Hepamerz Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe abdominal pain or persistent vomiting
- Signs of allergic reaction such as rash, itching, swelling, or difficulty breathing
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Severe diarrhea or dehydration
- Unusual fatigue or confusion
If experiencing severe symptoms, call emergency services immediately.
What is hepan l 150mg/100mg tablet used for?
This medicine is a combination of L-Ornithine L-Aspartate and Pancreatin used to support liver function and aid digestion in conditions like chronic liver disease and pancreatic insufficiency. It works by reducing ammonia levels and providing digestive enzymes.
- Generic Name: L-Ornithine L-Aspartate (150mg) + Pancreatin (100mg)
- Manufacturer: Arrowin Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 hepan l 150mg/100mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लीवर की कार्यक्षमता को सुधारने और पाचन में मदद करने के लिए इस्तेमाल की जाती है। इसमें एल-ऑर्निथिन एल-एस्पार्टेट और पैंक्रिएटिन होते हैं। यह अमोनिया के स्तर को कम करती है और पाचन एंजाइम प्रदान करती है। यह पुरानी लीवर बीमारी, हेपेटिक एन्सेफेलोपैथी और पैंक्रियाटिक अपर्याप्तता में उपयोगी है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, दस्त, पेट दर्द और सूजन शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी प्रतिक्रिया हो सकती है। किसी भी असामान्य लक्षण के लिए डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें। शराब का सेवन न करें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। बच्चों की पहुंच से दूर रखें।
💊 hepan l 150mg/100mg tablet Uses & Benefits
[{"condition":"Chronic liver disease","description":"Supports liver function and reduces ammonia levels in patients with chronic liver disease.","evidence":"Moderate"},{"condition":"Hepatic encephalopathy","description":"Helps lower blood ammonia and improve mental status in hepatic encephalopathy.","evidence":"Moderate"},{"condition":"Pancreatic insufficiency","description":"Provides pancreatic enzymes to aid digestion in patients with exocrine pancreatic insufficiency.","evidence":"Well-established"},{"condition":"Fatty liver disease","description":"May improve liver enzyme levels and support liver health in non-alcoholic fatty liver disease.","evidence":"Limited"}]
Off-label uses: [{"condition":"Chronic pancreatitis","description":"Sometimes used to relieve symptoms of chronic pancreatitis, but evidence is limited.","evidence":"Limited"},{"condition":"Post-cholecystectomy diarrhea","description":"May be used off-label to manage diarrhea after gallbladder removal.","evidence":"Limited"}]
Primary treatment for: Chronic liver disease with pancreatic insufficiency
Also treats: Hepatic encephalopathy, Fatty liver disease, Chronic pancreatitis
📋 Drug Information
| Generic Name(s) | L-Ornithine L-Aspartate (150mg) + Pancreatin (100mg) |
| Brand Name | hepan l 150mg/100mg tablet |
| Manufacturer | Arrowin Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a cool, dry place. Protect from light and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. L-Ornithine L-Aspartate provides substrates for the urea cycle, enhancing the conversion of ammonia to urea in the liver, which is then excreted by the kidneys. This helps reduce blood ammonia levels, which can be neurotoxic in liver disease. Pancreatin is a mixture of digestive enzymes (amylase, lipase, and protease) that substitute for deficient pancreatic enzymes, aiding the breakdown and absorption of carbohydrates, fats, and proteins in the small intestine. Together, they support liver detoxification and improve digestion.
Mechanism Steps
💡 How to Take hepan l 150mg/100mg tablet
Strength: Tablet containing L-Ornithine L-Aspartate 150 mg and Pancreatin 100 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times a day with meals, or as directed by your physician. The dose may vary depending on the indication, severity of liver disease, and pancreatic insufficiency. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal and hepatic function. Use with caution and monitor closely. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment, but use with caution and monitor liver function. |
| Maximum Daily Dose | The maximum daily dose should not exceed 3 tablets per day, or as prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of hepan l 150mg/100mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Antacids | Major | |
| Oral iron | Major | |
| Proton pump inhibitors | Moderate | |
| H2 blockers | Moderate | |
| Antidiabetics | Minor |
🚨 Major Interactions
- Antacids containing calcium or magnesium
- Oral iron supplements
⚡ Moderate Interactions
- Proton pump inhibitors (e.g., omeprazole)
- H2 receptor antagonists (e.g., ranitidine)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can worsen liver damage and may reduce the effectiveness of L-Ornithine L-Aspartate. It can also increase the risk of gastrointestinal side effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to L-Ornithine L-Aspartate or Pancreatin","Severe renal impairment","Acute pancreatitis","Acute exacerbation of chronic pancreatitis"]
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment.","Use with caution in patients with liver disease; monitor liver function.","Pancreatin may increase uric acid levels; monitor in patients with gout.","Do not use in patients with known hypersensitivity to pork proteins (pancreatin may be derived from porcine pancreas).","Consult doctor before use in pregnancy and lactation.","Avoid alcohol consumption.","Do not exceed the recommended dose."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before use.
💊 Overdose Management
Overdose of this medicine may cause gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal pain. In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive. Monitor for signs of hyperuricemia or allergic reactions.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet; swallow it whole with a glass of water. It is best taken with meals to enhance absorption and reduce stomach upset. Do not exceed the recommended dose. Inform your doctor if you have kidney or liver disease, diabetes, or any allergies. Avoid alcohol while taking this medicine as it may worsen liver condition. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children. Store in a cool, dry place away from direct sunlight. Do not use after the expiry date. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal or hepatic function. Use with caution and monitor closely. Dose adjustment may be necessary.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy. Safety during pregnancy is not established.
🏥 Post-Surgery Considerations
Consult your doctor before resuming this medicine after surgery. It is generally safe but may need to be withheld if you are unable to take oral medications.
🦷 Dental Procedures
No specific precautions. Inform your dentist about all medicines you take.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe. Avoid strenuous activities if you have severe liver disease or fatigue. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is not known to impair driving or operating machinery. However, if you experience dizziness or fatigue, avoid these activities until you feel better.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when taken as prescribed. Regular monitoring of liver and kidney function is recommended. Pancreatin may rarely cause hyperuricemia or fibrosing colonopathy with high doses. L-Ornithine L-Aspartate is well-tolerated. Do not stop without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A low-fat, high-fiber diet can complement treatment for liver and pancreatic conditions.
Evidence: Well-establishedCan help manage fatigue and improve quality of life.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, patients with chronic liver disease should receive hepatitis A and B vaccines as recommended by their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from light and moisture. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The digestive effects of pancreatin begin within 30 minutes to 1 hour. The effect on ammonia levels may take several days to weeks.
A: Inform your doctor about all medicines you take. Some interactions may require dose adjustments or separation of administration.
A: Consult your doctor before use. Safety is not established.
🤔 Common Patient Concerns
🔄 Substitutes for hepan l 150mg/100mg tablet
View AllAlternative brands with exact same active ingredient:
-
hepzem tabletZeelab Pharmacy Pvt Ltd ₹24.00 96.6% CHEAPER
-
davaindia l-ornithine l-aspartate+pancreatin 150mg/100mg tabletDavaindia Generic Pharmacy ₹28.00 96% CHEAPER
-
hepacure pn 150 mg/100 mg tabletMission Research Laboratories Pvt Ltd ₹45.54 93.5% CHEAPER
-
cegelec 150mg/100mg tabletMedicamen Biotech Ltd ₹46.00 93.4% CHEAPER
-
hepa gard 150mg/100mg tabletVermilion Healthcare Pvt Ltd ₹54.84 92.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure all liver diseases.
Fact: This medicine supports liver function but does not cure all liver diseases. It is used as part of a comprehensive treatment plan. - Myth: It can be taken without a prescription.
Fact: This medicine is a prescription drug and should only be taken under medical supervision.
🔄 Alternative Options
Generic Alternatives
- L-Ornithine L-Aspartate + Pancreatin combination tablets from other manufacturers
Brand Alternatives
- Hepamerz
- Other brands containing L-Ornithine L-Aspartate and Pancreatin