Endol Plus Oral Suspension: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe drowsiness or confusion
- Yellowing of skin or eyes (jaundice)
- Blood in vomit or stool
- Severe abdominal pain
- Unusual bruising or bleeding
- Seizures
If experiencing severe symptoms, call emergency services immediately.
What is herpex syrup used for?
This medicine is a combination of paracetamol and promethazine used for short-term relief of pain, fever, and allergic symptoms. It works by reducing pain and fever and blocking histamine. It should be taken exactly as prescribed.
- Generic Name: Paracetamol (250mg) + Promethazine (5mg)
- Manufacturer: Biostrass Health Sciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 herpex syrup के बारे में (Hindi Summary)
उपयोग: यह दवा पैरासिटामोल और प्रोमेथाज़ीन का संयोजन है, जिसका उपयोग दर्द, बुखार और एलर्जी के लक्षणों के अल्पकालिक उपचार के लिए किया जाता है। यह दर्द और बुखार को कम करने और एलर्जी के लक्षणों को नियंत्रित करने में मदद करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, धुंधली दृष्टि और जी मिचलाना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी प्रतिक्रिया या यकृत की क्षति हो सकती है।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। शराब का सेवन न करें। गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर से सलाह लें।
💊 herpex syrup Uses & Benefits
[{"condition":"Pain and fever with allergic symptoms","description":"Used for short-term relief of pain and fever when accompanied by allergic rhinitis or urticaria.","evidence":"Limited"},{"condition":"Nausea and vomiting with pain","description":"Promethazine component helps control nausea and vomiting, while paracetamol provides analgesia.","evidence":"Limited"}]
Off-label uses: [{"condition":"Insomnia with mild pain","description":"Sometimes used off-label for its sedative effects in patients with mild pain.","evidence":"Limited"}]
Primary treatment for: Pain and fever with allergic symptoms
Also treats: Allergic rhinitis, Urticaria, Nausea and vomiting
📋 Drug Information
| Generic Name(s) | Paracetamol (250mg) + Promethazine (5mg) |
| Brand Name | herpex syrup |
| Manufacturer | Biostrass Health Sciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not freeze. Keep the bottle tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Paracetamol reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system, though its exact mechanism is not fully understood. Promethazine is a phenothiazine antihistamine that blocks histamine H1 receptors, leading to reduced allergic symptoms, and also has anticholinergic and sedative effects by blocking muscarinic receptors and depressing the central nervous system.
Mechanism Steps
💡 How to Take herpex syrup
Strength: Each 5 mL of oral suspension contains Paracetamol 250 mg and Promethazine 5 mg.
Dosage Information
| Adult Dosage | The adult dosage of this medicine must be individualized by a qualified clinician based on the indication, age, weight, and renal and hepatic function. Typically, it is prescribed for short-term use. Do not self-medicate. Follow your doctor's instructions exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the sedative and anticholinergic effects of promethazine. Use with caution and lower doses may be required as determined by a clinician. |
| Renal Impairment | Dose adjustment may be necessary in patients with renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Paracetamol dose should be reduced or avoided in severe liver disease. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose of paracetamol should not exceed 4 grams (4000 mg) for adults, and promethazine should not exceed 100 mg per day. However, the exact maximum for this combination product must be determined by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of herpex syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Opioids | Major | |
| MAOIs | Major | |
| Anticholinergics | Moderate | |
| Alcohol | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- CNS depressants (e.g., opioids, benzodiazepines)
- Monoamine oxidase inhibitors (MAOIs)
⚡ Moderate Interactions
- Anticholinergics (e.g., atropine)
- Alcohol
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It increases the risk of liver damage from paracetamol and enhances the sedative effects of promethazine, leading to excessive drowsiness and impaired coordination.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to paracetamol, promethazine, or any component","Severe liver disease or severe hepatic impairment","Children under 2 years of age (unless directed by a doctor)","Patients with asthma or severe respiratory depression","Concurrent use with MAOIs"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Do not exceed recommended dose of paracetamol; risk of liver damage.","Avoid alcohol while taking this medicine.","Use with caution in elderly patients due to increased sensitivity to side effects.","Consult doctor before use in patients with glaucoma, urinary retention, or prostate enlargement.","May interfere with allergy skin testing; inform your doctor."]
🤱 Lactation Safety
Paracetamol is considered safe during breastfeeding. Promethazine may pass into breast milk and cause drowsiness in the infant; use with caution and consult your doctor.
💊 Overdose Management
Overdose of paracetamol can cause severe liver damage, which may be delayed. Seek immediate medical attention even if you feel well. Treatment includes activated charcoal if within 1-2 hours, and acetylcysteine as antidote. Promethazine overdose may cause severe drowsiness, seizures, and respiratory depression; supportive care is essential. Contact poison control or emergency services immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose, especially of paracetamol, as it can cause liver damage. Avoid alcohol while taking this medicine because it can increase the risk of liver problems and enhance drowsiness. This medicine may cause drowsiness; avoid driving or operating heavy machinery until you know how it affects you. Do not use this medicine for longer than directed without consulting your doctor. Keep out of reach of children. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine if you have severe liver disease or are allergic to any of its ingredients.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and anticholinergic effects of promethazine. Lower doses may be required. Also, the risk of liver and kidney problems is higher, so use with caution.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Paracetamol is generally considered safe, but promethazine should be used only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain and nausea, but only under medical supervision. It can interact with other medications used during surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with anesthetics or other medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities requiring alertness while taking this medicine due to the risk of drowsiness and dizziness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and impair your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also affect your ability to concentrate at work.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within a few days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been on long-term therapy without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use of paracetamol can increase the risk of liver damage, especially with high doses or alcohol. Promethazine may cause tolerance and dependence with long-term use. Regular monitoring of liver function may be required.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For pain and fever without allergic symptoms.
Evidence: Well-establishedFor allergic symptoms without pain or fever.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may be taken around the time of vaccinations if needed for fever or pain, but consult your doctor. It does not interact with vaccines.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from extreme heat or cold. If crossing time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Paracetamol starts working within 30-60 minutes, while promethazine's sedative effects may begin in 20-30 minutes.
A: It can be taken with or without food, but taking it with food may reduce stomach upset.
🤔 Common Patient Concerns
🔄 Substitutes for herpex syrup
View AllAlternative brands with exact same active ingredient:
-
Tyle P SyrupOsmed Formulations ₹21.00 25.1% CHEAPER
-
endol plus oral suspensionBangalore Antibiotics & Biologicals Pvt Ltd ₹34.00 21.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for everyone.
Fact: It is not safe for people with severe liver disease or those allergic to its components. - Myth: You can take extra doses if symptoms are severe.
Fact: Exceeding the dose can cause serious liver damage and other side effects.
🔄 Alternative Options
Generic Alternatives
- Paracetamol and Promethazine oral suspension