Histolin Plus Syrup: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is histolin plus syrup used for?
This medicine is a combination syrup containing citric acid and diphenhydramine. It is used to relieve allergy symptoms and urinary discomfort. It works by blocking histamine and alkalinizing urine. It may cause drowsiness, so avoid driving after taking it.
- Generic Name: Citric Acid (57mg) + Diphenhydramine (14.08mg)
- Manufacturer: Lincoln Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 histolin plus syrup के बारे में (Hindi Summary)
उपयोग: यह दवा एलर्जी के लक्षणों जैसे छींक, नाक बहना, खुजली और आंखों में पानी आना को कम करने के लिए उपयोग की जाती है। यह पेशाब में जलन को भी कम कर सकती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना और धुंधली दृष्टि शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यदि आपको दिल की धड़कन तेज होना, भ्रम, या पेशाब करने में कठिनाई हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे लेने के बाद गाड़ी न चलाएं क्योंकि इससे नींद आ सकती है। शराब और अन्य नींद लाने वाली दवाओं से बचें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें।
💊 histolin plus syrup Uses & Benefits
[{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, itching, and watery eyes due to allergies.","evidence":"Well-established"},{"condition":"Urticaria","description":"Reduces itching and hives associated with allergic skin reactions.","evidence":"Well-established"},{"condition":"Urinary discomfort due to acidic urine","description":"Citric acid alkalinizes urine, which may reduce bladder irritation and burning.","evidence":"Limited"},{"condition":"Motion sickness","description":"Diphenhydramine helps prevent nausea and vomiting associated with motion.","evidence":"Well-established"},{"condition":"Insomnia (short-term)","description":"The sedative effect of diphenhydramine may help with occasional sleeplessness.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Pruritus (itching) due to other causes","description":"Sometimes used off-label for itching not related to allergies.","evidence":"Limited"},{"condition":"Adjunct in anaphylaxis","description":"Not a first-line treatment but may be used as an adjunct after epinephrine.","evidence":"Limited"}]
Primary treatment for: Allergic rhinitis
Also treats: Urticaria, Motion sickness, Insomnia
📋 Drug Information
| Generic Name(s) | Citric Acid (57mg) + Diphenhydramine (14.08mg) |
| Brand Name | histolin plus syrup |
| Manufacturer | Lincoln Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Diphenhydramine is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing allergic symptoms. It also crosses the blood-brain barrier and causes sedation by blocking central H1 receptors. Citric acid is metabolized to bicarbonate, which alkalinizes urine, reducing bladder irritation from acidic urine.
Mechanism Steps
💡 How to Take histolin plus syrup
Strength: Each 5 mL contains Citric Acid 57 mg and Diphenhydramine 14.08 mg.
Dosage Information
| Adult Dosage | The usual adult dose is 5 to 10 mL (one to two teaspoons) every 4 to 6 hours as needed, not to exceed 4 doses in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the sedative and anticholinergic effects. Use with caution and consider a lower dose as advised by a clinician. |
| Renal Impairment | No specific dose adjustment is established. Use with caution in renal impairment and consult a clinician. |
| Hepatic Impairment | Use with caution in hepatic impairment. Dose adjustment may be needed as advised by a clinician. |
| Maximum Daily Dose | Maximum daily dose for adults is 40 mL (8 teaspoons) in 24 hours, not to exceed 4 doses. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of histolin plus syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| Alcohol | Major | |
| Benzodiazepines | Major | |
| Opioids | Major | |
| Tricyclic antidepressants | Moderate | |
| Fluoxetine | Moderate | |
| Paroxetine | Moderate | |
| Metoclopramide | Minor |
🚨 Major Interactions
- MAO inhibitors
- Alcohol
- Other CNS depressants (e.g., benzodiazepines, opioids)
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
🍷 Alcohol Interaction
Alcohol increases the sedative and CNS depressant effects of diphenhydramine. Avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to diphenhydramine or any component","Newborns and premature infants","Narrow-angle glaucoma","Bladder neck obstruction or symptomatic prostatic hypertrophy","Severe liver disease"]
⚠️ Warnings & Precautions
["May impair ability to drive or operate machinery.","Avoid alcohol and other CNS depressants.","Use with caution in elderly patients due to increased risk of confusion and falls.","Use with caution in patients with asthma, increased intraocular pressure, or cardiovascular disease.","Do not use for longer than recommended without medical advice."]
🤱 Lactation Safety
Diphenhydramine passes into breast milk and may cause drowsiness in the infant. Consult your doctor before use while breastfeeding.
💊 Overdose Management
Overdose may cause severe drowsiness, confusion, seizures, respiratory depression, and cardiac arrhythmias. Seek emergency medical attention immediately. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not drive or operate heavy machinery after taking it because it can cause drowsiness. Avoid alcohol and other sedatives while on this medicine. Inform your doctor if you have glaucoma, prostate problems, asthma, or liver or kidney disease. Do not use for longer than recommended without medical advice. Keep out of reach of children. If you are pregnant or breastfeeding, consult your doctor before use.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to confusion, dry mouth, urinary retention, and falls. Use with caution and consider lower doses.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy if you are taking this medicine regularly.
🏥 Post-Surgery Considerations
Inform your surgeon if you are taking this medicine as it may interact with anesthesia and other medications.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may cause dry mouth and interact with sedatives used in dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel drowsy or dizzy after taking this medicine. Stay hydrated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and impair your ability to drive or operate machinery. Avoid these activities until you know how it affects you.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects or if your symptoms do not improve within 7 days.
📅 Long-Term Use Effects
Long-term use of diphenhydramine may lead to tolerance, dependence, and cognitive effects, especially in the elderly. Regular monitoring is advised if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Identifying and avoiding triggers can reduce the need for medication.
Evidence: Well-establishedHelps clear nasal passages and reduce allergy symptoms.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. Consult your doctor before vaccination if you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It usually starts working within 15 to 30 minutes after taking it.
A: Consult your doctor before combining with other antihistamines to avoid additive effects.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine is safe for everyone.
Fact: It is not safe for people with certain conditions like glaucoma or prostate problems. - Myth: It is a cure for allergies.
Fact: It only relieves symptoms; it does not cure the underlying allergy.
🔄 Alternative Options
Generic Alternatives
- Diphenhydramine syrup
- Citric acid and diphenhydramine combination