Amexine 250mg/8mg Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing.
- Severe or persistent diarrhoea, especially if bloody or with mucus.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Unusual bruising or bleeding, or signs of infection like fever and sore throat.
- Severe skin rash with blistering or peeling.
- Decreased urine output or swelling in the legs or feet.
- Seizures or severe dizziness.
If experiencing severe symptoms, call emergency services immediately.
What is himox-b 250mg/8mg tablet used for?
This medicine is a combination of Amoxycillin, an antibiotic, and Bromhexine, a mucolytic. It is used to treat bacterial respiratory infections with thick mucus. It works by killing bacteria and thinning mucus, making it easier to cough out. Take it exactly as prescribed and complete the full course.
- Generic Name: Amoxycillin (250mg) + Bromhexine (8mg)
- Manufacturer: Solitaire Pharmacia Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 himox-b 250mg/8mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एमोक्सिसिलिन और ब्रोमहेक्सिन का संयोजन है। यह बैक्टीरियल श्वसन संक्रमण जैसे ब्रोंकाइटिस, निमोनिया और खांसी में उपयोग की जाती है जहां बलगम गाढ़ा होता है। एमोक्सिसिलिन बैक्टीरिया को मारता है और ब्रोमहेक्सिन बलगम को पतला करके बाहर निकालने में मदद करता है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द और त्वचा पर चकत्ते शामिल हैं। कुछ लोगों को चक्कर आना या मुंह में धातु जैसा स्वाद भी महसूस हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दस्त हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। दवा को भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। पर्याप्त पानी पिएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। शराब का सेवन न करें। यदि आपको कोई गंभीर या असामान्य लक्षण दिखे तो तुरंत डॉक्टर से मिलें।
💊 himox-b 250mg/8mg tablet Uses & Benefits
[{"condition":"Acute bronchitis with bacterial infection","description":"Used to treat bacterial bronchitis when thick mucus is present, helping to clear the infection and ease cough.","evidence":"Well-established for the antibiotic component; mucolytic component has supportive evidence."},{"condition":"Acute exacerbation of chronic bronchitis","description":"Prescribed when chronic bronchitis flares up due to bacterial infection, reducing bacterial load and thinning mucus.","evidence":"Well-established for the antibiotic component; mucolytic component has supportive evidence."},{"condition":"Community-acquired pneumonia (mild to moderate)","description":"May be used in some cases of pneumonia caused by susceptible bacteria, especially when mucus is thick.","evidence":"Established for amoxycillin; bromhexine is adjunctive."},{"condition":"Bronchiectasis with secondary infection","description":"Helps control bacterial infection and aids in clearing purulent secretions in bronchiectasis patients.","evidence":"Limited evidence for the combination; amoxycillin is used based on susceptibility."}]
Off-label uses: [{"condition":"Sinusitis with thick secretions","description":"Sometimes prescribed for bacterial sinusitis when mucus is thick and difficult to drain, though not a standard first-line combination.","evidence":"Limited"},{"condition":"Otitis media with effusion","description":"Rarely used off-label for middle ear infection with fluid, but not routinely recommended.","evidence":"Limited"}]
Primary treatment for: Bacterial respiratory tract infections with thick mucus
Also treats: Acute bronchitis, Chronic bronchitis exacerbation, Community-acquired pneumonia, Bronchiectasis with infection
📋 Drug Information
| Generic Name(s) | Amoxycillin (250mg) + Bromhexine (8mg) |
| Brand Name | himox-b 250mg/8mg tablet |
| Manufacturer | Solitaire Pharmacia Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from moisture and direct sunlight. Keep the capsules in their original blister pack or container until it is time to take them. Do not store in the bathroom. |
| Shelf Life | 24 months from the date of manufacture. Do not use after the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with different mechanisms. Amoxycillin works by binding to penicillin-binding proteins on the bacterial cell wall, inhibiting the cross-linking of peptidoglycan, which weakens the cell wall and leads to bacterial death. Bromhexine works by increasing the production of serous fluid in the respiratory tract and breaking down acidic mucopolysaccharide fibres in mucus, thereby reducing mucus viscosity and making it easier to cough up. The combination targets both the bacterial infection and the associated mucus congestion.
Mechanism Steps
💡 How to Take himox-b 250mg/8mg tablet
Strength: Capsule containing Amoxycillin 250 mg and Bromhexine 8 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one capsule taken two to three times a day, depending on the severity of the infection and your doctor's assessment. The exact dose and duration must be individualized by a qualified clinician based on the indication, your age, weight, kidney and liver function, and the severity of the infection. Always follow your doctor's prescription exactly. Do not self-adjust the dose. Complete the full course even if you feel better after a few days. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced kidney function, which can increase the levels of amoxycillin in the body. Your doctor may need to adjust the dose based on your kidney function. Regular monitoring of renal function is advised. Take this medicine exactly as prescribed and report any unusual symptoms to your doctor. |
| Renal Impairment | In patients with kidney impairment, the dose of this medicine may need to be reduced or the dosing interval lengthened. Your doctor will determine the appropriate dose based on your creatinine clearance. For severe renal impairment (creatinine clearance less than 30 mL/min), the dose may need to be adjusted significantly. Always inform your doctor about any kidney problems before taking this medicine. |
| Hepatic Impairment | In patients with liver impairment, this medicine should be used with caution. The dose may need to be adjusted, and liver function should be monitored. In severe liver disease, this medicine is contraindicated. Consult your doctor for personalized advice. |
| Maximum Daily Dose | The maximum daily dose of this medicine is not established from available information. The dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of himox-b 250mg/8mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Moderate | |
| Oral contraceptives | Moderate | |
| Probenecid | Moderate | |
| Tetracyclines | Moderate | |
| Antacids | Minor | |
| Laxatives | Minor |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
⚡ Moderate Interactions
- Oral contraceptives
- Probenecid
- Tetracyclines
🍷 Alcohol Interaction
Alcohol may worsen stomach irritation and dizziness caused by this medicine. It is advisable to avoid alcohol while taking this medicine, especially if you have a history of stomach ulcers or liver disease.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to penicillins, cephalosporins, or bromhexine.","History of severe allergic reaction (anaphylaxis) to any beta-lactam antibiotic.","Severe liver impairment.","Severe kidney impairment (dose adjustment required, consult doctor).","Phenylketonuria if the formulation contains aspartame.","Use in premature infants or neonates (due to bromhexine component)."]
⚠️ Warnings & Precautions
["Before starting this medicine, inform your doctor about all your medical conditions, especially kidney or liver disease, asthma, or allergies.","Tell your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements.","This medicine may reduce the effectiveness of oral contraceptives; use an additional non-hormonal method of contraception.","Do not use this medicine to treat viral infections like the common cold or flu, as it will not help and may cause unnecessary side effects.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be started.","If you develop severe diarrhoea, do not self-treat with anti-diarrhoeal drugs; consult your doctor.","Use with caution in elderly patients and those with kidney impairment; dose adjustment may be needed.","Avoid alcohol while taking this medicine to reduce the risk of stomach irritation and dizziness."]
🤱 Lactation Safety
Amoxycillin is excreted in breast milk in small amounts and is generally considered safe during breastfeeding. Bromhexine is also excreted in breast milk, but its effects on the nursing infant are not well established. Consult your doctor before using this medicine while breastfeeding. Monitor the infant for diarrhoea or thrush.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, diarrhoea, and abdominal pain. In severe cases, it may lead to crystalluria, renal failure, or seizures, especially in patients with kidney disease. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. Haemodialysis may be considered to remove amoxycillin from the blood in severe cases. There is no specific antidote for bromhexine; manage symptoms as they appear.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better, because incomplete treatment can allow the infection to return and may promote antibiotic resistance. Swallow the capsule whole with a glass of water. You may take it with or without food, but taking it with a meal can reduce stomach upset. If you have kidney problems, your doctor may need to adjust the dose. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Do not share this medicine with others, even if they have similar symptoms. Avoid alcohol while taking this medicine as it can worsen stomach irritation and dizziness. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not double the dose. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. Do not use it after the expiry date. If you experience any severe or unusual symptoms, contact your doctor immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can increase the levels of amoxycillin in the body and the risk of side effects. Your doctor may adjust the dose based on your kidney function. Regular monitoring of renal function is advised. Elderly patients may also be more susceptible to dizziness and falls; take precautions while moving around.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Amoxycillin is generally considered safe during pregnancy, but bromhexine is not recommended in the first trimester. Your doctor will weigh the benefits and risks and may prescribe an alternative if needed.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with other medications used during surgery. Your doctor may advise you to stop the medicine before surgery or adjust the dose. Do not stop the medicine without consulting your doctor.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. This medicine may interact with other medications used in dentistry, and your dentist may need to adjust your treatment plan. It is important to maintain good oral hygiene while taking this medicine to prevent oral thrush.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may feel tired or dizzy. Avoid strenuous exercise until you feel better. Light activities like walking are fine if you feel up to it. If you experience dizziness, avoid driving or operating heavy machinery. Consult your doctor before resuming intense exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or tiredness in some people. Avoid driving or operating machinery until you know how it affects you. It is advisable to take rest and stay home while you are contagious to prevent spreading the infection to others. If your work involves heavy physical activity, you may need to take it easy until you recover.
🛑 When to Stop This Medicine
Stop taking this medicine only after completing the full course prescribed by your doctor, even if you feel better. If you experience a severe allergic reaction, severe diarrhoea, or any other serious side effect, stop the medicine and seek immediate medical attention. Do not stop the medicine early without consulting your doctor, as it may lead to recurrence of infection and antibiotic resistance.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless prescribed by a doctor for a specific chronic condition. Prolonged use of antibiotics like amoxycillin can lead to antibiotic resistance, fungal overgrowth, and rarely, liver or kidney problems. Bromhexine is generally well tolerated for short-term use. If you need to take this medicine for more than 2 weeks, your doctor should monitor your liver and kidney function, and watch for signs of superinfection. Always follow your doctor's advice regarding the duration of treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps loosen mucus and relieve congestion.
Evidence: Well-established for symptom relief.Can help clear nasal passages and reduce congestion.
Evidence: Well-established for symptom relief.Techniques to help clear mucus from the airways.
Evidence: Well-established for respiratory conditions.💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are due for a vaccination, inform your doctor that you are taking this medicine. In general, antibiotics do not affect the safety or efficacy of vaccines, but it is always best to consult your healthcare provider.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel, as antibiotics may be subject to customs regulations. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, continue taking the medicine at evenly spaced intervals as close to your regular schedule as possible. Do not pack it in checked luggage; keep it in your carry-on bag. If you need to take a dose during travel, ensure you have access to safe drinking water.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to feel better within 24-48 hours, but it may take a few days for full effect. Complete the full course as prescribed.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Amoxycillin is generally considered safe during pregnancy, but bromhexine is not recommended in the first trimester. Consult your doctor before taking this medicine.
A: It is best to avoid alcohol as it can worsen stomach irritation and dizziness.
A: Store at room temperature, away from moisture and direct sunlight. Keep in the original container.
🤔 Common Patient Concerns
🔄 Substitutes for himox-b 250mg/8mg tablet
View AllAlternative brands with exact same active ingredient:
-
mycocin syrupAdcock Ingram Healthcare Pvt Ltd ₹24.48 41.7% CHEAPER
-
bromolin 250mg/8mg syrupCipla Ltd ₹26.16 37.7% CHEAPER
-
bromolin 250mg/8mg tablet dtCipla Ltd ₹29.36 30.1% CHEAPER
-
moxyna br 250mg/8mg capsuleHamax Pharmaceuticals ₹30.00 28.6% CHEAPER
-
moxind-br 250mg/8mg capsuleIndu Drugs Pvt Ltd ₹34.00 19% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine contains an antibiotic that only works against bacteria. The common cold is caused by viruses, so this medicine is not effective. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed, even if you feel better, to ensure the infection is fully cleared and to prevent resistance. - Myth: This medicine is safe to take without a prescription.
Fact: This medicine contains an antibiotic and requires a prescription. Self-medication can lead to incorrect use, resistance, and side effects. - Myth: Taking this medicine with alcohol is safe.
Fact: Alcohol can worsen stomach irritation and dizziness. It is best to avoid alcohol while taking this medicine.
🔄 Alternative Options
Generic Alternatives
- Amoxycillin 250 mg + Bromhexine 8 mg capsule (various manufacturers)
Brand Alternatives
- Amexine 250mg/8mg capsule