D Mithate 3MIU Injection (Colistimethate Sodium): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Decreased urine output or no urine for several hours
- Sudden swelling of face, lips, or throat
- Difficulty breathing or shortness of breath
- Severe muscle weakness or inability to move limbs
- Confusion, seizures, or slurred speech
- Severe abdominal pain or persistent diarrhoea
- Yellowing of skin or eyes
- Chest pain or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is ibicolist 3million iu injection used for?
This medicine is a hospital-only injectable antibiotic containing colistimethate sodium, used to treat serious infections caused by multidrug-resistant Gram-negative bacteria. It works by breaking down the bacterial outer membrane and is given under strict medical supervision because of its risk of kidney and nerve side effects.
- Generic Name: Colistimethate Sodium (3Million IU)
- Manufacturer: Indiabulls pharmaceutical ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ibicolist 3million iu injection के बारे में (Hindi Summary)
उपयोग: यह दवा कोलिस्टिमेथेट सोडियम नामक एंटीबायोटिक का इंजेक्शन है, जिसका उपयोग अस्पताल में गंभीर संक्रमणों के इलाज के लिए किया जाता है। यह उन बैक्टीरिया के खिलाफ काम करती है जो कई अन्य एंटीबायोटिक्स के प्रति प्रतिरोधी हो चुके हैं, जैसे कि एसिनेटोबैक्टर, स्यूडोमोनास और क्लेबसिएला। यह दवा निमोनिया, खून के संक्रमण, पेशाब की नली के संक्रमण और पेट के संक्रमण में दी जाती है। यह केवल डॉक्टर की देखरेख में अस्पताल में ही दी जाती है, क्योंकि इससे किडनी और नसों पर गंभीर दुष्प्रभाव हो सकते हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में किडनी पर असर, पेशाब कम आना, हाथ-पैरों में झनझनाहट या सुन्नपन, चक्कर आना, कमजोरी, जी मिचलाना, उल्टी और इंजेक्शन की जगह पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में तीव्र किडनी की समस्या, मांसपेशियों में कमजोरी, सांस लेने में कठिनाई, दौरे पड़ना और एलर्जी की प्रतिक्रिया हो सकती है। इन लक्षणों को तुरंत डॉक्टर को बताना चाहिए।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। इसे घर पर खुद से न लगवाएं। इलाज से पहले अपने डॉक्टर को अपनी सभी दवाओं, किडनी की बीमारी, एलर्जी और गर्भावस्था के बारे में बताएं। इलाज के दौरान किडनी की जांच और पेशाब की मात्रा पर नजर रखी जाती है। अगर पेशाब कम आए, हाथ-पैर सुन्न हों, मांसपेशियों में कमजोरी या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर को बताएं। दवा का कोर्स पूरा करें और बिना डॉक्टर की सलाह के बंद न करें।
💊 ibicolist 3million iu injection Uses & Benefits
[{"condition":"Multidrug-resistant Gram-negative infections","description":"Used to treat serious infections caused by carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae when other options are limited.","evidence":"Well-established in hospital settings"},{"condition":"Hospital-acquired pneumonia and ventilator-associated pneumonia","description":"Prescribed for severe lung infections caused by resistant Gram-negative bacteria, often in intensive care patients.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Used for resistant Gram-negative urinary infections, especially when kidney function is monitored closely.","evidence":"Established"},{"condition":"Bloodstream infections and sepsis","description":"Given for life-threatening bloodstream infections caused by resistant Gram-negative organisms.","evidence":"Established"},{"condition":"Intra-abdominal infections","description":"Used in combination with other antibiotics for complicated intra-abdominal infections caused by resistant bacteria.","evidence":"Limited to specific resistant organisms"}]
Off-label uses: [{"condition":"Aerosolised or nebulised therapy for resistant lung infections","description":"Sometimes used off-label by inhalation for adjunctive treatment of resistant respiratory infections, but this is not the approved route for this injection product.","evidence":"Limited"},{"condition":"Intraventricular or intrathecal administration for central nervous system infections","description":"Rarely used off-label for resistant meningitis or ventriculitis when systemic therapy is inadequate.","evidence":"Limited"}]
Primary treatment for: Multidrug-resistant Gram-negative bacterial infections
Also treats: Hospital-acquired pneumonia, Ventilator-associated pneumonia, Complicated urinary tract infections, Bloodstream infections, Intra-abdominal infections
📋 Drug Information
| Generic Name(s) | Colistimethate Sodium (3Million IU) |
| Brand Name | ibicolist 3million iu injection |
| Manufacturer | Indiabulls pharmaceutical ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Cell membrane active agent |
| Route of Administration | Parenteral (intravenous or intramuscular injection). This medicine is supplied as a powder for injection and must be reconstituted and administered by a qualified healthcare professional |
| Storage | Store the unreconstituted vial at controlled room temperature between 20°C and 25°C (68°F to 77°F). Protect from light and moisture. Once reconstituted, use immediately or store as directed by the manufacturer. Do not freeze. |
| Shelf Life | Refer to the expiry date printed on the vial. Do not use after the expiry date. Once reconstituted, the solution should be used within the time specified by the manufacturer, usually within 24 hours if refrigerated. |
| WHO Guideline | The World Health Organization includes colistin in its list of essential medicines for the treatment of serious infections caused by multidrug-resistant Gram-negative bacteria. It is recommended as a last-resort option when other antibiotics are not effective. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) recommends colistin as a reserve antibiotic for the treatment of infections caused by carbapenem-resistant Gram-negative bacteria, with strict adherence to antimicrobial stewardship and monitoring for toxicity. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Colistimethate sodium is an inactive prodrug that is hydrolysed in the body to colistin, a polymyxin antibiotic. Colistin binds to the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. This binding displaces calcium and magnesium ions, destabilises the membrane, increases permeability, and causes leakage of intracellular contents, leading to rapid bacterial death. Because of this mechanism, it is active against many multidrug-resistant Gram-negative bacteria, but it has no useful activity against Gram-positive bacteria, fungi, or viruses.
Mechanism Steps
💡 How to Take ibicolist 3million iu injection
Strength: Powder for injection, 3 million IU per vial.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the type and severity of infection, body weight, and kidney function. A typical adult dose may range from 2.5 to 5 mg of colistin base activity per kilogram per day, divided into two to four doses, but the exact dose and interval must be determined by the treating doctor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Doses are individualized based on weight, age, and kidney function, and must only be given under specialist supervision. |
| Elderly Dosage | Elderly patients are more likely to have reduced kidney function and are at higher risk of nephrotoxicity and neurotoxicity. Dose must be adjusted based on renal function and monitored closely. |
| Renal Impairment | Dose reduction is required in patients with renal impairment. The dose and dosing interval should be adjusted according to creatinine clearance or estimated glomerular filtration rate. Close monitoring of kidney function is essential. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment, but liver function should be monitored. Use with caution in patients with severe liver disease. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the indication, patient weight, and renal function. It must be determined by a qualified clinician. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ibicolist 3million iu injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | |
| Amphotericin B | Major | |
| Vancomycin | Major | |
| NSAIDs | Major | |
| Loop diuretics | Major | |
| Neuromuscular blockers | Major | |
| Cyclosporine | Moderate | |
| Tacrolimus | Moderate | |
| Cephalosporins | Moderate | |
| Anticholinergics | Minor |
🚨 Major Interactions
- Other nephrotoxic drugs (e.g., aminoglycosides, amphotericin B, vancomycin, NSAIDs)
- Neuromuscular blocking agents (e.g., vecuronium, pancuronium)
- Loop diuretics (e.g., furosemide)
⚡ Moderate Interactions
- Cephalosporins
- Cyclosporine
- Tacrolimus
🍷 Alcohol Interaction
Alcohol may increase the risk of kidney and liver problems and can worsen dizziness or drowsiness. It is best to avoid alcohol while receiving this medicine, especially in hospital settings.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to colistimethate sodium or other polymyxins","Severe renal impairment without appropriate dose adjustment and monitoring","Myasthenia gravis (may worsen muscle weakness)","Concurrent use with other nephrotoxic or neurotoxic drugs unless benefits outweigh risks"]
⚠️ Warnings & Precautions
["This medicine must be used only under medical supervision in a hospital setting.","Kidney function must be monitored before and during treatment.","Dose must be adjusted in patients with renal impairment.","Avoid concurrent use with other nephrotoxic or neurotoxic drugs if possible.","Use with caution in patients with neuromuscular disorders.","Not effective against viral, fungal, or Gram-positive bacterial infections.","Prolonged use may lead to overgrowth of non-susceptible organisms.","Ensure adequate hydration unless otherwise advised.","Do not use if the solution is cloudy or contains particles.","Follow strict aseptic technique during preparation and administration."]
🤱 Lactation Safety
Colistimethate sodium may pass into breast milk in small amounts. Breastfeeding should be discussed with the doctor, and the benefits and risks must be weighed before use.
💊 Overdose Management
Overdose may cause severe kidney damage, muscle weakness, and breathing difficulty. Treatment is supportive and symptomatic. There is no specific antidote. Immediate medical attention, monitoring of kidney function, and possibly dialysis may be required. Contact a poison control centre or emergency department immediately if overdose is suspected.
⏰ Missed Dose
Because this medicine is given by a healthcare professional in a hospital or clinic, missed doses are managed by the treating team. If you miss an appointment for your dose, contact your healthcare provider as soon as possible. Do not attempt to self-administer or double the dose.
Additional Safety Advice
This medicine must only be given by a trained healthcare professional in a hospital or supervised clinical setting. Do not attempt to use it at home or without medical supervision. Before treatment, inform your doctor about all your medicines, especially other antibiotics, diuretics, muscle relaxants, and kidney-affecting drugs. Your kidney function, urine output, and neurological status will be checked regularly during therapy. Tell your doctor immediately if you notice decreased urination, swelling, numbness, tingling, muscle weakness, or difficulty breathing. Do not stop or change the dose on your own, because incomplete treatment can lead to resistant bacteria. Use effective contraception if you are of childbearing potential, and inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Keep all follow-up appointments for blood tests and clinical review.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney damage and nerve problems from this medicine. Kidney function declines with age, so dose adjustment and close monitoring are especially important. Falls and confusion may occur; ensure a safe environment and report any new symptoms promptly.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this medicine with your doctor before conception. It should be used during pregnancy only if clearly needed and prescribed by a specialist. Effective contraception is advised during treatment unless otherwise directed.
🏥 Post-Surgery Considerations
This medicine may be used after surgery if a resistant infection develops. Your surgical team will monitor the wound, kidney function, and overall recovery. Follow all post-operative instructions and report any signs of infection or side effects immediately.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. There is no direct interaction with dental procedures, but your overall medical condition and kidney function should be considered. Your dentist may consult your doctor before planning any procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise while you are recovering from a serious infection. Gentle movement and physiotherapy may be recommended by your doctor. If you experience muscle weakness, dizziness, or breathing difficulty, stop exercising and seek medical advice.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or supervised setting, so it may require time away from work. You may feel tired, dizzy, or weak during treatment. Avoid driving or operating heavy machinery until you feel fully recovered and your doctor approves. Discuss your work schedule with your employer and healthcare team.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. The duration of treatment is decided by your doctor based on the infection and your response. If you experience severe side effects such as kidney problems, breathing difficulty, or muscle weakness, your doctor may stop or change the treatment. Always consult your healthcare provider before stopping.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of kidney damage and nerve problems. Regular monitoring of kidney function and neurological status is required. In some patients, kidney function may not fully recover after treatment. Prolonged use can also lead to bacterial resistance, so it should be used only for the prescribed duration and indication.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
If the bacteria are susceptible to safer antibiotics, those may be preferred.
Evidence: Well-establishedSometimes used with other antibiotics to improve efficacy and reduce resistance.
Evidence: Limited to specific scenariosDraining abscesses or removing infected devices can help resolve infection along with antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, patients with serious infections may have a reduced immune response to vaccines. Discuss routine vaccinations with your doctor after recovery.
📦 Storage Guide
✅ DO
Store the unreconstituted vial at room temperature (20-25°C)
❌ DON'T
Do not freeze the vial
✅ DO
Protect from light and moisture
❌ DON'T
Do not store in direct sunlight or in a bathroom
✅ DO
Keep in the original carton until use
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Use reconstituted solution within the time specified by the manufacturer
❌ DON'T
Do not use if the solution is cloudy or contains particles
✈️ Traveling with This Medicine
This medicine is given in a hospital or clinic and is not for self-administration during travel. If you are being discharged with a prescription for home infusion, carry the original packaging, a copy of your prescription, and a doctor's letter explaining the need for the injection. Store the vials at room temperature, protect them from light, and do not freeze. Check with your airline and destination country about carrying injectable medicines and customs requirements. Arrange for a healthcare professional to administer the dose at your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Improvement may be seen within a few days, but the full course must be completed as prescribed. Your doctor will monitor your response.
A: This medicine is usually given in a hospital. In some cases, home infusion may be arranged under strict supervision.
A: Avoid alcohol, other kidney-damaging medicines, and self-medication. Follow your doctor's instructions carefully.
A: It may cause dizziness or weakness. Avoid driving or operating machinery until you feel normal and your doctor approves.
🤔 Common Patient Concerns
🔄 Substitutes for ibicolist 3million iu injection
View AllAlternative brands with exact same active ingredient:
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guficol 3miu injectionGufic Bioscience Ltd ₹1,217.81 36.6% CHEAPER
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critimycin 3 miu injectionTorrent Pharmaceuticals Ltd ₹1,562.50 18.7% CHEAPER
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coly-suz 3miu injectionSuzan Pharma ₹1,629.00 15.2% CHEAPER
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Tinmax 3Million IU InjectionLemford Biotech Pvt Ltd ₹1,875.00 2.4% CHEAPER
-
wockstin 3miu injectionWockhardt Ltd ₹1,964.53 2.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken as a tablet or syrup.
Fact: This medicine is an injection and must be given by a healthcare professional. It is not available as an oral form for systemic infections. - Myth: This medicine is safe for any type of infection.
Fact: It is reserved for serious multidrug-resistant Gram-negative infections and is not effective against viruses, fungi, or Gram-positive bacteria. - Myth: You can stop the injection once you feel better.
Fact: You must complete the full course as prescribed by your doctor to prevent resistance and relapse. - Myth: This medicine has no serious side effects.
Fact: It can cause kidney damage and nerve problems, so close monitoring is required.
🔄 Alternative Options
Generic Alternatives
- Colistimethate sodium 3 million IU injection
Brand Alternatives
- D Mithate 3MIU Injection