Hisone 5 Tablet (Hydrocortisone 5mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe abdominal pain or vomiting blood
- Black, tarry stools
- Sudden severe headache or vision changes
- Chest pain or difficulty breathing
- Swelling of face, lips, or throat
- High fever with chills
- Extreme weakness or dizziness upon standing
- Confusion or hallucinations
If experiencing severe symptoms, call emergency services immediately.
What is hisone 5 tablet used for?
This medicine contains hydrocortisone, a corticosteroid used to treat adrenal insufficiency and inflammatory conditions. It works by replacing natural cortisol and reducing inflammation. Take it exactly as prescribed, with food, and never stop abruptly without medical advice.
- Generic Name: Hydrocortisone (5mg)
- Manufacturer: Samarth Life Sciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 hisone 5 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा हाइड्रोकॉर्टिसोन नामक स्टेरॉयड की श्रेणी में आती है। इसका उपयोग मुख्य रूप से एड्रिनल अपर्याप्तता (जैसे एडिसन रोग) के इलाज के लिए किया जाता है, जिसमें शरीर पर्याप्त कोर्टिसोल नहीं बना पाता। यह सूजन और एलर्जी को कम करने में भी मदद करती है। यह दवा शरीर में प्राकृतिक हार्मोन कोर्टिसोल की कमी को पूरा करती है। इसे डॉक्टर के बताए अनुसार ही लें, और अचानक बंद न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में भूख बढ़ना, वजन बढ़ना, नींद न आना, मूड में बदलाव, और शुगर लेवल बढ़ना शामिल हैं। लंबे समय तक उपयोग से हड्डियों का कमजोर होना, मोतियाबिंद, और संक्रमण का खतरा बढ़ सकता है। अगर आपको असामान्य लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे खाने के साथ लें ताकि पेट में जलन न हो। अचानक बंद करने से एड्रिनल क्राइसिस हो सकता है, इसलिए डॉक्टर की सलाह के बिना न रोकें। डायबिटीज हो तो शुगर की निगरानी करें। संक्रमण से बचें और टीकाकरण से पहले डॉक्टर से सलाह लें। गर्भावस्था में डॉक्टर से परामर्श करें।
💊 hisone 5 tablet Uses & Benefits
[{"condition":"Adrenal insufficiency (Addison's disease)","description":"Used as hormone replacement therapy to treat cortisol deficiency, helping to regulate blood pressure, blood sugar, and stress response.","evidence":"Well-established"},{"condition":"Congenital adrenal hyperplasia","description":"Helps suppress excess androgen production and replace deficient cortisol in patients with this inherited disorder.","evidence":"Well-established"},{"condition":"Inflammatory conditions (e.g., rheumatoid arthritis, inflammatory bowel disease)","description":"May be used to reduce inflammation and suppress immune response in various autoimmune and inflammatory disorders.","evidence":"Established"},{"condition":"Allergic reactions (severe)","description":"Can be used as adjunct therapy for severe allergic reactions, though injectable forms are preferred for acute management.","evidence":"Established"},{"condition":"Asthma (severe, chronic)","description":"May be used orally for long-term management of severe chronic asthma when inhaled corticosteroids are insufficient.","evidence":"Established"}]
Off-label uses: [{"condition":"Chronic fatigue syndrome","description":"Sometimes prescribed off-label for severe fatigue, but evidence is limited and risks may outweigh benefits.","evidence":"Limited"},{"condition":"Post-traumatic stress disorder (PTSD)","description":"Investigational use for preventing PTSD after trauma, but not standard practice.","evidence":"Investigational"}]
Primary treatment for: Adrenal insufficiency
Also treats: Congenital adrenal hyperplasia, Rheumatoid arthritis, Inflammatory bowel disease, Severe asthma, Severe allergic reactions
📋 Drug Information
| Generic Name(s) | Hydrocortisone (5mg) |
| Brand Name | hisone 5 tablet |
| Manufacturer | Samarth Life Sciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Glucocorticoids |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Keep in the original container, tightly closed. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization includes hydrocortisone in its Model List of Essential Medicines for the treatment of adrenal insufficiency and other conditions. Guidelines recommend hydrocortisone as the preferred corticosteroid for replacement therapy due to its short duration of action and minimal mineralocorticoid effect at replacement doses. |
| ICMR Guideline | The Indian Council of Medical Research recognizes hydrocortisone as a standard treatment for adrenal insufficiency and various inflammatory conditions. Dosing should be individualized based on clinical response and monitoring. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to glucocorticoid receptors in the cytoplasm of cells. Upon binding, the receptor-ligand complex translocates into the nucleus and interacts with specific DNA sequences called glucocorticoid response elements. This interaction alters the transcription of various genes, leading to decreased production of inflammatory mediators such as prostaglandins and leukotrienes, and increased production of anti-inflammatory proteins like lipocortin-1. Additionally, it suppresses the immune system by inhibiting the proliferation of lymphocytes and reducing the release of cytokines. At higher doses, it also has mineralocorticoid effects, promoting sodium retention and potassium excretion, which helps maintain blood pressure and fluid balance.
Mechanism Steps
💡 How to Take hisone 5 tablet
Strength: Hydrocortisone 5 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and clinical response. For adrenal insufficiency, the typical replacement dose is 15 to 25 mg per day divided into two or three doses, with the largest dose in the morning. For inflammatory conditions, doses may range from 20 to 240 mg per day depending on severity. Always follow your doctor's prescription exactly. Do not adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of corticosteroids. The lowest effective dose should be used, and renal and hepatic function should be considered. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is typically required for renal impairment, but caution is advised in patients with severe renal disease. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with severe hepatic impairment, the metabolism of hydrocortisone may be reduced, requiring dose adjustment. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose varies depending on the indication and patient factors. For replacement therapy, doses rarely exceed 30 mg per day. For anti-inflammatory purposes, doses up to 240 mg per day may be used under close supervision. Always follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of hisone 5 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ketoconazole | Major | |
| Rifampin | Major | |
| Ibuprofen | Moderate | |
| Furosemide | Moderate | |
| Metformin | Moderate | |
| Live vaccines | Major | |
| Phenytoin | Moderate | |
| Aspirin | Moderate | |
| Estrogens | Moderate |
🚨 Major Interactions
- Live vaccines
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
- CYP3A4 inducers (e.g., rifampin, carbamazepine)
- Antidiabetic agents
- Diuretics (e.g., furosemide)
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen)
- Anticoagulants (e.g., warfarin)
- Anticholinesterases (e.g., neostigmine)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase the risk of gastrointestinal bleeding and may worsen corticosteroid-related side effects such as fluid retention and mood changes. It can also affect blood sugar levels, which may be problematic for patients with diabetes.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Systemic fungal infections","Hypersensitivity to hydrocortisone or any component of the tablet","Administration of live vaccines during therapy","Untreated serious infections (unless used as adjunct with appropriate anti-infective therapy)"]
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly, as it can cause adrenal crisis.","Use with caution in patients with diabetes, as it can raise blood sugar.","May increase susceptibility to infections; avoid contact with contagious individuals.","Long-term use can lead to osteoporosis; ensure adequate calcium and vitamin D intake.","Regular eye exams are recommended to detect cataracts or glaucoma.","May cause mood changes or psychiatric symptoms; report severe changes to your doctor.","Use with caution in patients with hypertension, heart failure, or kidney disease.","Children on long-term therapy should be monitored for growth suppression.","Elderly patients may be more susceptible to side effects; use lowest effective dose."]
🤱 Lactation Safety
Hydrocortisone is excreted in breast milk in small amounts. It is generally considered safe during breastfeeding, especially at low replacement doses. However, high doses may suppress infant adrenal function. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose of hydrocortisone can lead to symptoms of corticosteroid excess, including severe hyperglycemia, hypertension, fluid retention, and electrolyte imbalances. Treatment is supportive and symptomatic. In case of acute overdose, seek immediate medical attention. Management may include monitoring of vital signs, blood glucose, and electrolytes, and adjusting the dose or discontinuing the medicine as directed by a healthcare provider.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your healthcare provider, as abrupt discontinuation can cause adrenal crisis. Take the tablet with food to reduce stomach upset. If you have diabetes, monitor your blood sugar closely because this medicine can raise glucose levels. Avoid contact with people who have contagious infections, as this medicine can weaken your immune system. Inform all your healthcare providers, including dentists, that you are taking this medicine before any surgery or procedure. Carry a medical alert card or wear a bracelet stating you are on corticosteroid therapy. Avoid live vaccines while taking this medicine. If you become pregnant or plan to become pregnant, talk to your doctor about the risks and benefits. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the side effects of corticosteroids, including osteoporosis, diabetes, and hypertension. The lowest effective dose should be used, and regular monitoring of bone density, blood sugar, and blood pressure is recommended. Falls prevention strategies are also important to reduce fracture risk.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. Hydrocortisone is generally considered safe during pregnancy, but the dose may need adjustment. Your doctor will monitor you closely throughout pregnancy to ensure optimal outcomes for both you and your baby.
🏥 Post-Surgery Considerations
If you are undergoing surgery, inform your surgeon and anesthesiologist that you are taking this medicine. You may need stress-dose steroids during and after surgery to prevent adrenal crisis. Your doctor will provide specific instructions for managing your medication around the time of surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. You may need additional corticosteroid coverage for stressful dental work. Your doctor or dentist will advise you on any dose adjustments needed.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can exercise, but avoid high-impact activities that may increase the risk of fractures if you have osteoporosis. If you experience joint pain or swelling, consult your doctor before starting a new exercise regimen. Stay hydrated during exercise, especially if you have adrenal insufficiency.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause mood changes, insomnia, or fatigue, which could affect your ability to drive or operate machinery. If you experience these side effects, avoid driving or operating heavy machinery until you know how the medicine affects you. It is important to inform your employer about your condition and any necessary accommodations, especially if you have adrenal insufficiency and need to manage stress or take medication during work hours.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If your doctor decides to discontinue it, they will provide a tapering schedule to prevent adrenal crisis. If you experience severe side effects, contact your doctor immediately; they may adjust the dose or switch to another medication. Never stop abruptly on your own.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to several complications, including osteoporosis, cataracts, glaucoma, high blood pressure, diabetes, and increased susceptibility to infections. It can also suppress the body's natural cortisol production, leading to adrenal insufficiency if stopped suddenly. Regular monitoring of bone density, blood sugar, blood pressure, and eye health is recommended. Your doctor may adjust the dose or recommend supplements like calcium and vitamin D to mitigate some risks. The lowest effective dose should be used for the shortest duration possible.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help reduce the need for high doses of corticosteroids in inflammatory conditions.
Evidence: ModerateCan complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedAnti-inflammatory diet may help manage conditions like arthritis.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided while taking this medicine because they can cause serious infections in immunosuppressed individuals. Inactivated vaccines are generally safe but may have reduced efficacy. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, adjust your dosing schedule gradually in consultation with your doctor. Carry enough supply for your entire trip, plus extra in case of delays. Store at room temperature and avoid leaving it in hot cars or direct sunlight. Check customs regulations for carrying prescription medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 to 2 hours after taking it. However, the full benefits for conditions like adrenal insufficiency may take a few days to weeks to become noticeable.
A: No, you should never stop this medicine abruptly without consulting your doctor. Sudden withdrawal can cause adrenal crisis, which is a medical emergency. Your doctor will guide you on tapering the dose gradually.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Yes, this medicine can cause weight gain due to increased appetite and fluid retention. Monitoring your diet and weight regularly can help manage this side effect.
A: Hydrocortisone is generally considered safe during pregnancy when medically necessary, but the dose may need adjustment. Always consult your doctor before taking any medicine during pregnancy.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: Hydrocortisone is only for skin problems.
Fact: Oral hydrocortisone is used for systemic conditions like adrenal insufficiency and inflammatory diseases. - Myth: You can stop hydrocortisone whenever you feel better.
Fact: Stopping suddenly can cause adrenal crisis. Always taper under medical supervision. - Myth: Hydrocortisone weakens your immune system permanently.
Fact: Immune suppression is dose-dependent and reversible after stopping, but long-term use requires monitoring.
🔄 Alternative Options
Generic Alternatives
- Hydrocortisone 5 mg tablet (various manufacturers)
Brand Alternatives
- Hisone 5 Tablet