Histrex-SR Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Irregular heartbeat or palpitations
If experiencing severe symptoms, call emergency services immediately.
What is histrex-sr tablet used for?
This medicine is an antihistamine used to treat allergic symptoms such as sneezing, runny nose, and itching. It works by blocking histamine, a substance in the body that causes allergic reactions. It may cause drowsiness, so avoid driving after taking it.
- Generic Name: Chlorpheniramine Maleate (8mg)
- Manufacturer: Orion Lifesciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 histrex-sr tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एलर्जी के लक्षणों जैसे छींक, नाक बहना, आंखों में खुजली और पानी आना, और त्वचा पर खुजली को कम करने के लिए उपयोग की जाती है। यह एलर्जिक राइनाइटिस, अर्टिकेरिया और कीट के काटने से होने वाली एलर्जी में प्रभावी है। यह दवा हिस्टामिन नामक पदार्थ को रोककर काम करती है जो शरीर में एलर्जी पैदा करता है। इस दवा से नींद आ सकती है, इसलिए वाहन चलाने या मशीन चलाने से बचें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, धुंधली दृष्टि, और जी मिचलाना शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज दिल की धड़कन, दौरे, या गंभीर एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। निर्धारित मात्रा से अधिक न लें। इस दवा के साथ शराब न लें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, वाहन न चलाएं। यदि आपको ग्लूकोमा, प्रोस्टेट बढ़ना, पेशाब रुकना, लीवर या किडनी की बीमारी है तो डॉक्टर को बताएं। बच्चों की पहुंच से दूर रखें।
💊 histrex-sr tablet Uses & Benefits
[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itchy and watery eyes, and nasal congestion associated with seasonal or perennial allergies.","evidence":"Well-established"},{"condition":"Urticaria","description":"Reduces itching and hives caused by allergic reactions.","evidence":"Well-established"},{"condition":"Common cold","description":"Provides symptomatic relief from runny nose and sneezing, though it does not treat the underlying viral infection.","evidence":"Established"},{"condition":"Insect bite reactions","description":"Helps reduce local itching and inflammation" class="semantic-link" title="Medicines for swelling">swelling from insect bites.","evidence":"Established"}]
Off-label uses: [{"condition":"Insomnia","description":"Sometimes used off-label for its sedative effects to promote sleep, but this is not a recommended use due to potential side effects.","evidence":"Limited"},{"condition":"Motion sickness","description":"May be used off-label to prevent nausea and vomiting associated with motion sickness, though other agents are preferred.","evidence":"Limited"}]
Primary treatment for: Allergic rhinitis
Also treats: Urticaria, Common cold, Insect bite reactions
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate (8mg) |
| Brand Name | histrex-sr tablet |
| Manufacturer | Orion Lifesciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | H1 Antihistaminics (First Generation) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by competitively blocking histamine H1 receptors on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. By binding to these receptors, it prevents histamine from exerting its effects, thereby reducing allergic symptoms such as vasodilation, increased vascular permeability, itching, and sneezing. It also has anticholinergic properties that contribute to dry mouth and other side effects.
Mechanism Steps
💡 How to Take histrex-sr tablet
Strength: Tablet, 8 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 8 mg taken orally every 8 to 12 hours as needed for allergic symptoms. The maximum recommended dose is 24 mg per day. However, the dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and response to treatment. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the side effects of this medicine, especially drowsiness, confusion, and anticholinergic effects. A lower initial dose may be considered, and the dose should be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, the dose may need to be reduced. Consult a healthcare professional for individualized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, the dose may need to be reduced. Consult a healthcare professional for individualized dosing. |
| Maximum Daily Dose | 24 mg per day |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of histrex-sr tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Alcohol | Major | |
| CNS depressants | Major | |
| Anticholinergics | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| Opioids | Moderate | |
| Antihypertensives | Minor | |
| Corticosteroids | Minor |
🚨 Major Interactions
- MAO inhibitors
- Alcohol
- Other CNS depressants (e.g., benzodiazepines, opioids, sleep aids)
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- Opioid analgesics
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and impair your ability to drive or operate machinery. Combining alcohol with this medicine can also increase the risk of central nervous system depression.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to chlorpheniramine or any component of the formulation","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Severe liver disease","MAO inhibitor therapy within the last 14 days","Newborns and premature infants"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Use with caution in patients with glaucoma, prostatic hypertrophy, urinary retention, or asthma.","May cause dry mouth, constipation, and blurred vision due to anticholinergic effects.","Do not use for prolonged periods without medical supervision.","Elderly patients are more susceptible to side effects such as confusion and falls."]
🤱 Lactation Safety
Chlorpheniramine Maleate is excreted in breast milk and may cause drowsiness in the nursing infant. It is generally not recommended during breastfeeding, especially in newborns and premature infants. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, seizures, coma, respiratory depression, and anticholinergic effects. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and symptomatic, including gastric lavage if within 1-2 hours of ingestion, activated charcoal, and monitoring of vital signs. There is no specific antidote. Physostigmine may be used cautiously for severe anticholinergic toxicity.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid alcohol and other central nervous system depressants while taking this medicine, as they can increase drowsiness. Do not drive or operate machinery until you know how this medicine affects you. Inform your doctor if you have glaucoma, prostate enlargement, urinary retention, liver disease, or kidney disease. This medicine may interact with other medications, so always disclose all medicines you are taking. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the sedative and anticholinergic effects of this medicine, such as confusion, dry mouth, constipation, and urinary retention. Use with caution and consider a lower dose. Regular monitoring for falls and cognitive changes is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed. Discuss alternative treatments for allergies that are safer during pregnancy.
🏥 Post-Surgery Considerations
This medicine may interact with anesthetics and other medications used during surgery. Inform your surgeon and anesthesiologist that you are taking this medicine before any surgical procedure.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it can cause dry mouth and may interact with medications used during dental procedures. It may also increase the risk of bleeding if combined with certain dental medications.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may affect your coordination. Avoid strenuous exercise or activities that require alertness until you know how this medicine affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to take it at bedtime if it makes you sleepy. Discuss with your doctor if your work requires alertness.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. For short-term use, stop as directed by your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tolerance, dependence, and increased risk of side effects such as cognitive impairment, especially in the elderly. It should be used for the shortest duration necessary. Regular monitoring of liver and kidney function may be advised for prolonged use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Identifying and avoiding allergens can reduce the need for medication.
Evidence: Well-establishedHelps clear allergens from nasal passages and reduce symptoms.
Evidence: EstablishedAllergy shots can provide long-term relief for certain allergies.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust your dosing schedule accordingly, but do not exceed the maximum daily dose. Check local customs regulations regarding carrying prescription medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after taking it.
A: Yes, you can take it with or without food, but taking it with food may reduce stomach upset.
A: This medicine can cause drowsiness. Avoid driving or operating machinery until you know how it affects you.
A: Consult your doctor before taking this medicine if you are pregnant or planning to become pregnant. It should be used only if clearly needed.
A: If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for everyone.
Fact: It is not safe for individuals with certain conditions like glaucoma or urinary retention, and it can cause drowsiness. - Myth: It can be taken with alcohol without any problems.
Fact: Alcohol increases the sedative effects and should be avoided. - Myth: It is non-drowsy.
Fact: This medicine commonly causes drowsiness; it is a first-generation antihistamine.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine Maleate 8 mg tablet
Brand Alternatives
- Histrex-SR Tablet