Anxit Plus 0.5 mg/25 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Thoughts of harming yourself or others
- Severe agitation, hallucinations, fever, or muscle stiffness (serotonin syndrome)
- Difficulty breathing, swelling of face, lips, or throat
- Seizures or convulsions
- Unusual bleeding or bruising
- Severe abdominal pain or yellowing of skin or eyes
- Irregular heartbeat or chest pain
If experiencing severe symptoms, call emergency services immediately.
What is hipzol-plus tablet used for?
This medicine is a combination of alprazolam and sertraline used to treat anxiety and panic disorders. Alprazolam provides rapid relief, while sertraline offers long-term control. It is a prescription-only medicine and should be taken exactly as directed by your doctor.
- Generic Name: Alprazolam (0.5mg) + Sertraline (25mg)
- Manufacturer: Gamete Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 hipzol-plus tablet के बारे में (Hindi Summary)
उपयोग: यह दवा अल्प्राजोलम और सर्ट्रालिन का संयोजन है, जिसका उपयोग चिंता विकार, पैनिक डिसऑर्डर और अवसाद के इलाज में किया जाता है। अल्प्राजोलम तेजी से चिंता को कम करता है, जबकि सर्ट्रालिन धीरे-धीरे मूड को स्थिर करता है। यह दवा केवल डॉक्टर के पर्चे पर ही लेनी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, थकान, मुँह सूखना, मतली, दस्त, पसीना आना और यौन समस्याएं शामिल हैं। गंभीर दुष्प्रभावों में सेरोटोनिन सिंड्रोम, एलर्जी, रक्तस्राव, आत्महत्या के विचार और दौरे शामिल हो सकते हैं। कोई भी गंभीर लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। शराब का सेवन बिल्कुल न करें। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको इसका असर पता न चल जाए। इस दवा को अचानक बंद न करें, क्योंकि इससे दौरे पड़ सकते हैं। डॉक्टर से सलाह लेकर ही धीरे-धीरे कम करें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से परामर्श करें।
💊 hipzol-plus tablet Uses & Benefits
- [{"condition":"Generalized Anxiety Disorder (GAD)","description":"This medicine helps reduce excessive, uncontrollable worry and tension.
- Alprazolam provides rapid relief while sertraline offers long-term control.","evidence":"Well-established for short-term use"},{"condition":"Panic Disorder","description":"Used to decrease the frequency and intensity of panic attacks.
- Sertraline is a first-line treatment, and alprazolam may be added for immediate symptom control.","evidence":"Well-established"},{"condition":"Depression with Anxiety","description":"The combination addresses both depressive symptoms and anxiety, which often occur together.","evidence":"Moderate evidence"},{"condition":"Social Anxiety Disorder","description":"May be prescribed to reduce anxiety in social situations, though SSRIs are preferred for long-term management.","evidence":"Limited evidence for combination"}]
Off-label uses: [{"condition":"Premenstrual Dysphoric Disorder (PMDD)","description":"Sertraline is sometimes used off-label for PMDD, but the combination with alprazolam is not standard.","evidence":"Limited"},{"condition":"Post-Traumatic Stress Disorder (PTSD)","description":"Sertraline may be used off-label for PTSD, but alprazolam is generally avoided due to risk of dependence.","evidence":"Limited"}]
Primary treatment for: Anxiety disorders
Also treats: Panic disorder, Depression with anxiety, Social anxiety disorder
📋 Drug Information
| Generic Name(s) | Alprazolam (0.5mg) + Sertraline (25mg) |
| Brand Name | hipzol-plus tablet |
| Manufacturer | Gamete Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Alprazolam enhances the inhibitory effect of gamma-aminobutyric acid (GABA) at GABA-A receptors, leading to increased chloride ion influx and neuronal hyperpolarization, which results in anxiolytic, sedative, and muscle relaxant effects. Sertraline selectively inhibits the reuptake of serotonin (5-HT) at the presynaptic neuronal membrane, increasing serotonin concentration in the synaptic cleft, which helps improve mood and reduce anxiety over time. The combination provides rapid symptom relief from alprazolam and sustained benefit from sertraline.
Mechanism Steps
💡 How to Take hipzol-plus tablet
Strength: Tablet containing alprazolam 0.5 mg and sertraline 25 mg.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the indication, severity of symptoms, age, and hepatic/renal function. Typically, treatment is started with a low dose and gradually increased. The usual starting dose is one tablet taken orally once or twice daily, but your doctor will determine the exact dose and frequency. Do not adjust the dose without medical advice. The alprazolam component is usually intended for short-term use, while sertraline may be continued for longer periods. Regular follow-up is essential. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are more sensitive to the effects of benzodiazepines and SSRIs. Lower doses are recommended, and careful monitoring for sedation, falls, and hyponatremia is necessary. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustment may be required in patients with severe renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Dose reduction is recommended in patients with hepatic impairment. Use with caution and monitor liver function. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the patient's condition and response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of hipzol-plus tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| CNS depressants | Major | |
| CYP3A4 inhibitors | Major | |
| Warfarin | Major | |
| NSAIDs | Moderate | |
| Tramadol | Moderate | |
| Diuretics | Moderate | |
| Antacids | Minor | |
| Cimetidine | Minor |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- CNS depressants (e.g., opioids, alcohol, barbiturates)
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)
- Warfarin
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Tramadol
- Diuretics
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol enhances the sedative effects of alprazolam and can lead to severe drowsiness, respiratory depression, and increased risk of accidents. It may also worsen the side effects of sertraline, such as dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to alprazolam, sertraline, or any component of the formulation","Concurrent use with MAO inhibitors or within 14 days of stopping MAOI","Narrow-angle glaucoma","Severe hepatic impairment","Acute narrow-angle glaucoma","Pregnancy and breastfeeding (unless clearly needed)"]
⚠️ Warnings & Precautions
["Risk of dependence and withdrawal with alprazolam. Use for shortest duration possible.","May impair ability to drive or operate machinery.","Increased risk of suicidal thoughts in patients under 25 years.","Serotonin syndrome risk when combined with other serotonergic drugs.","Increased bleeding risk, especially with NSAIDs, aspirin, or anticoagulants.","Hyponatremia risk, especially in elderly and those on diuretics.","Avoid abrupt discontinuation to prevent withdrawal seizures.","Use with caution in patients with respiratory insufficiency.","May worsen depression and increase suicide risk."]
🤱 Lactation Safety
Both alprazolam and sertraline are excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor. Potential risks to the infant include sedation, poor feeding, and weight loss.
💊 Overdose Management
Overdose can cause severe drowsiness, confusion, respiratory depression, coma, and death. Seek immediate emergency medical attention. Treatment includes supportive care, airway management, and administration of flumazenil (for benzodiazepine toxicity) under medical supervision. There is no specific antidote for sertraline overdose; management is symptomatic and supportive.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose. If you miss multiple doses, contact your doctor for guidance.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Avoid alcohol completely while taking this medicine, as it can dangerously increase sedation and impair breathing. Do not drive or operate heavy machinery until you know how this medicine affects you. Never stop this medicine suddenly, especially alprazolam, as it can cause withdrawal seizures or severe anxiety rebound. If you need to discontinue, your doctor will taper the dose gradually. Inform your doctor about all other medicines, supplements, and herbal products you are taking, especially MAOIs, other antidepressants, pain relievers, and blood thinners. Keep this medicine out of reach of children and pets. Store at room temperature away from moisture and heat. Do not use this medicine if you are pregnant, planning pregnancy, or breastfeeding without consulting your doctor. Regular follow-up with your doctor is essential to monitor your response and adjust the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative effects of alprazolam and the side effects of sertraline. Lower doses are recommended, and careful monitoring for falls, confusion, and hyponatremia is necessary. Regular review of the need for continued treatment is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Both alprazolam and sertraline may pose risks to the fetus. Your doctor may recommend alternative treatments or gradual discontinuation.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and increase sedation. Your doctor may advise temporary discontinuation before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may interact with local anesthetics or sedatives used during dental procedures. Your dentist may need to adjust the treatment plan.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid high-intensity or risky activities until you know how this medicine affects your alertness and coordination. Drowsiness and dizziness may increase the risk of falls or injuries.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may impair your ability to drive or operate machinery. It may also affect concentration and reaction time. Discuss with your doctor before returning to work, especially if your job involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will gradually taper the dose to prevent withdrawal symptoms. If you experience severe side effects or allergic reactions, seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of alprazolam can lead to tolerance, dependence, and withdrawal symptoms. Sertraline is generally safe for long-term use but may cause sexual dysfunction, weight changes, and emotional blunting. Regular monitoring of liver function, sodium levels, and mood is recommended. Periodic review of the need for continued alprazolam is essential.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A type of talk therapy that helps change negative thought patterns and behaviors related to anxiety.
Evidence: Well-establishedPractices that help reduce stress and anxiety by focusing on the present moment.
Evidence: Moderate evidencePhysical activity can reduce anxiety and improve mood.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check local customs regulations regarding controlled substances, as alprazolam may be regulated.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Alprazolam starts working within 30-60 minutes for anxiety relief. Sertraline takes 2-4 weeks to show full antidepressant and anxiolytic effects.
A: No, stopping suddenly can cause withdrawal symptoms and seizures. Always taper gradually under medical supervision.
A: The alprazolam component can cause dependence and addiction. It should be used for the shortest duration possible and only as prescribed.
A: Avoid alcohol, driving, and operating heavy machinery until you know how it affects you. Also avoid grapefruit juice.
🤔 Common Patient Concerns
🔄 Substitutes for hipzol-plus tablet
View AllAlternative brands with exact same active ingredient:
-
restyl plus 0.5 mg/25 mg tabletCipla Ltd ₹29.34 60.9% CHEAPER
-
alzolam plus 0.5mg/25mg tabletSun Pharmaceutical Industries Ltd ₹29.77 60.3% CHEAPER
-
anxizam plus 0.5 mg/25 mg tabletAthens Labs Ltd ₹29.81 60.3% CHEAPER
-
mcalm 0.5mg/25mg tabletGlobus Remedies Ltd ₹33.50 55.3% CHEAPER
-
alsert 0.5mg/25mg tabletLanark Laboratories Pvt Ltd ₹39.00 48% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Anxit Plus is a sleeping pill.
Fact: This medicine is primarily used for anxiety and panic disorders, not as a sleeping aid. It may cause drowsiness as a side effect. - Myth: You can stop taking Anxit Plus whenever you feel better.
Fact: Stopping abruptly can cause withdrawal symptoms and seizures. Always taper under medical supervision. - Myth: Anxit Plus works immediately for depression.
Fact: The sertraline component takes 2-4 weeks to show full antidepressant effects. Alprazolam provides faster anxiety relief.
🔄 Alternative Options
Generic Alternatives
- Alprazolam + Sertraline (generic)
Brand Alternatives
- Anxit Plus 0.5 mg/25 mg Tablet