

["Take with food to reduce gastrointestinal irritation.","Avoid alcohol consumption.","Do not use with other NSAIDs.","Use with caution in elderly patients due to increased risk of side effects.","Monitor blood pressure regularly if you have hypertension.","May impair ability to drive or operate machinery if you experience dizziness.","Consult your doctor if you have a history of gastrointestinal ulcers or bleeding.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Do not use for more than 7 days for pain without medical advice.","Report any signs of bleeding, bruising, or unusual fatigue."]

🤱 Lactation Safety

Dexibuprofen is excreted in breast milk in small amounts. It is generally considered compatible with breastfeeding, but consult your doctor before use. Monitor the infant for any signs of adverse effects.

💊 Overdose Management

Overdose of this medicine may cause symptoms such as nausea, vomiting, abdominal pain, headache, dizziness, drowsiness, and in severe cases, gastrointestinal bleeding, kidney failure, liver damage, and coma. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be administered if the patient presents within 1-2 hours of ingestion. Monitor vital signs and provide supportive care.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take the tablet with a full glass of water, preferably with or after food to reduce stomach upset. Do not take this medicine with other NSAIDs, including aspirin, ibuprofen, naproxen, or selective COX-2 inhibitors, unless directed by your doctor. Avoid alcohol consumption while taking this medicine as it can increase the risk of stomach bleeding. If you have a history of stomach ulcers, heart disease, kidney disease, liver disease, or high blood pressure, inform your doctor before taking this medicine. Do not use this medicine for more than 7 days for pain relief without consulting your doctor. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children. Store at room temperature away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor kidney function and blood pressure regularly.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs may affect ovulation and are generally avoided during pregnancy, especially in the third trimester.

🏥 Post-Surgery Considerations

This medicine may be used for postoperative pain, but it should be avoided in patients undergoing coronary artery bypass graft (CABG) surgery due to increased risk of cardiovascular events. Consult your surgeon before taking this medicine after any surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding. Your dentist may advise you to stop it temporarily.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce joint stress.
🥗
Regular low-impact exercise like swimming or walking.
😴
Practice good posture to reduce strain on joints.
💧
Include anti-inflammatory foods like omega-3 fatty acids in your diet.
🧘
Get adequate sleep to help your body recover.
🌞
Avoid smoking as it can worsen inflammation and increase cardiovascular risk.

🏋️ Exercise Considerations

While taking this medicine, you may engage in light exercise if you feel able. However, avoid high-impact activities that may worsen joint pain or cause injury. Listen to your body and rest if you experience pain or dizziness.

🥗 Diet Recommendations

Include omega-3 rich foods like fish, flaxseeds, and walnuts.
Reduce intake of processed and fried foods.
Stay well hydrated by drinking plenty of water.
Eat a balanced diet rich in fruits and vegetables.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause stomach upset, so take it with food. Generally, it does not significantly impact daily activities if taken as prescribed.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if you experience severe side effects such as gastrointestinal bleeding, kidney problems, liver problems, or allergic reactions. Do not stop taking it abruptly if you are on long-term therapy without consulting your doctor.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of gastrointestinal bleeding, kidney impairment, liver damage, and cardiovascular events. Regular monitoring of kidney and liver function, blood pressure, and complete blood count is recommended. Use the lowest effective dose for the shortest duration possible.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can complement medicine for chronic pain and improve joint function.

Evidence: Well-established
Acupuncture

May help reduce pain in some individuals.

Evidence: Moderate
Topical NSAIDs

May provide localized pain relief with fewer systemic side effects.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If crossing time zones, adjust dosing schedule accordingly, but do not take a double dose. Check customs regulations for carrying prescription medicines. Keep a list of your medications and allergies with you.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old office worker with chronic knee pain
Started this medicine as prescribed for osteoarthritis. Within 2 weeks noticed significant improvement in morning stiffness. Emphasized taking with food to prevent stomach upset.
💡 Lesson: Consistency with prescribed dose and taking with food improves both efficacy and tolerability.
👤 A 30-year-old woman with severe menstrual cramps
Took this medicine at the onset of cramps and experienced relief within an hour. She was advised to take it with food and not to exceed the recommended dose.
💡 Lesson: Taking the medicine early in the course of pain can provide better relief. Always follow dosage instructions.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.

Q: Is it safe to take with other painkillers?

A: Do not take this medicine with other NSAIDs unless directed by your doctor, as it can increase the risk of side effects.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for ibusoft 400mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine is completely safe and can be taken without a prescription.
    Fact: This medicine is a prescription NSAID and can cause serious side effects like gastrointestinal bleeding and cardiovascular events. It should only be taken under medical supervision.
  • Myth: This medicine can be taken on an empty stomach without any issues.
    Fact: Taking this medicine on an empty stomach increases the risk of stomach upset and ulcers. It should be taken with food.
  • Myth: This medicine is safe to use during pregnancy.
    Fact: This medicine should be avoided in the third trimester and used only if clearly needed in the first and second trimesters after consulting a doctor.

🔄 Alternative Options

Generic Alternatives

  • Dexibuprofen 400 mg tablet

Brand Alternatives

  • Ibusoft 400mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"Dexibuprofen","class":"NSAID (preferential COX-2 inhibitor)","half_life":"2-3 hours","common_uses":"Arthritis, musculoskeletal pain, dysmenorrhea","gi_risk":"Moderate","cardiovascular_risk":"Moderate"},{"medicine":"Ibuprofen","class":"NSAID (non-selective)","half_life":"2-4 hours","common_uses":"Pain, fever, inflammation","gi_risk":"Moderate to high","cardiovascular_risk":"Moderate"},{"medicine":"Naproxen","class":"NSAID (non-selective)","half_life":"12-17 hours","common_uses":"Arthritis, pain, inflammation","gi_risk":"Moderate to high","cardiovascular_risk":"Moderate"}]

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory