Dompimol Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Irregular heartbeat or palpitations
- Severe abdominal pain or distension
- Blood in vomit or stool
- Yellowing of skin or eyes (jaundice)
- Difficulty breathing or swelling of face, lips, or throat
- Uncontrollable muscle spasms or tremors
- Decreased urine output or dark urine
If experiencing severe symptoms, call emergency services immediately.
What is grenil 5mg/250mg suspension used for?
This medicine is a combination of domperidone and paracetamol used to treat nausea, vomiting, and associated pain or fever. It works by improving stomach emptying and reducing pain signals.
- Generic Name: Domperidone (5mg) + Paracetamol (250mg)
- Manufacturer: Karnataka Antibiotics & Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 grenil 5mg/250mg suspension के बारे में (Hindi Summary)
उपयोग: यह दवा डोम्पेरिडोन और पैरासिटामोल का संयोजन है, जिसका उपयोग मतली, उल्टी, पेट में ऐंठन और दर्द या बुखार के इलाज के लिए किया जाता है। यह पेट की गति को सुधारती है और दर्द को कम करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मुँह सूखना, सिरदर्द, नींद आना और पेट में हल्की ऐंठन शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन दिल की धड़कन अनियमित हो सकती है। यदि आपको सांस लेने में कठिनाई, चक्कर आना या त्वचा पर चकत्ते दिखें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। उपयोग से पहले बोतल को अच्छी तरह हिलाएं। सटीक माप के लिए मापने वाला कप या सिरिंज का उपयोग करें। इस दवा के साथ शराब न पिएं। यदि आपको दिल, जिगर या गुर्दे की समस्या है तो डॉक्टर को बताएं।
💊 grenil 5mg/250mg suspension Uses & Benefits
[{"condition":"Nausea and vomiting","description":"This medicine helps relieve nausea and vomiting by improving gastric emptying and reducing dopamine activity in the chemoreceptor trigger zone.","evidence":"Well-established"},{"condition":"Gastroparesis","description":"It is used to manage symptoms of delayed gastric emptying, such as bloating, nausea, and early satiety.","evidence":"Moderate"},{"condition":"Functional dyspepsia","description":"This combination may help reduce upper abdominal discomfort and nausea associated with functional dyspepsia.","evidence":"Moderate"},{"condition":"Migraine-associated nausea and pain","description":"The domperidone component helps with nausea, while paracetamol provides pain relief.","evidence":"Limited"}]
Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes prescribed off-label to improve gastric emptying in diabetic patients.","evidence":"Limited"},{"condition":"Prevention of chemotherapy-induced nausea","description":"May be used off-label as an adjunct antiemetic, though not first-line.","evidence":"Limited"}]
Primary treatment for: Nausea and vomiting
Also treats: Gastroparesis, Functional dyspepsia, Migraine-associated nausea
📋 Drug Information
| Generic Name(s) | Domperidone (5mg) + Paracetamol (250mg) |
| Brand Name | grenil 5mg/250mg suspension |
| Manufacturer | Karnataka Antibiotics & Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not freeze. Keep the bottle tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and the gastrointestinal tract. This blockade enhances gastric motility and accelerates gastric emptying without significant central nervous system effects because it does not readily cross the blood-brain barrier. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which reduces pain and fever. The combination provides symptomatic relief from nausea, vomiting, and associated pain or fever.
Mechanism Steps
💡 How to Take grenil 5mg/250mg suspension
Strength: Each 5 mL of suspension contains Domperidone 5 mg and Paracetamol 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10 mL (containing domperidone 5 mg and paracetamol 250 mg) taken up to three times daily, preferably before meals. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and clinical response. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine. Use with caution and adjust dose as needed based on renal and hepatic function. Consult a doctor for individualized dosing. |
| Renal Impairment | In patients with severe renal impairment (creatinine clearance < 30 mL/min), domperidone should be used with caution and dose reduction may be necessary. Paracetamol generally does not require dose adjustment in renal impairment, but frequent use should be avoided. |
| Hepatic Impairment | In patients with hepatic impairment, domperidone should be used with caution due to extensive hepatic metabolism. Paracetamol dose should be reduced or avoided in severe hepatic impairment to prevent liver toxicity. |
| Maximum Daily Dose | The maximum daily dose should not exceed 30 mL (domperidone 15 mg and paracetamol 750 mg) in adults. However, the exact maximum dose must be determined by a clinician based on individual factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of grenil 5mg/250mg suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Warfarin | Major | |
| Alcohol | Major | |
| Metoclopramide | Moderate | |
| Atropine | Moderate | |
| Carbamazepine | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor | |
| Ritonavir | Major | |
| Amiodarone | Major |
🚨 Major Interactions
- Ketoconazole, itraconazole, clarithromycin
- Warfarin
- Alcohol
⚡ Moderate Interactions
- Metoclopramide
- Anticholinergic drugs (e.g., atropine)
- Enzyme-inducing drugs (e.g., carbamazepine, phenytoin)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from paracetamol and may worsen drowsiness or dizziness caused by domperidone.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to domperidone or paracetamol","Severe hepatic impairment","Known QT prolongation or congenital long QT syndrome","Gastrointestinal bleeding, obstruction, or perforation","Prolactin-releasing pituitary tumor (prolactinoma)","Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)","Severe renal impairment (CrCl < 30 mL/min)"]
⚠️ Warnings & Precautions
["Use with caution in patients with heart disease or electrolyte imbalances.","Avoid in patients with known QT prolongation.","Do not exceed recommended dose of paracetamol to prevent liver damage.","Use with caution in elderly patients due to increased risk of side effects.","May cause drowsiness; avoid driving or operating machinery until effects are known.","Consult doctor before use in pregnancy or breastfeeding.","Do not use for prolonged periods without medical supervision."]
🤱 Lactation Safety
Domperidone is excreted in breast milk in small amounts. It may increase prolactin levels and milk production, but its use during breastfeeding should be discussed with a doctor. Paracetamol is considered safe during breastfeeding at recommended doses.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage from paracetamol and cardiac arrhythmias from domperidone. Seek immediate medical attention. Treatment includes activated charcoal if within 1-2 hours, N-acetylcysteine for paracetamol toxicity, and supportive care for domperidone effects. Monitor ECG and liver function.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Shake the bottle well before each use to ensure the medicine is evenly mixed. Use a proper measuring device to measure the dose accurately. Avoid drinking alcohol while taking this medicine as it can increase the risk of liver damage. Do not take other medicines containing paracetamol without consulting your doctor. Inform your doctor if you have heart, liver, or kidney problems before starting this medicine. Do not drive or operate heavy machinery if you feel drowsy after taking this medicine. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to side effects such as drowsiness, dizziness, and cardiac arrhythmias. Use with caution and monitor renal and hepatic function. Dose adjustment may be necessary.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Domperidone should be used only if clearly needed. Paracetamol is generally considered safe at recommended doses.
🏥 Post-Surgery Considerations
This medicine may be used post-operatively for nausea and vomiting, but consult your surgeon before use, especially if you have underlying heart conditions.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with certain anesthetics or medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise immediately after taking this medicine, especially if you feel drowsy or dizzy. Light activities like walking may help digestion.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some individuals. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take it when you can rest if needed.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if symptoms persist beyond 7 days, if you experience serious side effects, or if you develop signs of an allergic reaction. Do not stop abruptly if you have been on long-term therapy without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of cardiac arrhythmias, extrapyramidal symptoms, and hyperprolactinemia. Regular monitoring of ECG, liver function, and prolactin levels may be required. It should be used for the shortest duration necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Small, frequent meals and avoiding trigger foods can help manage nausea and gastroparesis.
Evidence: Well-establishedNatural antiemetic that may help with mild nausea.
Evidence: ModerateMay reduce nausea and vomiting in some patients.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription in case of customs checks. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing times gradually to maintain consistent intervals. Do not leave it in a hot car or checked luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30-60 minutes after oral administration.
A: Consult your doctor before taking any other medicines, as interactions may occur.
A: Pediatric dosing must be determined by a pediatrician; do not self-administer to children.
A: Take it as soon as you remember, but skip if it's almost time for the next dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for grenil 5mg/250mg suspension
View AllAlternative brands with exact same active ingredient:
-
dompimol suspensionEsquire Drug House ₹20.63 56% CHEAPER
-
athdom p 5 mg/250 mg suspensionAthens Labs Ltd ₹22.20 52.6% CHEAPER
-
degrain oral suspensionReantis Pharmaceuticals Pvt. Ltd. ₹35.00 25.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any stomach upset.
Fact: It is specifically for nausea, vomiting, and related conditions; it is not a general stomach remedy. - Myth: It is safe to take with alcohol.
Fact: Alcohol increases the risk of liver damage and should be avoided. - Myth: It can be used long-term without monitoring.
Fact: Prolonged use requires medical supervision due to potential side effects.
🔄 Alternative Options
Generic Alternatives
- Domperidone + Paracetamol suspension (generic)