Histac 300 Tablet (ranitidine 300mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain that does not go away
- Difficulty breathing or swelling of face, lips, or throat
- Yellowing of skin or eyes (jaundice)
- Unusual bruising or bleeding
- Confusion, hallucinations, or severe dizziness
- Very slow or irregular heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is h2loc 300mg tablet used for?
This medicine contains Ranitidine 300 mg, an H2-receptor antagonist that reduces stomach acid. It is used to treat ulcers, GERD, and heartburn. It works by blocking histamine H2 receptors on stomach cells. Take it exactly as prescribed by your doctor.
- Generic Name: Ranitidine (300mg)
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 h2loc 300mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा रैनिटिडीन 300 मिलीग्राम युक्त एक टैबलेट है जो पेट में एसिड का उत्पादन कम करती है। इसका उपयोग पेट और आंतों के अल्सर, गैस्ट्रोएसोफेजियल रिफ्लक्स रोग (जीईआरडी), और सीने में जलन के इलाज के लिए किया जाता है। यह दवा एच2 रिसेप्टर को ब्लॉक करके एसिड को कम करती है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, कब्ज, दस्त, मतली और पेट में असुविधा शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। दुर्लभ मामलों में भ्रम, हृदय गति में धीमापन, या रक्त विकार हो सकते हैं। यदि आपको असामान्य खून बहना, चकत्ते, या पीलिया जैसे लक्षण दिखें तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे पानी के साथ पूरा निगलें, चबाएं नहीं। भोजन के साथ या बिना भोजन के ले सकते हैं, लेकिन पेट खराब होने पर भोजन के साथ लें। शराब का सेवन न करें। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। गुर्दे या यकृत की समस्या हो तो डॉक्टर को बताएं। बच्चों की पहुंच से दूर रखें। सूखी और ठंडी जगह पर स्टोर करें।
💊 h2loc 300mg tablet Uses & Benefits
[{"condition":"Duodenal ulcer","description":"This medicine is used to treat active duodenal ulcers and to prevent their recurrence by reducing stomach acid production.","evidence":"Well-established"},{"condition":"Gastric ulcer","description":"This medicine helps heal benign gastric ulcers and reduces the risk of ulcer recurrence.","evidence":"Well-established"},{"condition":"Gastroesophageal reflux disease (GERD)","description":"This medicine reduces acid reflux symptoms such as heartburn and helps heal damage to the esophagus.","evidence":"Well-established"},{"condition":"Zollinger-Ellison syndrome","description":"This medicine is used to manage excessive stomach acid production in this rare condition.","evidence":"Well-established"},{"condition":"Heartburn and acid indigestion","description":"This medicine provides relief from occasional heartburn and acid indigestion by reducing stomach acid.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prevention of stress ulcers in critically ill patients","description":"Sometimes used off-label in hospital settings to prevent stress-related gastrointestinal bleeding.","evidence":"Limited"},{"condition":"Aspiration pneumonitis prophylaxis","description":"Occasionally used before surgery to reduce the risk of acid aspiration during anesthesia.","evidence":"Limited"}]
Primary treatment for: Duodenal ulcer
Also treats: Gastric ulcer, Gastroesophageal reflux disease, Zollinger-Ellison syndrome, Heartburn
📋 Drug Information
| Generic Name(s) | Ranitidine (300mg) |
| Brand Name | h2loc 300mg tablet |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | H2 Receptor Blocker |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Keep away from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by competitively blocking histamine H2 receptors located on the parietal cells of the stomach. By blocking these receptors, it prevents histamine from stimulating acid production. This leads to a reduction in both the volume of gastric acid secreted and the concentration of hydrogen ions in the stomach. It also reduces pepsin output. This medicine does not affect the production of intrinsic factor or gastrin. The acid-suppressing effect helps create an environment that allows ulcers to heal and reduces symptoms of acid reflux.
Mechanism Steps
💡 How to Take h2loc 300mg tablet
Strength: Immediate-release tablet, 300 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine for active duodenal ulcer is 150 mg twice daily or 300 mg once daily at bedtime. For maintenance therapy, 150 mg once daily at bedtime is common. For GERD, 150 mg twice daily is often used. For Zollinger-Ellison syndrome, higher doses may be needed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require dose adjustment based on kidney function. Use with caution and monitor for side effects such as confusion. |
| Renal Impairment | In patients with kidney impairment, the dose should be reduced. For creatinine clearance less than 50 mL/min, the usual dose is 150 mg once daily or 150 mg every 24 hours. Consult your doctor for personalized dosing. |
| Hepatic Impairment | No specific dose adjustment is usually required for mild to moderate liver impairment. Use with caution in severe liver disease. |
| Maximum Daily Dose | The maximum recommended daily dose is 300 mg for most indications, but higher doses may be used in Zollinger-Ellison syndrome under medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of h2loc 300mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Itraconazole | Major | |
| Atazanavir | Major | |
| Warfarin | Moderate | |
| Phenytoin | Moderate | |
| Theophylline | Moderate | |
| Antacids | Minor | |
| Metoclopramide | Minor |
🚨 Major Interactions
- Ketoconazole
- Itraconazole
- Atazanavir
⚡ Moderate Interactions
- Warfarin
- Phenytoin
- Theophylline
🍷 Alcohol Interaction
Avoid drinking alcohol while taking this medicine. Alcohol can increase stomach acid production and may worsen the condition being treated. It can also increase the risk of stomach irritation and bleeding.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ranitidine or any component of the tablet","Acute porphyria"]
⚠️ Warnings & Precautions
["Use with caution in patients with kidney impairment; dose adjustment may be needed.","Use with caution in patients with liver disease.","Elderly patients may be more sensitive to side effects such as confusion.","Do not use for minor stomach upset without medical advice.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose.","Consult your doctor if symptoms persist or worsen."]
🤱 Lactation Safety
This medicine passes into breast milk in small amounts. It is generally considered compatible with breastfeeding, but consult your doctor before use while nursing.
💊 Overdose Management
If you suspect an overdose, seek emergency medical attention immediately. Symptoms of overdose may include severe dizziness, fainting, or irregular heartbeat. Treatment is supportive and symptomatic. There is no specific antidote. Hemodialysis may be considered in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose on your own. Swallow the tablet whole with a glass of water; do not crush or chew it unless your doctor advises otherwise. This medicine can be taken with or without food, but taking it with food may help if you experience stomach upset. Avoid alcohol while taking this medicine because it can increase stomach acid and worsen your condition. Tell your doctor about all other medicines you are taking, especially ketoconazole, itraconazole, atazanavir, or blood thinners, as this medicine can interact with them. If you have kidney or liver problems, your doctor may need to adjust your dose. Do not use this medicine for longer than recommended without medical supervision. Keep this medicine out of the reach of children. Store it at room temperature away from moisture and direct sunlight. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Do not drive or operate heavy machinery if you feel dizzy after taking this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially confusion and dizziness. Dose adjustment may be needed based on kidney function. Monitor closely for any changes in mental status.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is generally considered safe, but your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
If you are undergoing surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may affect stomach acid levels during anesthesia. Your doctor may advise you to continue or temporarily stop it.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It is generally safe, but your dentist may take precautions if you have a history of ulcers or bleeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine. However, if you experience dizziness or fatigue, avoid strenuous activities. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. If you feel dizzy, avoid driving or operating heavy machinery. Otherwise, it should not significantly affect your daily activities. Take it as prescribed to manage your symptoms effectively.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. Your doctor will advise you on when and how to stop safely.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe, but some patients may experience vitamin B12 deficiency or increased risk of bone fractures with prolonged high-dose use. Regular monitoring may be needed if you take it for a long time. Do not use it for longer than recommended without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines like omeprazole or pantoprazole may be used as alternatives for more potent acid suppression.
Evidence: Well-establishedDietary changes, weight loss, and avoiding trigger foods can help manage acid reflux.
Evidence: Well-establishedIn severe cases of GERD or ulcers, surgery may be considered.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccinations as scheduled.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from moisture and direct sunlight. If crossing time zones, continue taking your doses at the same intervals as prescribed, but consult your doctor for specific advice. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts reducing stomach acid within 1 hour, but symptom relief may take a few days. Ulcer healing may take several weeks.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: It is generally considered safe, but you should only take it if prescribed by your doctor.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for h2loc 300mg tablet
View AllAlternative brands with exact same active ingredient:
-
afdiloc 300mg tabletAnglo-French Drugs & Industries Ltd ₹2.81 70.1% CHEAPER
-
veran 300mg tabletVega Pharma ₹6.56 30.2% CHEAPER
-
gertac 300mg tabletZydus Cadila ₹7.81 16.9% CHEAPER
-
renitab 300mg tabletMicro Labs Ltd ₹8.16 13.2% CHEAPER
-
zantid 300mg tabletJarson Pharmaceuticals ₹8.33 11.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure ulcers instantly.
Fact: This medicine helps reduce acid and allows ulcers to heal, but healing takes time. Complete the full course as prescribed. - Myth: This medicine is safe to take with any other medicine.
Fact: This medicine can interact with several drugs, including ketoconazole and warfarin. Always inform your doctor about all medicines you take. - Myth: You can stop this medicine as soon as you feel better.
Fact: Do not stop this medicine without consulting your doctor. Stopping early may cause symptoms to return or ulcers to recur.
🔄 Alternative Options
Generic Alternatives
- Ranitidine 300 mg tablet
Brand Alternatives
- Histac 300 tablet